云芝糖肽对胃癌患者手术及化疗时免疫功能的影响

目的：探讨云芝糖肽对胃癌患者手术及化疗时免疫功能的影响。方法：选择105例胃癌术后及32例胃癌化疗患者,根据是否应用云芝糖肽随机分为单纯手术组、手术合并云芝糖肽组、单纯化疗组及化疗合并云芝糖肽组,分别检测四组红细胞C3b受体花环（RBC-C3bRR）、免疫复合物花环（RBC-ICR）、T细胞亚群以及NK细胞活性。结果：胃癌术后患者中,手术合并云芝糖肽组RBC-C3bRR、CD3、CD4、CD4/CD8、NK细胞活性较单纯手术组显著升高（P〈0.01）,RBC-ICR较单纯手术组显著降低（P〈0.01）;胃癌化疗患者中,化疗合并云芝糖肽组RBC-C3bRR、CD3、CD4、CD4/CD8、NK细胞活性较单纯化疗组显著升高（P〈0.01）,RBC-ICR较单纯化疗组显著降低（P〈0.01）。结论：胃癌患者术后和化疗时合并应用云芝糖肽可明显改善机体的免疫功能。     

云芝糖肽镇痛作用研究进展

目的 验证云芝糖肤的镇痛作用并探讨其镇痛机制.方法 采用电刺激大鼠甩尾法测定其痛阈,观察不同剂量云芝糖肽对痛阑的影响.在大鼠侧脑室埋管,观察侧脑室注射IL-2受体α亚基单克隆抗体和纳洛酮对云芝糖肽提高大鼠痛阚的影响.结果 云芝糖肽灌胃6天后,大鼠痛阈升高,并有明显的量效关系.侧脑室给予IL-2受体α亚基单克隆抗体能有效阻断云芝糖肽提高大鼠痛阈的作用;侧脑室给予纳洛酮对云芝糖肽提高大鼠痛阈无明显影响.结论 云芝糖肽确有镇痛作用,其镇痛作用为中枢性的,其机制是云芝糖肽刺激T细胞分泌IL-2,IL-2进入脑内与IL-2受体结合而起作用,而并非与阿片受体结合.     

红桂木凝集素糖蛋白的特征及其糖肽键性质的分析

目的 探讨红桂木凝集素（Ａｒｔｏｃａｒｐｕｓ Ｌｅｎｇｎｓｎｅｎｓｉｓ Ｌｅｃｔｉｎ,ＡＬＬ）的糖蛋白特征及其糖肽键类型。方法 经Ｇａｌ－Ｓｅｐｈａｒｏｓｅ６Ｂ亲和柱层析,从红桂木种子纯化获红桂木凝集素。以链霉蛋白酶将ＡＬＬ降解,Ｓｅｐｈａｄｅｘ Ｇ－２５层析,分离得糖肽,用化学及物理方法分析单糖组成,以β－消除反应及凝集素结合试验分析糖肽键类型。结果 ＡＬＬ和糖肽均含氨基半乳糖、葡萄糖、甘露糖、     

云芝糖肽联合化疗治疗非小细胞肺癌临床观察

云艺糖胶囊（PSP）是从云芝COV－1菌株的深层培养菌丝体中提炼出云艺糖肽制成,具有抗多种肿瘤细胞的作用,并能对免疫功能和血象有保护和改善作用［‘］。我们于1997年5月～1998年5月应用PSP配合PVM方案,治疗非小细胞肺癌25例,结果报告如下。l材料与方法1．1人组对象凡经病理学或细胞学确诊为非小细胞肺癌;年龄＜70岁;一般状态（KPS）评分＞60分,估计存活时间＞3个月;以往治疗疗效已消除,并从未用过此方案者;无严重并发症,血象、肝、肾功能在正常范围均可人组。豆．2病例构成所有病例随机分为化疗加云艺糖肽组（A组）和单…     

云芝糖肽对晚期恶性肿瘤的治疗作用

目的 :评价云芝糖肽对晚期恶性肿瘤的治疗作用。方法 :晚期恶性肿瘤患者 2 5例 (男 16例 ,女 9例 ,平均年龄 60± 14a) ,随机分成 2组。治疗组 11例 ,口服云芝糖肽 5g ,每日 3次 ,一疗程为 2月 ,同时辅以对症治疗 ;对照组 14例 ,只应用对症治疗。对 2组治疗效果及免疫功能进行比较。结果 :2组间近期疗效及免疫指标比较无明显差异 ;2组间卡诺夫斯基健康状况评分和疼痛缓解总有效率比较有显著性差异 ,治疗组生存质量明显优于对照组。结论 :云芝糖肽可提高晚期恶性肿瘤患者生存质量 ,改善症状。云芝糖肽无不良反应。     

单色云芝多糖的结构研究

目的 研究单色云芝多糖(CUP)的化学结构,并与云芝多糖进行比较.方法 气相色谱分析糖组成,红外光谱(IR)、高碘酸氧化、甲基化、核磁共振(NMR)等方法确定多糖的结构.结果 CUP单糖组成为葡萄糖,相对分子质量约1.3×104,主要连接方式为β(1→3)连接,此外包括α-(1→3),β-(1→6),α-(1→4),(1→3,6)和(1→4,6)连接.结论 CUP的单糖组成和结构与云芝多糖相似,在相对分子质量、蛋白含量等方面有区别.     

云芝糖肽对小鼠活动的抑制作用

小鼠自发活动和转轮活动测试结果表明：云芝糖肽能抑制小鼠的自发活动和转轮活动。腹腔注射100mg／kg和200mg／kg云芝糖肽都能显著降低小鼠的自发横向和直向活动以及转轮活动（P＜0．01或P＜0．05），并显示了一定的星效关系。安定2.5／ks的作用明显高于云芝糖肽100ms／kg的作用（P＜0．01），而与其200ms／kg的作用相比，无显著差异（P＞0．05）。     

放射加云芝糖肽治疗食管癌前瞻性的远期疗效

放射加云芝糖肽治疗食管癌前瞻性的远期疗效姚伟强施学辉何少琴刘泰福曹世龙（上海医科大学肿瘤医院放疗科２０００３２）云芝糖肽（ＰＳＰ）是从云芝中提出的一种有效成份，已初步发现具有抗多种肿瘤细胞的作用和一定的免疫调节功能［１］。为进一步研究ＰＳＰ的临床价值...     

薄芝糖肽注射剂临床应用安全性监护

目的:探讨薄芝糖肽使用后安全性监护结果.方法:收集该院近年使用薄芝糖肽注射液的90例患者临床资料进行回顾性分析,统计薄芝糖肽使用过程中不良反应发生情况、用药前后肝功能指标及免疫指标检测结果变化情况,将所得数据给予统计学分析后得出结论.结果:90例使用薄芝糖肽治疗的患者发生与薄芝糖肽注射液相关的药物不良反应几率仅为6.67％;90例患者应用薄芝糖肽后,其各项肝功能指标均较之前有所变化,其中TBA、ALT、AST、DBL、TBL、ALP、r-GT、A/G水平上升,而ALB、TP、CHE水平下降,但给药前后肝功能指标检测结果所得数据对比并无显著差异(P＞0.05).结论:薄芝糖肽使用后安全性虽较高,但仍有部分患者出现相应不良反应,提示临床医生护士在静滴薄芝糖肽时需要严格按照相关说明书操作并于冲管后给药,药物治疗过程中医护人员密切观察药物反应并正确控制滴速,有利于降低薄芝糖肽使用不良反应发生率,保障患者生活质量及身心健康.     

西替利嗪联合薄芝糖肽治疗慢性荨麻疹的疗效观察

目的：观察西替利嗪联合薄芝糖肽治疗荨麻疹的疗效及安全性。方法：将80例慢性荨麻疹患者随机分成两组，每组40例。治疗组口服西替利嗪及肌注薄芝糖肽利嗪2周，对照组口服西替利嗪2周，观察并记录两组疗效。结果：治疗组与对照组的总有效率分别为87．5％和72．5％，两组比较有显著性差异（X^2=4．313，P〈0．05），药物不良反应轻微。结论：西替利嗪联合薄芝糖肽治疗慢性荨麻疹能提高临床疗效。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.