审因论治在肾病治疗中的应用

审因论治在肾病治疗中的应用鲁家法，马琼英肾炎是临床常见病、多发病，常因病情反复发作、病理变化不断进展而影响肾功能。中医学对肾炎的病因已有描述，概之为“外邪侵袭、脾肾亏损”，或因风寒而致的反复感冒，或因风热而引起咽痛、乳蛾肿大，或因湿热而致皮肤痈疖、脓...     

浅析环丙沙星的不良反应

环丙沙星是第三代喹诺酮类药物,具有抗菌谱广、抗菌力强、组织分布好、不易产生耐药性、毒副作用少等特点,已广泛应用于临床,该药不良反应多见消化道反应[1]。近年来,发现环丙沙星有一些散在性的少见不良反应的个案报道,现介绍如下。1　神经系统反应蔡海林[2]报道2例静脉滴注环丙沙星出现精神症状。其中1例男性患者,80岁,因冠心病并发支气管炎,给予静滴环丙沙星0.2g(bid)及氨力农、辅酶A、肌苷等治疗,当日晚上自言自语,语言带有幻觉色彩,并有双手摸空现象,烦躁不安,不能入睡。误认为病情恶化,给予血气分析、血清酶学测定、心电图等检查均无…     

补肾健脾方合益比奥对肾性贫血患者血清肿瘤坏死因子-α的影响

目的：联合使用中药验方补肾健脾方与低剂量促红细胞生成素(huEPO,益比奥)治疗肾性贫血(RA),并观察患者血清肿瘤坏死因子-α(TNF—α)水平的变化以探讨中西医结合治疗肾性贫血的可能机制。方法：已经确诊为RA的透析患者随机分为两组,补肾健脾方与益比奥治疗组(简称中西组),单用益比奥治疗组(对照组),两组均予透析、补充铁剂、叶酸及维生素B12及对症支持治疗。中西组予益比奥50IU／kg皮下注射,每周2次;并口服补肾健脾方,每天1剂,分2次服;对照组单纯用益比奥50IU／kg皮下注射,每周3次：疗程均为3个月。治疗前后均检测血红蛋白(Hb)、红细胞压积(Hct)、TNF—α,并观察疗效。结果：(1)两组治疗后Hb、Hct均较治疗前明显上升(P<0．01),两组治疗3个月Hb、Hct比较差异有显著性(P<0．05)。(2)两组治疗前血清TNF—α均明显高于正常;治疗后,中西组血清TNF—α下降,与治疗前比较差异有显著性(P<0．05);但对照组治疗前后血清TNF—α水平无明显变化。结论：补肾健脾方合益比奥可明显抑制血清TNF-α的产生．可能是中西组有效改善EPO敏感性的重要原因。     

抑郁症患者情绪图片反应特征及杏仁核反应模式的研究

Objective To explore the behavioral and related amygdaiar temporal response to emotional pictures in individuals with major depressive disorder(MDD).Methods Functional magnetic resonance imaging(fMRI)was adopted to examine the neural substrates of emotional pictures processing in 12 first-episode unmedicated MDD subjects(MDD)and 13 healthy controls(HC).Analyses were focused on the temporal dynamics of the blood-oxygen level dependant(BOLD)signal change in the amygdala across blocks of positive,neutral and negative emotional pictures.The crude score to emotional pictures was also recorded.Results(1)The crude score wag(6.6 ±0.2)to positive pictures and(4.7 ±0.1)to neutral pictures in depressed subjects,lower than that in HC(P＜0.01),and(3.4 ±0.3)to negativc pictures in depressed subjects,which was higher than that in HC(2.2±0.2,P＜0.01).(2)The bilateral amygdala showed attenuated and delayed response to the positive pictures.in which the right amygdala showed"group×time"interaction effect to positive pictures(P=0.002).For the negative pictures,there was"group×time"interaction effect in the left amygdala(P=0.008)and group main effect in the right amygdaia(P=0.007),with the attenuated BOLD signal change in MDD group.Conclusions It suggests that amygdala is one of the key neural substrates to the character of the depressed mood or loss of interest in individuals with MDD.Depressed subiects show the attenuated and blunted behavioral and amygdala response to emotional stimuli,which support the hypothesis of the unspecially blunted emotional response in major depressive disorder.     

肿节风防治化疗后血小板减少症的研究

目的:探讨肿节风对大剂量化疗后小鼠血小板减少的防治作用.方法:本研究以Babl/c纯系清洁级小鼠为实验对象,通过大剂量5-氟尿嘧啶腹腔注射复制血小板减少的动物模型,用肿节风稀释液从实验开始连续进行灌胃干预,分别在预处理前、化疗前、化疗后第2、第4及第7天测定小鼠血常规;并在化疗后第7天处死小鼠,行骨髓病理活检,观察骨髓造血情况.结果:经过肿节风预处理后,化疗前单药干预组及联合干预组小鼠外周血小板数量显著高于同期对照组(P＜0.05),化疗后两个实验组小鼠的血小板数量与对照组相比无显著下降(P＜0.05),而两实验组间无显著性差异(P＞0.05).骨髓病理检查结果提示,两实验组小鼠骨髓增生活跃,骨髓腔内可见巨核细胞,对照组小鼠骨髓增生低下,未发现巨核细胞.结论:肿节风具有对抗大剂量5-FU所造成的血小板减少的作用,从而预防并治疗化疗后血小板减少症的发生.     

药物防治后发性白内障研究进展

后发性白内障又称晶体后囊膜混浊(PCO),是白内障术后影响视力恢复的最常见的远期并发症之一。成人白内障术后2~5年PCO发生率50%,儿童发生率几乎100%[1]。虽然可以通过二期手术或YAG激光后囊膜切开术治疗,但不仅增加了额外费用,而且不可避免会出现新的并发症。目前国内外研究从改进白内障手术技巧、人工晶体(IOL)材料和设计以及药物三方面来防治PCO。笔者就药物防治PCO研究进展做一综述。1基于PCO机制起作用的药物研究1·1清除晶体上皮细胞(LEC)的药物在PCO发生机制的研究中,已经证实LEC的残留与增生是PCO形成的基础,术中清除L…     

融水苗族STR基因座D7S820、D13S317、D16S539的遗传多态性研究

目的：为了解广西融水苗族人群无关个体的3个短串联重复序列（short tandem repeat,STR）：D7S820、D13S317、D16S539遗传多态性分布情况.方法：用枸橼酸钠抗凝法采集融水苗族208份无亲缘关系的健康个体的血样（男102例,女106例）,酚-氯仿抽提法提取DNA,应用荧光标记复合扩增技术对血样DNA的3个STR基因座进行扩增,用ABI3100型遗传分析仪对扩增产物进行检测.结果：3个STR位点共检测出21种等位基因,62种基因型,频率分布分别在0.004 8～0.448 4和0.004 8～0.201 9之间,其中累积个人识别力0.998 6,累积非父排除率0.956 6,多态信息总量0.972 9;基因型的分布符合Hardy-Weinberg平衡定律（P＞0.05）.结论：苗族群体的3个STR位点具有高度多态性和遗传稳定性,符合孟德尔遗传规律,可以应用于个体识别和亲权鉴定,可作为广西苗族的民族遗传学研究和法医学鉴定的基础数据.     

顶空-GC法检测益脑胶囊中树脂残留物的量

目的：检测益脑胶囊中大孔枷脂残留物的量。方法：采用顶空-气相色谱法对树脂残留物正己烷、苯、甲苯、二甲苯、苯乙烯和二乙烯苯进行检测。结果：各组分在线性范围内呈良好线性关系，相关系数r〉0．999，回收率均在95％-105％内，各组分检出量均符合规定。结论：该方法简便可行，重现性好，结果可靠。     

福建莆田接受准分子激光矫治近视的人群调查

目的调查分析福建莆田地区接受准分子激光角膜屈光手术的近视人群.方法对2001年1月～2003年8月接受手术的1000例(1892眼)不记名方式进行调查分析.结果1000例中年龄20岁以下最多,(占40.00%);职业以学生最多,(占54.00%);手术目的以报考院校(38.00%)及公务员(25.00%)为主;地区分布以城镇(45.70%),沿海(35.10%)为主.结论患者的年龄、职业、手术目的、家庭经济条件均是影响近视人群选择角膜屈光手术的重要社会因素.     

血栓前体蛋白在急性缺血性脑血管病早期诊断中的价值

Objective To study the value of thromhus precursor protein(TpP)in early diagnosis of acute ischemic cerebrovascular disease.Methods The patients who showed completely or partly anterior circulation infarcts syndrome and were within 6 hours from onset on admission were observed dynamically.All patients were divided into thrombotic cerebral infarction(TCI)group(40 cases),transient ischemic attack (TIA)group(42 cases), and lacunar infarction(LI)group(37 cases).Concentrations of TpP in plasma obtained from three groups on admission were detected by enzyme linked immunosorbent assay(ELISA),then were compared with each other.The diagnostic value of plasma TpP to TCI within 6 hours from onset was analyzed with ROC curve.Results The level of TpP in TCI,TIA and LI group was(24.43±3.21),(15.51±2.65)and(13.52±5.45)mg/L respectively,and was significantly higher than that of healthy people (3.9±2.5)mg/L(P<0.01).The level of TpP was significantly higher in TCI group than that in TIA and LI group(P<0.01).The level of TpP was significantly higher in TIA group than that in LI group(P<0.01).The area under ROC curve for TpP to diagnose TCI was 0.979±0.013(P<0.01).The level of TpP on optimal cutoff was 19.1 mg/L.When the level of TpP was over 19.1 mg/L,TCI was determined with 95% sensitivity and 96%specificity, sum of which was largest of all.Conclusion The level of TpP can differentiate TCI from TIA and LI within 6 hours from onset.