复方角菜酸酯剂用于痔上黏膜环切钉合术后辅助治疗效果观察

目的 观察复方角菜酸酯剂用于痔上黏膜环切钉合术（PPH）后的辅助治疗效果观察.方法 将60例环状混合痔实施痔上黏膜环切钉合术的患者分为治疗组和对照组,各30例.治疗组术后予复方角菜酸酯栓联合复方角菜酸酯乳膏纳肛,对照组术后予应用复方角菜酸酯栓纳肛,术后连续使用2周.分别进行阶段性临床观察,对术后肛门疼痛、肛门坠胀感及吻合口水肿程度等临床症状作出评估.结果 术后两组临床疗效、术后创伤及并发症差异均有统计学意义（均P＜ 0.05）.结论 复方角菜酸酯剂用于痔上黏膜环切钉合术后辅助治疗效果好,值得临床推广.     

复方角菜酸酯栓促进重度痔病患者PPH术后康复

目的观察复方角菜酸酯栓促进重度痔病患者PPH术后的疗效。方法回顾分析重度痔病患者116例行PPH术后,根据采取治疗措施分为观察组(使用复方角菜酸酯栓)62例,常规组(未运用局部药物,仅常规PP粉液坐浴)54例,于术后第1,3,5,7天询问患者对疼痛的主观感受进行分度,对其创面水肿、肛周分泌物、出血、排便等情况做出评估。结果观察组术后第1,3,5天评分均较常规组低,差异有显著性(P<0.01);术后第7天两组得分差异无显著性(P>0.05)。观察组不适症状改善情况较常规组明显提早。结论复方角菜酸酯栓在重度痔病PPH术后应用疗效显著,对患者术后疼痛和水肿等局部症状控制效果良好,是一种有效地PPH术后恢复辅助用药。     

太宁栓用于PPH术后的临床疗效观察

目的观察太宁栓对痔病患者PPH术后的临床疗效。方法对90例患者PPH术后常规使用马应龙麝香痔疮膏,其中同时对48例患者加用太宁栓,比较两组对于术后疼痛、出血、水肿、排便情况、瘙痒的症状评分比较。结果太宁栓用于PPH术后肛门的治疗,显著减轻术后首次排便的疼痛及出血、水肿,与对照组比较差异具有显著性(P<0.05)。结论太宁栓具有减轻PPH术后早期肛门疼痛及出血、水肿的作用。     

前列安栓治疗Ⅲ型前列腺炎36例的临床观察

目的:观察前列安栓治疗Ⅲ型前列腺炎的临床疗效。方法:Ⅲ型前列腺炎患者60例,随机分为治疗组(n=36)和对照组(n=24),治疗组应用前列安栓,对照组应用野菊花栓。观察2组治疗前后的慢性前列腺炎症状积分指数(NIH-CPSI评分)和前列腺按摩白细胞计数(EPS-WBC)变化,并应用SPSS统计学处理方法分析处理。结果:治疗组效果优于对照组。前列安栓的综合治疗效果优于野菊花栓。结论:前列安栓是治疗Ⅲ型前列腺炎有效药物。     

复方角菜酸酯栓在内痔出血的临床应用

目的探讨复方角菜酸酯栓在内痔出血中的疗效。方法对35例内痔出血患者应用复方角菜酸酯栓治疗作为治疗组,36例应用痔疮膏治疗作为对照组,观察出血症状的改善情况,评估疗效。结果治疗组的总有效率为94.29%,明显优于对照组的69.44%（P〈0.05）;且治疗组局部黏膜水肿较对照组明显减轻,治疗期间未出现全身或局部不良反应。结论复方角菜酸酯栓对于内痔出血的临床疗效显著,用药安全。     

复方角菜酸酯栓在混合痔外剥内扎术后的临床应用

目的探讨复方角菜酸酯栓在混合痔外剥内扎术后的临床应用。方法对90例混合痔外剥内扎术后的患者分别应用复方角菜酸酯栓(42例,治疗组)和痔疮膏(48例,对照组)进行临床对比观察。结果复方角菜酸酯栓治疗肛肠疾病患者42例,总有效率92.3%,明显优于对照组,两组有非常显著性差异(P<0.01)。复方角菜酸酯栓对术后减轻疼痛﹑出血﹑水肿﹑促进创面愈合的功效明显优于对照组(P<0.05)。结论复方角菜酸酯栓对于混合痔外剥内扎术后可以减少不良反应,促进创口的愈合。     

复方角菜酸酯栓促进重度痔病患者PPH术后康复的临床观察

目的　观察复方角菜酸酯栓促进重度痔病患者PPH术后的疗效。方法　回顾分析重度痔病患者116例行PPH术后,根据采取治疗措施分为治疗组(使用复方角菜酸酯栓)62例,常规组(未运用局部药物,仅常规PP粉液坐浴)54例,于术后第1、3、5、7天询问患者对疼痛的主观感受进行分度,对其创面水肿、肛周分泌物、出血、排便等情况做出评估。结果　治疗组术后第1天、第3天、第5天评分均较常规组低,有显著性差异;术后第7天两组得分差异无统计学意义。治疗组不适症状改善情况较常规组明显提早。结论　复方角菜酸酯栓在重度痔病PPH术后应用疗效显著,对患者术后疼痛和水肿等局部症状控制效果良好,是一种有效地PPH术后恢复辅助用药。     

复方角菜酸酯栓用于肛门疾病伤口换药的临床观察

目的观察复方角菜酸酯栓对肛门伤口的疗效。方法将160例肛门伤口按随机数字表法分为观察组与对照组,观察组80例采用换药时1‰新洁尔灭棉球擦洗伤口后,将复方角菜酸酯栓放入肛门口内,再用黄连素油纱布覆盖伤口,每天一次,直至痊愈;对照组：80例用1‰的新洁尔灭棉球擦洗伤口后,直接用黄连素油纱布覆盖伤口,每天一次,直至痊愈。结果观察组：治愈时间（10±4）d,明显短于对照组（16±4）d,p〈0.01;观察组术后排便困难2例,明显少于对照组术后排便困难10例,观察组术后无出血,对照组术后出血6例。结论肛门疾病伤口用复方角菜酸酯栓换药,伤口愈合快,疗效显著。     

复方角菜酸酯乳膏在重度痔病患者PPH术后的疗效观察

目的:观察复方角菜酸酯乳膏在重度痔病患者痔上黏膜环形切除吻合术(PPH)术后的疗效。方法:随机将153例行PPH术的重度痔病患者分为治疗组和对照组,术后第1、3、5、7天询问患者对疼痛和坠胀感的主观感受并进行分度,对其创面水肿、出血、分泌物、首次排便等情况做评估。结果:治疗组术后第1、3、5天评分均较对照组低,差异有显著性(P<0.01);术后第7天,2组得分差异无显著性(P>0.05),治疗组不适症状改善情况较对照组明显提早。结论:复方角菜酸酯乳膏在重度痔病PPH术后应用疗效显著,其对患者术后疼痛和水肿等局部症状控制效果良好。     

多普勒引导痔动脉结扎联合外切内扎术治疗环状混合痔

目的:探讨多普勒引导痔动脉结扎联合减创外切内扎术治疗环状混合痔的疗效及特点。方法:将70例符合环状混合痔诊断且具备手术指征的患者,随机分为治疗组35例和对照组35例。对照组采用传统的M illigan-Morgan手术,治疗组采用DG-HAL+减创外切内扎术,比较2组在临床治疗效果、术中出血量、术后排尿、肛门狭窄、住院时间、术后肛门疼痛、肛缘水肿、控便能力等方面的差异。结果:2组临床治疗效果、术中出血量、术后排尿、肛门狭窄差异无统计学意义(P>0.05),而住院时间、术后肛门疼痛、肛缘水肿、控便能力差异有统计学意义(P<0.05~P<0.01)。结论:DG-HAL+减创外切内扎术治疗环状混合痔在住院时间、术后肛门疼痛、水肿、控便方面较传统术式具有一定的优势。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…