中药配合西医疗法治疗非IgA系膜增生性肾炎140例临床分析

通过对１４０例原发性非ＩｇＡ系膜增生性肾小球肾炎（ｎｏｎ－ＩｇＡＭｓＰＧＮ）患者疗效的回顾性分析，观察中西医结合治疗对该类患者临床类型、病理损害程度、中医证型与疗效的相关性。结果显示，临床缓解９１例（６５％），显效２３例（１６．４％），好转１５例（１０．７％），无效１１例（７．９％），表明原发性ｎｏｎ－ＩｇＡＭｓＰＧＮ的中西医结合治疗应注重临床与病理的检测，其疗效与病理损害的严重性有关；注重辨病与     

膜增殖性肾炎的中医证治探讨

膜增殖性肾炎的中医证治探讨刘宏伟中国中医研究院研究生部（北京１０００９１）膜增殖性肾炎又称系膜毛细血管性肾小球肾炎（简称ＭＰＧＮ），是一组以肾小球系膜细胞和系膜基质增生，并伴有毛细血管基膜增厚为特征的肾小球肾炎。临床上，本组病人常表现为肾病综合征，并...     

系膜增生性肾炎的中医研究进展

系膜增生性肾小球肾炎 (Ｍｅｓａｎｇｉａｌｐｒｏｌｉｆ ｅｒａｔｉｖｅｇｌｏｍｅｒｕｌｏｎｅｐｈｒｉｔｉｓ,简称ＭｓＰＧＮ)是一种以弥漫性肾小球系膜细胞增生及不同程度系膜基质增多为主要病理特征的原发性肾小球疾病。临床表现为水肿、腰痛、倦怠、乏力等。后期可发展为肾功能衰竭。我国原发性肾小球肾炎的发生率为 76 8% [1] ～ 81 7% [2 ] 其中ＭｓＰＧＮ约占有 2 9 7% [1] ～ 5 9 5 % [3] 。ＩｇＡ肾病大部分以弥漫性系膜增生病变为典型改变 ,故ＭｓＰＧＮ分为ＩｇＡ肾病型和非ＩｇＡ肾病型。对该病目前尚无特效的治疗方法 ,临床…     

中西医结合治疗表现为无症状性血尿的非IgA系膜增生性肾炎30例

目的：探讨中西医结合治疗表现为无症状性血尿的非IgA系膜增生性肾炎的疗效。方法：将表现为无症状性血尿的非IgA系膜增生性肾炎患者56例，随机分为2组。中西医结合治疗组30例，对照组26例。中西医结合治疗组采用地塞米松、氮芥结合中药辨证施治；对照组采用雷公藤多苷片口服治疗。结果：中西医结合治疗组总有效率96．67%，对照组总有效率76．92%，两组疗效比较差异有显著性意义（P〈0．01）。结论：中西医结合治疗表现为无症状性血尿的非IgA系膜增生性肾炎具有较好疗效。     

中药配合治疗系膜增生性肾炎44例疗效观察

对８２例临床表现为隐匿性肾炎、肾活检病理为系膜增生性肾炎患者,分别为中西医结合治疗组（４４例）、西药对照组（３８）例,进行对比观察,结果治疗组总有效率８４．４％;对照组总有效率为４７．４％,两组比较差异有显著性（Ｐ〈０．０１）,显示中西医结合治疗组的疗效明显优于西药对照组。     

系膜增生性肾炎的中医研究进展

系膜增生性肾小球肾炎 (ＭｅｓａｎｇｉａｌＰｒｏｌｉｆｅｒａｔｉｖｅＧｌｏｍｅｒｕｌｏＮｅｐｈｒｉｔｉｓ,简称ＭｓＰＧＮ)是一种临床常见的慢性肾脏疾患 ,是导致慢性肾衰的最主要原因。据我国流行病学的研究结果显示 ,在原发性肾小球疾病的发病中 ,原发性肾小球肾炎的发生率为 76 8% [1] ～81 7% 3 ] ,其中 ,系膜增生性肾小球肾炎约占 2 9 7[1] ～5 9 5 % [2 ] ,可分为ＩｇＡ肾病型和非ＩｇＡ肾病型两大类。本病的主要病理变化是肾小球系膜细胞增生、细胞外基质增多 ,临床表现为水肿、腰痛、倦怠乏力等 ,实验室检查可见蛋白尿、高脂…     

气阴两虚辨证在MesPGN中医治疗中的意义

随着肾脏病理学和中西医结合肾脏病学的发展 ,我们在治疗肾脏病时不再仅仅立足于疾病“显诸于外”的宏观表现 ,也渐渐认识到微观辨证的重要。重视微观辨证的思想 ,也是治疗原发性肾小球疾病时采用清利、化瘀的一个基础和根据。微观辨证主要包括肾脏病理学、免疫学、血液流变学、内分泌学等方面。因湿热、瘀血等病理产物与气阴两虚证的特殊关系 ,以及清利化瘀法与气阴两虚证的内在关联 ,使我们同时认识到气阴两虚辨证在原发性肾小球疾病 ,特别是在系膜增生性肾小球肾炎 (ＭｅｓＰＧＮ)发展和转归中的意义。本文作者拟就ＭｅｓＰＧＮ的中医气…     

黄芪注射液对肾病综合征患者肾小管的保护作用

目的：观察黄芪注射液对肾病综合征（ＮＳ）患者肾小管的保护作用，探讨其治疗慢性肾炎的作用机理。方法：将１２０例原发性ＮＳ患者随机分为黄芪组（ｎ＝６０）和对照组（ｎ＝６０），观察治疗前后血白蛋白（ＰＡＬｂ）、血β２微球蛋白（Ｐβ２ＭＧ）、尿β２ＭＧ（Ｕβ２ＭＧ）、尿γ谷氨酰转肽酶（ＵγＧＴ）、尿βＤ半乳糖苷酶（ＵＧａＬ）、尿乙酰βＤ氨基葡萄糖苷酶（ＵＮＡＧ）及尿２４小时蛋白定量（蛋白定量）的变化。结果：治疗后黄芪组ＵＮＡＧ、ＵＧａｌ、Ｕβ２ＭＧ、Ｐβ２ＭＧ，ＵγＧＴ均较对照组为低，ＰＡＬｂ较对照组为高，而蛋白定量无差异。结论：黄芪注射液通过改善ＮＳ患者低蛋白血症状态对肾小管起保护作用     

应用中西医结合治疗原发性肾病综合征30例临床体会

原发性肾病综合征(NS)是一组治疗难度较大的肾小球疾病，在病理类型上可表现所有。肾小球疾病的病理类型，例如：微小病变肾病、系膜增生性肾小球肾炎(包括IgA肾病)、局灶性肾小球硬化、膜性肾小球。肾炎、系膜毛细血管性。肾小球肾炎(膜增生性肾小球肾炎)、毛细血管内增生性肾小球肾炎等，我科于2000年～2003年以中西医结合治疗原发性肾病综合征30例，取得较好疗效，现将临床体会总结如下。     

肾炎3号方对肾小球系膜细胞增殖及其产生TNFα影响的实验研究

目的　探讨肾炎３号方对肾小球系膜细胞增殖及其产生 Ｔ Ｎ Ｆα的作用。方法　不同药物喂家兔后取其血清加入系膜细胞培养液中,观察其增殖情况及其产生 Ｔ Ｎ Ｆα的水平。结果　肾炎３号方可显著抑制正常及病理状态下肾小球系膜细胞增殖及其产生 Ｔ Ｎ Ｆα水平,有非常显著性差异（ Ｐ＜ ０．０１）。结论　肾炎３号方可抑制肾小球系膜细胞增殖及其产生 Ｔ Ｎ Ｆα水平,打破以系膜细胞为中心的调节网络,对以系膜增生为主的慢性肾炎有很好的治疗作用。     

微波消解-电感耦合等离子体质谱法测定脉络宁注射液中25种矿物质元素

目的建立微波消解-电感耦合等离子体质谱(ICP-MS)直接稀释测定脉络宁注射液中25种矿物质元素(Mg、Ca、Fe、Cu、Zn、Mn、Al、B、Ba、Co、Cr、K、Li、Mo、Na、Ni、P、Pb、Sr、Th、Ti、V、As、Cd和Hg)的方法。方法分别对微波消解条件和测试条件进行考察;样品经微波消解后,采用电感耦合质谱仪测定25种矿物质元素,并对测定方法学进行考察。结果确定最佳消解条件为3步缓慢升温:400 W 80℃升温10 min,保留5 min;600 W 120℃升温10 min,保留5 min;900 W 200℃升温20 min,保留20 min;25种矿物质元素在各自的线性范围内线性关系良好,r≥0.999 6,精密度、稳定性和重复性试验的RSD均符合定量分析要求;加标回收率为94.7%~106.1%,RSD在0.34%~2.79%。脉络宁注射液中检测出Mg、Ca、Fe、Cu、Zn、Mn、Al、B、Ba、Co、Cr、K、Li、Mo、Na、Ni、P、Pb、Sr、Th、Ti、V,未检出As、Cd和Hg。结论该方法简便、迅速、准确,适用于脉络宁注射液中25种矿物质元素的同时测定。     

Die Lateralität und Lateralitätsinstabilität in der Diagnostik und Therapie

The disturbance and instability of laterality are obstacles to diagnostics and therapy. Correction prior to starting therapy is required. They also predispose toward defined health problems and unspecific diseases. Numerous research activities provide evidence of the relevance of undisturbed laterality in diagnostics and therapy. Techniques of testing and therapeutic corrections will allow for optimized therapy success.     

Journal of Acupuncture and Tuina Science Instructions for Authors

The Journal of Acupuncture and Tuina Science, a journal with an international scope （IS SN 1672-3597, CN 31-1908/R, Bimonthly）, is embodied by ＇Springer Verlag＇ Database, Index Copernicus （IC） and Chinese Scientific and Technical Paper and Citations Data （CSTPCD）. You can search full text on http：//www, springerlink, com/content/1672 -3597.     

Yerba Mate or Paraguay Tea

正Beverages based on Ilex paraguariensis A.St.-Hil.are used in the south Brazil and other Latin American countries located at the so-called southern cone.It is known as chimarro or mate in south and southeast Brazil,tererêin     

Ethnopharmacologic study of chinese rhubarb

This paper deals with an interdisciplinary study covering historic, botanical, phytochemical, pharmacological and clinical aspects of rhubarb and related species, to lay stress on the correlation between plant phylogeny, chemical constituents and purgative activity.

It was found that the official rhubarbs were exclusively restricted in the Sect. Palmata e.g. Rheum palmatum R. palmatum var. tanguticum R. officinale; the following criteria may serve as their standard, viz., the presence of sennoside derivatives and rhein, the occurrence of the reduced form of rhein and aloe-emodin, the leaves with any kind of palmate incision. Comprehensive multivariate analyses showed that there is a very close relationship between the leaf incision, existence of sennosides or rhein and purgative activity.     

Wirksamkeit der Akupunktur bei der Therapie von idiopathischen Schmeckstörungen: Eine randomisierte Placebo-kontrollierte Studie

Background

At present, the state-of-the-art medication in treating idiopathic taste disorder (gustatory dysfunction) is zinc. If zinc medication was unsuccessful, not tolerated or if it is contraindicated the persons affected can hardly be helped.

Objectives

In a randomized placebo-controlled clinical trial an attempt was made to determine the efficacy of acupuncture.

Methods

The treatment group was treated with acupuncture needles, the placebo group with an inactive acupuncture-laser. Endpoints of the study were changes in the taste test, the quality of life and the severity of symptoms of depression (BDI) as well as mood changes (ZMS). Satisfaction with the success of the respective therapy was also evaluated. Data were collected before and after therapy and again for the treatment group 10 weeks after completion of the treatment period.

Findings

Treatment with real acupuncture showed a significant improvement in gustatory function as well as a significant improvement in psychological symptoms. Greater satisfaction with the treatment results was evident in the treatment group. The treatment results of acupuncture remained stable over a period of ten weeks after completion of the treatment.

Conclusion

Acupuncture was effective in the therapy of idiopathic taste disorders and therefore it is an effective alternative when zinc medication is not tolerated or unsuccessful. But it is also suitable as a therapy of first choice. Acupuncture can be considered as an extension of the therapeutic spectrum in the difficult treatment of taste disorders.     

Veränderungen der Herzratenvariabilität (HRV) während Low Level Lasernadelakupunktur: Placebokontrollierte Studie an 19 herzgesunden Probanden

Background

Experimental and clinical studies postulate a neurobiological mechanism of acupuncture by modulating central pain systems, neurohormones and -transmitters. It seems to be quite likely that the autonomic nervous system (ANS) plays an important mediating role in this neuromodulation.

Aim

In measuring heart rate variability (HRV), as a non-invasive approach to the ANS-function, the object of this study was to monitor probable acupuncture-induced changes of autonomic balance. The innovative technology of laser-needle acupuncture offers for the first time a stimulation method which fulfils the demands on a placebo-controlled acupuncture trial not requiring controversial sham acupuncture.

Method

19 healthy voluntary subjects underwent 3 treatments in randomized sequence, consisting of placebo-, 1-point- (PC 6) and simultaneous 3-point- (PC 6, LR 3, SI 3) laser-needle-stimulation over 20 minutes. Before, during and after placebo-/verum laser-needle acupuncture, HRV-data for normalized HF(high frequency)- and LF(low frequency)-Power (nHF, nLF) and their quotient nLF/nHF obtained by power spectrum analysis (FFT), were measured and analyzed statistically at 5 different time points (ANOVA repeated measures, p < 0,05).

Results

During both verum applications, the 1-point- (PC 6) as well as the simultaneous 3-point- (PC 6, LR 3, SI 3) laser-needle stimulation, significant changes of the ANS-activity were found in comparison to the placebo application. The most significant modification of HRV was an increase of nHF (p < 0,05 (PC 6), p < 0,0001 (PC 6, LR 3, SI 3)) as an expression of growing vagal activity during acupuncture.

Conclusion

Laser-needle acupuncture causes in 1-point-stimulation (PC 6) as well as in simultaneous 3-point-stimulation (PC 6, LR 3, SI 3) significant changes in HRV in comparison to placebo application. HRV-monitoring seems to be a suitable approach in exploration of acupuncture-induced changes of ANS and could possibly be established in combination with laser needle acupuncture as a standard for further scientific and clinical acupuncture investigations which are greatly needed.     

瑞香科五属植物中酚性聚合物的结构特征、分布及药理活性研究进展

瑞香科植物广泛分布于世界热带和温带地区,其中多种植物可供药用。在对该科植物的研究中发现,黄酮类、木脂素和香豆素等酚性化合物的低聚体为其重要的特征性成分,药理活性主要表现在抗肿瘤、抗炎、抗氧化、抗菌和抗病毒等方面。对已发现的酚性聚合体的化学结构、植物来源及药理活性进行综述,为瑞香科植物今后的研究和开发利用提供参考。     

HPLC法同时测定沉香化滞丸中11种成分

目的采用HPLC梯度洗脱法同时测定沉香化滞丸中沉香四醇、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚、大黄素、厚朴酚、木香烃内酯、去氢木香内酯、大黄酚、大黄素甲醚11种成分。方法采用Thermo Syncronis C18色谱柱(250 mm×4.6 mm,5μm),流动相为水-乙腈,梯度洗脱:0～10 min,20%乙腈;10～20 min,20%～40%乙腈;20～24 min,40%乙腈;24～26 min,40%～52%乙腈;26～30 min,52%乙腈;30～31 min,52%～90%乙腈;31～35 min,90%乙腈;35～40 min,90%～100%乙腈;40～43min,100%乙腈;43～45min,100%～20%乙腈;检测波长215nm,体积流量1.0m L/min,柱温30℃,进样量20μL。结果各成分在43 min内分离良好,沉香四醇、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚、大黄素、厚朴酚、木香烃内酯、去氢木香内酯、大黄酚、大黄素甲醚的线性范围分别为1.4～13.6、10.0～200.0、31.5～315.0、1.0～120.1、1.8～50.6、0.93～10.1、1.8～30.0、0.2～40.3、1.8～18.1、1.7～25.0、0.45～10.70μg/mL;样品中各成分的平均回收率均在98.90%～100.87%;11种成分精密度RSD在0.55%～1.54%;供试品溶液在30 h内稳定性良好,RSD在0.75%～1.94%;重复性RSD在0.39%～1.73%。6批次样品中沉香四醇、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚、大黄素、厚朴酚、木香烃内酯、去氢木香内酯、大黄酚、大黄素甲醚质量分数分别为92.0～201.0、511.5～9 033.0、5 475.0～12 635.5、54.5～5 095.5、192.0～2 137.5、117.0～391.5、106.5～1 281.5、13.0～136.5、93.5～199.0、177.0～1 207.0、33.5～251.5μg/g。结论本方法准确、快速、简便,重复性好,精密度高,适用于沉香化滞丸中多种活性成分的定量分析。