外科手术时机及方式对重症急性胰腺炎疗效的影响

目的:探讨重症急性胰腺炎(SAP)的治疗经验。方法:分析上海交通大学附属第六人民医院2003年1月至2006年1月收治的78例SAP患者临床资料,根据治疗方法不同分为三组,其中早期手术组21例,延期手术组12例,非手术组45例。结果:早期手术组、延期手术组、非手术组的并发症发生率分别为28.5%(6/21)、75%(9/12)、46.6%(21/45);病死率分别为14.3%(3/21)、33.3%(4/12)、17.8%(8/45)。三组之间的并发症发生率及病死率相比较均有显著差异性(P<0.05);其中早期手术组并发症发生率、病死率最低,非手术治疗组次之,延期手术组最高。结论:以个体化综合治疗措施为基础,恰当的选择手术时机与方式有助于提高重症急性胰腺炎疗效。     

重症急性胰腺炎的治疗方法选择与预后的关系

目的探讨重症急性胰腺炎治疗方法的选择及对预后的影响。方法对我院2009年3月-2010年3月间收治的158例重症急性胰腺炎患者进行分析观察,其中早期手术66例,延期手术36例,非手术治疗56例。对比三组患者并发症、病死率发生情况。结果早期手术组并发症的发生率为33.33%,延期手术组为16.67%,非手术组为7.14%,早期手术组并发症发生率显著高于非手术组,差异有统计学意义(P<0.05),早期手术组病死率显著高于另外两组,组间比较差异有统计学意义(P<0.05)。结论重症急性胰腺炎的治疗方法选择直接影响临床预后的结果,重症急性胰腺炎时,应避免在急性期手术,尽量先稳定病情,采用个体化的非手术或延期手术治疗。     

134例重症急性胰腺炎的治疗选择与预后分析

目的:探讨重症急性胰腺炎(Severe acute pancreatitis,SAP)的治疗方式与预后的关系。方法:对本院1990年1月至2 0 0 3年6月收治的134例SAP进行回顾性分析。结果:早期手术组、延期手术组和非手术治疗组的并发症发生率分别为80 .6 %、35 .3%和31.6 % ,病死率分别为32 .3%、14 .7%和13.1%。早期手术组与后两组比较,并发症发生率差异有非常显著性(P<0 .0 1) ,病死率差异有显著性(P<0 .0 5 )。早期手术组和延期手术组再手术率分别为5 1.6 %和14 .7% ,两组比较差异有非常显著性(P<0 .0 1)。结论:SAP的治疗方式是影响预后的重要因素,应尽量避免在急性期手术,而尽量采用非手术或延期手术治疗。     

重症急性胰腺炎23例治疗分析

目的　探索一种减少重症急性胰腺炎 (Severeacutepancreatitis ,SAP)并发症 ,降低其病死率的新途径。方法　将我院外科 1978- 0 2～ 2 0 0 1- 0 1治疗的SAP 2 3例按不同治疗阶段分为 2组。A组 :1978- 0 2～1993- 0 8的手术治疗为主的手术组 ;B组 :1993- 0 8～ 2 0 0 1- 0 1以周围静脉治疗为主的非手术组。结果　A组 15例 ,死亡 3例 ,病死率 2 0 % (3/ 15 ) ;B组 8例 ,死亡 1例 ,病死率 12 5 % (1/ 8)。结论　SAP以周围静脉给药为主治疗方法优于手术组     

区域动脉灌注治疗入院时的Ⅱ级重症急性胰腺炎

目的：探讨区域动脉灌注治疗入院时即合并有胰外脏器功能障碍的重症急性胰腺炎(亦称Ⅱ级重症急性胰腺炎，Ⅱ grade serve acute pancreatitis,SAP-Ⅱ)患者的可行性及其他治疗要点，以期提高疗效。方法：1999年8月以来，采用早期区域动脉灌注5—FU、奥曲肽治疗6例SAP—Ⅱ患者，并以自1995年6月至1999年7月间采用早期手术治疗的6例SAP—Ⅱ患者作为对照组，比较两组的病死率、并发症发生率、平均住院时间、平均住院费用。结果：手术组的病死率为50％，并发症发生率为100％，平均住院时间为76．3d，平均住院费用为18．4万元；早期区域动脉灌注组的病死率为0，并发症发生率为33．3％，平均住院时间为37．3d，平均住院费用为5．4万元，经x^2检验，二组的死亡率(P＜0．05)、并发症发生率(P＜0．05)的差异有显著性。结论：①早期采用区域动脉灌注针对重症急性胰腺炎的治疗是入院时SAP—Ⅱ患者的治疗关键。②妥善处理胰外脏器功能障碍是提高入院时SAP—Ⅱ患者疗效的重要环节。③手术治疗主要针对入院时SAP—Ⅱ患者晚期局部感染并发症与消化道瘘、大血管糜烂出血等。     

97例重症急性胰腺炎的治疗选择与预后分析

目的 探讨重症急性胰腺炎(severe acute pancreatitis,SAP)的治疗方式与预后的关系.方法 收集1998年1月～2006年12月收治的97例SAP进行回顾性分析.结果 早期手术组、延期手术组和非手术治疗组的并发症发生率分别为73.3%、33.3%和32.6%,病死率分别为36.7.5%和11.6%.早期手术组与后两组比较.并发症发生率差异有非常显著性(P<0.01),病死率差异有显著性(P<0.05).结论 SAP的治疗方式是影响预后的重要因素.应尽量避免在急性期手术,而尽量采用非手术或延期手术治疗.     

重症急性胰腺炎早期手术指征的探讨

目的：探讨重症急性胰腺炎患者早期手术指征。方法：回顾性分析1996—2001年收治的46例重症急性胰腺炎患者的临床资料；其中，非手术治疗9例，早期手术治疗25例，延期手术治疗12例。结果：非手术组病死率和并发症发生率均为11．1％，早期手术组病死率和并发症发生率分别为4．0％和16．0％，延期手术组病死率和并发症发生率分别为33．3％和41．7％，三组病死率差异有显著性(P＜0．05)，但并发症发生率差异无显著性(P＞0．05)。结论：早期手术对某些置症急性胰腺炎患者仍是必需的；经短期治疗后，腹胀未明显改善或有加剧，应考虑手术。     

重症急性胰腺炎外科手术15例

目的:探讨重症急性胰腺炎(SAP)外科手术干预的时机、指征、方式的选择.方法:回顾分析2000～2009年收治的26例重症胰腺炎的临床资料.结果:非手术治疗11例,手术治疗15例,总死亡率11.5%(3/26),总治愈率88.5%(23/26),其中非手术组治愈率81.8%(9/11),手术组治愈率93.3%(14/15).手术组的危重程度(APACHE-Ⅱ)评分明显高于非手术组.结论:正确地把握SAP的外科手术时机,合理地选择外科手术方式,才能达到最好的治疗效果.     

两种方式治疗重症急性胰腺炎结果的对比分析

目的研究重症急性胰腺炎(SAP)早期手术治疗和非手术治疗效果,探讨适宜的手术治疗时机和手术方式。方法对比分析1991-1997年以早期手术为主的29例SAP(早期手术组)与1998-2006年中早期采用非手术治疗为主的53例SAP(延期手术组)并发症的发生率和死亡率。结果延期手术组的并发症的发生率、死亡率明显低于早期手术组。结论SAP早期的急性炎症反应期治疗应以非手术疗法为主,对于十二指肠乳头结石嵌顿型和极重型SAP伴有早期腹腔室隔综合征的病例应果断实行外科干预,治疗方案要遵循"综合治疗"及"个体化治疗"的原则。     

重症急性胰腺炎68例治疗结果分析

目的探讨重症急性胰腺炎（SAP）手术时机与预后的关系。 方法对我院1998-01／2005—12收治的68例SAP病人的手术时机选择与并发症发生率、病死率和再手术率进行回顾性分析。 结果早期手术组、延期手术组和非手术组的并发症发生率分别为73．3％、33．3％和26．0％，早期手术组较后两组差异有显著意义（P〈0．05）；病死率分别为33．3％、13．3％和13．0％，早期手术组明显高于后两组（P〈0，05）；早期手术组再手术率为46．6％，而延期手术组仅为16．6％（P〈0。01）。 结论 SAP应避免在急性期手术，而应尽量采用非手术或延期手术治疗。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.