Asperger综合征儿童的心理理论研究

目的对Asperger综合征儿童进行心理理论研究.方法采用心理理论测题(包括表情理解题、有情节的虚假信念题和无情节的虚假信念题)对Asperger综合征儿童和幼儿及正常儿童和幼儿进行测试.结果在表情理解题目中,Asperger幼儿组通过率(59%)明显低于正常幼儿组(85%);在有情节和无情节的虚假信念测题中,Asperger幼儿组通过率(41%,9%)和儿童组的通过率(78%,61%)亦分别低于正常幼儿组(72%、40%)和儿童组(100%、97%),差异有显著性(P＜0.05).结论Asperger综合征患儿具有心理理论方面的障碍.     

广州市幼儿心理推测能力发展水平的研究

目的调查广州市幼儿心理推测能力的发展水平,探索其发展特征,为建立广州地区的常模标准提供实验依据.方法应用日本版"心理理论"课题测验和测具对613名3～6岁健康儿童进行测试,数据用SPSS 10.0进行统计分析.结果 3.5岁以后有92.20%的儿童可以通过哭泣表情的辨认测试,4.5岁以后83.30%的儿童可以对哭泣表情进行合理的推测,儿童虚误信念测试各题通过率随年龄增长呈上升趋势.结论幼儿心理推测能力随年龄增长而逐渐发展,不同的心理推测能力发展水平各异.     

广州市幼儿心理推测能力发展水平的研究

目的调查广州市幼儿心理推测能力的发展水平 ,探索其发展特征 ,为建立广州地区的常模标准提供实验依据。方法应用日本版“心理理论”课题测验和测具对 613名 3 6岁健康儿童进行测试 ,数据用SPSS 10 .0进行统计分析。结果 3 5岁以后有 92 .2 0 %的儿童可以通过哭泣表情的辨认测试 ,4.5岁以后 83 .3 0 %的儿童可以对哭泣表情进行合理的推测 ,儿童虚误信念测试各题通过率随年龄增长呈上升趋势。结论幼儿心理推测能力随年龄增长而逐渐发展 ,不同的心理推测能力发展水平各异     

Asperger综合征儿童智力水平分析

目的探讨Asperger综合征儿童的智力水平和结构特点.方法采用韦氏儿童智力量表(C-WISC)对40名Asperger综合征患儿和59名正常儿童进行智力测试.结果 Asperger综合征儿童大部分(80%)智商在正常范围内,一小部分(17.5%)有智力缺损;其总智商、言语智商和操作智商分别为88.78±22.79,92.80±21.84,86.45±21.04,均低于正常儿童(P ＜0.05);且言语智商高于操作智商者较多(P ＜0.05).结论大部分Asperger综合征儿童智力正常,智力发展不平衡者较多.     

Asperger综合征儿童智力水平分析

目的探讨Asperger综合征儿童的智力水平和结构特点。方法采用韦氏儿童智力量表(C-WISC)对40名Asperger综合征患儿和59名正常儿童进行智力测试。结果Asperger综合征儿童大部分(80% )智商在正常范围内,一小部分(17. 5% )有智力缺损;其总智商、言语智商和操作智商分别为88. 78±22. 79, 92. 80±21. 84, 86. 45±21. 04,均低于正常儿童(P<0. 05);且言语智商高于操作智商者较多(P<0. 05)。结论大部分Asperger综合征儿童智力正常,智力发展不平衡者较多。     

肥胖儿童血清25羟维生素D及胰岛素抵抗研究

目的：探讨儿童肥胖与血清25羟维生素D[25-（OH）D]及胰岛素抵抗的关系。方法：选取7~14岁肥胖儿童60例及正常体重儿童60例,抽血检测空腹血清25-（OH）D、血糖及胰岛素水平,采用胰岛素抵抗指数（HOMA-IR）评估胰岛素抵抗水平。比较两组血清25-（OH）D及胰岛素抵抗水平的差异。结果：肥胖儿童组血清25-（OH）D显著低于正常体重儿童组（P〈0.01）;肥胖儿童组HOMA-IR高于正常体重儿童组,差异有统计学意义（P〈0.01）;25-（OH）D与HOMA-IR呈负相关（r=-0.596,P〈0.01）。结论：肥胖儿童血清25-（OH）D低于正常儿童,且胰岛素抵抗水平高于正常体重儿童,对肥胖儿童监测25-（OH）D并适当补充维生素D,有利于改善胰岛素抵抗,减轻体重。     

咪达唑仑联合右美托咪定用于儿童MRI检查镇静

目的 评价咪达唑仑联合右美托咪定用于儿童磁共振成像（magnetic resonance imaging,MRI）检查镇静的有效性及安全性。方法 收集2021年8月至2022年7月在山东大学附属儿童医院镇静中心接受镇静行MRI检查的3773例患儿的病历资料。根据年龄将其分为婴儿组（年龄≤1岁,922例）、幼儿组（1岁<年龄≤3岁,1153例）和儿童组（3岁<年龄≤8岁,1698例）。镇静方案为咪达唑仑0.5mg/kg口服联合右美托咪定2μg/kg滴鼻,MRI检查前30min用药,使用Ramsay镇静量表评估镇静深度,评分≥5分视为达到深度镇静。统计并分析各年龄组患儿的一般资料、镇静成功率、入睡时间、苏醒时间及不良反应的发生情况。结果 共纳入分析患儿3773例,镇静成功3480例,总成功率92.2%。儿童组患儿的15min和30min镇静成功率显著低于婴儿组和幼儿组（P<0.05）;幼儿组患儿的45min和60min镇静成功率显著低于婴儿组和儿童组（P<0.05）;儿童组患儿的入睡时间显著长于婴儿组和幼儿组（P<0.001）;婴儿组患儿的苏醒时间显著长于幼儿组和儿童组（P<0.001）。总不良反应发生率为4.9%,儿童组患儿的总不良反应发生率显著低于婴儿组和幼儿组（P<0.001）。结论 口服咪达唑仑联合右美托咪定滴鼻可安全有效地用于8岁以下儿童的MRI检查镇静。年龄越小镇静成功率越高,苏醒时间越长,但总体不良反应发生率低,不失为儿童MRI检查镇静的一个安全有效的联合用药方案。     

注意缺陷多动障碍儿童128例智力结构及行为问题分析

目的：探讨注意缺陷多动障碍（ADHD）儿童的智力结构及临床行为特点,为临床进行有效干预提供依据。方法：选取ADHD儿童128例入组,相同年龄的正常儿童80例为对照组,采用韦氏儿童智力量表（C—WISC）、Achenbach儿童行为量表（CBCL,家长用）评定,进行比较分析。结果：ADHD组儿童总智商（FIQ）多在正常范围且低于正常对照组,操作智商（PIQ）高于言语智商（VIQ）（P〈0．01）。CBCL量表中ADHD儿童组的活动能力、交际能力、学校情况分值均低于正常儿童组,行为问题总分高于正常儿童（P〈0．05）。结论：ADHD儿童智商较正常儿童低,且智力发展存在不平衡,言语能力落后于操作能力。对比正常儿童,社交能力差,行为问题多。     

3～7岁孤独症儿童心理推测能力的实验研究

目的探明3～7岁孤独症儿童心理推测能力发展状况及其特征.方法应用 "心灵理论"测验用具对3～7岁20名孤独症儿童和361名正常儿童进行测试,使用SPSS 10.0分析测试结果.结果孤独症儿童心理推测能力处于较低水平波动,其虚误信念和表情辨认通过率明显低于同龄正常儿童(P<0.05),与发展水平相当的正常儿童比较,其虚误信念测试分数明显低(P<0.05),简单表情辨认能力则无差别(P>0.05);结论 3～7岁孤独症儿童心理推测能力明显落后于正常儿童,无随年龄增长而提高的发展趋势,简单表情辨认能力与其发展水平存在一定联系.     

儿童呼吸道异物的特点及预防策略

目的 探讨儿童呼吸道异物的特点及预防策略..方法 分析580例儿童呼吸道异物的病例资料,分为农村和城市患儿2类;再根据年龄分成婴儿组（＜1岁）、幼儿组（1～3岁）、学龄前儿童组（3-5岁）、学龄期儿童组（6～12岁）.结果 580例中,农村患儿565例,城市患儿15例;婴儿组植物性异物38例;幼儿组植物性异物469例,动物性异物3例;学龄前儿童组植物性异物26例,化学合成品类异物4例,动物性异物1例,金属性异物3例;学龄期儿童组植物性异物5例,化学合成品类异物27例,矿物性异物2例,金属性异物1例,动物性异物1例.结论 ①婴幼儿及学龄前期儿童呼吸道异物以植物性异物为主,学龄期儿童以化学合成品类异物为主.②加强民众的健康宣传教育,特别是农村地区民众的防范意识甚为重要.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.