多囊卵巢综合征患者发病机制及其治疗研究进展

多囊卵巢综合征(PCOS)是育龄期女性内分泌和代谢功能异常导致的一种排卵障碍性疾病。研究表明,胰岛素抵抗、雄激素水平增高、肥胖等在PCOS的发病过程中起重要作用。临床上观察到PCOS患者中肥胖患者的内分泌紊乱可导致其不良妊娠结局,同时,降低患者的体质量指数可改善不良妊娠结局。本文对PCOS的发病机制、PCOS与糖脂代谢异常的关系及其对生殖功能的影响作一综述。     

多囊卵巢综合征患者脂代谢异常的研究进展

多囊卵巢综合征(PCOS)是育龄妇女常见的内分泌代谢紊乱性疾病,患者临床表现复杂多样,其病理生理改变涉及范围广泛。患者大多存在一定程度的胰岛素抵抗以及高血压和肥胖,且在糖脂代谢方面都有不同程度的异常。各种研究表明,PCOS患者肥胖、胰岛素抵抗以及性激素的改变与患者的脂代谢紊乱之间有着很多联系。研究PCOS患者血脂代谢的异常以及不同亚型间可能存在的脂代谢差异对预防其远期并发症具有积极的临床意义。     

硫氧还蛋白相互作用蛋白与多囊卵巢综合征代谢紊乱的研究进展

多囊卵巢综合征(PCOS)是一种复杂的生殖内分泌疾病,主要特征为月经稀发或闭经、高雄激素血症、卵巢多囊样改变以及代谢紊乱。其中,胰岛素抵抗在PCOS患者中很常见。高糖通过糖类反应元件增加了血清硫氧还蛋白相互作用蛋白(TXNIP)的表达,导致胰岛素抵抗,从而加强了氧化应激,引起β细胞凋亡。由于PCOS妇女血清TXNIP水平较正常妇女明显偏高,因此通过探究TXNIP与PCOS的相关性,可以为寻找PCOS代谢紊乱治疗靶点提供新的依据与线索。     

多囊卵巢综合征与胰岛素抵抗的临床研究

目的探讨多囊卵巢综合征(PCOS)患者内分泌及代谢特征,为PCOS的正确诊断、合理治疗提供依据。方法1)随机选择PCOS患者50例,选择体检正常的妇女42例作为对照组,对比两组患者空腹及糖负荷后各个时点胰岛素水平。2)根据葡萄糖负荷60min、120min血胰岛素≥160mu/L分为胰岛素抵抗组28例,非胰岛素抵抗组22例。对比两组患者早卵泡期或闭经状态下各项性激素水平。结果PCOS患者血清中胰岛素值明显高于对照组(P<0.05);PCOS患者胰岛素抵抗组睾酮高于PCOS非胰岛素抵抗组,黄体生成素水平低于非胰岛素抵抗组(P<0.05)。结论PCOS患者存在高胰岛素血症,其性激素有不同改变,胰岛素抵抗者以睾酮升高为主,非胰岛素抵抗者以黄体生成素升高为主要变化。     

多囊卵巢综合征病因及治疗新进展

<正>多囊卵巢综合征(PCOS)是育龄期妇女常见的一种内分泌代谢异常综合性疾病。据国内外文献报道PCOS影响全世界6%~15%的育龄女性~([1]),是导致不孕症的主要原因之一。以月经稀发、排卵障碍、高雄激素水平、胰岛素抵抗(IR)为主要临床症状,PCOS患者出现代谢功能障碍及心血管疾病(CVD)的发病率也增加,包括胰岛素抵抗(IR)及高胰岛素血症~([2])、血脂异常、系统性亚健康炎性反应~([3])、2型糖尿病、动脉性     

成纤维细胞生长因子19(FGF19)与脂代谢的研究进展

 成纤维细胞生长因子19(fibroblast growth factor 19,FGF19)是在回肠末端特异性合成并分泌的细胞因子,属于FGFs的特殊成员之一。近年来自动物及细胞学的研究发现,FGF19不仅在胆汁酸代谢的调节中发挥重要作用,而且与多种心血管疾病危险因素密切相关。流行病学研究显示,2型糖尿病、代谢综合征及肥胖者FGF19水平降低。深入研究FGF19的生物学意义可能为肥胖及血脂紊乱的防治提供新的靶点。本文将介绍FGF19与脂代谢相关性的研究进展。     

多囊卵巢综合征113例临床及代谢特点

目的分析多囊卵巢综合征(PCOS)患者的临床特征、胰岛素抵抗(IR)发生情况、糖耐量受损和血脂代谢特征。方法回顾性分析113例PCOS患者临床资料和肝肾功能及血脂代谢情况,采用口服葡萄糖耐量试验(OGTT)、空腹胰岛素和稳态评估法(HOMAIR)评估糖代谢和胰岛素抵抗(IR)。对肥胖和非肥胖组患者各指标的差异性进行统计学分析。结果PCOS常见临床表现依次是月经稀发(86·72%)、高雄激素血症(67·25%)、胰岛素抵抗(56·64%)、超声呈PCO征(54·86%)、LH/FSH比值升高(52·22%)。肥胖和中心型肥胖发生率分别为26·55%和23·89%。糖耐量受损和糖尿病率为15·25%和4·42%。脂代谢异常表现为高密度脂蛋白(HDL)降低(32·74%)及甘油三酯升高(11·5%)。14·16%PCOS诊断代谢综合征(MS)。肥胖和非肥胖组腰臀比、空腹胰岛素、甘油三酯、HDL和尿酸差异有显著性。结论PCOS患者肥胖发生率低于国外报道,但胰岛素抵抗和糖、脂代谢异常发生率较高,应高度重视PCOS患者IR和代谢紊乱所致MS等远期并发症的防治。     

多囊卵巢综合征与胰岛素抵抗和多种脂肪细胞因子的关系

多囊卵巢综合征(PCOS)是育龄期女性常见的内分泌代谢性疾病,目前认为主要与内分泌功能紊乱、下丘脑-垂体-卵巢轴调节功能异常、高胰岛素血症和胰岛素抵抗(IR)、肾上腺内分泌功能异常有关。脂肪组织不仅具有调节能量储存作用,同时还是一个内分泌器官,可分泌各种脂肪细胞因子,如脂联素、瘦素、内脂素、抵抗素、Chemerin等,这些因子通过其表达的增强或减弱不同层面参与机体内分泌代谢过程,包括能量代谢、胰岛素作用及脂类代谢等的调节,并参与肥胖、IR、血压及炎症等疾病的发生。     

多囊卵巢综合征代谢异常的相关机制的论述

多囊卵巢综合征(PCOS)是一种女性常见代谢紊乱的生殖内分泌疾病;以雄激素过高的临床或生化表现、持续无排卵、卵巢多囊样改变为特征,常伴有胰岛素抵抗和肥胖;临床表现为月经失调、不孕、多毛、痤疮和脱发,血脂、血糖异常。代谢综合征(MS)是一组以肥胖和内分泌代谢紊乱的严重影响人类健康的临床症候群,主要表现为血糖异常、血脂异常,其中心环节是肥胖和胰岛素抵抗。PCOS与MS有许多共同的内分泌代谢特征,两者关系密切,所以在临床工作中,对患代谢异常的女性,要警惕PCOS的发生,而对患PCOS的女性要预防代谢异常的发生PCOS妇女应在代谢综合征的诊断基础上进行筛查。这对代谢异常和PCOS的早期诊断、采取个性化的治疗方案、定期检查并防止并发症有积极的意义。     

脂联素的研究现状

近年的研究表明,脂肪组织不仅是能量储存器官,也是活跃的内分泌器官,由脂肪组织专一表达的脂联素通过其受体调节内皮功能、免疫功能、糖脂代谢,抗胰岛素抵抗及动脉粥样硬化,在代谢性疾病的发生、进展中发挥了重要作用.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.