绿茶儿茶素与抗癌药联合应用对二株人肝癌细胞生长的影响

目的：研究绿茶儿茶素（GTC）与抗癌药阿霉素（ADM）,5－氟尿嘧啶（5－Fu)和阿糖胞苷（AraC)联合应用对人肝癌细胞体外生长的抑制作用。方法：应用MTT法检测GTC先于抗癌药,抗癌药作用后或与抗癌药同时作用,对BEL－7402和SMMC－7721人肝癌细胞的生长抑制作用。结果：GTC与抗癌药有相加性抑瘤效应。结论：GTC很可能具有临床应用前景。     

碳酸锂对放化疗癌症患者的抗氧化作用

目的 :观察碳酸锂 (Li2 CO3)对放化疗癌症患者体内的抗氧化物和过氧化物水平的影响。方法 :应用生化分析法测定癌症患者体内的血细胞超氧化物歧化酶 (SOD)、谷胱苷肽过氧化物酶 (GSH Px)活力 ,血清巯基(-SH)和血浆丙二醛 (MDA)含量。结果 :癌症患者在放化疗前、后与对照组相比 ,SOD、GSH Px、-SH水平均显著降低 ,MDA水平升高 (P <0 0 1) ;Li2 CO3 联合治疗组与放化疗后相比 ,SOD、GSH Px、-SH水平上升 (P <0 0 1,除第一疗程 -SH水平变化不明显外 ) ,MDA水平有下降趋势。结论 :Li2 CO3 可提高放化疗癌症患者体内抗氧化物水平 ,抑制脂质过氧化     

路泰对晚期癌症患者临床止痛效果的研究

目的通过路泰控释片对晚期癌症镇痛效果研究,评估美国路坦公司生产路泰控释片对晚期癌症的止痛效果。方法每位癌症疼痛患者每12小时口服路泰控释片30mg。结果通过开放性实验研究,观察200例晚期癌症疼痛患者,疼痛完全缓解率(CR)67%,明显缓解率(PR)21%,总缓解率(RR)88%。无明显毒副作用,个别病例可出现短暂眩晕、便秘及恶心、呕吐,停药后毒副作用可自行消失,无明显蓄积毒性及吗啡样成瘾性。结论通过路泰控释片对200例晚期癌症疼痛患者的止痛效果观察研究,路泰控释片的止痛效果确切,副作用小,值得在临床上推广应用。     

六步癌症告知模型配合健康教育对肺癌化疗患者消极心理状态与希望指数的影响

目的：探讨六步癌症告知模型配合健康教育对肺癌化疗患者的康复影响。方法：将60例肺癌化疗患者按随机数字表法分为两组，即对照组30例，采用健康教育；观察组30例，在对照组护理基础上采用六步癌症告知模型。对比两组消极心理、希望水平及生活质量的变化。结果：观察组护理后消极心理状态优于对照组，希望水平、SAQ评分水平及生活质量均高于对照组(P<0.05)。结论：六步癌症告知模型配合健康教育可减轻肺癌化疗患者消极心理，提高患者希望水平，应用效果好。     

甲羟孕酮提高中晚期癌症患者生存质量的临床观察

目的：观察甲羟孕酮对晚期癌症患者食欲、体重及生存质量的影响。方法：甲羟孕酮500mg，1d 1次口服，连服4周--6周，治疗34例中晚期癌症患者。结果：进食量增加28例(82．4％)，体重增加23例(67．5％)，生存质量改善26例(76．5％)。未见明显副作用。结论：甲羟孕酮在改善晚期癌症患者的生存质量方面有较好疗效。     

碳酸锂合并氯氮平治疗急性期躁狂症的对照研究

躁狂抑郁症,急性期躁狂状态、病情急、危害性大,已为国内、外精神病学界所公认。因此,探讨快速疗效,特别是毒副作用较小的治疗方法,具有较大的实用价值。碳酸锂系躁狂症的首选药物之一,但其奏效较慢(奏效时间为10天左右),氯氮平对中枢去甲肾上腺素能(NE能)神经元有明显抑制作用,镇静作用强,控制精神运动性兴奋效果好,且奏效快,具此我们于1993年开始,对碳酸锂合并氯氮平快速控制急性躁狂状态,进行了临床疗效观察,现报道如     

瓜蒌泻心汤对急性躁狂症的辅助治疗作用

目的:观察碳酸锂与瓜蒌泻心汤联合应用对急性躁狂症的疗效和安全性。方法:采用对治疗组患者给予瓜蒌泻心汤和碳酸锂口服,对照组患者给予碳酸锂口服,以Bech-Rafaelsen,躁狂量表(BRMS)和治疗中出现的症状量表(TESS)在治疗前及治疗第1、2、4、6周末分别评定两组患者的急性躁狂症改善表现及药物不良反应。结果:两组治疗后均有显著疗效,两组疗效相仿(P>0.05)。治疗组不良反应明显小于对照组(P<0.01)。结论:碳酸锂结合瓜蒌泻心汤治疗急性躁狂症疗效可靠,不良反应小,服药依从性好。     

脑神经生长素治疗急性颅脑损伤的临床观察

目的：探讨脑神经生长素(CNG)对急性颅脑损伤的临床疗效。方法：选择急性颅脑损伤GCS6-12分的患者予CNG治疗，随机以类似伤情不用CNG治疗病例为对照，观察意识觉醒，用药后GCS和随访GOS的变化。结果：意识清醒缩短，临床症状好转加快，GOS综合生活质量增高。结论：CNG适用于急性颅脑损伤治疗并无毒副作用。     

“古方”外敷药对膝关节损伤的临床研究

目的：观察“古方”外敷药治疗膝关节损伤的疗效。方法：治疗组(40例)每天用“古方”外敷药1次，连用1周。对照组(10例)每天用消炎止痛膏，连用1周。结果：治疗组总有效率92．5％，对照组60％。结论：“古方”外敷药具有活血化瘀，消肿止痛，改善局部血液循环，消除炎症及修复损伤的作用。未发现任何毒副作用，有较高的临床应用价值。     

碳酸锂联合丙戊酸镁缓释片治疗双向情感障碍躁狂发作患者的效果观察

目的:探讨碳酸锂联合丙戊酸镁缓释片治疗双相情感障碍躁狂急性发作患者的临床疗效及安全性。方法:选择双相情感障碍躁狂急性发作患者78例,随机分为观察组和对照组,每组各39例。对照组患者予以碳酸锂治疗;观察组患者给予碳酸锂和丙戊酸镁缓释片联合治疗。两组患者均治疗4周。记录两组患者治疗前后的BRMS评分及TESS评分。结果:治疗后,观察组患者的BRMS总分为(7.4±5.2)分,显著低于对照组(14.7±3.5)分(P<0.05);观察组患者的躁狂发作次数、住院次数及住院时间均少于对照组(P<0.05);治疗后,两组患者的TESS评分比较,差异无统计学意义(P>0.05)。结论:碳酸锂联合丙戊酸镁缓释片治疗双相情感障碍躁狂发作患者,可有效控制其躁狂发作次数及住院时间,临床效果显著,且安全性高,值得临床应用推广。     

碳酸锂对大白鼠血细胞影响的研究

本实验采用切割鼠尾静脉取血法,利用大白鼠Co~(60)照射后的血象明显低于正常的病理模型,观察大白鼠给药(碳酸锂)前后血象变化。给药后WBC明显高于给药前,(P<0.001)证实碳酸锂升高白细胞作用的可靠性。提示该药不仅是防治躁狂症和预防双相情感性精神病复发的首选药,而且为良好的升白细胞药物。     

The use of lithium carbonate to correct leukopenia during cancer treatment

Leukopenia is a common complication noted in patients receiving radiotherapy and/or chemotherapy but no effective method has been reported so far to correct this complication. In the field of psychiatry, lithium carbonate used in treating depression has been noted to have induced leukocytosis as a side effect. From July 1985 to December 1987, a total of 111 patients receiving radiotherapy and/or chemotherapy with leukopenia were included in this study. There were sixty nine patients who received lithium carbonate and the remaining forty two patients served as control group were allowed to stop their primary treatment temporarily without medication during their period of leukopenia. For the group given lithium carbonate, 79% of the patients were able to recover their white blood count (WBC) above 3,000/cu.mm. within 5 days and finished their primary treatment smoothly. For the control group, it took them on the average about 11.8 days of rest in order to recover their WBC level to 3,000/cu.mm. and above. Reports in the recent literature indicates that the average toxic level is around 1.5 mEq/l to 2.0 mEq/l. In our study, the average serum lithium level before administration is 0.44 mEq/l, it reached 0.59 mEq/l and 1.08 mEq/l after the fifth and the 10th day of intake respectively. From this laboratory data, obviously no patient reached the toxic level and no side effects were noted clinically. Based on these figures, we can see clearly that lithium carbonate can shorten the period of leukopenia in comparison to the control group which was not given any medication.     

碳酸锂?强的松对甲状腺功能亢进症131I治疗患者的影响

目的:研究碳酸锂?强的松应用对甲状腺功能亢进症(甲亢)患者131I治疗剂量和疗效的影响?方法:75例甲亢患者随机分为3组:对照组25例,患者仅接受131I治疗;碳酸锂组25例,患者接受131I治疗的同时口服碳酸锂0.75 g/d(从治疗前3 d至治疗后7 d);强的松组25例,患者接受131I治疗的同时口服强的松1 mg/(kg·d),后以每周5 mg逐渐减量至停用?治疗过程中根据甲状腺重量计算治疗需要的131I剂量,6个月后观察患者的治疗效果?结果:与对照组相比,碳酸锂组患者131I剂量明显减少(P < 0.05),但治疗效果无明显改善(P > 0.05);与对照组相比,强的松组患者131I治疗量有所升高,但无统计学差异(P > 0.05),而疗效却明显增加(P < 0.05)?结论:碳酸锂可以减少甲亢患者131I治疗的剂量,但对治疗效果无改善作用;强的松对131I治疗剂量无显著影响,但可以增加131I治疗甲亢的疗效?     

异搏定对膀胱癌耐药性的逆转研究

目的通过钙通道阻滞剂异搏定阻止抗癌药物从细胞内排出,探讨肿瘤细胞抗药性逆转的可能性。方法利用氮唑化合物(MTT)试验方法及高效液相色谱分析(HPLC)方法检测应用异搏定后肿瘤细胞对抗癌药物敏感性的改变。结果发现异搏定对膀胱癌敏感细胞(EJ)的生长无影响,而对膀胱癌耐药细胞(EJ-R)则随着异搏定质量浓度的增加,化疗药物的抗癌作用逐渐增强。结论异搏定通过阻滞钙通道,降低P-GP170排出抗癌药物的作用,使癌细胞内抗癌药物浓度得到保证,达到杀死肿瘤细胞的目的,即癌细胞抗药性得到逆转。     

A study of the expression of p53 in posttransfection cells with rAdp53 gene and inhibitory activity in vitro

Objective To investigate the inhibitory effect and IC50 (50% inhibiting concentration) of the recombinant adenoviral p53 gene (rAdp53) in colorectal cancer cells in vitro and to guide clinical practice. Methods We evaluated the efficiency (IC50)of the rAdp53 and six kinds of anti-cancer drugs(5-fluorouracil, tegafur, mitomycin c, cisplatin, oxaliplatin, paclitaxel) in human colorectal cancer cell line-174 through the cell culture and MTT chemosensitivity assay to make sure the anti-cancer capability of rAdp53.Expression of p53 protein in transfection cells of colorectal cancer line-174 with rAdp53 was evaluated by immunohistochemical staining. Results The rAdp53 is a dose- and time-dependent anti-cancer drug, its IC5o is 5.73×1011 VP/ml, but its effect was not obvious when compared with other anti-cancer drugs. In control group, the immunohistochemistry stain was negative. However,rAd-p53 of five different concentrations were all positive in infected colorectal cancer cells with rAd-p53 and the earliest positive result would present 24 hours after infection. Conclusion The rAdp53 has good anti-cancer efficacy is colorectal cancer cell line174 in vitro. But its anti-cancer efficacy was less than those of the classical chemical medicine mitomycin c, 5-fluorouracil and cisplatin etc., when it was used alone.     

急性脑梗死患者血白细胞数变化及其对病情进展的影响

目的：探讨急性脑梗死患者血白细胞数的变化其对脑梗死预后的影响。方法：检测了82例急性脑梗死患者血白细胞数变化和神经功能损评分的关系，同时探讨脑梗死灶大小与血白细胞数的关系。结果，大灶脑梗死患者血白细胞数增高较小灶脑梗死患者明显，高血白细胞脑梗死组患者的神经功能缺损评分较非高血白细胞组脑梗死患者有显著升高，同时高血白细胞组脑梗死患者的神经功能恢复也较缓慢，结论：血白细胞增高对急性脑梗死患者的病情进展及预后有着重要影响。     

Clinical effect of chemotherapy combined with Chinese herbs and western drugs on leukocytes of gastric cancer patients

This study observed the effect of chemotherapy combined with Chinese herbs and western drugs on white blood cell count in 31 patients with gastric cancer. These patients were divided into 3 groups: (1) Fu Zheng (strengthen the body resistance) with invigorating the Spleen and Kidney recipe; (2) Fu Zheng with western drugs raising WBC and enhancing immunity; (3) Gong Xiao (eliminating the evil factors and mass) with promoting blood circulation to remove blood stasis recipe or eliminating the evil factors and mass recipe. After chemotherapy, the mean of WBC count was greater than 4.0 X 10(9)/L in group I; less than 3.5 X 10(9)/L in group II; less than 3.0 X 10(9)/L in group III. Because of WBC count below 3.0 X 10(9)/L, in group II there were 5 cases (5/14) whose chemotherapies had to be discontinued, and in group III there were 4 cases (4/6). While all patients were completed their chemotherapies in group I. Its statistical difference was significant (P less than 0.05). It suggested that invigorating the Spleen and Kidney recipe had specific effect on decreasing the toxicity and side effect of chemotherapy, preventing bone marrow suppression and leukopenia, and was better than western drugs used in group II. It showed in the treatment of cancer with TCM, we must pay attention to the relationship between the Fu Zheng and the Gong Xiao.     

麻醉药品、一类精神药品使用措施与效果研究

目的:探讨一种切实可行的麻醉药品、一类精神药品医院使用管理方法。方法:加强医护人员癌症疼痛处理新知识的学习和临床应用,对癌症患者信息实行局域网内管理,并对新措施实施前后的数据进行统计学处理,一类精神药品使用方法类同。结果:经三级止痛阶梯疗法治疗的患者癌痛理想控制率为90.6%,药物依赖性产生率为3.1%,患者满意度为94.8%;非经系统治疗患者癌痛理想控制率为67.5%,药物依赖性产生率为27.5%,患者满意度为54.9%。结论:将麻醉药品、一类精神药品纳入局域网管理,对癌症患者进行三级止痛阶梯疗法系统治疗对于癌症患者疼痛的解除、提高抗癌疗效、延长病人存活天数都有积极意义。     

中西医结合治疗躁狂型精神病68例疗效观察

目的:探讨龙胆泻肝汤加减与碳酸锂药物治疗躁狂型精神病疗效。方法:将68例躁狂型精神病患者随机分为龙胆泻肝汤加减合用碳酸锂34例(实验组),和单用碳酸锂34例(对照组),治疗6周为一疗程,采用躁狂症量表(BRMS)减分法进行评分。结果:龙胆泻肝汤加减合用碳酸锂(实验组)治疗躁狂型精神病,可以加快病情痊愈,总有效率为94.1%;单用碳酸锂组(对照组)总有效率为70.6%。实践证明实验组与对照组疗效具有显著性差异(0.01相似文献