新生儿低血糖高危因素与防治的临床研究

目的：分析引起新生儿低血糖的高危因素及临床特点，为诊治提供依据。方法：对368例易发生低血糖者连续观察血糖监测。结果：检出低血糖95例，临床症状多不典型，且无特异性，常见疾病为窒息36例（37．89％），早产儿及小于胎龄儿25例（26．31％），喂养困难17例（17．98％），溶血7例（7．37％），感染7例（7．37％），母亲患糖尿病6例（6．32％）。结论：新生儿血糖易受各种生理及病理因素影响产生波动，对于有低血糖高危因素的新生儿要监测血糖，及时发现，及时纠正，避免低血糖引起中枢神经系统损伤。     

高危新生儿低血糖检测分析及防治

目的探讨新生儿低血糖的临床特点、诊断标准及高危因素。方法采用美国产稳步血糖仪足跟采血测定318例有围生期高危因素的新生儿血糖，并以103例正常足月儿作为对照。结果高危儿发生低血糖共101例占24％，正常足月儿12例占2％，二组发生率差异有统计学意义（P〈0.01）。其中以母患糖尿病的新生儿发生率最高。低血糖持续时间：≤24h 75例，～48h 17例，〉48h 19例；反复低血糖16例，高血糖8例。结论对有低血糖高危因素的新生儿在生后24h内要连续监测血糖，尤其是8h内应常规监测血糖水平，以便及时发现及时采取措施，避免发生伤残、死亡。     

140例新生儿低血糖临床诊治及病因分析

目的：探讨新生儿低血糖的临床特点和高危因素,以求为临床诊治提供依据。方法：监测并分析广东省潮安区人民医院收治的250例存在血糖高危因素的新生儿的血糖水平。结果：250例高危因素新生儿中140例出现低血糖症状,其中12例（8.6％）患儿的母亲有糖尿病史,26例（18.6％）患儿喂养困难,34例（24.3％）患儿存在围生期窒息,18例（12.9％）患儿感染硬肿症或败血症,28例（20％）患儿为早产儿,24例（17.1％）患儿为足月小样儿。140例患有低血糖的新生儿中有10例出现青紫症状、26例出现嗜睡症状、11例出现抽搐症状、15例出现呼吸暂停症状、8例出现吸吮力差症状、70例为无症状型低血糖。结论：常规检测具有高危因素的新生儿的血糖水平,以及早发现和治疗,从而减少、避免低血糖对新生儿造成的损伤。     

母婴同室足月新生儿低血糖发生率的调查

目的对入住母婴同室的足月正常体质量的新生儿低血糖发生率的进行调查,旨在为早期发现新生儿低血糖提供参考。方法对入住母婴同室的足月正常体质量的157例新生儿进行常规的微量血糖监测。结果157例新生儿共检出低血糖症26例。剖宫产87例,发生低血糖症21例,发生率为24．14％;自然分娩70例,发生低血糖症5例,发生率为7．14％。两者差异有统计学意义（P〈0．01）。有高危因素的剖宫产母亲的新生儿62例,发生低血糖14例,发生率为22．58％;因社会因素剖宫产母亲的新生儿25例,发生低血糖7例,发生率为28．0％。两者差异无统计学意义（P〉0．05）。结论对所有新生儿均要监测血糖,及时发现并纠正低血糖,以免引起新生儿中枢神经系统损害,遗留神经系统后遗症。     

新生儿低血糖96例临床分析

目的探讨新生儿低血糖症发生的危险因素，为临床防治提供依据。方法对存在有低血糖危险因素的新生儿进行血糖监测。结果检出低血糖96例，总发生率为7．9％。本组资料中新生儿窒息及早产是新生儿低血糖的主要因素，且在早产儿中小于胎龄儿发生率高于适于胎龄儿。结论对于有低血糖高危因素的新生儿要监测血糖，及时发现，及时治疗，避免低血糖造成脑损害。     

新生儿低血糖症50例临床分析

目的对50例新生儿低血糖症发病相关因素分析,探讨引起新生儿低血糖症的病因、临床特点,为临床诊治提供一定的参考依据。方法对我院住院新生儿780例进行常规血糖监测。结果①低血糖症的发生与胎龄有关（=7.78,P〈0.01）;②低血糖症的发生与出生体重有关（=20.36,P〈0.005）。③常见病因为窒息14例（28%）,硬肿症9例（18%）,喂养困难6例（12%）,感染5例（10%）,母亲患糖尿病5例（10%）,开奶延迟4例（12%）,出血症4例（8%）,先天性心脏病3例（6%）。结论对于有低血糖高危因素的新生儿要监测血糖,及时发现并及时纠正低血糖,以免引起新生儿中枢神经系统损伤,遗留神经系统后遗症。     

早产儿血糖紊乱的特点及皮质醇水平变化的研究

目的：探讨早产儿血糖紊乱的特点及影响血糖变化的高危因素。方法：163例早产儿进行血糖及皮质醇监测．并以80例足月新生儿为对照。分低血糖组和高血糖组进行比较分析。对早产儿胎龄、日龄、静脉输葡萄糖、危重度、血皮质醇水平等因素进行分析。结果：早产儿发生血糖异常均高于对照组（P〈0．05），一般早产儿组以低血糖为主．发生率37．04％．危重早产儿组以高血糖多见，发生率41，46％。两组低血糖发生率无显著性差异，而高血糖发生率有显著性差异（P〈0．005）。一般早产儿组早期皮质醇水平低于足月新生儿组，而危重早产儿组明显高于足月新生儿组．3组比较有显著性差异。分析表明，胎龄、日龄、未静脉输糖是影响早产儿低血糖的高危因素，而危重度、静脉输糖、皮质醇水平是影响高血糖的高危因素。结论：早产儿血糖紊乱发生率高，危重疾病能激发早产儿应激反应，早产儿血糖紊乱有一定特点及高危因素。加强早产儿血糖监测，并给予合理输液、输糖管理可有效防治早产儿血糖紊乱。     

新生儿低血糖36例临床分析

目的探讨新生儿低血糖的危险因素及临床特点,为诊治提供依据。方法对存在低血糖高危因素的468例新生儿进行血糖监测。结果检出低血糖36例,临床症状多不典型,无特异性,常见于早产儿、低体重儿、巨大儿、新生儿窒息、母亲患糖尿病患儿等。结论对于有低血糖高危因素的新生儿要监测血糖,及时发现,及时纠正,避免低血糖引起中枢神经系统的损害。     

新生儿低血糖18例病因分析

目的:探讨引起新生儿低血糖的高危因素及临床特点,提高对低血糖的诊治水平。方法:对存在低血糖高危因素的新生儿170例进行血糖监测,并对其临床资料进行分析。结果:检出低血糖18例,临床症状多不典型,而且无特异性,容易漏诊,常见疾病为窒息、黄疸、早产儿及小于胎龄儿、感染,喂养困难、巨大儿。结论:对于有低血糖高危因素的新生儿均应严密监测血糖,并应尽早喂养或鼻饲,避免或减少低血糖引起的脑损伤。     

92例早产儿血糖紊乱高危因素分析

目的探讨早产儿血糖紊乱的高危因素及临床特点。方法采用微量法对92例早产儿进行连续血糖监测。结果血糖持续正常28例（30．5％）,异常64例（69．5％）;胎龄〈31周的早产儿（10．7％）无一例血糖持续正常;8例低体重早产儿（1200—1500g）空腹血糖全部异常;高低血糖交替发生18例（19．6％）;恢复正常血糖水平时问平均4．5d,最长达45d;重度窒息组全部异常,其中8例为高血糖,3例高血糖持续不能纠正死亡。结论低出生体重、胎龄、1分钟Apgar评分是早产儿发生血糖紊乱的高危因素,胎龄越小、体重越低、1分钟Apgar评分越低血糖紊乱发生率越高。持续高血糖不能纠正往往预示病情危重预后差。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.