深圳市观澜街道从业人员乙肝病毒感染情况调查

目的了解深圳市从业人群乙型肝炎病毒感染状况. 方法采用酶联免疫吸附实验（ELISA）对100 262例体检者检验HBsAg,并对其中5 486例HBsAg阳性者的乙型肝炎标志物（HBVM）作了同步检验,对各种组合模式进行了统计和分析. 结果从业人群乙肝感染率为8.05%,其中男性为10.15%,女性为6.40%,男性明显高于女性（P＜0.01）,不同行业间感染率差异无显著性（P＞0.05）. 结论在乙肝感染者中存在十种不同情况的组合,其中26.08%的感染者传染性较强,约1%的感染者存在不同亚型的二次感染或自身病毒变异的可能.     

性病门诊性传播疾病病原体感染情况调查

目的:了解性病门诊性传播疾病(STD)病原体感染的流行情况.方法:对1124例就诊者分别检测沙眼衣原体、解脲支原体、梅毒螺旋体、人乳头瘤病毒、白色念珠菌、淋病奈瑟菌和人类免疫缺陷病毒7种病原体.结果:STD感染率为59.0%,其中36.0%为混合感染;沙眼衣原体感染率最高,为40.1%;女性人乳头瘤病毒感染率高于男性(P=0.005);STD患者主要集中在21～30岁、高中及以下学历、工人和干部职业;STD病原体感染者与未感染者相比,二者在性别、年龄和婚姻情况的差异均无统计学意义(P＞0.05);STD病原体感染者平均性伴数高于非感染者(P=0.005).结论:性病门诊就诊者STD感染率较高,其中沙眼衣原体所占比率最高;女性人乳头瘤病毒感染率高于男性;21～30岁、低学历者、工人和干部为STD的主要感染群体;多性伴数者更易感染STD;STD的混合感染不容忽视.     

健康体检者HBV血清标志物组合分析

目的了解人群中HBsAg携带、感染现状及HBV血清标志物组合。方法采用ELISA法对1257名体检者进行HBV血清五项标志物检测。结果乙肝病毒携带率27.29%,感染率38.50%,HBsAg携带率男性16.55%,女性10.74%,男性高于女性。而抗-HBs阳性率男性显著低于女性343例HBsAg阳性者中“大三阳”11.77%,“小三阳”10.34%。结论对无临床症状的携带感染者要重点进行乙肝防治,进行必要的体检,有利于乙肝病人的早发现、早诊断、早隔离、早治疗及易感人群的保护。     

夫妻配偶双方生殖器人乳头瘤病毒感染情况分析

目的 探讨女性宫颈人乳头瘤病毒(HPV)感染者其男性配偶外生殖器HPV感染情况以及男女双方HPV亚型吻合情况。 方法 收集2017年11月—2019年4月在温州医科大学附属第一医院就诊的443对女性宫颈HPV阳性者及其男性配偶的临床资料,采集男性的外生殖器上皮细胞和女性的宫颈脱落细胞,检测其HPV感染情况,总共包含27种高危和低危亚型,并对结果进行分析。 结果 在443例男性中检测出HPV阳性216例,感染率为48.76%,检出率前3位HPV亚型为HPV53、52、16,均为高危亚型,其妻子HPV感染率前3位同样为:HPV53、16、52。男女双方在低危亚型的检出率不一致,男性前2名分别是HPV43、61,而女性是HPV81、6。将216对性伴侣双方HPV阳性的基因亚型配对,结果显示HPV完全吻合率为26.39%(57/216),部分吻合率为36.11%(78/216),总体吻合率为62.50%(135/216),以1种HPV吻合为主,其中高危亚型占多数。 结论 女性宫颈HPV感染者其男性配偶外生殖器HPV感染率偏高。配偶双方均感染HPV者其HPV亚型吻合度高,尤其在高危亚型上。建议常规对女性宫颈HPV阳性者的男性配偶进行HPV筛查和治疗,从而提高双方HPV的清除率。      

西宁地区精神病患者HBV病毒感染情况调查

目的:调查精神病患者乙肝病毒(HBV)感染情况,以便采取合理有效的防治措施.方法:采用酶联免疫吸附试验(ELISA)法,对336例的初诊精神分裂症病人进行HBV标志物的检测和分析.结果:精神病人HBV感染率为41.37 %,感染率男性显著高于女性(P<0.05);随着病种、职业、居住地、年龄不同,HBV感染率亦不相同,但差别无显著性(P均>0.05).结论:精神病患者乙肝病毒感染率高于人群,对这类患者应采取监测、隔离、治疗等措施防止HBV的传播感染,也利于减少医院内感染.     

乙肝病毒感染者能结婚生育吗？

据不完全统计,我国慢性乙肝病毒感染者达1．2亿,其中半数以上的感染途径是由母亲或父亲传染给孩子的。因此,许多乙肝病毒感染者都很担心自己能否正常结婚和生育。     

乙型肝炎病毒家庭内传播的社区调查分析

检测 2 6 0例乙型肝炎病毒 (HBV)感染者家庭成员的乙肝五项指标 (HBV M )和HBV DNA。对 96例HBV感染者的配偶婚前注射乙肝疫苗 (HBVV)和 /或高效价乙肝免疫球蛋白(HBIG) ;对 4 6例HBV感染的孕妇及其新生儿采用HBVV和HBIG行母婴阻断 ;2年后检测所有被观察者的血清HBV M。结果示男性HBV感染者的配偶HBV感染率较高 (19 9% ) ,而女性感染者的子女HBV感染率较高 (36 4 % ) ;婚前注射HBVV可使HBV感染率明显降低 ;采用HBIG加HBVV母婴阻断可显著降低新生儿的HBV感染率。     

203例慢性乙肝病患者夫妻传染情况的临床分析

目的 探讨慢性乙肝患者通过夫妻关系,偶被传染慢性乙肝病的比率.方法 随机抽查203例慢性HBV感染者,患者的配偶进行乙肝五项定性(HBsAg、HBsAb、HBeAg、HBeAb、HBcAb)检查,中HBV感染者必须检查肝功能及肝胆脾B超,要时检查HBV-DNA或上腹CT.结果 检查证明患者配偶患有慢性乙肝病(慢性乙型肝炎、乙肝肝硬化、HBV携带者)以及婚后有急性乙肝病史的共23人,被抽查总数的11.3%.结论 夫妻接触感染慢性乙肝病的比率与其他社会人群慢性HBV的感染率大致相同.     

贵州省黔西县彝族健康人群HBV感染血清流行病学调查

目的 :了解贵州省黔西县彝族乙型肝炎病毒 (HBV)感染状况。方法 :采用酶联免疫吸附试验 (ELISA)进行HBV标志物的检测和分析。结果 :10 6例彝族人标本中 ,检出HBV感染 6 2人 ,感染率高达 5 8 5 % ,其中男性感染率为 70 2 % ,女性感染率为 4 9 15 % ,男性显著高于女性 (P <0 0 5 ) ,HBV各项阳性率男性均稍高于女性 ,但经 χ2 检验 (P >0 .0 5 )无统计学意义。结论 :彝族人群中HBV感染率高于全国 5省平均水平 (42 2 6 % ) ,亦高于我省罗甸县农村健康人群HBV感染率 (5 4 4 4 % )。     

南通市开发区普通工人乙肝病毒HBsAg感染情况调查

为了解南通市开发区普通工人乙肝病毒感染情况,采用酶联免疫法对我市开发区普通工人17447例乙肝表面抗原(HBsAg)进行检测。结果17447例中男性感染303例(2.67%),女性149例(2.45%),男女感染率差异无统计学意义(P>0.05);外来务工人员HBsAg阳性392例(3.05%),本地务工人员阳性60例(1.30%),外来务工人员乙肝病毒HBsAg感染率明显较本地务工人员高(P<0.01)。所在工厂规模>200人组HBsAg阳性294例(2.07%),≤200人组HB-sAg阳性158例(4.84%),大规模工厂普通工人乙肝病毒HBsAg感染率较低(P<0.01)。因此要加强对小规模工厂乙肝防治知识宣传力度、对健康人群的疫苗接种和对乙肝病毒感染者的管理和治疗。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.