舒芬太尼对腹腔镜下胆囊切除应激反应的抑制作用

目的观察舒芬太尼全凭静脉麻醉对腹腔镜下胆囊切除术心血管应激反应的抑制作用。方法择期行腹腔镜下胆囊切除术患者40例,ASAI-Ⅱ级,随机分为舒芬太尼组和芬太尼组。舒芬太尼组0.6μg/kg诱导,持续静脉输注舒芬太尼0.01μg/（kg.min）维持;芬太尼组3μg/kg诱导,持续静脉输注芬太尼0.05μg/（kg.min）;记录麻醉诱导前（T1）、气管插管后2min（T2）、气腹完全充气后10分钟（T3）、胆囊切除时（T4）及术毕拔管后2min（T5）的心率（HR）、平均动脉压（MAP）。结果与T1时比,舒芬太尼组T2、T4时MAP均明显低于T1时（P〈0.05）,HR无明显变化（P〉0.05）;与T1时比,芬太尼组T3、T4、T5时MAP明显高于T1时（P〈0.05）,HR也明显增快（P〈0.05）。除T1外,舒芬太尼组各时点MAP均明显低于芬太尼组（P〈0.05）;T5时点舒芬太尼组心率明显慢于芬太尼组（P〈0.05）。结论腹腔镜下胆囊手术病人,5舒芬太尼较芬太尼更有效抑制麻醉手术的伤害刺激的应激反应,异丙酚用量亦较少。     

瑞芬太尼联合丙泊酚在老年人腹腔镜胆囊手术中的应用观察

[目的]评价以瑞芬太尼、丙泊酚为主的全凭静脉麻醉在经腹腔镜行胆囊切除术中对老年人血流动力学及部分激素的影响。[方法]将80例A队Ⅱ～Ⅲ级的拟行腹腔镜胆囊切除术的老年患者随机分成两组（瑞芬太尼、丙泊酚诱导并维持的R组和芬太尼、丙泊酚诱导并维持的F组）,每组40例。记录两组麻醉前、麻醉后即刻、气腹后即刻、气腹后15min及术毕的平均动脉压（MAP）、心率（HR）,检测患者麻醉前、气腹后即刻、气腹后15min血浆皮质醇（C0）和去甲肾上腺素（NE）浓度,并记录术毕清醒时间。[结果]两组患者插管后即刻和气腹后即刻R组MAP、HR显著低于F组（P〈0．05）。R组血浆C0和NE浓度,气腹后即刻和气腹后15min显著低于F组（P〈0．05）。[结论]以瑞芬太尼、丙泊酚为主的全凭静脉麻醉较以芬太尼、丙泊酚为主的全凭静脉麻醉用于腹腔镜手术能够更有效地抑制气管插管和二氧化碳气腹所致的应激反应。     

舒芬太尼与芬太尼麻醉对老年腹腔镜胆囊切除术患者血流动力学的影响

目的:探讨舒芬太尼与芬太尼麻醉对老年腹腔镜胆囊切除术患者血流动力学的影响.方法:我院于2009年6月至2011年6月共收治腹腔镜胆囊切除术老年患者160例,按照麻醉方法不同将患者分为两组,舒芬太尼组和芬太尼组.舒芬太尼组采用舒芬太尼联合瑞芬太尼和丙泊酚实施麻醉;芬太尼组采用芬太尼联合瑞芬太尼和丙泊酚实施麻醉.记录两组患者在麻醉诱导各时间点的收缩压(SBP),舒张压(DBP)以及心率(HR)等血液动力学指标的变化.结果:与诱导前比较,两组患者分别给予舒芬太尼或者芬太尼后,SBP,DBP和HR等指标显著性下降,舒芬太尼组较芬太尼组下降更明显(P<0.05).在插管和拔管时,两组SBP,DBP和HR明显上升,且舒芬太尼组明显低于芬太尼组,具有统计学意义(P<0.05).结论:舒芬太尼和芬太尼均可抑制气管插管时血液动力学的变化,舒芬太尼效果更加稳定,适合于老年腹腔镜胆囊切除术患者的麻醉.     

舒芬太尼与芬太尼对妇科腹腔镜手术气腹时脑电双频指数及血流动力学的影响

目的研究比较舒芬太尼与芬太尼对妇科腹腔镜手术气腹时脑电双频指数（BIS）和血流动力学的影响,为临床药物选择提供参考。方法选择60例ASAI～II级要求行腹腔镜子宫切除的患者,随机分为舒芬太尼组（S）和芬太尼组（F）,每组30例。两组均采用芬太尼＋丙泊酚＋罗库溴铵诱导一次顺利插管成功,S组在气腹前5分钟追加舒芬太尼10μg,F组追加等效剂量的芬太尼50μg,分别记录追加药物前,气腹镜置入时,气腹后5分钟,气腹后10分钟两组的收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）、心率（HR）和BIS。结果 F组在气腹后的5分钟和10分钟SBP、DBP、MAP、BIS与气腹前比较均显著升高（P〈0.05）,HR变化不明显。S组在气腹后5分钟和10分钟的SBP、DBP、MAP、HR、BIS均明显低于F组（P〈0.05）。S组的SBP、DBP、MAP、HR、BIS与气腹前相比差异无显著性（P〉0.05）。结论 BIS能有效地反映腹腔镜气腹时患者的麻醉深度,舒芬太尼对腹腔镜手术气腹时的循环稳定性明显优于芬太尼,更适合于腹腔镜手术。     

舒芬太尼麻醉对老年腹腔镜胆囊切除术患者血流动力学的影响

目的探讨舒芬太尼麻醉对老年腹腔镜胆囊切除术患者血流动力学的影响。方法择期行腹腔镜胆囊切除术老年患者160例,年龄60～88岁,体重指数小于35 kg/m2,美国麻醉医师协会(ASA)分级在Ⅰ～Ⅱ级,按照麻醉方法不同将患者分为舒芬太尼组和芬太尼组,每组80例。舒芬太尼组采用舒芬太尼和丙泊酚实施麻醉;芬太尼组采用芬太尼和丙泊酚实施麻醉。记录两组患者在麻醉诱导前、诱导后、插管时及拔管后各时间点的收缩压(SBP)、舒张压(DBP)及心率(HR)的变化。结果两组分别与诱导前比较,诱导后的SBP、DBP和HR显著性下降,芬太尼组较舒芬太尼组下降更明显(P<0.05)。在插管和拔管时,两组患者SBP、DBP和HR明显上升,但舒芬太尼组明显低于芬太尼组,差异具有统计学意义(P<0.05)。结论舒芬太尼和芬太尼均可影响气管插管时及抜管时血流动力学的变化,但是舒芬太尼对血流动力学稳定性更佳,适合于老年腹腔镜胆囊切除术患者的麻醉。     

舒芬太尼和芬太尼麻醉诱导对冠脉旁路移植术患者血流动力学的影响

目的比较舒芬太尼和芬太尼麻醉诱导对冠脉旁路移植术（CABG）患者血流动力学的影响。方法将60例ASAⅡ-Ⅲ级择期非体外循环CABG患者随机分为芬太尼组（F组）和舒芬太尼组（S组）各30例，F组以芬太尼10ug／kg，S组以舒芬太尼1ug／kg，均配伍咪唑安定0．05mg／kg、维库溴铵0．08mg／kg缓慢诱导。分别于麻醉诱导前、麻醉诱导后气管插管前、插管后1、5和10min监测平均动脉压（MAP）、心率（HR）、心排血指数（CI）和中心静脉压（CVP）等血流动力学参数。结果与芬太尼相比，舒芬太尼麻醉诱导更平衡，血液动力学更稳定。结论舒芬太尼用于非体外循环CABG麻醉更容易维持血液动力学稳定，麻醉效果更佳，安全性更高。     

舒芬太尼与芬太尼麻醉对老年腹腔镜胆囊切除术患者血流动力学的影响分析

目的分析舒芬太尼与芬太尼麻醉对老年腹腔镜胆囊切除术（LC）过程中患者的血压（舒张压DBP、收缩压SBP）、心率（HR）的影响。方法舒芬太尼组和芬太尼组各64例分别应用舒芬太尼和芬太尼联合瑞芬太尼和丙泊酚实施麻醉手术。结果T1、T2、T3、T4阶段舒芬太尼组患者的DBP及SBP值明显低于芬太尼组（P〈0．05）;但麻醉后舒芬太尼组患者的血压变化较芬太尼组更稳定;各阶段两组患者HR比较也无显著差异（P〉0．05）。结论舒芬太尼较芬太尼具有更好的血压稳定性,能够稳定心血管系统的生理功能,非常适用于老年LC患者的临床麻醉。     

丙泊酚复合阿芬太尼静脉麻醉对腹腔镜胆囊切除术患者的麻醉效果研究

目的:探讨丙泊酚复合阿芬太尼静脉麻醉对腹腔镜胆囊切除术(LC)患者的麻醉效果.方法:选取94例择期LC患者为研究对象,按照麻醉方式不同分为舒芬太尼组和阿芬太尼组,每组各47例.舒芬太尼组麻醉维持阶段采用丙泊酚复合舒芬太尼麻醉;阿芬太尼组采用丙泊酚复合阿芬太尼麻醉.观察两组患者气管插管即刻(T0)、术中5 min(T1)、拔管即刻(T2)和拔管后10 min(T3)的心率(HR)、平均动脉压(MAP)、血清皮质醇(Cor);比较两组患者自主呼吸恢复时间、麻醉苏醒时间及不良反应情况.结果:舒芬太尼组T2时HR、MAP和血清Cor水平较T1时升高(P<0.05);阿芬太尼组T0～T3时HR无明显变化(P>0.05),T2时MAP、血清Cor水平较T1时升高(P<0.05);两组间T0～T3时HR、MAP、血清Cor水平比较,差异无统计学意义(P>0.05).阿芬太尼组自主呼吸恢复时间、苏醒时间短于舒芬太尼组(P<0.05).阿芬太尼组不良反应率低于舒芬太尼组(P<0.05).结论:LC术中采用阿芬太尼和舒芬太尼分别复合丙泊酚麻醉维持,在稳定血流动力学和减轻手术应激方面效果相当,但阿芬太尼复合丙泊酚麻醉恢复时间更短,不良反应少更轻.     

舒芬太尼对非体外冠脉旁路移植术中血流动力学指标的影响

目的观察和评估舒芬太尼和芬太尼对非体外冠脉旁路移植术（OPCABG）中血流动力学指标的影响。方法将60例患者随机分为舒芬太尼组和芬太尼对照组,记录从进入手术室起至手术结束期间的血流动力学指标的变化,同时记录术中主要药物的用量。结果两组患者的心率（HR）和平均动脉压（MAP）均在麻醉诱导后降低,在气管插管及手术强刺激后升高。在诱导后插管前即刻舒芬太尼组MAP高于对照组（P〈0.05）;关闭胸骨后1min舒芬太尼组MAP低于对照组（P〈0.05）;插管后1min舒芬太尼组HR低于对照组（P〈0.05）;术中去氧肾上腺素的使用量舒芬太尼组低于对照组（P〈0.05）。结论与芬太尼相比,舒芬太尼术中的心血管状态更稳定,更适合非体外冠脉旁路移植术的麻醉。     

舒芬太尼诱导对气管插管条件和血流动力学的影响

目的：通过对舒芬太尼在全身麻醉诱导中的应用,评价其对插管时应急反应的抑制效果。方法：选择拟行腹腔镜手术的患者60例,随机分为舒芬太尼组（S组）和芬太尼组（F组）;两组患者给予咪达唑仑后,S组以舒芬太尼静注,F组以芬太尼静注,然后均给予依托咪酯及罗库溴铵;记录诱导各时点的收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）、心率（HR）,由同一麻醉医生插管后评价插管条件。结果：（1）在给予芬太尼或舒芬太尼后,SBP、DBP、MAP及HR均较诱导前明显下降（P〈0.01）,S组SBP、MAP较F组下降明显（P〈0.05）;在插管后即刻,除HR（P〈0.05）外,两组间差异无统计学意义（P〉0.05）;在插管后2、4min,F组HR高于插管前（P〈0.05）,S组上述指标与插管前比较P〉0.05;（2）S组插管条件评分为优秀者多于F组（P〈0.05）。结论：舒芬太尼在全射麻醉诱导中应用,可以使插管前后的血流动力学更加平稳,插管条件更好。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…