面颈旋转皮瓣加胸锁乳突肌岛状皮瓣一期修复面颊部洞穿性缺损

1986年以来,我们采用面颈旋转皮瓣加胸锁乳突肌岛状皮瓣即时修复7例颊癌切除术后面颊洞穿性缺损。效果满意,现报告如下。临床资料本组7例均确诊为颊部鳞癌,肿瘤都穿透面颊皮肤。其中男性5例,女性2例。年龄45～61岁。肿瘤分期2例为T_4N_(16)M_0,5例为T_4N_0M_0。面部皮肤缺损最大6cm×4.5cm,颊部缺损最大7.5cm×6cm。除一例胸锁乳突肌岛状皮瓣边缘有1cm×1cm坏死外,共余皮瓣全部成活。面部皮肤缺损都采用面颈旋转皮瓣修复,颊部缺损用胸锁乳突肌岛状皮瓣修复。皮瓣的设计与手术方法一、面颈瓣的设计与手术方法:在口角旁或口角外作切口,沿颏旁向颌下延伸,在颌下4～5     

足跟大面积皮肤缺损的显微外科治疗

目的 报道应用腓肠神经营养血管逆行岛状皮瓣及吻合血管的足背皮瓣修复足跟部较大面积皮肤缺损的临床效果.方法 临床治疗36例足跟及足踝部大面积皮肤缺损的病例,其中应用腓肠神经营养血管逆行岛状皮瓣修复足跟皮肤缺损25例,皮瓣面积最大30 cm×14 cm,最小11 cm×7 cm,应用吻合血管的足背皮瓣修复足跟皮肤缺损11例,皮瓣面积最大14 cm×11 cm,最小9 cm×6 cm.结果 皮瓣全部成活,术后有1例腓肠神经营养血管逆行岛状皮瓣远端少许皮肤坏死,经换药切痴后用中厚皮片植皮愈合.所有病例均经3个月～3 a随访,患肢正常步态行走,皮瓣耐磨,两点辨别觉4～7 cm.结论 腓肠神经营养血管逆行岛状皮瓣及足背皮瓣皮肤质量较好,不臃肿,供皮面积较大,适合修复足跟部较大面积皮肤缺损.     

岛状皮瓣在四肢损伤修复中的应用

我们自1995年1月～2000年1月应用岛状皮瓣修复手部创伤12例,修复下肢损伤3例,效果满意,现报告如下. 临床资料 本组15例,男14例,女1例,年龄18～56岁,平均37岁.急诊手术12例,择期手术3例,均为外伤造成软组织缺损,无法用皮片移植或轴型皮瓣转移来修复,而采用岛状皮瓣修复.皮瓣种类:前臂桡动脉逆行岛状皮瓣,修复拇指及第一掌骨开放性骨折处皮肤及软组织缺损2例,修复手掌部及拇指间隙软组织缺损1例,手背2例;指侧方指固有动脉逆行岛状皮瓣修复手指背侧及末节软组织缺损4例;示指近节背侧第一掌背动脉岛状皮瓣修复拇指皮肤及软组织缺损3例;足背动脉岛状皮瓣修复内、外踝处皮肤及软组织缺损各1例;小腿内侧动脉岛状皮瓣修复胫前溃疡1例.皮瓣面积最小为1.5cm×1.5cm,最大为13cm×7cm,皮瓣供区均采用中厚皮片移植.15例皮瓣完全成活.随访1年2个月,功能及外形恢复满意.     

踝周围、足跟及足背部软组织缺损的修复

目的探讨远端为蒂的腓肠神经伴行血管岛状皮瓣修复踝周围、足跟部及远端营养血管为蒂的外踝上岛状皮瓣修复足背部软组织缺损的效果.方法对30例踝周围、足跟部软组织缺损患者采用远端为蒂的腓肠神经伴行血管岛状皮瓣修复,皮瓣面积最大5 cm×6 cm,最小为3 cm ×4 cm;对20例足背部软组织缺损患者采用外踝上皮瓣修复,皮瓣面积最大9 cm×6 cm,最小5 cm×4 cm.结果50例皮瓣完全存活,随访3周～24个月,皮瓣质地优良,外观及功能满意.结论远端为蒂的腓肠神经伴行血管岛状皮瓣及远端营养血管为蒂的外踝上岛状皮瓣分别为修复踝周围、足跟及足背部软组织缺损的良好方法.     

腓肠神经营养血管岛状皮瓣的临床应用

目的　总结逆行腓肠神经营养血管岛状皮瓣的临床应用经验。方法　以腓肠神经及其营养血管为蒂的逆行岛状皮瓣修复胫前、踝部、足跟部软组织缺损创面 2 3例 ,皮瓣大小为 ( 3cm× 5cm)～( 8cm× 1 5cm)。结果　 1 9例完全成活 ,3例出现水泡及边缘 0 .5cm左右皮肤坏死 ,经换药愈合 ,1例远侧部分皮肤坏死 ,移植游离皮片得以修复。 2 1例获随访 3～ 6个月 ,1 6例皮瓣恢复保护性感觉 ,另 5例感觉无恢复。无溃疡、瘘管、骨髓炎出现。结论　此皮瓣不损伤小腿重要血管及神经 ,血供可靠 ,解剖容易 ,是修复小腿中下部、踝部和足跟部软组织缺损的理想皮瓣     

皮神经营养血管蒂岛状皮瓣修复手足烧伤创面的临床观察

目的　探讨皮神经营养血管蒂岛状皮瓣修复烧伤创面的临床效果。方法　采用带前臂外侧皮神经、尺神经腕背支、腓肠神经、腓浅神经营养血管蒂的逆行岛状皮瓣修复手足部位烧伤后软组织缺损创面 10例。皮瓣面积最大 11cm× 10cm ,最小 5cm× 4cm。结果　 9例皮瓣完全成活 ,1例部分成活。随访 6～ 17个月 ,皮瓣质地优良 ,外观及功能满意。结论　此类皮瓣血供充分 ,不牺牲主干血管 ,切取容易 ,旋转弧度大 ,能够满意地修复手足附近烧伤后软组织缺损创面。     

指背动脉蒂逆行岛状皮瓣修复指端皮肤缺损的临床研究

目的 介绍一种修复手指末端皮肤缺损的新型逆行岛状皮辩.方法 应用指背动脉为蒂,设计成逆行岛状皮瓣,从2002年6月～2006年10月,临床应用掌背指背动脉蒂逆行岛状皮瓣修复手指末端皮肤缺损30例,皮瓣面积1.2 cm×1.4 cm～2.4cm×3.2 cm.结果 临床应用30例,皮瓣全部成活,效果满意.结论 以指背动脉为蒂设计成逆行岛状皮瓣,该皮瓣设计合理、血供可靠、操作简便,适用于手指末端软组织缺损的修复.     

应用胸脐岛状皮瓣修复会阴部缺损

目的探讨胸脐岛状皮瓣修复会阴部缺损的临床应用。方法总结14例使用胸脐岛状皮瓣修复会阴部缺损患者的临床经验,并分析其临床效果。结果本组14例患者皮瓣均一期成活,皮瓣大小为8～20cm×10～25cm,其中13例术后随访6个月,临床效果佳,患者满意。结论胸脐带蒂皮瓣修复会阴组织缺损是一种较理想的治疗方法。     

手指指腹缺损的4种修复方法

目的　研究用手指部皮瓣修复指腹缺损的临床效果。方法　应用手指掌侧推进皮瓣、指侧方神经血管蒂岛状皮瓣、指侧方逆行岛状皮瓣、食指背侧皮瓣修复指缺损 64例 ,创面面积为 1 0cm× 1 1cm～ 3 0cm× 5 .0cm。结果　 64例的皮瓣全部成活 ,术后随访 1～ 2年 ,指腹外形满意 ,感觉恢复良好。结论　应用手指皮瓣修复指腹缺损 ,手术简单、效果好、供区影响小 ,是理想的手术方法。     

5种带皮神经的岛状皮瓣修复拇指指腹软组织缺损

目的探讨5种带皮神经的岛状皮瓣修复拇指指腹软组织缺损的手术方法及临床效果。方法采用拇指尺或桡背侧皮神经伴行血管岛状皮瓣、示指背侧岛状皮瓣、中指尺侧或环指桡侧指神经血管蒂岛状皮瓣修复拇指腹缺损28例,皮瓣均含有感觉神经,皮瓣切取的最大面积5.5 cm×3 cm。结果28例皮瓣全部成活,经6~12个月随访,拇指指腹外形及感觉功能恢复优良,指腹两点辨别觉5~12 mm。结论严格选择适应证,5种带感觉神经的皮瓣血供可靠,操作简单,可较好的恢复拇指指腹的外形和感觉。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.