脑利钠肽在原发性高血压靶器官损害中的意义

脑钠肽（BNP）又称B型利钠肽,在心血管疾病的诊断、治疗及预后判断等方面具有重要价值,是临床上与心血管疾病密切相关的一项生物化学指标。本文就BNP的一些生理特性及其在原发性高血压及其靶器官损害中的研究进展作一综述。     

心血管疾病中脑钠肽的变化

脑钠肽（brain natriuretic peptide，BNP），又称B型利钠肽，在心血管疾病的诊断、治疗及预后判断等方面具有重要价值，是临床上与心血管疾病密切相关的一项生化指标。本文就BNP的一些生理特性及其在心血管疾病中的研究进展作一综述。     

AMI早期冠脉成形术患者心房利钠肽和脑利钠肽的连续变化

脑利钠肽(BNP)与心房利钠肽(ANP)有类似的利钠、利尿及降压活性。BNP也存在于心脏。血浆BNP水平增加见于充血性心力衰竭、高血压和左室肥大,说明BNP是一种对心血管疾病具有病理生     

氨基本段B型利钠肽前体检测对心力衰竭诊治的临床意义

<正>利钠肽家族主要由A型利钠肽(ANP)、B型利钠肽(BNP)、C型利钠肽(CNP)、肾利钠肽及树眼镜蛇属利钠肽等组成。其中,BNP和氨基末段BNP前体(NT-pro BNP)主要在心脏负荷增加时由心肌细胞分泌,是人体中一类重要的心脏生物标志物,对于多种心血管疾病,尤其是心力衰竭(HF)的诊治具有重要的临床意义。本文就NT-pro BNP的来源,与心功能的关系及其对HF诊断、治疗及预后的价值作一简要阐述。1 NT-pro BNP与BNP BNP是在1988年由日本学者Sudoh等〔1〕首次从猪大脑中     

心力衰竭患者血浆B型钠尿肽变化及临床意义

血浆B型钠尿肽(BNP)又称脑利钠肽，是继心钠肽(ANP)后利钠肽系统的又一成员，主要来源于心室，是反映心血管疾病的一个重要指标。本文旨在探讨不同程度心力衰竭患者的BNP变化及临床意义。     

脑钠肽检测的临床应用进展

脑钠肽(BNP)有利钠、利尿、扩张血管及松弛平滑肌作用和对抗心室重塑,减少心肌肥厚和心室扩大的作用.BNP血浆浓度是监测许多疾病发生、发展、预后的一项良好指标,尤其在心血管疾病.检测血浆BNP水平是心肺疾病鉴别诊断.心血管疾病诊断和评估疗效、预后以及指导改善预后的重要指标.     

老年左乳癌患者术后放疗后N端脑钠肽水平的变化

<正>脑钠肽(BNP)又称B型利钠肽,是继心钠肽(ANP)后利钠肽系统的又一成员,主要来源于心室,是反映左心室功能的敏感指标。目前关于BNP的临床研究主要集中在心力衰竭的诊断、鉴别诊断、多种心血管疾病的预后评估以及对急慢性心力衰竭的治疗,近年来,BNP也用于心功能不全的检测。N端脑钠尿肽前体(NT-pro BNP)与BNP一样均为pro-BNP裂解产物,可敏感反映患者心肌损伤程度。乳腺癌术后放疗时,由于肿瘤     

Copeptin在心血管疾病中的研究

Copeptin（和肽素）是精氨酸加压素原C末端的一部分,近年来研究发现其在心血管疾病的诊断及预后争J断等方面有重要价值,特别是在晚期心力衰竭的预后判断方面甚至优于B型利钠肽（B-typenatriureticpeptide,BNP）和N末端B型利钠肽原（N-terminalpro-B-typenatriureticpeptide,NT-proBNP）,现就copeptin的一些生理特性及其在心血管疾病中的研究作一综述。     

B型利钠肽与心血管疾病关系的研究现状

B型利钠肽(BNP)在心血管疾病中的临床应用是近年来国际上的研究热点,已成为国际公认的诊断心力衰竭的血浆标志物,被美国心脏病协会(AHA)列为2003年度医学十大进展之一。临床研究发现BNP通过利尿、利钠、扩血管、抑制肾素-血管紧张素-醛固酮系统及交感神经系统的过度反应,参与调节血压、血容量及盐平衡,对心力衰竭、高血压病、心房颤动(AF)等心血管疾病的诊断、预后判断和治疗均有重要价值。本文对BNP与上述心血管疾病关系的研究及应用现状作一阐述。1B型利钠肽与心力衰竭心力衰竭时,随神经-内分泌系统,包括交感神经系统和肾素-血管紧…     

Copeptin在心血管疾病中的研究

Copeptin(和肽素)是精氨酸加压素原C末端的一部分,近年来研究发现其在心血管疾病的诊断及预后判断等方面有重要价值,特别是在晚期心力衰竭的预后判断方面甚至优于B型利钠肽(B-type natriuretic peptide,BNP)和N末端B型利钠肽原(N-terminal pro-B-type natriuretic peptide,NT-proBNP),现就copeptin的一些生理特性及其在心血管疾病中的研究作一综述.     

Fibrodysplasia (myositis) ossificans progressiva (FOP)

Clinical Rheumatology -     

Erythropoiesis Inhibiting Factor(s) (EIF)

The specificity and toxicity of the urinary erythropoiesis inhibiting factor (EIF) has been tested both in vivo and in vitro. When EIF was given to ESF stimulated erythropoietically suppressed polycythaemic mice and to mice at maximal endogenous erythropoietic stimulation, a reduction of the erythroid bone marrow cells, the erythropoietic ³H-TdR L.I. and the total number of bone marrow cells were observed. No effect was seen on the myelopoietic bone marrow cells. An unspecific toxic effect was unlikely, since addition of EIF did not alter the proliferation of lymphoblastic cells nor change the glucose utilization of bone marrow cells in vitro. Neither did the amount of dead bone marrow cells increase after being incubated with EIF for 72 h. The results indicate that the urinary EIF is a non-toxic, cell specific inhibitor on erythropoiesis.     

脂蛋白（a）和载脂蛋白（a）多态性与女性冠心病的相关性研究

冠心病（ＣＨＤ）在病因、发病年龄等诸多方面存在性别差异。载脂蛋白（ａ）［ａｐｏ（ａ）］多态性与脂蛋白（ａ）［Ｌｐ（ａ）］血浆水平对女性ＣＨＤ影响的资料甚少。我们通过检测３５例女性ＣＨＤ患者和４５例女性正常对照者的ａｐｏ（ａ）多态表型及Ｌｐ（ａ）水平，并与相应的男性组对比分析，发现含有等位基因Ｓ１、Ｓ２、Ｂ的ａｐｏ（ａ）低分子量表型的ＣＨＤ患者，女性占３７．１４％，显著高于对照组，而男性仅占２５．７１％，与对照组比较差异无显著性。在女性中低分子量表型发生ＣＨＤ危险度为对照组的４．７倍，在男性中仅为１．４倍。提示：低分子量表型对女性ＣＨＤ的影响大于男性。Ｌｐ（ａ）水平在两性ＣＨＤ组均明显高于对照组，而两性之间则差异无显著性。     

Compound heterozygosity of Hb D(Iran) (beta(22) Glu-->Gln) and beta(0)-thalassemia (619 bp-deletion) in India

The present report describes the hematologic and molecular study of the second case of Hb D(Iran) associated with beta(0)-thalassemia (619 bp-deletion) found in India and the first case in which the mutations have been identified at molecular level. The patient showed hypochromic, microcytic red cell picture with reduced red cell indices. The characterization of the hemoglobinopathy was made by electrophoretic and chromatographic techniques and confirmed by sequencing of the beta-globin gene. Both the propositus and her father were found to be carriers of the gene for beta(0)-thalassemia owing to the 619 bp-deletion mutation as seen by the polymerase chain reaction (PCR). Single base substitution GAA > CAA (indicative of Hb D(Iran)) in the heterozygous form was seen in the propositus as well as the mother by sequencing.     

Molecular stability and function of hemoglobins Hasharon (alpha(2)47 (CD5)Asp----His beta 2) and Hasharon (alpha(2)47 (CD5)Asp----His delta 2)

The molecular stability and function of hemoglobin (Hb) Hasharon (alpha 2 H beta 2) and Hb Hasharon2 (alpha 2 H delta 2) were studied and compared to Hbs A, A2 and S. Hb Hasharon and Hb Hasharon2 had slightly lower P50 values than Hb A and Hb A2 but had normal responses to organic phosphates. The molecular stability of Hb Hasharon and Hb Hasharon2 (as measured by mechanical shaking and heat denaturation at 60 degrees C) were less than Hb A and Hb A2 but greater than Hb S in the oxy- and carbonmonoxy-forms. In the met-form, however, Hb Hasharon and Hb Hasharon2 were less stable than hemoglobins S, A and A2. The oxy-form of Hb Hasharon forms methemoglobin at a faster rate than Hb A and Hb S. The mechanical and heat stabilities and the rate of methemoglobin formation of oxy-Hb Hasharon were studied in the presence of sulfisoxazole. This drug increased the rate of methemoglobin formation, thus causing a further decrease in the stability of Hb Hasharon. The relationship between these laboratory findings and previously observed clinical findings associated with Hb Hasharon are discussed.