手术治疗腰椎管狭窄合并椎间盘突出症的疗效分析

目的;分析手术治疗腰椎管狭窄合并椎间盘突出症疗效,方法：回顾性分析156例腰椎管狭窄合并椎间盘突出症患者术前,手术及术后随访等临床资料。结果：156例腰椎管狭窄合并椎间盘突出症患者中全椎板切除103例,半椎板切除38例,开窗术15例,术后疗效优良率全椎板切除95％,半椎板切除90．1％,开窗术86．2％,腰背肌锻炼好的患者无一例发生脊柱不稳,结论：全椎板切除治疗腰椎管狭窄合并椎间盘突出症疗效优于半椎板切除术和开窗术,三种方法对脊柱稳定性影响没有显著差异。     

中央型腰间盘突出症手术方式与疗效分析

目的:探讨单侧或双侧椎板开窗与全椎板切除治疗中央型腰间盘突出症的疗效.结果:表明全椎板切除创伤大,出血多,中远期随访出现脊柱不稳.单侧或双侧椎板开窗创伤小,远期并发症少,疗效评定优良率高.对于外侧偏中央型及中央型间盘突出不大的腰间盘突出症患者,采用单侧或双侧椎板开窗减压,间盘摘除是较可取的手术方式.对于特大的中央型间盘脱出合并腰椎管狭窄,出现马尾神经损害者骨质增生严重,可考虑行全椎板切除减压.若术前存在腰椎不稳,还须行椎板间植骨,内固定融合.     

半椎板切除显微手术治疗椎管内肿瘤的临床研究

目的探讨半椎板切除显微手术治疗椎管内肿瘤的临床疗效及优点。方法 176例术前经MRI确诊并经术后病理证实的椎管内肿瘤患者按照随机数字法分为半椎板切除显微手术组（n=88）和全椎板切除术组（n=88）,分别行半椎板切除显微手术或全椎板切除术切除肿瘤,比较两组患者手术时间、术中出血量、肿瘤完全切除率、术后平均住院时间及临床症状改善情况,评价术后6个月的脊柱稳定性,并观察术后并发症发生情况。结果半椎板切除显微手术组手术时间及平均住院时间均短于全椎板切除术组（t=7.53,P〈0.01;t=4.88,P〈0.05）;术中出血量少于全椎板切除术组（t=11.28,P〈0.01）;术中肿瘤完全切除率略高于全椎板切除术组,但差异无统计学意义（χ2=0.96,P〉0.05）。半椎板切除显微手术组出院时临床症状改善率略高于全椎板切除术组,但差异无统计学意义（χ2=1.22,P〉0.05）。半椎板切除显微手术组88例均脊柱稳定性良好,全椎板切除术组11例出现脊柱不稳定（χ2=4.60,P〈0.05）。半椎板切除显微手术组术后1例发生脑脊液漏,3例发生感染;全椎板切除术组2例出现局部疼痛,1例肌肉无力,3例脊柱后突畸形。结论半椎板切除显微手术治疗椎管内肿瘤创伤小,手术及住院时间短,术中出血少,疗效确切,能最大限度地维持术后脊柱的稳定性,值得临床推广应用。     

手术治疗腰椎管狭窄合并椎间盘突出症的疗效分析

目的:分析手术治疗腰椎管狭窄合并椎间盘突出症疗效。方法:回顾性分析156例腰椎管狭窄合并椎间盘突出症患者术前、手术及术后随访等临床资料。结果:156例腰椎管狭窄合并椎间盘突出症患者中全椎板切除103例,半椎板切除38例,开窗术15例,术后疗效优良率全椎板切除95％,半椎板切除90.1％,开窗术86.2％,腰背肌锻炼好的患者无一例发生脊柱不稳。结论:全椎板切除治疗腰椎管狭窄合并椎间盘突出症疗效优于半椎板切除术和开窗术,三种方法对脊柱稳定性影响没有显著差异。     

手术治疗腰椎间盘突出并侧隐窝狭窄症33例分析

目的：讨论腰椎间盘突出并侧隐窝狭窄症形成的解剖机制、诊断要点及手术治疗的最佳方式。方法：对1994年到1998年手术治疗的33例腰椎间盘突出并侧隐窝狭窄症进行4年随访并总结分析。结果：经椎板间开窗手术效果优于经半椎板、全椎板切除手术效果。结论：经椎板间开窗是手术治疗腰椎间盘突出并侧隐窝狭窄症的最佳方式。     

全椎板切除治疗老年退变性颈椎管狭窄症

目的:总结颈椎全椎板切除治疗老年颈椎管狭窄的临床应用效果。方法:对23例老年颈椎管狭窄患者行颈椎全椎板切除术。全部患者随访2～7年,平均随访3.2年。结果:术前JOA评分平均9.5分,随访时JOA评分平均14.6分,改善率为82.6%,其中优14例,良3例,可2例,差4例。结论:颈椎全椎板切除术是治疗老年退变性颈椎管狭窄症,手术简便,并发症少,是安全有效的手术方法。     

椎板间开窗与全椎板切除术治疗腰椎间盘突出症的疗效对比

目的 对比椎板间开窗与全椎板切除术治疗腰椎间盘突出症近期及远期效果及术后腰椎不稳的发生率，为手术方法的选择提供依据。方法 将138例腰椎间盘突出症患者按手术方式分组对比术后疗效及椎间不稳发生情况。结果 两种手术方式术后近期效果相近，远期椎板间开窗术效果较好，腰椎不稳定发生率较低。结论 对于不伴中央椎管狭窄的腰椎间盘突出症来说，选择椎板间开窗术更为适宜。     

全椎板切除后椎板再生机制的实验研究

目的：探讨全椎板切除后椎板再生的机制。方法：以家兔为动物模型行全椎板切除术后,肉眼观察,切片病理观察、ＣＴ扫描和三维结构重建,计算机图像分析定量测定。结果：全椎板切除后在椎板缺损部位纤维化,首先是骨组织缺损的边缘软骨组织形成,然后再演变为骨组织,最后形成再生椎板。椎板再生后椎管面积和矢状径比正常椎管小（Ｐ〈０．０１）。结论：椎板再生是软骨内骨化的过程,并证实了椎板再生的方式是骨组织逐渐再生。再生的     

全椎板切除脊柱内固定治疗老年退行性腰椎管狭窄症的疗效分析

目的:分析全椎板切除脊柱内固定治疗老年退行性腰椎管狭窄症(DLSS)的临床疗效。方法:两组患者入院后立即对病情进行观察,并同时根据病情检查结果行手术治疗,术中实施全身麻醉或局部麻醉,根据神经受压部位取俯卧位或侧卧位;采用部分椎板切除术治疗对照组患者,观察组的治疗方法为全椎板切除脊柱内固定术。结果:观察组的优良率为85.29%,对照组为55.88%,观察组的优良率高于对照组,两组差异有统计学意义(P<0.05)。结论:利用全椎板切除脊柱内固定手术治疗DLSS患者,能够获得显著疗效,可以在临床中推广使用。     

全椎板切除和半椎板切除治疗老年腰椎管狭窄症临床效果对比

目的:探讨全椎板切除和半椎板切除治疗老年腰椎管狭窄症临床效果对比情况。方法:分析全椎板切除和半椎板切除治疗老年腰椎管狭窄症患者临床资料,依据手术治疗方式不同进行临床分组,全椎板切除组451例和半椎板切除组167例。结果:半椎板切除组术中出血量和手术时间均明显低于全椎板切除组,差异均有统计学意义(P<0.05),两组临床治疗的优良率差异无统计学意义(P>0.05)。结论:半椎板切除治疗老年腰椎管狭窄症的创伤小,出血少,两组临床治疗效果无明显差异,均值得临床借鉴应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.