参麦注射液治疗冠心病心绞痛30例疗效分析

本文采用参麦注射液对30例冠心病心绞痛进行治疗前、后对照分析,结果表明:本药对临床症状改善,静息缺血性心电图变化改善率分别为93.3％和75％,部分血液流变异常指标获得改善。提示该药是治疗冠心病心绞痛较为安全有效的药物。     

金钠多注射液治疗缺血性脑血管病患者血液流变学的观察

目的　探讨金钠多注射液在治疗缺血性脑血管病时血液流变学的改变。方法　选择 4 0例缺血性脑血管病 ,包括脑血栓 9例 ,多发性腔梗 2 4例 ,单发性腔梗 7例。给金钠多注射液 2～ 4支 /次 ,1～ 2次 /d静点 ,1 4d为 1个疗程。每例病人采静脉血 5mL ,测血液流变学各项指标。结果　治疗前后血液流变学各指标变化较明显。结论　应用金钠多注射液治疗缺血性脑血管病 ,血液流变学各项异常指标均有下降。故可推论该药为治疗缺血性脑血管病较理想的药物     

川芎嗪注射液对老年高黏血症的影响

川芎嗪注射液主要成份川芎嗪是从中药川芎根茎中提纯精制而成的液体制剂,为探讨该药对老年高黏血症的影响,我们从2001年5月至2003年4月对每年老干部健康体检中发现血液流变学明显异常的患者,随机分为治疗组和对照组各50例,治疗前后进行血液流变学指标检测,并进行对比观察。1     

从血液流变学角度探讨川芎嗪治疗脑血栓形成的机理

本文报告了48例急性脑血栓形成患者用川芎嗪治疗前后六项血液流变性指标的测定结果,以25例年龄、性别与病人组构成相近的正常人作对照组。病人组治疗前此六项指标与对照组相比均有显著差异(P<0.01),此异常改变在本病的发生上可能起着重要作用。治疗后。此六项指标明显改善,且与临床症状的好转呈平行关系。提高红细胞和血小板表面电荷、减少它们的聚集、改善血液流变性和微循环可能是该药治疗本病取得疗效的主要原因之一。     

抗结核治疗致血液系统损害63例临床分析

目的:探讨门诊肺结核患者标准化疗方案致血液系统异常的发生率、类型、原因、预防对策及预后。方法:对我中心结防科2008年1月-2010年12月1 033例入项接受标化方案治疗引起血液系统异常的患者63例进行整理和分析。结果:63例患者中白细胞总数降低58例,发生率为5.6%;中性粒细胞降低29例;酸性粒细胞降低13例;中性粒细胞和酸性粒细胞同时下降为16例。血小板受损5例,发生率为0.5%。血液系统损害出现时间多为化疗强化期,维持抗结核的同时积极升血治疗最终完成疗程或治愈62例,1例因严重溶血中断治疗。结论:抗结核病药物引起血液系统异常较为常见(6.1%),类型呈多样化,病因多,表现不典型,门诊抗结核治疗虽有风险,但加强监测,及时发现正确处理,就能有效保障用药安全,提高患者的治愈率。     

结核病合并血液系统异常106例临床分析

目的探讨结核病合并血液系统异常的临床特点。方法选取2015年1月至2018年10月我科收治的106例结核病初治患者,对其临床资料进行回顾性分析,进行血常规与血清学检查,记录相关指标异常情况,同时观察治疗转归情况。结果通过对106例结核病患者的血常规检查发现,100.0%的病例存在HB下降、PLA升高情况,有27.36%病例中性粒细胞升高,23.58%的病例降低。血清学检查发现白蛋白、钠、氯均表现为下降,比例高达100.0%。本组患者经抗结核治疗,病情好转的同时血液系统异常也得到改善,提示血液系统异常是由结核病引起的。结论分析结核病合并血液系统异常表现能够指导临床治疗方案的选择,应当引起医务工作者重视。     

糖尿病的血液流变学变化

我们用东北蝮蛇抗栓酶治疗Ⅱ型糖尿病取得较好疗效。为探讨该药对糖尿病的治疗作用和机理,对14例糖尿病进行了血液流变学检测,并设20例健康者进行对照分析。其中应用蝮蛇抗栓酶治疗10例糖尿病患者,并进行了治疗前后血液流变学对比检测。现将结果报告如下。     

内分泌和月经异常

060436子宫异常出血合并血液系统出血性疾病的临床处理/孙爱军…∥中国医刊.—2004,39(12).—25～27了解血液系统出血性疾病导致的子宫异常出血的情况,探讨妇科干预和治疗的方法及效果。回顾性分析北京协和医院17年间合并血液系统出血性疾病的有月经的妇女,了解子宫出血异常出血的比例,并进一步对子宫异常出血的患者进行分析,了解妇科治疗的情况,包括药物和手术治疗。结果:合并血液系统出血性疾病有月经的妇女,发生子宫异常出血的比例高达63%,其中以血小板减少性紫瘢(48%)、再生障碍性贫血(27%)、骨髓异常增生综合征(15%)为多见。48例药保守…     

子宫异常出血合并血液系统出血性疾病的临床处理

目的了解血液系统出血性疾病导致的子宫异常出血的情况,探讨妇科干预和治疗的方法及效果. 方法回顾性分析北京协和医院17年间合并血液系统出血性疾病的有月经的妇女,了解子宫异常出血的比例, 并进一步对子宫异常出血的患者进行分析,了解妇科治疗的情况,包括药物治疗和手术治疗. 结果合并血液系统出血性疾病有月经的妇女,发生子宫异常出血的比例高达63%,其中以血小板减少性紫癜(48%)、再生障碍性贫血(27%)、骨髓异常增生综合征(15%)为多见.48例药物保守治疗, 18例有手术指征者接受了妇科手术,其中14例临床表现为子宫大量出血单纯由于血液病造成者7例,采取刮宫手术与子宫内膜切除术各3例,其中各有1例因手术失败,复发而改子宫切除术,1例直接行子宫切除术;另外7例子宫出血者同时合并有妇科手术指征而行子宫切除术;术前、术中与术后纠正凝血功能异常如血小板数量低非常重要,可防止再次发生出血.结论造成育龄妇女异常子宫出血的血液系统疾病常见的是血小板减少性紫癜、再生障碍性贫血、骨髓异常增生综合征等.通常保守药物治疗可达到止血目的(76.2%),但出血多,保守治疗效果差,需及时行手术治疗,包括子宫内膜切除术和子宫切除术.多科合作对围手术期病人的监测至关重要,可有效防止并发症的发生.     

磷酸川芎嗪缓释胶囊对肺心病血液流变学的影响

作者采取随机化,安慰剂胶囊对照,交叉对比方式观察了16例急性期肺心病人口服磷酸川芎嗪缓释胶囊后的血液流变学的变化。结果表明,磷酸川芎嗪缓释胶囊口服治疗后,肺心病人的全血和血浆粘度降低,红细胞压积和血浆纤维蛋白原减少,反映了该药对血液流变学有异常的改善作用。其机理可能是川芎嗪降低血小板聚紧性,抑制血栓形成。这一抗凝作用与减少内源性花生四烯酸的释放,调节TXA_2/PGI_2的平衡有关。川芎     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…