全文获取类型
收费全文 | 2638篇 |
免费 | 375篇 |
国内免费 | 228篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 58篇 |
妇产科学 | 91篇 |
基础医学 | 169篇 |
口腔科学 | 46篇 |
临床医学 | 462篇 |
内科学 | 395篇 |
皮肤病学 | 14篇 |
神经病学 | 86篇 |
特种医学 | 79篇 |
外国民族医学 | 2篇 |
外科学 | 330篇 |
综合类 | 578篇 |
预防医学 | 152篇 |
眼科学 | 35篇 |
药学 | 295篇 |
3篇 | |
中国医学 | 142篇 |
肿瘤学 | 280篇 |
出版年
2024年 | 16篇 |
2023年 | 198篇 |
2022年 | 281篇 |
2021年 | 247篇 |
2020年 | 203篇 |
2019年 | 137篇 |
2018年 | 78篇 |
2017年 | 74篇 |
2016年 | 83篇 |
2015年 | 133篇 |
2014年 | 295篇 |
2013年 | 256篇 |
2012年 | 267篇 |
2011年 | 258篇 |
2010年 | 173篇 |
2009年 | 156篇 |
2008年 | 92篇 |
2007年 | 97篇 |
2006年 | 88篇 |
2005年 | 44篇 |
2004年 | 11篇 |
2003年 | 7篇 |
2002年 | 6篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1998年 | 4篇 |
1997年 | 6篇 |
1996年 | 1篇 |
1995年 | 4篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 3篇 |
排序方式: 共有3241条查询结果,搜索用时 729 毫秒
1.
Xiao-Long Tang Yan-Dong Miao Deng-Hai Mi 《World journal of gastrointestinal oncology》2022,14(1):366-368
The present letter to the editor is in response to the research “Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis” by Elshaarawy et al in World J Gastroenterol 2021; 13(5): 424–439. The preoperative assessment of the liver reserve function in hepatocellular carcinoma (HCC) patients with cirrhosis is crucial, and there is no universal consensus on how to assess it. Based on a retrospective study, Elshaarawy et al investigated the impact of various classical clinical indicators on liver failure and the prognosis after hepatectomy in HCC patients with cirrhosis. We recommend that we should strive to explore new appraisal indicators, such as the indocyanine green retention rate at 15 min. 相似文献
2.
Qiangsheng He Chongfei Huang Xiwen Qin Yuanyuan Yu Di Tang Junjie Huang Zi Chong Kuo Yuyao Ling Deli Mao Bin Xia Wenjing Li Kuiqing Lu Man Yang Yulong He Wenbo Meng Jinqiu Yuan Yihang Pan 《International journal of cancer. Journal international du cancer》2023,153(5):942-949
Recent epidemiological studies suggested that proton pump inhibitor (PPI) use was associated with an increased risk of biliary tract cancer (BTC), however, confounders were not adequately controlled. Our study aimed to evaluate PPI use and subsequent risk of BTC and its subtypes in three well-established cohorts. We conducted a pooled analysis of the subjects free of cancers in UK Biobank (n = 463 643), Nurses' Health Study (NHS, n = 80 235) and NHS II (n = 95 869). Propensity score weighted Cox models were used to estimate marginal HRs of PPIs use on BTC risk, accounting for potential confounders. We documented 284 BTC cases in UK Biobank (median follow-up: 7.6 years), and 91 cases in NHS and NHS II cohorts (median follow-up: 15.8 years). In UK biobank, PPI users had a 96% higher risk of BTC compared to nonusers in crude model (HR 1.96, 95% CI 1.44-2.66), but the effect was attenuated to null after adjusting for potential confounders (HR 0.95, 95% CI 0.60-1.49). PPI use was not associated with risk of BTC in the pooled analysis of three cohorts (HR 0.93, 95% CI 0.60-1.43). We also observed no associations between PPI use with risk of intrahepatic (HR 1.00, 95% CI 0.49-2.04), extrahepatic bile duct (HR 1.09, 95% CI 0.52-2.27) and gallbladder cancers (HR 0.66, 95% CI 0.26-1.66) in UK Biobank. In summary, regular use of PPIs was not associated with the risk of BTC and its subtypes. 相似文献
3.
穴位埋线是长效针灸,是在传统针具和针法基础上建立和发展起来的,是针灸技术的发展和延伸,穴位埋线的核心技术是穿刺技术,穴位埋线的三大要素中,针具、埋藏物、穿刺技巧之间是互相影响、互相促进的。针具的改进成功实现了穴位埋线疗法的第一次飞跃,埋藏物的改进成功实现了穴位埋线疗法的第二次飞跃,穿刺技术的改进和创新是穴位埋线疗法的第三次飞跃。 相似文献
4.
Jingjing He Lingyi Zhang Dan Guo Xingwen Han Hui Zhang Liang Wang Youcheng
Zhang 《Oncologie》2020,22(1):1-12
Hepatocellular carcinoma (HCC) ranks the sixth place of most common
cancers. Meanwhile, it is the tertiary mortality cause of cancer. There is no
effective therapeutic method to prevent and treat the liver cancer. Sinomenine is a
kind of Chinese traditional medicine herbal, it is reported that it can inhibit the
viability of several cancer cells. The study is to explore whether sinomenine is also
able to inhibit the cell viability of HCC and its potential mechanism. The IC50 of
sinomenine in BEL-7402 cells was 5.351 mmol/L, and the IC50 of sinomenine in
SMMC-7721 cells was 6.204 mmol/L. The gene expression results showed the
relative expression of FGF2, CCND2, DCN, F3, MMP7, NRG1, HMGB1,
TRIM29, HAS2, EHF, CTGF, PLK2 were down-regulated, and the relative
expression of VEGF A, CITED2, NUPR1, DDX58, IRF9, NAMPT, MMP1,
NDRG1, HMGA2, PPARGC1A, IFIT2, PARP9, HEY1, LOX, ETV1, ISG15,
BACH, CYLD were up-regulated. Moreover, the IPA analysis results suggested
that IFIT3, IFIT1, OAS1, MX1, IRF9, IFI6, IFITM1, ISG15 were up-regulated in
BEL-7402 cells treated with sinomenine by activating IFNA2. The findings
presented in this study may provide a promising method for the prevention and
treatment of liver cancer. 相似文献
5.
目的 评价碳离子和质子治疗胰腺癌(PaC)的安全性和有效性。方法 检索数据库纳入碳离子和质子治疗PaC的临床研究,检索时间为自建库至2019年6月。两位研究者独立筛选文献、提取资料。采用STATA 12.0和MetaAnalyst Beta 3.13软件进行Meta分析。结果 共纳入8篇文献,包含459例PaC患者。效应模型Meta分析显示,碳离子和质子治疗PaC的2、3、5级胃肠道溃疡发生率分别为7%、2%、0;2、3、4级厌食症发生率分别为6%、3%、0;1、2年总生存率(OS)分别为77%、45%;2年局部控制率为81%;1年无局部进展率为88%;1年局部复发率为15%。碳离子和质子治疗PaC的2、3、2~3级胃肠道溃疡发生率分别为6.8%、1.5%、9.2%和3.5%、8.3%、6.1%(均P>0.05);1、2年OS分别为77.1%、44.4%和77.6%、49.7%(P均>0.05)。结论 碳离子和质子治疗PaC安全有效,两者的安全性和有效性相似。 相似文献
6.
Cadmium is a toxic metal that can damage the brain and other organs. This study aimed to explore the protective effects of Potentilla anserine L. polysaccharide (PAP) against CdCl2-induced neurotoxicity in N2a and SH-SY5Y cells and in the cerebral cortex of BALB/c mice. In addition, we aimed to identify the potential mechanisms underlying these protective effects. Relative to CdCl2 treatment alone, pretreatment with PAP prevented the reduction in cell viability evoked by CdCl2, decreased rates of apoptosis, promoted calcium homeostasis, decreased ROS accumulation, increased mitochondrial membrane potential, inhibited cytochrome C and AIF release, and prevented the cleavage of caspase-3 and PARP. In addition, PAP significantly decreased the CdCl2-induced phosphorylation of CaMKII, Akt, and mTOR. In conclusion, PAP represents a potential therapeutic agent for the treatment of Cd-induced neurotoxicity, functioning in part via attenuating the activation of the mitochondrial apoptosis pathway and the Ca2+-CaMKII-dependent Akt/mTOR pathway. 相似文献
7.
目的采用Meta分析方法评价18F-脱氧葡萄糖正电子发射计算机体层摄影(18F-FDG PET/CT)和增强CT(CECT)诊断经导管肝动脉化疗栓塞术(TACE)术后存活或复发病灶的临床价值。方法根据PRISMA报告规范开展Meta分析。检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方和维普数据库中18F-FDG PET/CT和CECT诊断TACE术后存活或复发病灶的临床研究,时间至2019-04。由2位研究人员独立筛选文献、提取资料,根据诊断准确性研究质量评价工具-2(QUADAS-2)评价纳入研究的偏倚风险后,采用Stata 12.0软件进行Meta分析,计算其汇总敏感度(Sen)和特异度(Spe),绘制受试者工作特征曲线(SROC)并计算曲线下面积(AUC)。结果共纳入10篇18F-FDG PET/CT及13篇CECT诊断TACE术后存活或复发病灶的原始研究,分别包括322例患者的467个病灶和748例患者的943个病灶。Meta分析显示,18F-FDG PET/CT诊断TACE术后存活或复发病灶的Sen=0.92(95%CI为0.87~0.94)、Spe=0.95(95%CI为0.82~0.99)、AUC=0.97(95%CI为0.93~0.99);CECT诊断TACE术后存活或复发病灶的Sen=0.72(95%CI为0.66~0.78)、Spe=0.99(95%CI为0.93~1.00)、AUC=0.87(95%CI为0.83~0.89)。此外,CECT诊断TACE术后存活或复发Sen(Z=2.34,P=0.02)和AUC(Z=2.21,P=0.03)值低于18F-FDG PET/CT,差异有统计学意义。结论相比于CECT,18F-FDG PET/CT对TACE术后存活或复发病灶具有较高诊断效能,可视为TACE术后存活或复发病灶有效的影像学诊断方法。 相似文献
8.
9.
目的:观察黑逍遥散对阿尔茨海默症(AD)小鼠海马和脑皮层钙调蛋白依赖性激酶2α(CaMKⅡα)及其磷酸化表达水平的干预效应。方法:30只APP/PS1双转基因雄性小鼠称体质量并按随机原则分为模型组、盐酸多奈哌齐组、黑逍遥散组,每组10只。同月龄、同种系的野生型C57BL/6雄性小鼠10只为空白组。盐酸多奈哌齐组(6 g·kg~(-1))、黑逍遥散组(3. 25 mg·kg~(-1))分别连续给药90 d后,Morris水迷宫检测行为学变化,免疫组化和蛋白免疫印迹法检测小鼠海马区和脑皮层CaMKⅡα蛋白及其磷酸化的表达。结果:干预90 d后,与空白组比较,AD模型组小鼠,逃避潜伏期显著延长,跨原平台和有效区域次数显著减少(P 0. 01),小鼠海马区及脑皮层Ca MKⅡα蛋白表达显著减弱或降低,而p-CaMKⅡα蛋白表达显著升高(P 0. 05,P 0. 01);与模型组比较,盐酸多奈哌齐和黑逍遥散组小鼠的逃避潜伏期均显著缩短、跨原平台次数均显著增加(P 0. 01),小鼠海马区及脑皮层Ca MKⅡα蛋白显著增强或升高,p-CaMKⅡα蛋白表达显著降低(P 0. 05,P 0. 01)。结论:黑逍遥散通过调节AD小鼠不同脑区参与细胞记忆形成机制的关键蛋白Ca MKⅡα及其磷酸化表达,进而发挥改善AD小鼠的学习记忆能力。 相似文献
10.