安清益智胶囊的质量标准研究

目的：研究安清益智胶囊的质量标准。方法：采用TLC对芹菜籽挥发油组分进行色谱鉴别。采用GC法测定正丁基苯酞的含量。结果：正丁基苯酞在6.25-200mg范围内有良好的线性关系。回收率为100.9%。RSD为1.75%。结论：研究建立的方法对安清益智胶囊能够准确。快速的地进行定性,定量检测。     

正丁基苯酞的合成及结构表征

目的合成正丁基苯酞并对其结构进行表征。方法以邻甲酰基苯甲酸为原料与格氏试剂进行反应,研究不同投料比对反应产率的影响,并通过质谱、紫外可见光谱、红外光谱、核磁共振氢谱表征反应产物结构。结果邻甲酰基苯甲酸与格氏试剂投料比为1:2.5时的产率最高,达49%。反应产物经确证为正丁基苯酞。结论本方法安全性高、原料成本低、步骤简便易行。     

n-丁基苯酞合成方法研究

目的研究n-丁基苯酞的合成方法及理化性质.方法详细归纳了目前关于n-丁基苯酞的合成方法,总结绘制各方法的合成路线图,并逐一对它们进行叙述比较.结果非对称异构合成方法成为热点.结论 n-丁基苯酞合成方法的研究比较对进一步开发该药的非对称异构合成及其药理活性的研究具有重要的参考价值.     

dl-3-正丁基苯酞软胶囊治疗椎-基底动脉供血不足疗效观察

目的：评价dl-3-正丁基苯酞软胶囊治疗椎-基底动脉供血不足的临床疗效。方法：收集椎-基底动脉供血不足患者124例,其中,治疗组66例采用dl-3-正丁基苯酞软胶囊治疗,对照组58例采用复方丹参片治疗。60d后观察两组的临床疗效。结果：治疗组总有效率为87.88%（58/66）,对照组总有效率为68.97%（40/58）,差异有统计学意义（P〈0.05）。结论：dl-3-正丁基苯酞软胶囊对椎-基底动脉供血不足有明显疗效。     

苯骈呋喃酮类化合物的质谱裂解特征研究

目的研究丁苯酞等5个苯骈呋喃酮类化合物的质谱裂解特征。方法对于手性拆分的丁苯酞及丙苯酞采用质谱分析,丁烯苯酞的两个顺反异构体采用液相-质谱联用技术进行分离分析,并对5个苯骈呋喃酮类化合物的多级质谱裂解规律进行了详细解析。结果通过得到离子碎片的组成结构,可以进一步推断得出5个复杂的差向异构体或顺反异构体化合物形成碎片离子的裂解途径。结论该法简便、快速、准确,有助于对此类结构化合物更多的研究。     

44例急性期轻中度后循环缺血的临床分析

目的应用dl13-正丁基苯酞软胶囊与艾灸联合,对病情处于急性期的轻中度后循环缺血患者实施治疗的临床效果进行研究。方法抽取88例病情处于急性期的轻中度后循环缺血患者,随机分为对照组和治疗组,平均每组44例。采用dl-3-正丁基苯酞软胶囊对照组患者实施治疗;采用dl-3-正丁基苯酞软胶囊与艾灸方式联合对治疗组患者实施治疗。结果治疗组患者后循环缺血病情治疗效果明显优于对照组;病情控制时间和临床治疗实际时间明显短于对照组;两组均未出现任何不良反应。结论应用dl-3-正丁基苯酞软胶囊与艾灸联合对病情处于急性期的轻中度后循环缺血患者实施治疗的临床效果非常明显。     

芹菜籽胶囊的制备与质量研究

目的 研究芹菜籽胶囊的制备工艺,并对其质量进行评价.方法和结果 以颗粒成型性和流动性为指标,采用单因素分别考察微晶纤维素、微粉硅胶和乳糖用量,确定最佳处方为:药物浸膏42％,微粉硅胶26％,微晶纤维素30％,交联聚乙烯吡咯烷酮2％.微粉硅胶对挥发油有很好的吸附性,对颗粒的黏性、成型性和流动性影响最大.对优选处方制备的3批制剂进行装量差异、水分测定、总黄酮和苯酞类成分含量的质量评价实验,结果表明芹菜籽胶囊的质量符合要求.结论 本实验制备的芹菜籽胶囊颗粒成型性和流动性好,制备工艺简单,质量可控,适用于工业化生产.     

盐析辅助水蒸气蒸馏法对川芎挥发油提取的影响研究

目的:探讨盐析辅助水蒸气蒸馏法对川芎挥发油提取的影响。方法:采用气相色谱-质谱联用(GC-MS)仪对氯化钠、磷酸氢二钠辅助水蒸气蒸馏法和传统水蒸气蒸馏法提取的川芎挥发油成分进行分析,同时以丁烯基苯酞和藁本内酯的总含量为指标进行定量比较。结果:水蒸气蒸馏所得挥发油中得到17种化合物,挥发油提取率为0.15%,丁烯基苯酞和藁本内酯的平均总含量为4.09 mg/g;氯化钠辅助水蒸气蒸馏法得到15种化合物,挥发油取率为0.29%,丁烯基苯酞和藁本内酯的平均总含量为4.15 mg/g;磷酸氢二钠辅助水蒸气蒸馏法得到15种化合物,挥发油提取率为0.11%,丁烯基苯酞和藁本内酯的平均总含量为3.31 mg/g。结论:盐析辅助水蒸气蒸馏法与传统水蒸气蒸馏法相比,所提川芎挥发油成分差别不大,氯化钠辅助可提高出油率,但对丁烯基苯酞和藁本内酯含量无明显影响;磷酸氢二钠辅助会降低出油率,丁烯基苯酞和藁本内酯含量也稍有降低。     

RP—HPLC法测定川芎挥发油中丁基苯酞的含量

目的采用HPLC法测定川芎挥发油中丁基苯酞的含量。方法用Kromasil C18(250 mm×4.6 mm,5μm);以0.05mol/L醋酸钠溶液-乙腈(45∶55)用醋酸调节pH4.0为流动相;检测波长228 nm;流速1.0 mL/min;柱温40℃。结果丁基苯酞在浓度9.7~311.0μg/mL范围内呈良好的线性关系(r=0.999 9)。平均回收率为98.5%,RSD为1.12%。测得川芎挥发油中丁基苯酞的含量分别为13.12%、13.83%、13.54%。结论本方法简便,准确,重复性好,可用于川芎挥发油中丁基苯酞的含量测定。      

通脉益智胶囊治疗血管性痴呆的临床研究

目的 观察通脉益智胶囊治疗血管性痴呆的临床疗效.方法 对用通脉益智胶囊治疗的31例与用脑复康治疗的25例进行随机对照观察,评定其提高智能、改善主要症状的效果.结果 治疗组治愈2例、显效5例、好转18例、无效6例,愈显率22.6%、总有效率80.6%;对照组显效2例、好转12例、无效11例,愈显率8%、总有效率56%.2组总有效率比较,P相似文献   

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

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