轻度认知障碍

记忆和认知减退是正常老化不可避免的现象。痴呆、轻度认知障碍和正常老化是出现在老年人中的不同程度的认知减退状态。在有关痴呆的研究中，随着对痴呆认识的深入，由于中晚期治疗效果不佳，研究的注意力转向了早期诊断和干预。轻度认知障碍(Mild Cognitive Impairment，MCI)是指介于正常老化与痴呆之间的一种过渡阶段的认知障碍，     

丁苯酞软胶囊治疗轻中度血管性痴呆临床疗效观察

血管性痴呆(VD)是脑血管病后产生的进行性智能障碍综合征,包括缺血性、出血性及脑缺血缺氧损害引起的痴呆.其主要症状为智能障碍,包括认知能力、记忆力、判断和思维能力、计算力和社会生活能力的减退,伴随着情感、性格的改变[1].研究显示,血管性痴呆是导致老年性痴呆的第2位原因,发病率仅次于阿尔茨海默病[2].血管性痴呆是可逆的、可治疗的.早期对血管性痴呆进行有效干预可以改善患者症状,提高患者生存质量,从而减轻社会和家庭的负担.因此,笔者观察丁苯酞软胶囊治疗血管性痴呆对患者精神状态和日常生活活动能力以及血浆同型半胱氨酸的影响,并观察其安全性.现将相关的临床资料总结报道如下.     

无痴呆型血管性认知功能障碍的诊断和治疗进展

血管因素是独立于年龄的导致痴呆的第二大危险因素.在血管性认知损害(VCI)早期即无痴呆型血管性认知功能障碍(VCIND)甚至认知损害发生之前,血管性因素以及脑血管病是唯一可治疗的,并且能够延缓甚至逆转痴呆进展的干预靶点.因此早期诊断出VCIND的病例,治疗血管性因素及脑血管病,有利于VCI的一级预防和二级预防.现对VCIND的诊断、预防和治疗的进展作一综述.     

血管性认知功能减退和痴呆共识

背景和目的:共识综述了血管因素导致的认知功能减退和痴呆的依据(1990至2010年5月1日的文献资料).老年人的血管性认知功能减退(VCI)和痴呆很常见.该文对VCI的定义、神经病理、基础科学和病理生理学、神经影像学、血管及其相关危险因素,以及可能的预防和治疗进行了回顾及评论.该共识可作为指南,使临床医生对VCI和痴呆的预防和治疗有全面的了解.方法:写作组成员由2位主席(美国的Philip B.Gorelick和意大利的Angelo Scuteri)根据其既往的相关工作领域提名,并经美国心脏病联合会卒中理事会的学术指南监管委员会、流行病学预防医学理事会和稿件监管委员会批准.     

老年痴呆症药物治疗进展

老年痴呆症系指发生在老年期的各种痴呆综合征，包括阿尔茨海默病（AD）、血管性痴呆（VD）及混合性痴呆。临床症状主要有认知功能减退（痴呆）和非认知功能损害（精神症状）两类。主要病理特征是大脑萎缩、脑组织内老年斑、脑血管沉淀物和神经元纤维缠结。确切的病因尚未得到充分阐明。目前的治疗方法主要是应用药物作用于不同的神经递质传递系统，增强中枢神经系统的高级活动，减轻疾病过程中所出现的各种症状，延缓痴呆的进一步发展。     

运动认知功能减退综合征的血液生物标志物及影像学研究进展

随着人口老龄化,痴呆发病率居高不下。痴呆不仅能降低患者的个人生活质量,也为家 庭及社会带来了沉重的负担,因此关于痴呆的治疗及预防一直是人们关注的焦点。近年来,运动认知 功能减退综合征作为一个重要的研究模型,利用步速减慢对个体认知能力的下降进行评估,了解由痴 呆前状态发展为痴呆的病理生理机制。现对与运动认知功能减退相关的血液生物标志物及影像特点进 行综述,现加深对其发生的生物学机制的理解。     

音乐治疗对痴呆患者精神行为症状影响的研究进展

痴呆是一类常见的老年疾病,痴呆患者除认知功能受损外,精神行为症状也较为常见。由于药物治疗的不良反应等问题,音乐治疗作为一项重要的非药物性干预措施获得了临床工作的重视。音乐治疗对于精神行为症状有着较为广泛的干预效果,患者淡漠、激越、焦虑、抑郁等症状均能获得较好的改善。而个体化及主动式的音乐治疗方式相比传统、被动式的治疗方式有着更为显著的效果。     

认知训练在遗忘型轻度认知功能障碍患者中应用的 研究进展

阿尔茨海默病（AD）是常见的进行性中枢神经系统退行性疾病,以进行性认知功能下降为 主要临床特征,是导致痴呆的主要原因。遗忘型轻度认知功能障碍（a-MCI）是轻度认知功能障碍（MCI） 的一种亚型。研究表明,a-MCI 大多会进展为 AD,积极干预 a-MCI 是延缓或减少 AD 发生的关键。目前 用于治疗 a-MCI 的药物均缺少大样本的循证医学证据,临床科研工作者越来越关注认知训练在 a-MCI 非 药物治疗领域的研究。认知训练的研究在 a-MCI 患者的非药物干预方面具有广阔的应用前景。现就认 知训练在 a-MCI 患者临床中应用的研究进展进行综述。     

多奈哌齐治疗痴呆的系统评价

<正>痴呆是由多种中枢神经系统变性或缺血过程所引起的、影响患者社会或职业能力的认知功能缺陷综合征。痴呆影响患者的认知、行为和功能,并造成看护负担,迄今为止尚无根治方法,目前的药物干预只能延缓其进展和改善症状。多奈哌齐(donepezil)是一种胆碱酯酶抑制剂[1],它可有效选择性抑制中枢神经系统中乙酰胆碱的降解,增加神经细胞突触间隙乙酰胆碱的浓度,改善痴呆患者的记忆和智能状态。过去常用于AD的治疗。     

血管性认知功能障碍危险因素的研究进展

血管性认知功能障碍(VCI)是指血管因素导致的从轻度认知功能障碍到痴呆的一大类综合征,包括血管性非痴呆性认知功能障碍( VCI-ND),血管性痴呆(VD)和混合型痴呆(MD)[1].VCI概念的提出弥补了VD概念的滞后性,体现了早期预防和早期干预的新观念.VD是迄今为止惟一可以预防的痴呆,早期治疗具有可逆性,在日常生活受到影响前进行干预,可避免发展到不可逆的VD晚期阶段[2,3].并且,近年来研究[4-6]发现,VCI与Alzheimer病(AD)具有许多共同的病理基础、危险因素和可能的相互作用机制,因此,有关参与VCI进展的危险因素的资料对于痴呆的一级和二级预防具有至关重要的作用.鉴于此,现就近年来VCI危险因素的研究进展综述如下.     

早年创伤对认知功能影响的研究进展

早年创伤是一个全球普遍存在的问题,严重影响儿童、青少年的大脑发育,继而导致认知功能、人格水平、社会行为的改变。早年创伤主要是父母、监护人或其他年长者对孩子施加躯体虐待、躯体忽视、情感虐待、情感忽视或性虐待。美国一项调查显示：儿童虐待事件的发生率高达1．2％[1]。早年创伤影响认知功能的多个领域,包括学习／工作记忆、视觉空间能力、执行功能、言语智能、复杂推理搜决策、学业表现等比]。创伤造成的认知功能改变是目前国内外神经科学和精神医学领域研究的热点,但其发病机制仍不明确,鉴于早年创伤与认知功能的关系问题,现就早年创伤对大脑发育、神经认知的影响加以综述。     

Effect of Ganoderma lucidum spore on expression of insulin-like growth factor-1, nuclear factor-kappa B, and neuronal apoptosis in the epileptic rat brain*★

BACKGROUND：It has been reported that Ganoderma lucidum spore powder, a very well known Chinese traditional medicine, can affect immunoregulation, free radical scavenging, and anti-hypoxia responses. OBJECTIVE： To investigate the effect of Ganoderma lucidum spore powder on expression of insulin-like growth factor-1 （IGF-1）, nuclear factor-κB （NF-κB） and neuronal apoptosis in rats with pentylenetetrazol （PTZ）-induced epilepsy. DESIGN, TIME AND SETTING： A cellular and molecular biology experiment with randomized controlled study design was performed at the Central Laboratory of Basic Medical College of Jiamusi University from June to August 2005. MATERIALS： Thirty healthy, adult, male, Wistar rats were selected and randomly divided into 3 groups （10 rats per group）： control, epilepsy model, and Ganoderma lucidum spore powder. A sub-eclampsia PTZ dose （35 mg/kg） was intraperitoneally injected to induce epilepsy in the latter two groups. Wild Ganoderma lucidum spore powder （30 g/L） was provided by the wild Ganoderma lucidum plant nursery at Jiamusi, China. Immunohistochemical detection and terminal deoxynucleotidyl transferase-mediate dUTP nick end-labeling （TUNEL） kits were purchased from Wuhan Boster Biological Technology Co., Ltd., China. METHODS： Ganoderma lucidum spore powder was intragastrically administered at a dose of 10.0 mL/kg, once a day for 28 days. In the epilepsy and control groups, an equivalent volume of normal saline was intragastrically administered. MAIN OUTCOME MEASURES： Immunoreactivity for IGF-1 and NF-κB/P65 were detected by immunohistochemical staining. Neuronal apoptosis was detected using TUNEL methods. RESULTS： The hippocampus and cerebral cortex of rats with PTZ-induced epilepsy exhibited a higher number of apoptotic cells at high magnification （×400）, compared with the control group. Expression of IGF-1 and NF-κB were higher in the epilepsy group, compared with the control group （P 〈 0.01）. In Ganoderma lucidum spore-treated rats,     

Differential cognitive responses to guqin music and piano music in Chinese subjects： an event-related potential study

Objective To compare the cognitive effects of guqin （the oldest Chinese instrument） music and piano music. Methods Behavioral and event-related potential （ERP） data in a standard two-stimulus auditory oddball task were recorded and analyzed. Results This study replicated the previous results of culture-familiar music effect on Chinese subjects： the greater P300 amplitude in frontal areas in a culture-familiar music environment. At the same time, the difference between guqin music and piano music was observed in NI and later positive complex （LPC： including P300 and P500）： a relatively higher participation of right anterior-temporal areas in Chinese subjects. Conclusion The results suggest that the special features of ERP responses to guqin music are the outcome of Chinese tonal language environments given the similarity between Guqin＇s tones and Mandarin lexical tones.     

Brain network markers of abnormal cerebral glucose metabolism and blood flow in Parkinson＇s disease

Neuroimaging of cerebral glucose metabolism and blood flow is ideally suited to assay widely-distributed brain circuits as a result of local molecular events and behavioral modulation in the central nervous system. With the progress in novel analytical methodology, this endeavor has succeeded in unraveling the mechanisms underlying a wide spectrum of neurodegenerative diseases. In particular, statistical brain mapping studies have made significant strides in describing the pathophysiology of Parkinson＇s disease （PD） and related disorders by providing signature biomarkers to determine the systemic abnormalities in brain function and evaluate disease progression, therapeutic responses, and clinical correlates in patients. In this article, we review the relevant clinical applications in patients in relation to healthy volunteers with a focus on the generation of unique spatial covariance patterns associated with the motor and cognitive symptoms underlying PD. These characteristic biomarkers can be potentially used not only to improve patient recruitment but also to predict outcomes in clinical trials.     

Effect of bilobalide B on cholinergic hippocampal neurons exposed to cholesterol and apolipoprotein E4*☆

BACKGROUND： Extracts of ginkgo biloba leaves have been reported to improve nerve function and activity in Alzheimer＇s disease, which is associated with reduced secretion of cholinergic neurotransmitter in hippocampal neurons. OBJECTIVE： To validate the protective effect of bilobalide B against in vitro injury of cholinergic neurons of the hippocampus induced by combined cholesterol and apoE4 DESIGN, TIME AND SETTING： This randomized, controlled animal experiment was performed in the Pathology Laboratory, Tianjin University of Traditional Chinese Medicine from July 2003 to July 2006. MATERIALS： Neonatal Wistar rats, 1-day-old, both male and female, and mean body mass of 5 g were selected for this study. Cholesterol and apolipoprotein E4 （apoE4） were purchased from Sigma Company （USA）, bilobalide B was purchased from Tianjin Zhongyi Pharmaceutical Factory, batch number 20050312. METHODS： Hippocampal neurons were divided into three groups： a normal control group （routinely added media）, a model group （exposed to media containing 40 mg/L cholesterol and 30 mg/L apoE4 for 24 hours） and a bilobalide B group （exposed to media containing 160 mg/L bilobalide B for 16 hours, and then with addition of 40 mg/L cholesterol and 30 mg/L apoE4 for an additional 24 hours）. MAIN OUTCOME MEASURES： Levels of acetylcholine （ACh） and activity of acetylcholinesterase （ACHE） and choline acetyltransferase （CHAT） in hippocampal neurons were determined by microdosage hydroxylamine colorimetry, hydroxylamine colorimetry and radiological chemistry, respectively. RESULTS： The ACh level was significantly lower in the model group than that in the normal control group （P 〈 0.01）, while it was markedly higher in the bilobalide B group than in the model group （P 〈 0.05）. Activity of AChE was significantly decreased in the model group compared with the normal control group （P 〈 0.05）. However, there was no significant difference between the model group and the bilobalide B group ?     

Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord

Objective To investigate changes of 5-hydroxytryptamine （5-HT） and its synthesis rate-limiting enzyme tryp-tophan hydroxylase （TPH） in the ventral horn of spinal cord after exercise-induced fatigue, and to further discuss the mecha- nism of exercise-induced central fatigue at spinal level. Methods Sixteen healthy adult Wistar rats were randomly divided into 2 groups： exercise-induced fatigue group and control group. Immunohistochemical staining for 5-HT and TPH in the ventral horn were performed and analysized quantitatively. The mean optic densities of 5-HT and TPH positive fibers or terminals were measured by computerized image analyzer. Results Both 5-HT and TPH positive fibers/terminals decreased in the exercise-induced fatigue group. The immunohistochemical staining was weaker and the mean optic densities decreased obviously in the fatigue group compared with those in the control group （P 〈 0.05）. Conclusion 5-HT and TPH in the ventral horn of spinal cord might be involved in exercise-induced fatigue.     

Naoxintong dose effects on inflammatory factor expression in the rat brain following focal cerebral ischemia

BACKGROUND： Certain components of tetramethylpyrazine, a traditional Chinese medicine, exhibit protective effects against brain injury. OBJECTIVE： To investigate the effects of different Naoxintong doses on expression of nuclear factor-kappa B （ kB）, interleukin-6, tumor necrosis factor-α, and complement 3 in rats following focal cerebral ischemia. DESIGN, TIME AND SETTING： The randomized experiment was performed at the Laboratory of Neurology, Second Hospital of Hebei Medical University from June 2004 to June 2006. MATERIALS： A total of 150 adult, healthy, male, Sprague Dawley rats, weighing 280-320g, were selected. Naoxintong powder （mainly comprising szechwan lovage rhizome, milkvetch root, danshen root, and radix angelicae sinensis） was obtained from Buchang Pharmacy Co., Ltd. in Xianyang City of Shanxi Province of China, lot number 040608. METHODS： The rats were randomly assigned into sham operation, saline, high-dose Naoxintong, moderate-dose Naoxintong, and low-dose Naoxintong groups, with 30 rats in each group. Rat models of middle cerebral artery occlusion were established using the suture method, with the exception of the sham operation group. Rats in the high-dose, moderate-dose and low-dose Naoxintong groups received 4, 2, and 1 g/kg Naoxintong respectively, by gavage. Rats in the saline group were treated with 1 mL saline by gavage All rats were administered by gavage at 5 and 23 hours following surgery, and subsequently, once per day. MAIN OUTCOME MEASURES： At 6, 24, 48, 72 hours, and 7 days following model establishment, brain water content was measured. Histopathological changes in brain tissues were detected using hematoxylin-eosin staining. Expression of nuclear factor- kB, interleukin-6, tumor necrosis factor- α, and complement 3 was examined by immunohistochemistry. RESULTS： A total of 150 rats were included in the final analysis with no loss. Brain water content was significantly increased in the ischemic hemisphere of rats from the saline, as well as the high-dose, mo     

Effects of realgar on stress proteins, inflammatory mediators, and complement in brain tissue and serum of rats with inflammatory brain injury*☆

BACKGROUND：The Chinese herbal compound realgar exerts detoxification effects as an adjuvant. It is suggested that realgar exerts detoxification via the following pathways： in the pathological state, realgar corrects the oxidative stress state by increasing stress levels, activating some endogenous protective factors and antagonizing the excessive release of inflammatory factors, as well as inhibiting complement activation. OBJECTIVE： To observe the changes in stress proteins, inflammatory mediators, and complement in the brain tissue and serum of rats with inflammatory brain injury, which have been treated with the Chinese herbal compound Angong Niuhuang, and to compare the efficacy of Angong Niuhuang with that of realgar, to verify the mechanism of action of realgar. DESIGN, TIME AND SETTING： Randomized, controlled, cytological experiment, performed in the Institute of Clinical Pharmacology, Guangzhou University of Traditional Chinese Medicine in March 2006. MATERIALS： Thirty-six healthy, male, Sprague Dawley rats received 250 U/kg Bordetella pertussis via the common carotid artery within 15 seconds to induce inflammatory brain injury. Reagents and kits were as follows： Realgar and Angong Niuhuang powder （Foshan Second Pharmaceutical Factory, China）, Bordetella pertussis diagnostic antigen （National Institute for the Control of Pharmaceutical and Biological Products, China）, heat shock protein 70 （HSP70） enzyme-labeled immunosorbent assay （ELISA） kit （Stressgen, USA）, tumor necrosis factor-α （TNF-α） ELISA kit （Biosource, USA）, nitric oxide synthase （NOS） kit, Coomassie brilliant blue protein kit （Nanjing Jiancheng Bioengineering Co.,Ltd., China）, and complements C3 and C4 （Shanghai Kehua Dongling Diagnositic Products Co.,Ltd., China）. METHODS： Thirty-six rats were randomly and evenly divided into the following six groups： normal control, model, high-, middle-, and low-dose realgar-treated, and Angong Niuhuang-treated groups. At one hour prior to establish     

Effects of transection of cervical sympathetic trunk on cerebral infarct volume and oxygen free radical levels in rats with focal cerebral ischemia/reperfusion injury*★

BACKGROUND： Stellate ganglion block （SGB） plays a protective role on the brain, but the precise mechanism of action is not clear. OBJECTIVE： To simulate SGB by transection of the cervical sympathetic trunk （TCST） and to investigate the TCST effects on changes in cerebral infarct volume and oxygen free radical levels in rats with focal cerebral ischemia/reperfusion injury. DESIGN, TIME AND SETTING： A complete randomized control animal experiment was performed at the Institute of Neurological Diseases of Taihe Hospital, Yunyang Medical College from February to December 2005. MATERIALS： A total of 101 healthy Wistar rats, weighing 280-320 g, of both genders, aged 17-18 weeks, were used in this study. 2, 3, 5-triphenyltetrazolium chloride （TTC） was purchased from Changsha Hongyuan Biological Company. Superoxide dismutase （SOD）, malondialdehyde （MDA） and nitric oxide （NO） assay kits were provided by Nanjing Jiancheng Bioengineering Institute. METHODS： Rats were randomly divided into a TCST group, a model group and a sham operation group. Successful models were included in the final analysis, with at least 20 rats in each group. After TCST, rat models of focal cerebral ischemia/reperfusion injury were established in the TCST group by receiving middle cerebral artery occlusion （MCAO） by the intraluminal suture method for 2 hours, followed by 24 hours of reperfusion. Rat models of focal cerebral ischemia/reperfusion injury were made in the model group. Rats in the sham operation group underwent experimental procedures as for the model group, threading depth of 10 mm, and middle cerebral artery was not ligated. MAIN OUTCOME MEASURES： Brain tissue sections of ten rats from each group were used to measure cerebral infarct volume by TTC staining. Brain tissue homogenate of another ten rats from each group was used to detect SOD activities, MDA contents and NO levels. Rat neurological function was assessed by neurobehavioral measures. RESULTS： Cerebral infarct volume was bigger in the     

癫癇社区防控策略可使更多农村地区癫癇患者受益

癫癇是一种临床常见的神经系统疾病。常于儿童和青少年期发病,若不接受正规治疗可反复发作,甚至迁延终身。该病不仅严重影响患者本人身体和心理健康,也给其家庭带来巨大痛苦和沉重的经济负担。据估计,全球约有逾50×106例癫癇患者,其中80%在发展中国家,发展中国家癫癇患病率是发达国家的2~3倍,且60%~90%的患者未接受治疗或仅接受非正规治疗[1-2]。癫癇的高患病率、高病死率及其对患者身心造成的严重不良影响已引起社会各界的重视,针对癫癇的各方面研究正在不断加强,