基于复杂网络技术对电针治疗乳腺增生病处方分析

目的基于复杂网络技术分析电针治疗乳腺增生病的核心穴位及配伍穴相关性,并对电针波型进行探讨。方法检索中国期刊全文数据库(CNKI)、万方数据库、维普网数据库(VIP)中从1954年1月1日到2018年12月31日公开发表的电针治疗乳腺增生病的临床中文文献,利用Excel表格工具建立电针治疗乳腺增生病数据库,利用Matlab2014a软件进行节点中心性分析和聚类分析,利用Gephi0.9.1软件制作复杂网络示意图对分析结果进行描述和展示,利用Excel表格工具制作电针治疗乳腺增生病不同波形比例饼状图并分析其规律。结果选定43条电针处方:电针治疗乳腺增生病主穴核心度前三位依次为膻中穴、足三里、肩井穴;配伍穴位核心度前三位依次为太冲穴、太溪穴、脾俞穴;经络核心度前三位依次为足阳明胃经、任脉、足少阳胆经。配伍穴位相关性分析中,相关性频度前三位组合依次为太冲穴-太溪穴、太冲穴-肾俞穴、太冲穴-三阴交。电针波形中以连续波与疏密波常见,均具有较高的临床应用价值。结论电针治疗乳腺增生病处方以足阳明胃经为最多,其次为任脉;电针波型以连续波为主。     

Randomised trial of long term effect of acupuncture for shoulder pain

Guerra de Hoyos JA, Andres Martin Mdel C, Bassas y Baena de Leon E, Vigara Lopez M, Molina Lopez T, Verdugo Morilla FA, Gonzalez Moreno MJ. Pain. 2004 Dec;112(3): 289-98.The objective of the study is to compare the efficacy of electro-acupuncture with placebo-acupuncture for the treatment of shoulder pain. This study comprised of a prospective, randomized, placebo controlled trial, with independent evaluator set in a Public primary care clinic in Spain. The participants are patients aged from 25 to 83 years with shoulder pain. Patients were randomly allocated to two treatments over eight weeks, with electro-acupuncture or skin non-penetrating placebo-acupuncture, both able to take diclofenac if needed for intense pain. Primary outcome measure was the difference between groups in pain intensity (visual analogue scale – VAS). Secondary outcomes were differences between groups in pain intensity measured by Lattinen index, in range of motion (goniometer), functional ability (SPADI), quality of life (COOP-WONCA charts), NSAIDS intake, credibility (Borkoveck and Nau scale) and global satisfaction (10 points analogue scale). Assessments were performed before, during and three and six months after treatment. At six month follow-up after treatment the acupuncture group showed a significantly greater improvement in pain intensity compared with the control group [VAS mean difference 2.0 (95 % CI 1.2–2.9)]. The acupuncture group had consistently better results in every secondary outcome measure than the control group. Acupuncture is an effective long-term treatment for patients with shoulder pain (from soft tissues lesions) in a primary care setting. q2004 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.     

电针灸治疗精神药物所致肥胖症的临床观察

目的:探讨电针灸治疗精神药物所致肥胖症的疗效。方法:(1)治疗对象为服用精神药物所致的肥胖症患者。(2)符合肥胖症的诊断标准。(3)排除妊娠期、哺乳期患者,共计65人。(4)在主穴的基础上,根据辨证分型配合次穴。(5)先针刺,然后接通G6805-2多用治疗仪。(6)总疗程30次。结果:总有效率为89.23%。结论:电针是精神药物所致肥胖症的安全有效的治疗方法之一,并对治疗精神药物所致肥胖症提出了一些干预措施。     

THE ROLE OF P_1-PURINERGIC RECEPTORS IN THE SPINAL MECHANISMS OF ACUPUNCTURE ANALGESIA

It has been extensively proved that electro-acupuncture elicit analgesia in bothextensive areas and local region via supraspinal structures and spinal cord.The present investigationwas to study the role of P_1-purinergic receptors in the spinal mechanisms of weak electroacupuncture-induced analgesia.Leg withdrawal latency(LWL)to noxious radiant heat focused on the ankle regionwas used to assess the effects of acupuncture and that of P_1-purinergic(adenosine)receptor antago-nists,theophylline and caffeine on the electro-acupuncture(EA)analgesia.EA prolonged the LWLby 16.7%±20.3%,with an after-effect lasting about 15 min.Both theophylline and caffeineblocked the EA-induced prolongation of LWL in a dose-dependent manner at the doses of 1.6-16 mg/kg.These results suggest that P_1-purinegic receptor is involved in the spinal mechanisms of weak EAproduced analgesia in the rat.     

EXPERIMENTAL SPINAL CORD TRAUMATIC INJURY OF THE CAT TREATED WITH ELECTRO-ACUPUNCTURE

44 cats were used in this experiment. The spinal cords of 40 animals were injuredat about L_1 level by using Allen's method (400g/cm) and randomly divided into 2 groups: A)electro-acupuncture treatment group (n=20) and B) control group(n=20). 2 weeks after spinalcord injury, 80% of animals in the treatment group were survival and 45% of animals in the con-trol group were survival. There was significant difference between these two groups (p<0. 05).The motor evoked potential was recorded two weeks after spinal cord injury. The latency of theshort latency peak was 15. 61±4. 98 mS and the amplitude was 10. 61 0. 59 mV in the treatmentgroup; and 21. 7±5. 02 mS and 0. 56±0. 32 mV in the control group. Both latency and amplitudewere significant different between the two groups (P<0. 05, P<0. 05). The Anti-NF-H (neuro-filament) was determined at 2 and 4 weeks respectively after spinal cord injury. The more NF-Hpositive labeling fibers were found in the treatment group than in the control group (P<0. 01 ).The     

电针“委中”穴对大鼠腰多裂肌损伤后的再生促进作用及对IGF-1表达的影响

目的观察电针委中穴对腰部多裂肌损伤后的干预作用及对胰岛素样生长因子1(insulin like growth factor 1,IGF-1)表达的影响,探求委中穴对大鼠腰肌损伤后再生修复的可能机制。方法雄性SD大鼠120只,随机分为空白组、模型对照组、模型组、电针委中组、电针肾俞组,共5组,观察3个时间点(4天、7天、14天)的变化,每个时间点8个样本。将0.5%布比卡因盐酸盐溶液按每点100μL注射于模型组和电针组大鼠L4、L5水平的多裂肌上。模型对照组采用同样方法注射生理盐水,空白组不做处理。造模后进行电针双侧委中穴或肾俞穴分别治疗4天、7天、14天,HE染色观察肌细胞形态学的改变,免疫组化方法检测肌细胞IGF-1的表达。结果造模前后多裂肌形态学改变显著,损伤后第14天仍未完全恢复。电针委中组与电针肾俞组从形态学上优于模型组。第4、7天模型组多裂肌IGF-1的表达显著高于空白组(P0.01);第4天电针委中组表达显著高于模型组(P0.01),电针委中组表达高于电针肾俞组(P0.05),电针肾俞组表达高于模型组(P0.05),而在第14天,电针肾俞组表达显著高于模型组与电针委中组(P0.01)。结论电针委中穴和电针肾俞穴均能够促进大鼠腰多裂肌损伤后的再生,电针委中穴在肌肉损伤的早期效果显著。     

针药结合治疗排卵功能障碍性不孕症38例疗效观察

目的:观察电针配合桂枝茯苓胶囊治疗排卵功能障碍性不孕症的临床疗效。方法:将76例患者随机分成2组各38例,治疗组行电针配合桂枝茯苓胶囊治疗,对照组肌肉注射人绒毛膜促性腺激素(HCG),观察2组排卵率和妊娠率。结果:2组的排卵率比较,差异无显著性意义(P=0.05),但治疗组的妊娠率高于对照组,差异有显著性意义(P<0.05)。结论:电针配合桂枝茯苓胶囊治疗排卵功能障碍性不孕症有较好疗效,值得临床推广应用。     

穴位埋线治疗卒中后假性球麻痹吞咽障碍的临床研究

目的：观察穴位埋线治疗卒中后假性球麻痹吞咽障碍的临床疗效。方法：将符合研究标准的90例合并吞咽障碍的假性球麻痹患者随机分为治疗组（45例）和对照组（45例）,两组均给予常规的脑血管病治疗、吞咽训练和吞咽电刺激治疗．治疗组在此基础上给予穴位埋线治疗,对照组给予电针治疗,治疗1个疗程后评价其,艋床疗效。结果：两组总有效率均为97．78％．两组的总有效率差异无统计学意义（P〉0．05）。结论：穴位埋线和电针治疗卒中后假性球麻痹的临床疗效相当,但穴位埋线只需每2周治疗1次,患者更易于接受。     

电针对糖尿病大鼠学习记忆的影响

目的：探讨电针对糖尿病所致学习记忆损害的防治作用。方法：采用四氧嘧啶腹腔注射法制备糖尿病大鼠模型，观察电针6周后糖尿病大鼠血糖、体重的变化，并用Morris水迷宫法观察电针对糖尿病大鼠学习记忆的影响。结果：（1）治疗后电针组与模型组的体重均明显低于正常组，电针组体重明显高于模型组（P＜0．05）；（2）电针组治疗前后血糖差异非常显（P＜0．01），但仍然高于正常组（P＜0．01）；（3）模型组的逃避潜伏期较正常组明显延长，P＜0．01。电针组的逃避潜伏期较模型组明显缩短，P＜0．05，与正常组比较，其逃避潜伏期仍较长，但两之间差异无显性，P＞0．05。与正常组比较，模型组大鼠每天的逃避潜伏期均较正常组延长，差异有显意义，P＜0．05或P＜0．01。与模型组比较，电针组第1、2、4、5天的每天逃避潜伏期均较模型组明显缩短，P＜0．05或P＜0．01；电针组第3天的逃避潜伏期较模型组有所缩短，但差异无显意义，P＞0．05。与正常组比较，电针组大鼠每天逃避潜伏期均较正常组延长，但差异无显意义，P＞0．05。结论：（1）电针能够降低糖尿病大鼠血糖并增加其体重。（2）电针能够改善糖尿病大鼠的学习记忆能力。     

DVC微量注射VIP对大鼠GMBF放大和电针调整效应

目的：采用中枢迷走神经背核复合体（DVC）微量注射血管活性肠肽（VIP）,观察胃黏膜血流量（GMBF）变化和电针对GMBF的调整作用。方法：采用脑立体定位仪对大鼠中枢进行定位和注射,电针足三里穴,用氢气清除法测定GMBF;放射免疫法测量外周血中VIP含量。结果：DVC微量注射VIP后,血中VIP含量增加（P＜0．01）,GMBF明显增加（P＜0．01）。电针（EA）足三里穴加强了GMBF放大效应。结论：DVC注射VIP对GMBF有放大效应,证实在神经－内分泌－免疫网络系统（NEIS）中VIP是重要的神经肽,DVC是VIP作用的社会中枢特异性部位之一,电针具有协同作用。