全文获取类型
收费全文 | 215960篇 |
免费 | 21165篇 |
国内免费 | 12925篇 |
专业分类
耳鼻咽喉 | 1969篇 |
儿科学 | 3231篇 |
妇产科学 | 1923篇 |
基础医学 | 25580篇 |
口腔科学 | 3858篇 |
临床医学 | 26132篇 |
内科学 | 25380篇 |
皮肤病学 | 2357篇 |
神经病学 | 8754篇 |
特种医学 | 7918篇 |
外国民族医学 | 65篇 |
外科学 | 20597篇 |
综合类 | 44491篇 |
现状与发展 | 54篇 |
一般理论 | 12篇 |
预防医学 | 18798篇 |
眼科学 | 4299篇 |
药学 | 25198篇 |
250篇 | |
中国医学 | 14921篇 |
肿瘤学 | 14263篇 |
出版年
2024年 | 547篇 |
2023年 | 2840篇 |
2022年 | 5768篇 |
2021年 | 9665篇 |
2020年 | 7720篇 |
2019年 | 5979篇 |
2018年 | 6495篇 |
2017年 | 6541篇 |
2016年 | 5823篇 |
2015年 | 9132篇 |
2014年 | 11466篇 |
2013年 | 12476篇 |
2012年 | 17625篇 |
2011年 | 18648篇 |
2010年 | 14835篇 |
2009年 | 12534篇 |
2008年 | 14023篇 |
2007年 | 13860篇 |
2006年 | 12591篇 |
2005年 | 10798篇 |
2004年 | 7978篇 |
2003年 | 7222篇 |
2002年 | 5843篇 |
2001年 | 5075篇 |
2000年 | 4299篇 |
1999年 | 3054篇 |
1998年 | 1723篇 |
1997年 | 1841篇 |
1996年 | 1288篇 |
1995年 | 1259篇 |
1994年 | 1136篇 |
1993年 | 797篇 |
1992年 | 984篇 |
1991年 | 908篇 |
1990年 | 808篇 |
1989年 | 740篇 |
1988年 | 660篇 |
1987年 | 576篇 |
1986年 | 548篇 |
1985年 | 437篇 |
1984年 | 378篇 |
1983年 | 307篇 |
1982年 | 279篇 |
1981年 | 229篇 |
1980年 | 198篇 |
1979年 | 198篇 |
1978年 | 192篇 |
1977年 | 210篇 |
1976年 | 191篇 |
1974年 | 154篇 |
排序方式: 共有10000条查询结果,搜索用时 149 毫秒
71.
William G. Breen Krishan R. Jethwa Nathan Y. Yu Grant M. Spears William S. Harmsen Robert C. Miller Jonathan B. Ashman William G. Rule Terence T. Sio Michelle A. Neben-Wittich Michael G. Haddock Amit Mahipal Mark J. Truty Christopher L. Hallemeier Kenneth W. Merrell 《Practical radiation oncology》2021,11(1):e63-e69
PurposeOur purpose was to determine the effect of chemoradiotherapy (CRT) on patient-reported quality of life (QOL) for patients with intact pancreas cancer.Methods and MaterialsWe reviewed a prospective QOL registry for patients with intact, clinically localized pancreatic ductal adenocarcinoma treated with CRT between June 2015 and November 2018. QOL was assessed pre-CRT (immediately before CRT, after neoadjuvant chemotherapy) and at the completion of CRT with the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) and its component parts: FACT-General (FACT-G) and hepatobiliary cancer subscore (HCS). A minimally important difference from pre-CRT was defined as ≥ 6, 5, and 8 points for FACT-G, HCS, and FACT-Hep, respectively.ResultsOf 157 patients who underwent CRT, 100 completed both pre- and post-CRT surveys and were included in the primary analysis. Median age at diagnosis was 65 years (range, 23-90). National Comprehensive Cancer Network resectability status was resectable (3%), borderline resectable (40%), or locally advanced (57%). Folinic acid, 5-fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) (75%) or gemcitabine and nab-paclitaxel (42%) were given for a median of 6 cycles (range, 0-42) before CRT. Radiation therapy techniques included 3-dimensional conformal (22%), intensity modulated photon (55%), and intensity modulated proton (23%) radiation therapy to a median dose of 50 Gy (range, 36-62.5). Concurrent chemotherapy was most commonly capecitabine (82%). Sixty-three patients (63%) had surgery after CRT. The mean decline in FACT-G, HCS subscale, and FACT-Hep from pre- to post-CRT was 3.5 (standard deviation [SD], 13.7), 1.7 (SD 7.8), and 5.2 (SD 19.4), respectively. Each of these changes were statistically significant, but did not meet the minimally important difference threshold. Pancreatic head tumor location was associated with decline in FACT-Hep. Nausea was the toxicity with the greatest increase from pre- to post-CRT by both physician-assessment and patient-reported QOL.ConclusionsFor patients with intact pancreatic adenocarcinoma, modern CRT is well tolerated with minimal decline in QOL during treatment. 相似文献
72.
Jie Qian Wei Nie Jun Lu Lele Zhang Yanwei Zhang Bo Zhang Shuyuan Wang Minjuan Hu Jianlin Xu Yuqing Lou Yu Dong Yanjie Niu Bo Yan Runbo Zhong Wei Zhang Tianqing Chu Hua Zhong Baohui Han 《International journal of cancer. Journal international du cancer》2020,146(11):3124-3133
This study aimed to compare the differences in characteristics and prognoses between Asian and white patients receiving immunotherapy for nonsmall cell lung cancer (NSCLC). We studied 390 patients who received atezolizumab as part of the POPLAR or OAK trial, and analyzed the differences in baseline characteristics, outcomes and genetic mutations in blood samples between Asian and white patients. Overall survival (OS) was longer in Asian compared to white patients (median OS: 18.7 vs. 11.1 months; p = 0.005). Race was identified as an independent prognostic factor for OS (Asian vs. white: hazard ratio 0.647, 95% confidence interval 0.447–0.936, p = 0.021), together with performance status, histology, baseline sum of the longest tumor diameters (BLSLD) and number of metastatic sites. The two groups also differed in terms of characteristics including smoking history, BLSLD, epidermal growth factor receptor (EGFR) mutation frequency, programmed death-ligand 1 expression and blood-based tumor-mutation burden. Blood mutations of STK11, EGFR, KEAP1, POLE, GRM3, ATM and STAG2 were associated with treatment response, and TP53, KEAP1, APC, RB1, CREBBP, EPHA5 and STAG2 mutations were associated with OS. The blood-based mutation profiles differentiated between Asian and white patients, especially in relation to EGFR (23.8 vs. 8.5%), TP53 (30.2 vs. 46.9%) and STK11 (1.6 vs. 12.3%) mutations (all p < 0.05). The different clinicopathological features and mutation profiles in Asian and white patients may explain the superior outcome following atezolizumab treatment in Asian patients with NSCLC. The results of this study have important implications for further studies on racial disparities in relation to immunotherapy. 相似文献
73.
癌性肠梗阻(MBO)是指原发性或转移性恶性肿瘤本身及其抗肿瘤治疗引起的肠梗阻,是晚期肿瘤患者的常见并发症,总体发生率3%~15%。目前,MBO的治疗仍缺乏统一、有效的治疗规范,大多数医院都采用对症处理的。本文在总结数百例治疗经验基础上,提炼出“减(压)、加(营养)、抑(制消化液分泌)、激(素)、利(尿)、动(运动及促进肠蠕动)”六字方针,简单、实用、有效,通过临床观察,该方案能改善患者症状,恢复经口进食率,提高生活质量和手术治疗的机会,缩短住院时间及降低治疗费用,尽管尚缺乏前瞻性的随机对照研究结果,仍值得推广。 相似文献
74.
75.
76.
选取明确诊断抗中性粒细胞胞浆抗体(ANCA)相关性血管炎患者1例作为研究对象,描述病程中的临床表现、诊疗思路及相应的检查结果。患者明确诊断后,调整治疗方案最终好转出院。ANCA相关性血管炎表现多样化,临床诊疗中应时刻警惕。 相似文献
77.
78.
目的:探讨单孔胸腔镜下肺癌手术术后胸腔引流时间的影响因素。方法:本研究采用回顾性分析方法,回顾我院2018年01月至2019年12月原发性肺癌患者经单孔胸腔镜手术治疗的病例199例。按照术后胸腔引流时间分为两组,Ⅰ组(术后胸腔引流时间<5天)和Ⅱ组(术后胸腔引流时间≥5天)。对于影响术后胸腔引流时间的可能因素在两组间先采用单因素分析的方法筛选,再将筛选出来的对术后胸腔引流时间可能有意义的影响因素进行二项Logistic多因素回归分析。结果:经单因素分析及二项Logistic多因素回归分析结果显示:年龄≥60岁、手术部位、肺段切除术、胸膜粘连、手术时间≥180 min、术后早期下床活动是术后胸腔引流时间的独立影响因素(P<0.05)。结论:对于具有多个延长术后胸腔引流时间的独立影响因素的患者,应制定个体化管理方案,尽可能减少术后胸腔引流时间,减少住院天数,加快患者康复。 相似文献
79.
目的 探讨糖尿病前期的中医证型及证素分布特点。方法 检索中国知网、万方及维普三大数据库中收录的自建库以来有关糖尿病前期证型的临床研究文献,对中医证型进行规范整理,建立数据库,提取证素,运用数据挖掘技术中的关联分析、聚类分析探究证素分布规律。结果 共纳入10篇文献,总有效病例1620例,证型经规范处理后整理为18个,主要证型为脾虚痰湿证。共提取证素13个,主要病位证素为脾,主要病性证素为气虚、湿和痰,关联分析显示脾—湿支持度和置信度最高,聚类分析结果可得到3个聚类组。结论 糖尿病前期病位在脾,气虚、脾、痰、湿是常见证素,临床诊治糖尿病前期应注重从脾论治,需辨证施治。 相似文献
80.