现代医学模式下亚健康概念特征属性的思考及其意义

通过系统回顾近10余年亚健康概念的研究,认为现阶段亚健康概念的研究中存在有亚健康特征属性没有明确、概念内涵与表述方式的冲突以及辨识标准缺乏共识等局限,提出亚健康现代医学模式健康观的概念内容与其生物医学模式下表述方式的冲突是导致亚健康特征属性认识歧义的根源。认为我们应基于现代医学模式下健康的概念来定义亚健康的特征属性,应建立以临床不适与生存质量为核心的亚健康状态测量与辨识标准。提出亚健康的特征属性是指非疾病所致的躯体上、心理上不适或社会适应能力降低的健康不完满或低质量状态及其体验。本文还就亚健康状态持续时间等实际问题提出了自己的看法。     

数据挖掘在中医学术流派研究中的应用

在中医学术流派研究中存在着大量的数据,利用数据挖掘技术可以获得隐藏在这些数据中的有用信息。文章结合赵炳南学术流派研究的实例,简要阐述了利用数据挖掘进行中医学术流派研究的可行性和先进性,并提出了数据挖掘的实施步骤和具体的工具、算法。     

十八反、十九畏文献研究

目的:在文献整理的基础上,分析研究古今人们对中药配伍禁忌的经验、认识,归纳整理包含十八反、十九畏等药物在内的中药配伍禁忌药物,方便临床查阅。方法:本研究采用文献研究的方法,主要检索建国后中国期刊全文数据库所收载的有关中药配伍禁忌研究的期刊文献,选取具有代表性且重要性的文献资料,进行归类整理分析。结论:文献研究表明十八反、十九畏不是绝对的临床配伍禁忌,在有限制的条件下,部分可以同方使用的。     

论计算针灸学

21世纪是信息科学时代,信息的载体就是数据。计算机等学科的迅猛发展,为针灸学领域储备了大量的数据,但是这些数据背后蕴含哪些尚未发现的特征与规律,缺乏系统深入的挖掘研究,严重制约了针灸学的学科发展。作为传统针灸学与现代科学相结合而形成的新兴前沿交叉学科,计算针灸学应运而生,以针灸学中的现象和规律、理论作为研究对象,以解决针灸医学的关键科学问题和提高针灸临床疗效为最终目标,为针灸科学研究铺开一条多学科交叉融合的高速路。     

中医临床实践指南中高血压病中医辨证分类及中成药使用概况

近年来我国高血压病患病率逐年上升,中医药在防治高血压病方面有重要作用。目前,高血压病中医辨证诊断和中成药使用混乱,中医临床实践指南是规范临床诊疗技术的行业标准,可以指导临床诊断、用药,从而提高临床疗效。现从高血压病中医临床实践指南的角度介绍高血压病中医证类、主症及对证中成药,以便于指导临床合理、规范使用中成药。     

"调肾阴阳"法治疗虚证

补虚之法,历有分歧,“健脾”与“补肾”各执己见。中国中医科学院著名中医学家沈绍功教授深刻领悟了张景岳的“阴阳论”,并结合几十年的临床经验,倡导“健脾不如补肾,补肾不如调肾”的观点,并自拟“调肾阴阳方”,用于虚证治疗,疗效极著。     

上市后降血压药物的不良反应研究概况

高血压病为临床上常见的严重危害人类健康的病症,其发病率高居榜首且逐年上升。将高血压患者的血压控制在正常或理想水平,可以减少并发症的发生,提高患者的生活质量,但是高血压患者必须坚持长期（或终身）规律性用药,这是当前治疗高血压病及预防高血压并发症的唯一有效方法。但在用药过程中,由于个体差异的因素,某些患者在服药过程中会有异常表现。现介绍近十年抗高血压药的主要不良反应。     

中药疗法改善中度氟骨症患者肢体关节功能的随机对照研究

Objective To observe the improving effect in joint function of moderate skeletal fluorosis treated by traditional Chinese medication(main ingredient was Strychnine).Methods From December 2007 to July 2009,120 moderate skeletal fluorosis patients met the inclusion criteria were divided into the treatment group(60 cases)and the control group(60 cases)in the skeletal fluorosis hospital of Xinzhou,the treatment group was given basic treatment and traditional Chinese medication,the control group wa8 given basic treatment and placebo.The treatment lasted 12 weeks,follow up 24 weeks.Before treatment,after treatment 4 weeks,8 weeks,12 weeks,36 weeks,a third party evaluate comprehensive function of both upper and lower limb and joint dysfunction.Results The main effect of both drugs was statistically significance in the scores of the upper forearm in the finger by touching the posterior contralateral ear, upper arm touched by the finger back in the opposite corner subscapularis function, lower limb function and single-joint dysfunction(F values were 4.08,14.32,35.81,13.02, all P<0.05), the main effect of time also was significant (F values were 82.63,72.82,277.33,328.16, all P<0.05),①the upper forearm in the finger by touching the posterior contralateral ear functions:At the time of 8,12 weeks,scores of the treatment group were lower than those of before treatment and control group (all P<0.05);At the time of 36 weeks,scores of the treatment group were lower than that 12 weeks(all P<0.05);At the time of 8,12,36 weeks, scores of the control group were lower than those of before treatment(all P < 0.05);②upper arm function, namely fingers touching the opposite corner subscapularis:At the time of 4,8,12 weeks, scores of the treatment group were lower than those of before treatment(all P<0.05); At the time of 36 weeks, scores of the treatment group were lower than that 12 weeks(all P<0.05); At the time of 8,12,36 weeks, scores of the treatment group were lower than those of the control group (all P<0.05);③Lower extremity functions: At the time of 8,12 weeks,scores of the treatment group were lower than those of before treatment and control group (all P<0.05);At the time of 36 weeks, scores of the treatment group were lower than that 12 weeks(all P<0.05) ; At the time of 8,12,36 weeks, scores of the control group were lower than those of before treatment (all P<0.05);④single joint functions:At the time of 4,8,12 weeks,scores of the treatment group were lower than those of before treatment(all P<0.05); At the time of 36 weeks,scores of the treatment group were lower than that 12 weeks(all P<0.05) ; At the time of 8,12,36 weeks, scores of the control group were lower than those of before treatment(all P<0.05);At the time of 4,8,12,36 weeks, scores of the treatment group were lower than those of control group(all P<0.05);⑤At the end of treatment and follow-up,the improvement rate in joint functions in the treatment group were 88.33% (53/60),93.33% (56/60); the control group were 28.07%(16/57),40.35%(23/57), (Fisher test, P<0.01,X2=56.21, P<0.01). Conclusion Traditional Chinese medication(its main ingredient is Strychnine), an effective drug for improving joint dysfunction in patients suffering from moderate skeletal fluorosis, is simple and effective.     

基于个体化诊疗平台2型糖尿病合并代谢综合征证候规律研究

目的基于个体化诊疗数据采集平台,探讨265例2型糖尿病合并代谢综合征的证候特征、分布及演变趋势。方法采集来自多中心的临床病例,运用无尺度网络等数据挖掘方法对其进行分层、横断面研究。结果病程>10年者,其血瘀、气虚、阴虚发生率均较其它组高(P<0.001或0.01),血瘀证的发生率最高,达95.08%,其发生构成比是:血瘀>气虚>阴虚>湿热>热盛>血虚。病程5～10年者证候发生构成比:热盛>气虚>血瘀>阴虚>湿热>血虚。病程<5年者证候发生构成比:热盛>气虚>血瘀>湿热>阴虚。结论2型糖尿病合并代谢综合征的证候特征随病程的增加而表现为:阴虚热盛、气虚阴虚、气虚血瘀的演变过程。血瘀证贯穿于整个病程始终,兼夹证呈多样性、个体化分布。     

四君子汤对利血平所致脾虚大鼠肠道黏膜TGF-β和TNF-α表达的影响

目的:观察四君子汤对利血平所致脾虚大鼠肠道黏膜免疫功能的影响。方法:雄性SD大鼠120只,腹腔注射利血平造成大鼠脾虚模型,四君子汤作为治疗药物,并分高、低剂量组,选用阿托品作为阳性对照药,并设自然恢复组与治疗组相对比。进行小肠PP结计数;并运用流式细胞仪检测PP结中T细胞亚群含量;ABC染色法,并运用图像分析空肠中细胞因子(TNF-α和TGF-β)的表达。结果:各组间在小肠PP结数量及其中的T淋巴细胞亚群无显著差异。模型组大鼠的空肠中TGF-β的表达较正常组降低,四君子汤高剂量组空肠内TGF-β表达较脾虚组显著升高,但与正常组亦有显著差异(P<0.05)。阳性药物和自然恢复组的TGF-β含量较脾虚组无显著差异,显著降低于正常组(P<0.05)。模型组大鼠的空肠中TNF-α的表达较正常组显著升高(P<0.05),而四君子汤低剂量组、高剂量组、阿托品组及自然恢复组的TNF-α表达均较脾虚组显著降低(P<0.05)。结论:四君子汤可以通过增加空肠内TGF-β表达,降低TNF-α表达,对利血平脾虚大鼠黏膜免疫功能有一定的调节作用,对PP结数量及其中的T淋巴细胞亚群无显著影响。