筋膜皮瓣修复关节部位电烧伤20例临床观察

近年来,本院采用筋膜皮瓣修复电烧伤所致关节部位损伤20例,肢体功能恢复良好,疗效满意,现报道如下. 1临床资料本组20例,男18例,女2例,年龄30～45岁,平均35岁.患者均为电烧伤所致关节部位开放性损伤,其中高压电烧伤15例,低压电烧伤5例.创面最大8 cm×15 crm,最小4 cm×5 cm.腋部5例,肘部5例,膝部7例,踝部3例.肩胛区最大筋膜皮瓣8 cm× 24 cm,供区能直接缝合,小腿最大筋膜皮瓣5 cm× 15 cm,采用逆行筋膜皮瓣修复踝关节,顺行筋膜皮瓣修复膝关节,前臂最大皮瓣6 cm×20 cm修复肘关节.急诊入院者伤后3～5 d手术,术中切取筋膜皮瓣时,必需将深筋膜包括在皮瓣内,在深筋膜深层与肌肉之间掀起皮瓣,肩胛区供区可直接缝合.前臂小腿部位需用皮片修复,植皮能一期愈合,所制作皮瓣全部成活,无其它并发症,关节功能恢复满意.     

含腓肠神经营养血管的筋膜蒂岛状皮瓣修复足踝软组织缺损

目的: 探讨应用腓肠神经营养血管筋膜蒂岛状皮瓣修复软组织缺损的临床效果。方法: 对小腿远端、足踝部皮肤软组织缺损病例,采用含腓肠神经营养血管的筋膜蒂岛状皮瓣转移修复,切取皮瓣面积4cm×5cm~10cm×15cm。结果: 临床应用12例,皮瓣全部成活。结论: 此皮瓣血运可靠,切取简便安全,覆盖范围大,可有效地修复小腿远端及足部软组织缺损。     

远端蒂腓肠神经筋膜皮瓣修复小腿下段与足踝部软组织缺损

目的探讨应用远端蒂腓肠神经筋膜皮瓣修复小腿下段与足踝部软组织缺损的方法和临床效果。方法应用远端蒂腓肠神经筋膜皮瓣修复小腿下段与足踝部软组织缺损29例,修复部位:小腿下1／3及跟腱区13例,外踝及足背外侧区7例,内踝及足内侧区6例,足跟及足底3例。皮瓣面积最大为13 cm×8 cm,最小为6 cm×3 cm,蒂长4-11 cm。结果29例术后皮瓣全部成活,术后27例获6个月至3年随访,其中24例皮瓣外观、血运、质地、色泽、弹性好,3例皮瓣经Ⅱ期修整,外形改善,皮瓣供受区无严重并发症发生。结论远端蒂腓肠神经筋膜皮瓣修复小腿下段与足踝部软组织缺损操作简便,不需牺牲小腿主要动脉,皮瓣成活率高,并发症少,是修复足踝部软组织缺损的较好方法。     

小腿内侧逆行筋膜蒂皮瓣修复小腿下段、踝足部创面(附11例报告)

1987年10月以来，我科采用小腿内侧逆行筋膜蒂皮瓣修复小腿下段、踝足部创面共11例，疗效满意，报告如下。临床资料：本组11例，男9例，女2例，年龄9～67岁。车祸伤4例，机器防3例，外伤溃疡8例，骨折内固定术后溃疡2例。足部创面5例，小腿下设辟部创面2例，小腿下段胜前创面4例。取皮瓣最大面积20cm×10cm。皮瓣均全部成活，都达到完全修复创面。典型病例：例1，男，28岁。左足车轮压伤，1～4趾缺失，足远端创面11cm×9cm，部分骨外露。伤后14天行小腿内侧逆行筋股蒂皮瓣足远端创面修复术。皮瓣12CulX9Cth，远端平演骨下线，筋膜蒂14CulK…     

带腓肠神经营养血管蒂逆行岛状筋膜皮瓣的临床应用

目的总结带腓肠神经营养血管蒂逆行岛状筋膜皮瓣的临床应用效果.方法对21例小腿下段足及踝部软组织缺损的病例,采用带腓肠神经营养血管蒂逆行岛状筋膜皮瓣修复,其中创伤致软组织缺损15例,慢性溃疡4例,疤痕切除术后2例.皮瓣面积最大13cm×9cm,最小5cm×3cm.结果19例皮瓣全部存活,2例远端部分坏死,经游离植皮后创面愈合,所有软组织缺损均修复,骨骼、肌腱外露均覆盖.随访5个月～1.5年,平均9个月,皮瓣质地优良,外观及功能满意.结论该皮瓣血运可靠,手术操作及设计简便,不损伤小腿的主要血管,可理想修复足跟、内外踝、跟腱区和小腿下1/3软组织缺损.     

腓肠神经营养筋膜皮瓣修复小腿远端及足踝部软组织缺损的临床应用

目的:探讨腓肠神经营养筋膜皮瓣修复小腿远端、足踝部软组织缺损的临床应用效果。方法:应用腓肠神经营养筋膜皮瓣修复小腿远端骨外露6例,足踝部软组织缺损9例,皮瓣面积(4 cm×4 cm)～(12 cm×10 cm)。结果:15例皮瓣全部成活,外形良好,功能恢复满意。结论:该皮瓣手术操作简单、安全,是修复小腿远端、足踝部软组织缺损的理想方法。     

股前外侧皮瓣移植修复小腿前外侧软组织缺损8例护理体会

目的:总结应用股前外侧皮瓣游离移植修复小腿前外侧软组织缺损的临床效果及护理体会。方法:应用股前外侧皮瓣游离移植修复创伤性小腿皮肤软组织缺损、骨及内固定物外露8例。结果:8例共移植16个皮瓣,缺损面积5.0 cm×8.0 cm～15.0 cm×23.0 cm,移植面积7.0 cm×10.0 cm～17.0 cm×25.0 cm;皮瓣携带的穿支数3支2例,2支5例,1支1例,单个穿支最大切取面积12.0cm×20.0 cm;血管蒂长5.5～14.5cm,16个皮瓣全部成活。结论:游离股前外侧皮瓣血管蒂长、切取面积大,可携带股外侧肌形成肌皮瓣,是修复小腿大面积软组织缺损的理想皮瓣,因此类手术精细,时间较长,故围手术期护理对于皮瓣成活至关重要。     

腓肠神经营养血管蒂逆行岛状筋膜皮瓣的临床应用

目的 探讨腓肠神经营养血管蒂逆行岛状筋膜皮瓣的临床应用范围及效果.方法 2002年3月～2006年11月对13例小腿下1/3段及足踝部软组织缺损的病例切取腓肠神经营养血管蒂逆行岛状筋膜皮瓣进行创面转移修复,皮瓣面积最大15cm×10cm,最小6cm×5cm.结果 13例中11例皮瓣全部存活,2例远端皮缘缺血坏死,经局部换药及游离植皮后创面愈合.随访12例,失访1例,随访时间6～18 个月,软组织缺损创面修复满意且外形良好.结论 该皮瓣的神经营养血管血供可靠,术中切取简单易行且安全,成功率高,是修复小腿下1/3段、足踝部软组织缺损的理想皮瓣.     

腓肠神经营养血管逆行筋膜蒂皮瓣修复下肢远端软组织缺损

目的观察腓肠神经营养血管逆行筋膜蒂皮瓣修复下肢远端软组织缺损的效果。方法应用带筋膜蒂的腓肠神经营养血管逆行岛状皮瓣修复下肢远端软组织缺损7例。结果7例皮瓣全部成活,皮瓣最大面积14cm×11cm,术后随访6~24个月,效果满意。结论腓肠神经营养血管皮瓣血液循环丰富,皮瓣成活率高,是修复下肢远端软组织缺损的理想方法。     

腓肠神经营养血管蒂逆行岛状筋膜皮瓣的临床应用

目的探讨腓肠神经营养血管蒂逆行岛状筋膜皮瓣的临床应用范围及效果。方法2002年3月～2006年11月对13例小腿下1/3段及足踝部软组织缺损的病例切取腓肠神经营养血管蒂逆行岛状筋膜皮瓣进行创面转移修复,皮瓣面积最大15cm×10cm,最小6cm×5cm。结果13例中11例皮瓣全部存活,2例远端皮缘缺血坏死,经局部换药及游离植皮后创面愈合。随访12例,失访1例,随访时间6￣18个月,软组织缺损创面修复满意且外形良好。结论该皮瓣的神经营养血管血供可靠,术中切取简单易行且安全,成功率高,是修复小腿下1/3段、足踝部软组织缺损的理想皮瓣。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…