关节镜下双束重建膝前交叉韧带的疗效及安全性分析

目的 探讨膝前交叉韧带（ACL）发生损伤后采用关节镜下双束重建与传统单束重建的疗效差异及安全性评价.方法 抽选我院2008年3月～2013年5月收治的131例膝ACL损伤患者,根据术式的不同随机分为对照组（n=65例,采用关节镜下ACL单束重建）和观察组（n=66例,采用关节镜下ACL双束重建）,观察治疗12个月后两组患者IKDC膝关节功能评分、Lysholm稳定性评分、Tegner体育量表评分的差异.结果 两组治疗前IKDC、Lysholm以及Tegner评分比较差异无显著性（P＞0.05）;治疗12个月后,观察组患者的IKDC、Lysholm以及Tegner评分明显高于对照组（P＜0.05）.以KT-1000测定观察组患者术后关节屈膝90.的移动度明显低于对照组（P＜0.05）;屈膝90.关节活动优良率明显高于对照组（P＜0.05）.两组MRI及X线复查安全性比较差异无显著性（P＞0.05）.结论 双束重建比单束重建更能满足膝关节生物力学平衡,恢复膝关节稳定性,值得临床推广.     

膝关节镜微创手术对膝关节半月板损伤的疗效研究

目的:分析对膝关节半月板损伤患者行以膝关节镜微创手术治疗的疗效。方法:择取70例膝关节半月板损伤患者,将其随机分成两组,对照组35例患者行以保守治疗,研究组35例患者行以膝关节镜微创手术治疗,对照分析两组临床疗效。结果:经对照分析,从临床总有效率来看,研究组高于对照组,差异有统计学意义(P<0.05);治疗前两组膝关节活动度、视觉模拟评分法(VAS)评分、Lysholm评分、Tegner评分、IKDC评分对比差异均无统计学意义(P>0.05),治疗后研究组膝关节活动度大于对照组,VAS评分低于对照组,Lysholm评分高于对照组,Tegner评分高于对照组,IKDC评分高于对照组,差异有统计学意义(P<0.05)。结论:对膝关节半月板损伤患者行以膝关节镜微创手术治疗的疗效确切,可以改善膝关节活动度,减轻疼痛程度,还可以改善膝关节功能以及活动情况,具有显著临床价值。     

膝关节镜下应用不同自体材料重建前交叉韧带对患者的影响

探究膝关节镜下应用不同自体材料重建前交叉韧带（ACL）对患者围术期指标、膝关节功能和影像学变化的影响。方法 回顾性分析2019年1月—2021年1月湖北民族大学附属民大医院收治的124例重建ACL患者临床资料,根据患者使用自体材料进行分组,观察组实施自体腘绳肌腱（半腱肌+股薄肌）移植重建（n=62）,对照组实施自体半腱+1/2腓骨长肌移植重建（n=62）。探究两组患者围术期指标（手术时长、切口长度、术中出血量、编织后移植物直径）差异;比较两组患者治疗前、治疗3个月后、治疗6个月后膝关节功能Lysholm评分差异;分析两组患者治疗6个月后影像学变化差异;分析两组患者术后并发症差异。结果 观察组患者手术时长、切口长度、术中出血量、编织后移植物直径均低于对照组（P＜0.05）;治疗3、6个月后两组患者Lysholm评分均较治疗前上升（P＜0.05）,治疗3个月后观察组患者Lysholm评分高于对照组（P＜0.05）,治疗6个月后两组患者Lysholm评分比较差异无统计学意义（P＞0.05）;治疗6个月后,膝关节X线检查结果的影像学变化比较差异无统计学意义（P＞0.05）;两组患者膝前痛、伸膝受限、切口感染、胫骨骨道偏移、关节肿胀发生情况比较差异无统计学意义（P＞0.05）。结论 自体腘绳肌腱移植重建与自体半腱+1/2腓骨长肌移植重建相比,对重建ACL患者围术期影响更小,且不影响患者早期膝关节功能恢复,常规情况下无需切取腓骨长肌腱来重建ACL,但对于腘绳肌腱比较细的患者可以考虑选择自体半腱+1/2腓骨长肌移植重建     

PCL重建术后本体感觉早期恢复情况的临床对比研究

目的 探讨并比较膝关节镜下自体半腱肌和股薄肌腱单束与双束重建PCL后本体感觉的早期恢复情况.方法 选取2008年9月～2010年5月潍坊医学院附属医院骨科PCL断裂后应用自体半腱肌和股薄肌腱单双束重建患膝共18例,其中单束重建组10例,双束组8例,正常膝关节对照组15例,单束重建组和双束重建组于术后6个月时和正常膝关节对照组同时完成膝关节被动位置重现偏差值检查和单足跳测试以评价膝关节本体感觉功能,同时对其Lysholm评分进行观察,将结果进行分析比较.结果 重建PCL两种术式之间患膝的被动位置重现偏差值、单足跳成绩及Lysholm评分,差异均无统计学意义（P〉0.05）;两种术式重建PCL患膝的被动位置重现偏差值、单足跳成绩及Lysholm评分结果分别与正常对照组比较,差异有统计学意义（P〈0.05）.结论 两种术式重建PCL后早期患膝的本体感觉恢复情况无差异,但并未恢复到正常水平.     

关节镜手术治疗慢性膝关节骨性关节炎的疗效分析

目的：探讨关节镜手术与保守方法治疗慢性膝关节骨性关节炎的临床疗效。方法整群选择该院骨科自2012年1月一2013年12月收治的114例慢性膝关节骨性关节炎患者为研究对象,并且按照随机数字表法分为对照组和观察组,每组57例。对照组患者接受保守治疗,观察组患者接受膝关节镜手术治疗。采用膝关节综合评分表和Lysholm评分系统评价治疗效果。结果治疗6个月后观察组患者优良率明显高于对照组患者,差异具有统计学意义(95.74%vs 72.34%,P＜0.05）。对照组治疗前后Lysholm评分分别为[(43.56±5.01）vs(68.56±6.46）],观察组治疗前后Lysholm评分分别为[(43.25±4.28）vs(86.24±7.04）],治疗后两组Lysholm评分较前均明显升高(与同组治疗前相比,P＜0.05）,且观察组升高更为明显(与对照组治疗后相比,P＜0.05）。结论膝关节镜手术治疗慢性膝关节骨性关节炎效果显著,对患者创伤小,有利于术后膝关节功能恢复,值得在临床中推广应用。     

膝关节镜技术联合胫骨高位截骨治疗膝内侧骨性关节炎的疗效

探讨膝关节镜技术联合胫骨高位截骨（HTO）治疗膝内侧骨性关节炎疗效及对围术期指标和术后并发症的影响。方法 回顾性分析我院2016年1月—2021年6月88例膝内侧骨性关节炎患者的临床资料,根据手术方式不同分为观察组（n=48）及对照组（n=40）。对照组采用膝关节镜技术治疗,观察组采用膝关节镜技术联合HTO治疗。比较两组围术期指标、手术前后日常生活活动能力、疼痛程度、膝关节功能、炎症因子、并发症、满意度。结果 观察组术中出血量、手术时间均高于对照组,住院时间短于对照组（P＜0.05）;观察组术后日常生活活动能力量表（ADL）评分高于对照组,视觉疼痛模拟评分（VAS）低于对照组（P＜0.05）;观察组术后膝关节活动度（ROM）、Lysholm评分、HSS评分高于对照组（P＜0.05）;观察组术后膝关节液TNF-α、IL-6水平低于对照组（P＜0.05）;两组并发症发生率比较,差异无统计学意义（P＞0.05）;术后随访6个月时,观察组满意度自评分高于对照组（P＜0.05）。结论 在膝内侧骨性关节炎的治疗中,膝关节镜技术联合HTO具有良好的疗效,能缩短住院时间,提高日常生活活动能力,减轻术后疼痛,改善膝关节功能,缓解炎症反应,且术后并发症少,患者满意度高     

膝关节多发韧带损伤关节镜下重建方法的临床应用

目的 探讨膝关节多发韧带损伤关节镜下重建方法的应用价值.方法 选取2011年5月～2013年3月收治的50例膝关节多发韧带损伤患者,依据随机数字表法将患者分为治疗组与对照组,每组25例.对照组患者给予保守治疗,治疗组患者给予关节镜下重建治疗,然后对两组患者的膝关节功能及不良反应发生情况进行统计分析.结果 两组患者治疗前后的Lysholm膝关节功能评分和主动关节活动范围之间的差异均具有统计学意义（P＜0.05）,治疗组患者的提升幅度较大;治疗前两组患者的Lysholm膝关节功能评分和主动关节活动范围之间的差异均不具有统计学意义（P＞0.05）,治疗后治疗组患者的Lysholm膝关节功能评分明显比对照组患者高,主动关节活动范围明显比对照组患者大,且术后不良反应发生率明显比对照组患者低,差异均具有统计学意义（均P＜0.05）.结论 膝关节多发韧带损伤关节镜下重建方法较保守治疗方法具有较好的应用效果,值得临床推广应用.     

为100例膝关节损伤患者进行关节镜手术治疗的疗效分析

分析为100例膝关节损伤患者进行手术治疗的临床疗效。方法：将我院收治的100例膝关节损伤患者分为对照组和观察组,为对照组患者进行常规手术治疗,为观察组患者进行关节镜下手术治疗,观察两组患者的临床疗效。结果：观察组患者治疗的总有效率为92.0%,对照组患者治疗的总有效率为68.0%,观察组患者治疗的总有效率优于对照组患者,差异显著（P＜0.05）,有统计学意义。在进行治疗前,两组患者的 Lysholm膝关节功能评分相比较,差异不显著（P＞0.05）,无统计学意义。在进行治疗后,观察组患者的Lysholm膝关节功能评分明显高于对照组患者,差异显著（P<0.05）,有统计学意义。结论：为膝关节损伤患者进行关节镜下手术治疗可减少其手术创伤,促使其膝关节功能更快地恢复,提高其膝关节功能的评分,取得理想的疗效,而且安全性较高,此法值得在临床上推广使用。     

3D打印导板在关节镜下膝前交叉韧带重建中的临床应用

目的 比较在3D打印技术辅助下行前交叉韧带（anterior cruciate ligament, ACL）重建与传统治疗方案在手术时间、股骨骨隧道长度、术后近期疗效的差异。方法 选取2017年6月—2018年5月收治的ACL断裂患者30例,随机分为两组,每组15例,观察组予以关节镜下3D导板辅助ACL重建手术治疗,另外一组为对照组（传统重建组）,两组均采用单束重建,观察对比两组患者手术时间、股骨骨隧道长度及术后Lysholm膝关节评分（术后疗效评价）。结果 全部患者均随访3个月以上,观察组手术时间（46.3±12.2）min,股骨骨隧道长度（42.47±3.248）mm,术后3个月Lysholm膝关节评分(95.35±5.05)分;对照组手术时间（61.5±20.2）min,股骨骨隧道长度（42.67±5.678）mm,观察组骨隧道较对照组集中。Lysholm膝关节评分(88.18±9.80)分;其中观察组的手术时间和术后Lysholm膝关节评分较对照组差异有统计学意义(P＜0.05),而平均住院日差异无统计学意义（P＞0.05）。结论 3D导板辅助下前交叉韧带重建手术时间更短,术后膝关节Lysholm评分更优,股骨骨隧道长度更稳定可控。     

同侧腘绳肌腱联合部分腓骨长肌腱移植治疗膝关节后交叉韧带合并后外侧复合体损伤效果观察

目的 探讨自体同侧腘绳肌腱联合部分腓骨长肌腱治疗膝关节后交叉韧带合并后外侧复合体损伤的效果.方法 15例经证实为膝关节后交叉韧带伴后外侧复合体损伤患者,均采用自体腘绳肌肌腱重建后交叉韧带、部分腓骨长肌腱加强后外侧复合体的手术方法.术前、末次随访时均记录膝关节后侧、后外侧不稳定程度,膝关节IKDC、Lysholm功能评分,以系统评估膝关节功能.结果 本组术后均获得随访12～24个月,患者膝关节后侧、后外侧不稳定程度较术前均明显改善（均P＜ 0.05）;Lysholm评分及IKDC评分术前与末次随访时差异均有统计学意义（P＜0.05）.结论 自体腘绳肌肌腱及部分腓骨长肌腱重建后交叉韧带、后外侧复合体的手术方法能够恢复膝关节后侧及后外侧结构的稳定性.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.