罗扰素治疗慢性乙型、丙型肝炎近期疗效观察

对36例慢性病毒性肝炎随机分为两组,按1990年上海肝炎会议制定的诊断标准分型,其中慢性迁延型肝炎10例(乙肝8例,丙肝2例)。慢性活动型肝炎26例(乙肝20例,丙肝6例)。治疗组罗扰素300万u,每周3次肌注,对照组为一般保肝治疗,疗程3个     

宋代道德理想主义的重建与道德价值的高标简

宋不同于魏晋隋唐,在于士大夫有一种重建道德理想、匡正世风的道德使命和责任担当意识。置重个体的道德修为和道德操守,推崇以天下为己任的担当意识,强烈的道德建设使命感,与渴望在政治和社会生活中建功立业、创业垂统,成为有宋一代诸多士大夫的价值追求和人生理想。宋代道德理想主义源于对唐末五代道德生活经验教训的深刻总结,其重建内容涉及道德性命的关注与研究,先忧后乐精神的提出与弘扬,圣贤气象的仰慕与追求等方面,士大夫精神在重建和挺立道德理想主义中得以形成,并成为宋代道德理想主义的精神支撑。     

Enclose Ⅱ在148例非体外循环冠脉旁路移植术中的临床应用分析

目的 总结冠脉搭桥近端吻合辅助器（Enclose Ⅱ）在不停跳冠状动脉脉旁路移植术（OPCAB）中应用的临床经验和体会.方法 自2009年8月至2013年5月我们对148例冠心病患者在施行OPCAB手术时应用Enclose Ⅱ行主动脉近端吻合,男性109例,女性39例,年龄51～83（60.1±3.2）岁.结果 应用Enclose Ⅱ完成近端吻合口298个,其中大隐静脉与升主动脉近端吻合263个,桡动脉35个,平均（2.01±0.80）个吻合口/例.围术期无死亡,无心肌梗死和脑卒中,术中未出现升主动脉破裂和急性主动脉夹层.结论 OPCAB术中应用EncloeⅡ完成近端吻合口,减少和减轻了对升主动脉的操作和损伤,尤其对主动脉钙化严重的患者,能有效避免因主动脉操作而引起主动脉破裂和急性主动脉夹层的发生,降低因斑块脱落引起的围术期心肌梗死和脑卒中的发生.     

新生儿足跟血与脐带血TSH水平的对比观察

以新生儿血中TSH水平为指标监测一个地区碘缺乏的程度及碘盐防治的效果是ICCIDD推荐的方法,并已被许多国家广泛采用。1995年4月ICCIDD理事会建议在开展全民新生儿筛查的国家,使用高灵敏度的药盒,当TSH<5mIU/L的比例达97％即可作为非缺碘的标志,而不再用其他指标(即盐碘、尿碘、甲肿率等)。目前我国的新生儿筛查工作已在许多城市普遍开展,并正在扩展至广大农村。新生儿     

26752名新生儿先天性甲状腺功能低下筛查

对１９９３～１９９４年天津农村２６７５２名新生儿筛查情况进行了初步分析。结果显示，１９９４年筛查率较１９９３年显著提高。５７例初筛阳性，其中７例确诊为先天性甲状腺功能低下，发病率为１／３８２２．７例病儿有５例早期出现临床症状，２例误诊为其它疾病，３例被漏诊。７例病儿均通过儿保医生追访后给予明确的诊断及治疗。本文提示开展新生儿筛查，特别是在医疗水平较低的农村，无疑是至关重要的。     

羊水细胞培养方法的建立

宫内胎儿遗传病的早期诊断又称产前诊断,是近十年来产科诊断学上的一项重要进展,也是预防性优生学的一种手段。用培养的羊水细胞作染色体分析与细胞化学分析,可以诊断胎儿的各种染色体疾病和先天性代谢异常。用羊水细胞作性染色质检     

一例三代遗传性9号染色体臂间倒位inv(9)(p13;q12)

在产前诊断中发现1例已遗传三代的9号染色体臂间倒位。按标准方法获得淋巴细胞与羊水细胞的中期分裂相。全部标本均常规地作了 G 带和 C 带。每例计数30～223个中期分裂相。先证者是—4(?)月的胎儿,其羊水细胞的核型是46,XX,inv(9)(p 13;q 12)。父亲与外祖母核型正常,但母亲,多发畸形儿与外祖父的核型与胎儿相同。讨论了臂间倒位的诊断意义。     

Caroli氏病八例报告

Caroli氏病也称先天性肝内胆管囊状扩张症,以前文献多认为它是一种罕见的肝内胆道疾病。近年来,由于对本病的认识和诊断技术的提高,临床发现日渐增多。本院近年收治并获病理证实的Caroli氏病8例,现报告如     

超声斑点追踪技术对系统性红斑狼疮患者局部心肌收缩功能的评价

目的 应用超声斑点追踪技术(STI)评价系统性红斑狼疮(SLE)患者局部心肌收缩功能.方法 ①SLE组36例,健康对照组24名,分别记录并存储每位被检者心尖位左心室3个长轴切面高帧频二维动态图像,应用自动功能成像软件(AFI)检测左心室壁18节段收缩期峰值应变(S),记录并比较各参数测值.②在对照组中随机取20名被检者,双盲条件下,由同一观察者不同时间及2名观察者分别测量每位被检查者心肌收缩期峰值应变值,2组问计量资料比较采用非配对t检验,并利用Pearson相关分析法分析其相关性.结果 对照组左心室各壁S值自基底段向心尖段逐渐增加,心尖段与基底段、中间段差异有统计学意义(P＜0.05),不同室壁对应节段间差异无统计学意义(P＞0.05);同一室壁各节段心肌收缩期峰值应变达峰时间基本一致.SLE组除前间隔和前壁外各室壁S值自基底段向心尖段逐渐增加[(-18.7+4.2)%,(-16.3±9.4)%,(-18.1±10.5)%与(-19.0±9.0)%,(-18.6±7.9)%,(-17.7±1.4)%],心尖段与基底段、中间段差异均无统计学意义(P＞0.05);SLE组各室壁各节段S值明显低于对照组,差异均有统计学意义(P＜0.05);SLE组同一室壁各节段心肌收缩期峰值应变达峰时间一致性差.同一观察者不同时间及2名观察者问对心肌收缩期峰值应变值的测量相关性良好(P＜0.01).结论 STI技术发现SLE患者与健康对照组差异有统计学意义,SLE患者心肌损害表现为左室局部心肌收缩期峰值应变减低.

Abstract：

Objective To assess the vaIue of speckle tracking imaging (STI) in quantifying the regional myocardial strain in systemic lupus erythematosus (SLE) group.Methods ① Sixty subjects were divided into SLE group and normal group.High frame rate two-dimensional images were recorded from the apical two-chamber view,long-axis view and four-chamber view of the left ventricle (LV).Peak systolic strain of each view of 18 segments were measured by automated functional imaging (AFI) software of 2-DSE.All parameters were compared between the two groups.② Twenty cases were randomly taken from the normal group.The same observer at different times and two observers measure the strain of left ventricular respectively.The results of the measurement between the two groups were compared with unpaired t test and its relevance was analyzed using Pearson's correlation analysis.ResultsLeft ventricular two-dimensional longitudinal strain gradually increased from the base to apex in the normal group.There were statistically differences between the apical segments and the basal,middle segments of every left ventricular wall (P＜0.05).The same wall segment time to peak myocardial systolic peak strain was consistent.Left ventricular two-dimensional longitudinal strain gradually increased from the base to apex in the SLE group,except for the anterio-septal and anterior wall [ (-18.7±4.2)％,(-16.3±9.4)％,(-18.1±10.5)％ vs (-19.0±9.0)％,(-18.6±7.9)％,(-17.7±1.4)％ ].There was no statistically significant difference between the apical segments and the basal,middle segments of every left ventricular wall(P＞0.05).All parameters of S were significantly higher in the normal group than those of the SLE group.The difference was statistically signoficant (P＜0.05).The time to peak systolic peak strain of every segments was not consistent.The results from the same observer at different times and peak systolic myocardial strain measurements by the two observers were correlated well(P＜0.01).Conclusion The myocardial function assessment by STI technology in the SLE patients is significantly different from that of the normal control:SLE patients with left ventricular myocardial damage can be manifested as reduced regional myocardial systolic peak strain.