胃赛乐治疗慢性萎缩性胃炎的临床研究

目的　探讨自制胃赛乐胶囊治疗慢性萎缩性胃炎的临床疗效。方法　随机分为两组 ,治疗组 30例 ,服用胃赛乐胶囊 ,对照组 30例 ,服用雷尼替丁和胃乐宁。结果　两组治疗前后对比 ,胃赛乐组较西药组症状明显改善 (P <0 .0 5 ) ,胃镜检查对比病理症状 ,胃赛乐组较西药组疗效有显著差异 (P <0 .0 5 )。治疗组治愈总有效率80 .0 0 % ,对照组总有效率 70 .0 0 % ,两组之间有明显差异 (χ2 =11.4 0 ,P <0 .0 1)。结论　胃赛乐胶囊治疗慢性萎缩性胃炎优于对照组 ,疗效稳定 ,无副作用 ,安全可靠。     

胃乐舒颗粒剂对慢性浅表性胃炎疗效的临床研究

目的 :研究胃乐舒颗粒剂对慢性浅表性胃炎的疗效。方法 :经内镜确诊为慢性浅表性胃炎患者 2 4 0例 ,随机分为治疗组和对照组各 1 2 0例。治疗组给予胃乐舒颗粒剂 ,每次 1 0 g,1日 3次 ;对照组给予养胃冲剂 ,每次 1 5 g,1日 3次 ,疗程均为 6周。结果 :治疗 6周后 ,两组消化道症状均有显著改善 ( P<0 .0 5 )。其中治疗组缓解上腹饱胀、上腹痛、嗳气等症状的有效率分别为 79.4%、72 .1 %、74.2 % ,胃粘膜的炎症改善有效率为 80 .0 % ,活动性炎症消失率为 5 8.1 % ,Hp清除率为60 .4% ,均显著高于对照组 ( P<0 .0 5 ) ,且不良反应轻微 ,发生率仅 5 % ,与对照组无显著性差异 ( P>0 .0 5 )。结论 :胃乐舒颗粒剂是一种安全、有效的治疗慢性胃炎的药物。     

胃安颗粒治疗慢性萎缩性胃炎的临床与实验研究

目的 :观察胃安颗粒对慢性萎缩性胃炎的疗效。方法 :慢性萎缩性胃炎 1 45例随机分成治疗组 1 0 5例 ,对照组 40例 ,观察治疗前后胃粘膜病理改变、HP清除情况和症状体征改善情况。结果 :治疗组治疗后胃粘膜腺体萎缩好转 ,有效率 81 .90 % ,明显优于对照组的 62 .5 0 % ( P<0 .0 5 )。治疗组症状总有效率 91 .43% ,对照组 77.5 % ,两组比较 P<0 .0 5。HP清除率治疗组63.89% ,对照组 2 3.81 % ,两组比较 P<0 .0 5。动物实验显示胃安颗粒修复病变大鼠胃粘膜腺体、改善腺体泌酸功能优于对照组 ( P<0 .0 5 )。结论 :胃安颗粒是治疗萎缩性胃炎的有效药物。     

疏肝健脾和胃法治疗肝气犯胃型慢性浅表性胃炎20例临床观察

目的观察中药疏肝健脾和胃法治疗肝气犯胃型慢性胃炎的临床疗效;方法 将40例患者随机分为治疗组与对照组.治疗组20例应用疏肝健脾和胃法治疗,对照组20例应用三九胃泰胶囊治疗,治疗2个月为1个疗程.结果 治疗组总有效率为95%,疗效优于对照组的75%,差异有统计学意义(P<0.05);治疗组胃镜改善总有效率为90%%,高于对照组的70%,差异有统计学意义(P<0.05).结论 疏肝健脾和胃汤治疗慢性萎缩性胃炎疗效显著,且无不良反应.     

旋覆代赭汤治疗慢性胃炎69例疗效观察与体会

目的 探讨旋覆代赭汤治疗慢性胃炎的疗效.方法 对69例慢性胃炎患者使用旋覆代赭汤加减治疗,观察疗效.结果 (1)临床疗效:本组总有效率为90%;(2)胃镜疗效:本组总有效率为75%;(3)病理疗效:本组总有效率为78%.(4)在15例萎缩性胃炎中有6例伴肠上皮化生,经治疗消失4例;肝胃不和21例,临床有效率为10%,胃镜有效率为85%,病理有效率为80%,P<0.05.结论 旋覆代赭汤治疗慢性胃炎疗效稳定,值得临床推广.     

百胃胶囊治疗慢性胃炎的临床观察

目的 :观察百胃胶囊治疗慢性胃炎 (脾虚证 )的疗效及毒副作用。方法 :治疗组用百胃胶囊每次 1 .5 g,1日 3次 ,疗程 1个月。对照组用养胃冲剂每次 1 5 g,1日 3次 ,疗程 1个月。结果 :百胃胶囊组显效 78% ,总有效率 95 % ;养胃冲剂组显效 6 5 % ,总有效率 92 .5 %。两组显效率差异有显著性意义 ,P<0 .0 5。结论 :百胃胶囊对慢性胃炎 (脾虚证 )有理想疗效 ,并无毒副作用 ,值得推广     

山甲愈萎汤治疗萎缩性胃炎疗效观察

目的:观察山甲愈萎汤治疗萎缩性胃炎的临床疗效及探讨其疗效的作用机理。方法:将符合诊断标准的萎缩性胃炎患者随机分为治疗组和对照组各56例和28例。结果:治疗组总有效率94.6%,对照组总有效率为50%,经统计学处理,差异有显著性(P<0.05);治疗组自身前后及与对照组相比较,临床症状、胃镜像、病理疗效均有显著性差异(P<0.05)。结论:山甲愈萎汤对萎缩性胃炎具有祛瘀散结、通络行气调补脾胃的功效。     

幽门螺杆菌感染与慢性胃炎相关性

目的探讨幽门螺杆菌(Hp)感染与慢性胃炎发生及发展相关性。方法对行胃镜检查2 789例慢性胃炎病人的胃镜及病理检查结果进行回顾性分析,研究慢性胃炎与Hp感染关系。结果中老年组(40～87岁)Hp感染发生率明显高于青年组(18～39岁),差异有显著性(χ2=46.60、29.08,P<0.01);不同性别组间Hp感染的发生率差异无显著性(P>0.05)。活动性胃炎组Hp感染率为99.0%,中重度感染占51.5%,均明显高于非活动性胃炎组(χ2=179.93,P<0.01)。慢性浅表性胃炎的Hp感染率为83.6%,慢性萎缩性胃炎为95.4%,二者比较差异有显著性(χ2=28.88,P<0.01)。Hp感染阳性组重度胃炎、肠上皮化生及异型增生的发生率均较Hp阴性组高,差异有显著性(uc=-30.19～-13.17,P<0.01)。结论慢性胃炎的发生和发展与Hp感染密切相关。     

丽珠胃三联联合胃复春治疗HP阳性萎缩性胃炎临床疗效观察

目的观察丽珠胃三联联合胃复春片治疗幽门螺杆菌阳性萎缩性胃炎的临床疗效、病理改变及与HP转阴的相关情况,探讨治疗HP阳性萎缩性胃炎安全有效的方法。方法将胃镜、病理诊断以及HP检测阳性的萎缩性胃炎患者58例随机分为两组,即治疗组(胃复春联合丽珠胃三联)29例,对照组(单用丽珠胃三联)29例,疗程均为3个月(丽珠胃三联服2周为一个疗程)。结果临床总有效率:治疗组为89.7%,对照组为68.9%,两组比较P<0.05;病理复查总有效率:治疗组为82.8%,对照组为65.5%,两组比较P<0.05;HP转阴率:治疗组为93.1%,对照组为89.7%,两组比较P>0.05。结论胃复春联合丽珠胃三联是治疗HP相关性萎缩性胃炎的安全、有效药物。     

甲磺酸加替沙星片治疗急性细菌性感染多中心临床研究

目的 :评价国产甲磺酸加替沙星片的疗效及安全性。方法 :试验组 115例患者接受甲磺酸加替沙星片 2 0 0mg口服 ,每日 2次 ;对照组 10 8例接受盐酸环丙沙星片 2 5 0mg ,每日 3次 ,疗程 7d～ 14d。结果 :试验组与对照组总痊愈率分别为 90 .4 %与77.8% ,有显著性差异 (χ2 =6 .74 ,P <0 .0 1) ;总有效率分别为 95 .7%与 89.8% ,无显著性差异 (χ2 =2 .85 ,P >0 .0 5 )。在呼吸系统、泌尿系统与皮肤软组织轻、中度细菌感染中 ,试验组与对照组的痊愈率、有效率比较均无显著性差异 (P >0 .0 5 ) ;在生殖道感染中 ,试验组痊愈率显著高于对照组 (χ2 =6 .72 ,P <0 .0 1) ,有效率相似 (χ2 =3.0 5 ,P >0 .0 5 )。试验组与对照组各种致病菌感染的痊愈率分别为 90 .3%与 79.6 % ,有显著性差异 (χ2 =4 .4 6 ,P <0 .0 5 ) ;有效率分别为 95 .1%与 90 .3% ,两者相似(χ2 =1.71,P >0 .0 5 ) ;细菌清除率分别为 97.1%与 89.2 % ,有显著性差异 (χ2 =4 .85 ,P <0 .0 5 )。两组不良反应发生率分别为 13.8%和 13.9% (P >0 .0 5 )。结论 :国产甲磺酸加替沙星片治疗轻、中度急性细菌感染安全、高效。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…