高血压脑出血术后早期高压氧综合治疗32例体会

目的：观察高压氧(HBO)综合治疗高血压脑出血术后的疗效。方法：HBO治疗组32例，给予HBO综合治疗，压力2．0ATA，经面罩吸氧1h，中间吸空气5min，匀速减压20min至常压。对照组同样给常规治疗。结果：HBO治疗组总有效率近100％，治愈53．1％，有效46．3％，无效0．对照组27例，治愈44．4％，好转48．1％，无效7．5％。结论：HBO综合治疗效果明显，疗效优于对照组．     

高压氧下支气管哮喘发作1例

患男，32岁，患支气管哮喘病史6年余，病情反复发作。在病情未发作时行高压氧治疗。采用GYS-08型多人空气加压舱，治疗压力0．2MP．(2ATA)，升压时间20min，面罩吸纯氧30min，休息10min，再吸氧30min，减压30min，每日1次，12次为1疗程。在治疗前13次，病人一般情况良好，未出现异常反应。当接受第14次高压氧治疗过程中，病人哮喘发作，自感胸闷，     

高压氧对快速减压应激损伤动物脑组织PGs的作用研究

目的：探讨高压氧(hyperbaric oxygen,HBO)对快速减压动物脑组织前列腺素的影响。方法：将豚鼠分为快速减压组、高压氧组和对照组。快速减压组动物置于小加压舱内，5min加压至0．6MPa，并在该压力下暴露60min,用19min减压至常压，出舱，形成减压应激损伤；高压氧组：同快速减压组形成减压应激损伤，再在0．25MPa氧压下暴露60min；对照组：不进行加、减压和吸氧处理。用酶免测定法测定脑组织中PGs含量。结果：高压氧暴露后脑组织中的PGE2、TXB2和6—K—PGF1n含量明显降低，其中PGE2降为快速减压组的2％，TXB2降为快速减压组的35％，6—K—PGF1n降为快速减压组的22％。结论：高压氧能使快速减压动物脑组织中PGs含量明显降低。     

不同气压下氧疗法联合治疗重型颅脑损伤137例

目的：探讨不同气压下氧疗法联合应用对有合并症的重型颅脑损伤的治疗效果。方法；197例有合并症的重型颅脑损伤病人分为联合氧疗法组（A组）和常规高压氧治疗组（B组）。A组：采用面罩或吸氧头罩吸纯氧，从0．10Mpa（常压。常压氧治疗，NBO）环境压力下逐渐进入0．16Mpa、0．20Mpa环境压力下治疗（高压。高压氧治疗，HBO）：B组：直接进入常规高压氧治疗。比较两组的治疗效果。并利用心电、呼吸、血压、血氧全程监护．观察患者对治疗的反应和适应性。结果：两组治疗效果、治愈率比较差异具有显著意义（P〈0．01）．联合氧疗法组明显优于常规高压氧治疗组；联合氧疗法组开始治疗的时间明显早于高压氧组．开始治疗的早晚与疗效直接相关，越早治疗治愈率越高；两组病人治疗后血氧饱和度均明显提高，心律失常好转．比较蓑异无显著性（P〉0．05）；高压氧治疗时心率、血压、呼吸的变化与常压氧治疗比较差异有显著性（P〈0．01）。结论：对有合并症的重型颅脑损伤病人早期采用不同气压下氧疗法联合治疗，是既有效又安全的治疗方案，可明显提高治愈率，降低残死率，提高生存质量。     

高压氧对脑梗塞患者血液流变学的影响

我们对34例脑梗塞病人行高压氧治疗前后的血液流变学作了对比观察,以探讨高压氧对血液流变学的影响。 高压氧治疗是在2.5ATA(0.25 MPa)环境下面(?)吸氧,加压、减压及稳定时间共90分钟。每     

高压氧结合针灸药物综合治疗突发性耳聋的临床观察

目的观察高压氧结合针灸药物综合治疗突发性耳聋的临床疗效。方法选择48例突发性耳聋病人,高压氧治疗为主,0．25MPA面罩式吸氧,升压至0.25MPA,吸氧30min,休息10min,再吸氧30min,减压出舱;联合针灸药物治疗1～3个疗程。结果治愈30例,占62．5％,显效11例,占229％;好转5例,占10.42％;无效2例,占42％。总有效率95.8％。结论高压氧联合针灸药物治疗突发性耳聋过程中起到相互促进作用．治疗时间短有效率高。     

高压氧治疗急性一氧化碳中毒迟发性脑病50例疗效分析

目的观察高压氧对急性一氧化碳中毒迟发性脑病的治疗作用。方法应用国产纯氧舱对50例患者进行以高压氧为主的治疗，压力0．25mPa～0．2mPa，稳压时间50min，升减压时间各15min，吸氧总时间80min。结果治愈10例(20％)，显效22例(44％)，好转11例(22％)，无效7例(14％)，总有效率(86％)。结论高压氧是治疗一氧化碳中毒迟发性脑病的安全有效的重要方法。     

老年急性肠梗阻保守治疗与手术治疗疗效比较

目的：探讨老年急性肠梗阻保守治疗与手术治疗的疗效。方法：回顾性我院2013年1月至2014年6月收治的老年急性肠梗阻患者95例,患者根据病情采用保守治疗（ A组）与手术治疗,其中在保守治疗48 h内无效改为手术治疗为B组、48 h后由保守治疗改为手术治疗为C组, A组患给予胃肠减压、维持水、电解质及酸碱平衡、胃管注入石蜡油、肠外营养支持治疗等保守治疗,B组和C组患者根据病情采用手术疗法,记录并比较两组患者经过治疗后肠坏死情况、死亡病例数、恢复时间及临床疗效。结果：A组肠坏死率差异有统计学意义（ P＜0．05）;三组间病死率差异无统计学意义（ P＞0．05）;A组日后时间均明显短于B和C组,且B组日后时间短于C 组,差异均有统计学意义（ P＜0．05）;A组经过治疗后总有效率为97．5％、B组患者有效率为93．3％、C组患者有效率为92．0％,三组间总有效率差异无统计学意义（ P＞0．05）。结论：老年急性肠梗阻要根据患者病情采取合适的治疗方案,以期取得较好临床疗效。     

高压氧对脊髓损伤椎管减压术后功能恢复的影响(附68例报告)

目的：探讨脊髓损伤椎管减压术后病人，促进功能缺损恢复、降低致残率的方法。方法：对128例脊髓损伤椎管减压术后功能康复期病人，随机分为高压氧治疗组68例，对照组60例，常规治疗药物相同。结果：高压氧治疗组功能恢复治愈率为20．6％，总有效率为97．1％，均高于对照组，两组差异显著（P＜0．05）。结论：高压氧是促进脊髓损伤术后病人功能缺损恢复的有效方法，具有疗程短、见效快、致残率低等优点。     

高压氧治疗绝经期综合征18例分析

目的 通过对绝经期综合征的高压氧治疗,以了解高压氧的治疗机制和确切疗效.方法 采用山东烟台宏远氧舱厂生产的GY-2800型空气加压氧舱,加压戴面罩吸纯氧,治疗压力为2.0 ATA,稳压吸氧30 min,改吸舱内空气5 min,再吸纯氧30 min,升、减压各20 min,每日1次,12次为1个疗程.结果 18例患者通过高压氧治疗后,使紊乱的生理功能得到相应的改善.结论 高压氧是治疗绝经期综合征的有效方法.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.