突触融合蛋白1A与2型糖尿病

突触融合蛋白1A属于突触前膜受体，参与突触小泡膜与突触前膜的融合及神经递质释放，传递神经信息。近年研究表明，突触融合蛋白1A也存在于胰岛β细胞膜及微粒体膜上，参与钙依赖性的胰岛素分泌，影响含胰岛素的分泌颗粒胞吐；对2型糖尿病的动物模型和患者研究显示突触融合蛋白1A与2型糖尿病有内在联系。     

冲击波治疗骨折不愈合和延迟愈合23例报告

[目的]探讨体外冲击波对骨折不愈合和延迟愈合的治疗作用及安全性。[方法]采用冲击波骨科治疗机治疗23例骨折不愈合或延迟愈合患者，冲击电压为7．0～12．0kV，冲击能量0．056～0．250mJ／mm^2，冲击1000～3600次，焦点压力10．2～37．2MPa。根据患者情况治疗5～8次，每次间隔3～7d。[结果]治疗后随访12～18个月，定期复查X线片，23例中，5例无效，18例有明显骨痂生长并最终骨折完全愈合，骨折愈合时间平均为14周，12个月后有效率78．1％，治疗后未观察到明显血管神经损伤、内固定断裂等并发症。用冲击波治疗骨折不愈合和延迟愈合简单有效、安全经济，可作为首选方法。     

前列通瘀提取液对前列腺平滑肌细胞增殖与凋亡的作用

目的:研究前列通瘀提取液对体外培养前列腺基质平滑肌细胞增殖与凋亡的作用。方法:分别以1、2、10、50、100×10-5g/L 5种不同浓度前列通瘀提取液作用体外培养前列腺基质平滑肌细胞,采用MTT和TUNEL法分别测定抗增殖指数和凋亡指数。结果:5种不同浓度前列通瘀提取液作用48 h后抗增殖指数分别为50.61%、53.52%、56.92%、65.53%、72.94%,抗增殖效果随着浓度增大而增大。100×10-5g/L前列通瘀提取液作用24、48、72 h后凋亡指数与对照组比较差异无显著性。结论:(1~100)×10-5g/L前列通瘀提取液体外作用前列腺基质平滑肌细胞具有显著的抗增殖作用。     

入院患者的耐甲氧西林金黄色葡萄球菌菌血症：1997—2003年牛津夏州的队列研究

本研究选择英国牛津夏州一所教学医院及地区综合医院，搜索1997—2003年医院信息系统及微生物学数据库中的信息，分析患者入院2日内血培养中甲氧西林耐药性金黄色葡萄球菌（MRSA）及甲氧西林敏感性金黄色葡萄球菌（MSSA）检测结果，确定入院患者MRSA及MSSA发生率及决定因素。     

心肺复苏早期应用氨茶碱与传统方法的比较研究

目的探讨心肺复苏(CPR)早期应用氨茶碱的临床意义.方法将100例心脏骤停(CA)患者,随机分成观察组(肾上腺素+氨茶碱组)、对照组(肾上腺素组),对照组按照传统CPR方法,静脉注射肾上腺素;观察组在传统方法的基础上早期加用氨茶碱静注.对两组在6h、24h存活率及正常出院方面进行统计学分析. 结果①两组在性别、年龄、疾病构成方面无统计学差异(P＞0.05);②两组在肾上腺素剂量、开始使用时间、直流电除颤等方面比较无统计学差异(P＞0.05);③观察组6h存活率与对照组比较有显著性差异(P＜0.05);两组24h存活率无统计学差异,但在正常出院方面观察组略优于对照组.结论①早期使用氨茶碱可提高6h存活率,正常出院略优于单使用肾上腺素组(对照组);②早期使用氨茶碱可能对最终生存率有益.     

应用输尿管镜放置双J管早期治疗输尿管阴道瘘

Objective To evaluate the clinical effect of placing double J stent using a ureteroscope in early managing ureterovaginal fistula.Methods Twenty-eight patients cases with ureterovaginal fistula from 2002 to 2008 were treated early with placing double J stent using a ureteroscope and the clinical data were reviewed.Results Twenty-two of 28 cases were treated and double J stent was placed in them by a uretero-scope and 75% (21/28)of cases were cured.Four of 21 cases were treated twice by a ureteroscope and were cured finally.7 cases with failure ureterovaginal treatment underwent ureterocystostomy and were cured.The follow-up from 6 months to 33 months (average 10.1±6.4 months)showed that all of the 28 cases had been cured and had no urinary fistula.Conclusion Placing double J stent using a ureteroscope is the first choice of operative procedure for the early treatment of ureterovaginal fistula.     

纳洛酮与地塞米松治疗肾综合征出血热原发性休克的研究

目的　研究纳洛酮和地塞米松治疗肾综合征出血热 (HFRS)原发性休克的疗效。方法　将 110例原发性休克患者随机分为治疗组与对照组。治疗组 5 6例予以纳洛酮 0 .8～ 1.2mg、静脉缓慢注射 ,之后 1.2～ 1.6mg加入 2 5 0ml液体中滴注 ,每分钟 2 0～ 3 0滴 ;地塞米松 2 0mg、静脉注射。对照组 5 4例予以阿拉明 2 0～ 3 0mg与多巴胺 40～ 60mg加入2 5 0ml液体中滴入 ,每分钟 15～ 3 0滴。结果　治疗后 1h休克纠正率治疗组与对照组分别为 89 2 9% ( 5 0 /5 6)和 68.5 2 %( 3 7/5 4) ,P <0 0 0 5 ;越过少尿期率分别为 14 .2 9% ( 8/5 6)与 3 .70 % ( 2 /5 4) ,P <0 0 5 ;肾功能恢复正常天数分别为 12 .96±1.76天和 14 .75± 1.92天 ,P <0 0 0 1;病死率分别为 3 .5 7% ( 2 /5 6)和 12 .96% ( 7/5 4) ,P <0 0 5。结论　纳洛酮与地塞米松治疗HFRS原发性休克疗效明显优于阿拉明与多巴胺     

应用输尿管镜放置双J管早期治疗输尿管阴道瘘

Objective To evaluate the clinical effect of placing double J stent using a ureteroscope in early managing ureterovaginal fistula.Methods Twenty-eight patients cases with ureterovaginal fistula from 2002 to 2008 were treated early with placing double J stent using a ureteroscope and the clinical data were reviewed.Results Twenty-two of 28 cases were treated and double J stent was placed in them by a uretero-scope and 75% (21/28)of cases were cured.Four of 21 cases were treated twice by a ureteroscope and were cured finally.7 cases with failure ureterovaginal treatment underwent ureterocystostomy and were cured.The follow-up from 6 months to 33 months (average 10.1±6.4 months)showed that all of the 28 cases had been cured and had no urinary fistula.Conclusion Placing double J stent using a ureteroscope is the first choice of operative procedure for the early treatment of ureterovaginal fistula.     

血浆同型半胱氨酸水平与Alzheimer病的关系

本研究探讨血浆同型半胱氨酸(Hcy)水平在Alzheimer(AD)发病中的可能意义.