探讨蒙药加味壮西-21味治疗慢性溃疡性结肠炎的临床疗效

目的观察探讨蒙药加味壮西-21味治疗慢性溃疡性结肠炎的临床治疗效果。方法将我院从2014年2月至2016年3月诊治的150例慢性溃疡性结肠炎患者选取为此次研究对象,将其随机分成对照组与观察组,对照组患者进行西药合剂治疗,观察组患者采用蒙药加味壮西-21味进行治疗。观察对比两组患者的治疗效果。结果观察组患者的治疗有效率显著高于对照组,数据差异较大,具有统计学意义(P0.05)。观察组患者治疗前后的结肠镜检查结果差异明显,具有统计学意义(P0.05)。结论应用蒙药加味壮西-21味治疗慢性溃疡性结肠炎,其治疗效果显著,对比西药治疗具有较大的优势,明显改善了患者临床症状,促进患者的恢复。     

5-氨基水杨酸与甲硝唑治疗溃疡性结肠炎疗效对比观察

目的 :观察 5 -氨基水杨酸 (以下简称 5 -ASA)对溃疡性结肠炎的疗效。方法 :将 92例患者随机分为两组 :治疗组 48例 ,对照组 44例 ,均随访观察 1年。治疗后以临床症状及纤维结肠镜检查判定治疗效果。结果 :5 -ASA组 ,总有效率 95 .83% ;而对照组 (甲硝唑组 ) ,总有效率仅 45 % ,两组患者辅助用药完全相同。两组间疗效对比有显著性差异 (P <0 .0 5 )。结论 :5 -ASA治疗溃疡性结肠炎疗效好 ,复发率低。     

溃疡性结肠炎的内镜特点和临床分析

目的探讨溃疡性结肠炎的内镜特点,总结和分析内镜下溃疡性结肠炎的临床表现,提高本病的诊治水平。方法收集我院2003年1月～2009年5月收治的经结肠镜检查及病理确诊的32例溃疡性结肠炎患者的临床资料,观察其内镜特点和内镜表现,并进行临床分析。结果在本组32例患者中,男女之比分别为0.77:1,平均发病年龄(38.4±4.2)岁,经结肠镜检查确诊的溃疡性结肠炎患者病变范围:直肠及乙状结肠炎占53.13%,左半结肠炎占31.25%,全结肠炎占6.25%,次全结肠占6.25%,右侧结肠占3.13%。结论溃疡性结肠炎的病程短,癌症发生率及并发症低,结肠镜是诊断溃疡性结肠炎的主要方法。     

水交换结肠镜在老年困难结肠镜患者中的应用研究

目的 探讨水交换结肠镜在老年困难结肠镜检查中的应用价值。方法 采用自身对照研究的方法,选取2021年1～10月在浙江医院收治的65～80岁采用注气法行结肠镜检查后确定为困难结肠镜的患者60例,2周后采用水交换法再次进行结肠镜检查,同一患者两次检查均由同一高年资内镜医生操作,在非麻醉状态下进行,结果分为注气组和水交换组。比较两组检查过程中患者腹痛的程度、进镜成功率、进镜时间、检查总时间、息肉检出率等指标。结果 两组在检查过程中均出现不同程度的腹痛情况,注气组平均腹痛视觉模拟评分(visual analogue scale, VAS)为3.24±1.30分,明显高于水交换组(1.26±0.97分),差异有统计学意义(P<0.05)。在进镜成功率方面,注气组和水交换组均较高,分别为90.00%和96.67%,差异无统计学意义(P>0.05)。但在进镜时间和检查总时间方面,水交换组分别为9.13±4.16min和16.56±4.31min,明显低于注气组(19.52±6.99min和26.87±6.93min),且水交换组的息肉检出率为61.11%,高于注气组(38.89%),以上...     

艾迪莎与柳氮磺胺吡啶治疗溃疡性结肠炎的近期疗效比较

目的 观察艾迪莎治疗溃疡性结肠炎的疗效及安全性.方法 82例溃疡性结肠炎患者随机分为艾迪莎组和柳氮磺胺吡啶组.4周后对两组患者的临床症状及结肠镜检查所见进行对比,对药物疗效进行评价并观察药物不良反应.结果 对治疗组和对照组,除临床症状血便两者无显著性差异(ρ＞0.05)外,其余临床症状腹痛、腹泻、腹胀均有显著性差异(ρ＜0.01).两组间患者治疗前后结肠镜检查进行对比,治疗组总体有效率为88.7%;对照组总体有效率为60.6%,两者有显著性差异(ρ＜0.01).治疗组和对照组不良反应发生率分别为0、21.1%,两者有显著性差异(ρ＜0.01).结论 艾迪莎是一种治疗溃疡性结肠炎的安全有效药物.     

水交换法结肠镜检查对老年缺血性肠病患者应激反应及肠系膜上动脉血流动力学的影响

目的 探讨水交换法结肠镜检查和注气法结肠镜检查对老年缺血性肠病患者应激反应指标及肠系膜上动脉血流动力学的影响.方法 选择2017年11月至2020年11月于河南省南阳市第二人民医院消化内镜诊疗中心复查结肠镜的已确诊缺血性肠病的老年患者46例,根据检查方法不同分成2组:水交换法结肠镜检查组(Ⅰ组)和注气法结肠镜检查组(Ⅱ...     

老年溃疡性结肠炎48例分析

目的：回顾分析老年人群（≥60岁）溃疡性结肠炎的临床特点。方法：选取榆林市第一医院医院2000年5月-2007年5月间确诊为溃疡性结肠炎的住院患者共284例，对其临床特点进行观察，比较老年溃疡性结肠炎患者（≥60岁）与非老年溃疡性结肠炎患者（20～59岁）间是否存在差异。结果：284例溃疡性结肠炎患者中，≥60岁者48例（16．9％）。在老年溃疡性结肠炎患者中，腹痛、黏液脓血便、单纯血便、黏液便、便秘、发热、腹胀、贫血、肠外表现、并发症和癌变的发生率与非老年患者均无显著性差异（P〉0．05）；腹泻的发生率低于非老年患者（P〈0．05），而腹泻与便秘交替则高于非老年组（P〈0．05）。老年组病变位于直肠者明显少于非老年组（P〈0．01），病变为广泛性在老年组则明显多于非老年组（P〈0．01）。结论：老年溃疡性结肠炎临床表现及病情程度与非老年组无明显差异，腹泻与便秘交替较多见，病变部位广泛性较非老年组为多，可能系老年患者胃肠功能易紊乱及免疫力、环境因素不同有关。结肠镜检查结合活检是老年溃疡性结肠炎最可靠的诊断方法。     

不同类型老年结肠炎的临床特征差异对比研究

目的研究老年缺血性结肠炎(IC)与老年溃疡性结肠炎(UC)临床特征的差异。方法回顾性分析2010年7月~2015年12月我院收治的54例老年IC患者和50例老年UC患者的临床资料,比较两组患者的临床特征。结果两组患者基础疾病、临床表现、结肠镜检查及病理学检查、实验室检查等比较,差异具有统计学意义(P0.05)。与IC组比较,UC组患者病程较长,存在心脑血管等基础疾病者较少(P0.05)。UC组腹泻和黏液脓血便发生率较高,而IC组单纯血便的发生率较高(P0.05)。结肠镜及病理组织检查结果显示,IC组患者病变部位多累及乙状结肠和/或降结肠,直肠受累少见;病变为区域局限性,正常黏膜与病变黏膜分界清楚,溃疡为纵行或不规则形,病理特异性表现为含铁血黄素沉积和血管内血栓形成。UC组病变多起源于直肠,累及肠壁全周,病变呈连续性分布,溃疡呈散在针尖地图样,病理特异性表现为隐窝脓肿。实验室检查结果显示,IC组D-二聚体水平明显高于UC组,C反应蛋白(CRP)和血小板计数(PLT)水平明显低于UC组(P0.05)。结论根据基础疾病、临床表现、实验室检查、结肠镜及病理特征进行综合分析,有助于IC和UC的鉴别诊断。     

221例下消化道出血的结肠镜检查结果分析

目的探讨下消化道出血患者结肠镜检查的临床意义。方法对221例下消化道出血患者常规进行结肠镜检查,并对其结果进行分析。结果老年组大肠癌多、痔疮多,而溃疡性结肠炎少,青年组溃疡性结肠炎多,其他病因各组情况相近。结论纤维结肠镜检查可明确大多数患者出血原因,建议将结肠镜检查作为下消化道出血的首要检查手段。     

1 548例结肠炎症的结肠镜结果分析

目的探讨结肠镜检查对结肠炎症病因诊断的价值。方法本院2003年7月。2006年2月行肠镜检查2112例，发现结肠炎症病例l548例，回顾性分析结肠炎症疾病病因。结果本地区结肠炎症的发生以慢性结肠炎、结肠息肉、结肠癌为最常见，溃疡性结肠炎次之，克罗恩病较少。结论结肠镜检查对慢性结肠炎症的病因诊断及鉴别有重要的临床价值。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.