天枢超声中药透入治疗阿片类所致肝郁脾虚型便秘的临床观察

ObjectivesTo observe the clinical effect on opioid-induced constipation of liver stagnation and spleen deficiency treated with the ultrasonic penetration of the No.1 constipation herbal formula at Tiānshū (天枢 ST25).MethodsA total of 126 patients that were in compliance with the inclusion criteria were randomized into an acupoint group (41 cases), a Chinese medication group (42 cases) and a western medication group (43 cases). In the acupoint group, the ultrasonic penetration of the No.1 constipation herbal formula at bilateral Tiānshū (天枢 ST25) were given. In the Chinese herbal medication group, the No.1 constipation herbal formula was prescribed for oral administration. In the western medication group, polyethylene glycol electrolyte powder was prescribed for oral administration. The treatment was given once a day, for 14 days totally. Before and after treatment, the constipation symptom score, the score of the patient assessment of constipation quality of life (PAC-QOL), the situation of nitric oxide synthetase (NOS) in serum were observed in each group. The safety indicators in the observation included diarrhea, allergic reaction, liver dysfunction, skin lesions, etc.ResultsA total of 122 cases accomplished the trial. The total effective rate was 82.5% in the acupoint group, 80.48% in the Chinese medication group and 78.04% in the western medication group. The constipation symptoms were all relieved in the three groups, indicating the statistical significance as compared with those before treatment (P < 0.01, P < 0.05). In the acupoint group and the western medication group, the improvements in the three symptom items, i.e. distention or scurrying pain in the chest, hypochondriac region or the bilateral sides of the abdomen, depression or irritability and poor appetite, were better than the western medication group (P < 0.01, P < 0.05). The improvements in all of the symptoms in the acupoint group were better than the Chinese medication group (all P < 0.05). The PAC-QOL score was improved in each group after treatment and it was different significantly in statistics as compared with that before treatment in each group. After treatment, the improvement of PAC-QOL score in the acupoint group and the Chinese medication group was better than that in the western medication group (both P < 0.05), and the improvement in the acupoint group was better than the Chinese medication group (P < 0.05). As to serum NOS, after treatment, it was different significantly as compared with that before treatment in each group (all P < 0.05), the improvement in the acupoint group was better than that of either the Chinese medication group or the western medication group, indicating the statistical significance (both P < 0.05). The incidence of adverse reaction in the acupoint group was less and different significantly as compared with the western medication group (P < 0.01), and it was different statistically as compared with the Chinese medication group (P < 0.05).ConclusionThe ultrasonic penetration of the No.1 constipation herbal formula at Tiānshū (天枢 ST25) is effective on opioid-induced constipation of liver stagnation and spleen deficiency. This therapy achieves the significant therapeutic effect and presents the good compliance in treatment. Hence, it deserves to be further promoted in clinical application.     

龙血竭超微粉滴丸的制备工艺

以外观质量和溶出特征为指标,以单因素试验和正交设计优化龙血竭超微粉滴丸的制备工艺,并选择二阶导数法作为工艺筛选中类龙血素B的含量测定方法.     

慢性高尿酸血症肾病的中医治疗研究进展

<正>慢性高尿酸血症肾病是人体嘌呤代谢异常,造成尿酸生成过多或无法通过肾脏排泄,导致血尿酸升高,尿酸盐达到饱和后在肾脏组织内沉积最终导致肾功能损伤的疾病。高尿酸血症发病时间并没有明确的季节性,多好发于肥胖人群以及长期肉食酗酒人群,男性患者发病数量明显高于女性,西方国家发病率高于东方国家[1～3]。近年来,由于我国饮食结构逐渐转向以高蛋白、高嘌呤饮食为主,我国慢性高     

补肾活血排毒法组方中药对慢性肾脏病大鼠肾脏细胞凋亡的影响

目的 观察补肾活血排毒法组方中药对慢性肾脏病大鼠的治疗作用及细胞凋亡的影响.方法 采用单侧输尿管梗阻(UUO)动物模型,将SD雄性大鼠分为假手术组、UUO模型组、补肾活血排毒法中药低剂量治疗组和高剂量治疗组,自动生化分析仪检测肾功能;苏木素-伊红(HE)染色检测肾脏组织病理损伤;TUNEL法检测肾组织细胞凋亡;Western blot法检测B淋巴细胞瘤2(Bcl-2)、Bcl-2相关X蛋白(Bax)水平.结果 与UUO模型组相比,补肾活血排毒法中药各剂量组血肌酐(Scr)、尿素氮(BUN)均明显下降(P＜0.05).病理观察,模型组可见肾小管上皮细胞凋亡、坏死、脱落,炎性细胞浸润,补肾活血排毒法中药各剂量组均较UUO模型组肾损伤程度轻(P＜0.05).TUNEL法检测UUO模型组细胞凋亡数较假手术组明显增多,补肾活血排毒法中药各剂量组可显著减少细胞凋亡数目(P＜0.05).与UUO模型组相较,补肾活血排毒法中药各剂量治疗组Bcl-2水平明显上调,Bax水平下调,Bcl-2/Bax比值升高(P＜0.05).以上结果均呈剂量依赖性.结论 补肾活血排毒法中药能明显下调血清肌酐和尿素氮水平,抑制UUO大鼠肾脏细胞凋亡,调节Bcl-2、Bax水平.     

超声对急性膝关节前交叉韧带断裂的诊断价值

目的 评价高分辨力超声对急性膝关节前交叉韧带（ＡＣＬ）断裂的诊断价值。方法 采用７．５ＭＨｚ线阵探头,对３３例临床拟诊急性ＡＣＬ断裂患者术前行超声检查,并与关节镜手术结果比较。结果 超声诊断符合者３１例,假阴性２例,诊断正确率９３．３％。结论 高分辨力超声对急性ＡＣＬ断裂的诊断简便、无创、准确,具有较高的临床实用价值。     

红花酒改善终末期肾病患者动静脉内瘘临床效果研究进展

红花酒对动静脉内瘘有一定保护作用,在临床中用于促进终末期肾病(ESRD)患者动静脉内瘘(A V F)的成熟,提升ES RD患者生存质量.按照国医大师郑新"肾病多瘀论",活血化瘀不仅是治疗肾脏疾病的重要方法之一,也是治疗AVF并发症的重要手段.本文就红花酒在改善ESRD患者AVF的临床效果进行综述.     

中西医结合治疗60例抑郁性胃肠病临床疗效研究

目的：观察中西医结合治疗抑郁性胃肠病临床疗效。方法：选择2013年5月至2014年5月入我院接受治疗抑郁性胃肠病患者60例，将其按照治疗方式的不同分为对照组与试验组，两组人数均为30例。对照组30例患者采用单纯西药治疗，试验组30例患者在对照组治疗方式的基础上加用中药进行治疗。结果：两组患者在经过治疗，试验组的整体有效率为90.0%，对照组的整体有效率为40.0%，两组患者的临床疗效存在显著差异，具有统计学意义，P<0.05。结论：采用中西医结合治疗抑郁性胃肠病的临床效果显著，值得在临床上推广使用。