原发性高血压患者颈动脉粥样硬化与血尿酸及C反应蛋白的关系探讨

目的探讨原发性高血压患者颈动脉粥样硬化程度与血尿酸及C反应蛋白(CRP)的关系。方法将122例原发性高血压患者按颈动脉硬化程度分为内中膜增厚组、斑块形成组和管腔狭窄组,分别测定其与34例正常内膜对照组的血尿酸及CRP的浓度,观察颈动脉粥样硬化程度与血尿酸及CRP的关系。结果斑块形成组和管腔狭窄组的血尿酸及CRP的浓度显著高于内中膜增厚组及对照组(P<0.05)。结论血尿酸及CRP与原发性高血压患者的颈动脉粥样硬化程度有关。     

原发性高血压病患者颈动脉粥样硬化与血尿酸及超敏C反应蛋白的关系

目的:比较不同程度颈动脉粥样硬化与血尿酸及超敏C反应蛋白的关系,观察血尿酸与超敏C反应蛋白二者的相关性。方法:利用彩色多普勒超声检查将150例原发性高血压患者按颈动脉硬化程度分为颈动脉正常组、颈动脉内膜增厚组和颈动脉斑块形成组,分别测定各组血尿酸及超敏C反应蛋白的浓度,观察颈动脉粥样硬化程度与血尿酸及超敏C反应蛋白的关系。结果:各组的血尿酸及超敏C反应蛋白的浓度差异有统计学意义(均P<0.05)。超敏C反应蛋白与血尿酸浓度呈正相关。结论:血尿酸及超敏C反应蛋白的浓度与原发性高血压病患者的颈动脉粥样硬化程度有关。     

高血压病患者颈动脉粥样硬化程度与血尿酸浓度水平的相关性研究

目的探讨高血压病患者颈动脉粥样硬化程度与血尿酸(UA)水平的关系.方法128例高血压病患者行双侧颈动脉超声多普勒检查,依据颈动脉粥样硬化(狭窄)程度分为5组,同时检查血UA值.结果5组间血UA值分别为:内膜增厚组(267±52)μmol/L;内膜斑块形成组(325±50)μmol/L;管腔轻度狭窄组(347±50)μmol/L;管腔中度狭窄组(389±48)μmol/L;管腔重度狭窄组(17±48)μmol/L.5组间比较差异均有统计学意义(P＜0.05或P＜0.001).结论高血压病患者颈动脉粥样硬化(狭窄)程度与血尿酸浓度水平呈正相关.     

血管内皮生长因子及富含半胱氨酸蛋白61与高血压颈动脉粥样硬化的关系

目的:研究血清血管内皮生长因子(vascular endothelial growth factor,VEGF)及富含半胱氨酸蛋白61 (cysteine-rich 61,CYR61)与原发性高血压患者颈动脉粥样硬化程度之间的关系.方法:收集2011年6月～2013年4月就诊的120例原发性高血压患者,根据颈动脉粥样硬化的程度分为颈动脉的内膜中层厚度(intima media thickness,IMT)正常组、IMT增厚组和斑块形成组,分别测定3组血清VEGF和CYR61浓度,分析其与颈动脉粥样硬化程度的关系.结果:血清VEGF和CYR61浓度:斑块形成组均显著高于其他两组(P均＜0.05),IMT增厚组显著高于IMT正常组(P＜0.05);高血压颈动脉粥样硬化(IMT增厚组和斑块形成组)患者血清VEGF浓度与CRY61浓度呈显著正相关(r=0.452,P＜0.05),VEGF、CRY61浓度均与IMT呈显著正相关(r分别为0.877、0.613,P均＜0.05).结论:血清VEGF和CYR61浓度与颈动脉粥样硬化的程度呈正相关,其可能作为原发性高血压患者颈动脉粥样硬化程度的判断指标.     

血管内皮生长因子及C反应蛋白与高血压颈动脉粥样硬化的关系

目的:研究血管内皮生长因子(Vascular endothelial growth factor,VEGF)及C反应蛋白(C-reactive protein,CRP)与原发性高血压患者颈动脉粥样硬化的程度之间的关系。方法:将60例原发性高血压患者按颈动脉粥样硬化的程度分为颈动脉的内膜中层厚度(Intima media thickness,IMT)正常组,IMT增厚组和斑块形成组,分别测定其VEGF和CRP的水平,分析两者与动脉粥样硬化程度的关系。结果:IMT增厚组的VEGF和CRP的水平显著高于IMT正常组(P<0.01),斑块形成组的VEGF和CRP的水平显著高于IMT增厚组(P<0.01)。结论:VEGF和CRP水平与原发性高血压患者颈动脉粥样硬化的程度相关,血VEGF和CRP水平可作为原发性高血压患者病情判断的观察指标。     

中老年人颈动脉粥样硬化的超声评价及相关性探讨

【目的】探讨中老年人颈动脉粥样硬化的超声结构和脉压差、血脂、血糖、血尿酸的相关关系。【方法】采用百胜DU8型彩色超声诊断仪,5～12MHz探头,将368例患者按颈动脉硬化程度分为内膜中膜增厚组、斑块形成组和管腔狭窄组,分别测定其与对照组的总胆固醇、甘油三脂、血糖、血尿酸、脉压差,观察颈动脉粥样硬化程度与血脂、血糖、血尿酸、脉压差的关系。【结果】斑块形成组和管腔狭窄组血脂、血糖、血尿酸、脉压差显著高于内膜中膜增厚组和对照组（P〈0.05）。Logistic多元回归分析发现,颈动脉粥样硬化程度与总胆固醇、甘油三脂、血糖、血尿酸、脉压差呈显著正相关（P〈0.05）。【结论】总胆固醇、甘油三脂、血糖、血尿酸、脉压差是颈动脉粥样硬化的独立危险因素。及时检测患者血脂、血糖、血尿酸、脉压差和颈动脉粥样硬化情况,评价病变程度,对疾病的早期防治具有重要的价值。     

老年高血压病患者颈动脉粥样硬化与血清高敏C反应蛋白、脂蛋白(a)及尿酸关系

目的 探讨血清高敏C反应蛋白、脂蛋白(a)及尿酸水平变化与老年高血压病患者颈动脉粥样硬化程度的关系.方法 选取老年高血压病患者64例.根据颈动脉粥样硬化的程度分为颈动脉内膜中层的厚度(IMT)正常组、颈动脉IMT增厚组及颈动脉斑块形成组3组.分别测定血清高敏C反应蛋白、脂蛋白(a)及尿酸在各组血清中的浓度变化,对其结果进行统计分析.结果 随着内膜中层厚度增加,血清高敏C反应蛋白、脂蛋白(a)及尿酸水平相应增高,3组间比较差异有统计学意义(P＜0.05).老年高血压病患者伴有颈动脉粥样硬化(IMT增厚组和斑块形成组)者血清高敏C反应蛋白、脂蛋白(a)及尿酸进行相关性分析,结果表明三者相互之间呈正相关关系(P＜0.05).结论 老年高血压病患者的血清高敏C反应蛋白、脂蛋白(a)及尿酸水平变化与颈动脉粥样硬化关系密切.     

原发性高血压患者血清白介素-6、高敏C反应蛋白水平与颈动脉粥样硬化程度关系的研究

目的探讨原发性高血压患者血清白介素-6（IL-6）、高敏C反应蛋白（hs—CRP）与颈动脉粥样硬化程度的关系。方法选择原发性高血压患者120例,按颈动脉超声检测结果分为内膜增厚组、斑块形成组和管腔狭窄组,测定三组患者的血清IL-6和hs-CRP水平,进行统计学分析。结果颈动脉粥样硬化程度越严重,IL-6和血清hs-CRP水平越高,三组间比较差异有统计学意义（P〈0．05）。结论原发性高血压患者血清IL-6和hs—CRP水平与动脉粥样硬化程度关系密切,原发性高血压患者IL-6、hs-CRP浓度与颈动脉内膜中层厚度（IMT）呈正相关关系（P〈0．01）。适当降低血清IL石和hs．cRP,可防止动脉粥样硬化进展,减轻高血压靶器官损害。     

Relationship of carotid artery atherosclerosis and high-sensitivity C-reactive protein with acute cerebral infarction

目的 探讨颈动脉粥样硬化及血清超敏C-反应蛋白(hs-CRP)与急性脑梗死的关系.方法 入选急性脑梗死患者96例为研究组,以年龄和性别相匹配的健康体检者60例作为对照组,用彩色多普勒超声检测颈动脉粥样硬化斑块数量、性质及管腔狭窄程度,采用免疫散射比浊法测定血清hs-CRP水平.结果 急性脑梗死组颈动脉斑块检出率显著高于对照组(P＜0.05);急性脑梗死组检出颈动脉管腔狭窄＞50%和易损斑块显著高于对照组(P＜0.05);急性脑梗死组血清hs-CRP水平显著高于对照组(P＜0.05);有易损斑块患者血清hs-CRP水平显著高于稳定斑块患者(P＜0.05).结论 颈动脉粥样硬化管腔狭窄＞50%和易损斑块均是导致脑梗死的重要病因,血清hs-CRP水平可反映颈动脉粥样硬化斑块的稳定性.     

原发性高血压患者超敏C反应蛋白和血尿酸的表达及其与硕动脉粥样硬化的关系

目的探讨原发性高血压患者超敏C反应蛋白（hs—CRP）和血尿酸的表达及其与颈动脉粥样硬化的关系。方法选取102例原发性高血压患者,采用彩色多普勒超声进行颈总动脉内-中膜厚度（IMT）测量,确定其颈动脉粥样硬化发生情况。并根据超声检查结果,对不同患者[颈动脉粥样硬化者（包括斑块形成者、IMT增厚者）及IMT正常者]的甘油三酯（TG）、总胆固醇（TC）、血压、血hs—CRP、尿酸等进行检测,并作组间比较及血hs—CRP和尿酸与颈动脉粥样硬化的相关性分析。结果超声检查结果示颈动脉粥样硬化患者78例。颈动脉粥样硬化患者与IMT正常者TC、TG、收缩压及舒张压均无明显差异（P〉0．05）,但颈动脉粥样硬化患者hs—CRP浓度和尿酸水平均明显高于IMT正常者（均P〈0.05）。斑块形成者及IMT增厚者血hs—CRP浓度和尿酸水平均显著高于IMT正常者f均P〈0．01）;而且斑块形成者血hs—CRP浓度明显高于IMT增厚者（P〈0．05）,但尿酸水平与IMT增厚者并无明显差异（P〉0.05）。hs—CRP浓度及血尿酸水平均与IMT呈明显正相关（均P〈0．05）。结论hs—CRP及血尿酸与原发性高血压病患者的颈动脉粥样硬化程度有关。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.