An Approach to Emotion Recognition Using Brain Rhythm Sequencing and Asymmetric Features

Emotion can be influenced during self-isolation, and to avoid severe mood swings, emotional regulation is meaningful. To achieve this, efficiently recognizing emotion is a vital step, which can be realized by electroencephalography signals. Previously, inspired by the knowledge of sequencing in bioinformatics, a method termed brain rhythm sequencing that analyzes electroencephalography as the sequence consisting of the dominant rhythm has been proposed for seizure detection. In this work, with the help of similarity measure methods, the asymmetric features are extracted from the sequences generated by different channel data. After evaluating all asymmetric features for emotion recognition, the optimal feature that yields remarkable accuracy is identified. Therefore, the classification task can be accomplished through a small amount of channel data. From a music emotion recognition experiment and a public DEAP dataset, the classification accuracies of various test sets are approximately 80–85% when employing an optimal feature extracted from one pair of symmetrical channels. Such performances are impressive when using fewer resources is a concern. Further investigation revealed that emotion recognition shows strongly individual characteristics, so an appropriate solution is to include the subject-dependent properties. Compared to the existing works, this method benefits from the design of a portable emotion-aware device used during self-isolation, as fewer scalp sensors are needed. Hence, it would provide a novel way to realize emotional applications in the future.

     

桃仁的研究进展

桃仁为蔷薇科植物桃或山桃的种子,具有活血祛瘀、润肠通便、止咳平喘等功效。目前对桃仁的研究仍主要集中于其活性成分苦杏仁苷的测定及其质量控制,而对其他单体成分的药理作用机制仍不明晰。综述桃仁在传统理论指导下的现代研究进展,包括其性味、炮制、配伍、质量控制,以及其化学成分和药理、毒理等方面的研究。建议对桃仁提取物中的单体成分在心血管保护、神经保护、免疫调节、抗肿瘤以及肝肾保护等药理作用机制方面进行更深入的探讨,为其资源开发和临床应用提供更详实的理论依据。     

肿瘤生物学研究热点与抗肿瘤中药研发策略

肿瘤生物学研究近年来取得长足进展,肿瘤免疫、肿瘤干细胞、细胞自噬、上皮-间质转化等已成为肿瘤学研究热点。对这些肿瘤生物过程的详尽阐明,为这种多因素导致细胞异常增殖,发病率和死亡率均居重大疾病之首肿瘤疾病治疗,也为抗肿瘤中药的药理评价、原理阐明和创新药研发提供了提供了新的靶标、新的契机与新的研究策略。     

HPLC同时测定芪骨胶囊中5种成分的含量

目的:建立芪骨胶囊的多成分指标定量方法。方法:采用高效液相色谱法同时测定芪骨胶囊中松果菊苷、朝藿定B,朝藿定C,淫羊藿苷和柚皮苷的含量,Platisil-C18色谱柱(4.6 mm×250 mm,5μm),以甲醇-乙腈-水为流动相进行梯度洗脱,流速1 m L·min-1,检测波长270 nm,柱温30℃。结果:松果菊苷,柚皮苷,朝藿定B,朝藿定C,淫羊藿苷分别在91~3 094 ng(r=0.999 8),19~646 ng(r=0.999 7),11~374 ng(r=0.999 5),25~850 ng(r=0.999 5),29~986 ng(r=0.999 6)与峰面积呈良好的线性关系;平均回收率分别为98.9%(RSD 1.2%),99.1%(RSD 1.3%),99.1%(RSD 1.5%),99.4%(RSD 1.5%),99.3%(RSD 1.5%)。结论:所建立的方法简便、准确、重复性好,可用于芪骨胶囊的质量控制。     

Overview of Taiwan's Indigenous Ethnopharmacology in the Perspective of Traditional Knowledge Protection

Ethnopharmacology, the study of ethnic use of drugs, opens up the crucial gateway to understanding and promoting traditional medicine in the new age. Taiwan is a unique region where traditional medicine and herbal therapeutics have been benefiting its people of multiple races for centuries. This article overviews Taiwan''s indigenous traditional medicine and the emerging status of ethnopharmacology study, and outlines the global scenario of the inheritance and development of traditional medicine. In such a scope of knowledge protection, this article particularly highlights the challenges with bioprospecting and biopiracy, and summarizes the current measures for protection of traditional knowledge in Taiwan. Finally, based upon these analyses, we propose rational strategies for promoting Taiwan''s ethnopharmacology, from multiple angles of resource, economy, policy and law. We conclude that four measures, namely (1) protecting the natural environment of biodiversity, (2) avoiding unnecessary conflicts caused by bioprospecting and biopiracy, (3) strengthening the international collaboration, and (4) upgrading the legal system of traditional intelligence, would be the right paths for Taiwan to protect its invaluable heritage of traditional medicine and the knowledge of ethnopharmacology therein.     

基于药效物质基础的中药药物代谢动力学

中药药物代谢动力学（中药药动学）研究是近年来兴起的中药研究的新领域,研究了一些中药和复方,提出了一些相关的理论假说,但总体上尚处于初期的探索阶段,需进一步地深入研究。本文总结与评述了中药药动学近年来的研究进展,探讨了中药药动学的概念、中药药动学研究的特点与难点,从而提出了基于药效物质基础的中药药动学研究模式的设想。     

熊果酸自微乳的制备及其生物利用度

目的:制备熊果酸自微乳给药体系,建立HPLC-MS方法研究熊果酸自微乳的生物利用度和药物动力学.方法:以OP乳化剂、吐温-20、异丙醇和油酸制备熊果酸自微乳给药系统,并考察其稳定性、粒径和Zeta电位.通过口服给药,研究其体内的生物利用度和药物动力学.结果:所制备的熊果酸自微乳在1个月内稳定,平均粒径32.74 nm,Zeta电位4.21 mV.自微乳的相对生物利用度326.5％;缓释片的相对生物利用度256.6％;相对与缓释片,自微乳的相对生物利用度为127.2％.结论:所制备的自微乳给药系统能提高熊果酸的生物利用度.     

我国药品不良反应的文献计量学研究

目的探索和评价我国有关药品不良反应相关文献的现状,找到发展方向。方法通过中文期刊全文数据库（CNKI）检索出相关文献,对文献的时间分布、期刊分布、作者分布及文献涉及的内容等方面进行评价研究。结果我国对药品不良反应的研究呈增长趋势,现已形成核心作者群,医院和政府机构是文献的主要来源;《中国药物警戒》等5种期刊为药品不良反应的核心期刊;在具体研究内容上基本可以分为7大类,且以要素类和体系类居多;课题基金来源丰富,但多集中于东部地区。结论我国药品不良反应研究工作进展显著,但研究方向和方法仍需改进。     

不同产地夏枯草中抗非小细胞肺癌成分科罗索酸的差异比较

目的:比较不同产地夏枯草中抗非小细胞肺癌活性成分科罗索酸的含量差异。方法:通过四甲基偶氮唑蓝(MTT)和吖啶橙(AO)/溴化乙啶(EB),评价科罗索酸对非小细胞肺癌细胞的增殖抑制以及凋亡作用;建立高效液相色谱法,比较14个产地夏枯草中科罗索酸的含量差异。结果:科罗索酸抑制SPC-A-1人非小细胞肺癌的生长增殖(IC50=1.05×10-6mol/L),并且诱导SPC-A-1细胞凋亡。14个产地夏枯草中科罗索酸的含量差异较大,山西产地的含量最高,河南-2产地的含量最低。结论:科罗索酸为夏枯草中的抗非小细胞肺癌的活性成分,不同产地夏枯草的科罗索酸含量差异较大。