中药壮骨胶囊治疗Ⅰ型原发性骨质疏松症74例临床研究

目的 探讨中药壮骨胶囊对Ⅰ型原发性骨质疏松症的疗效及其与骨代谢的关系。方法 采用益肾健脾的中药壮骨胶囊治疗７４例绝经后妇女原发性骨质疏松症，并与钙尔奇Ｄ治疗的３１例作对照。结果 ３个月后其总有效率达９１．８９％，骨质疏松程度、血ＡＬＰ、ＣＴ、Ｅ２皆显著改善，且显著优于对照组（Ｐ〈０．０５～０．０１）。无明显副反应。结论 绝经后妇女骨质疏松症主要由肾虚所致，采用中药补肾健脾治疗，疗效显著优于补钙、雌     

壮骨胶囊治疗Ⅰ型骨质疏松症93例生化指标观察

９３ 例绝经后妇女骨质疏松症经用壮骨胶囊（ 益肾健脾） 治疗后症状、体征显著改善，优良率达９３．５ ％ ，骨密度明显升高（Ｐ＜０ ．０１） ，血清钙、磷、骨钙素（ＢＧＰ） 治疗前后无明显差异，而血清碱性磷酸酶（ＡＬＰ） 显著降低，血清降钙素（ＣＴ）明显上升（Ｐ皆＜０ ．０１） ，说明壮骨胶囊治疗Ⅰ型骨质疏松症有效，在生化指标上起到调节作用，显著优于采用钙尔奇Ｄ治疗的对照组。     

壮骨胶囊治疗Ⅰ型骨质疏松症93例生化指标观察

９３例绝经后妇女骨质疏松症经用壮骨胶囊（益肾健脾）治疗后症状,体征显著改善,优良率达９３．５％,骨密度明显升高（Ｐ〈０．０１）,血清钙,磷,骨钙素（ＢＧＰ）治疗前后无明显差异,而血清碱性磷酸酶（ＡＬＰ）显著降低,血清降钙素（ＣＴ）明显上升（Ｐ皆〈０．０１）,说明壮骨胶囊治疗Ｉ型骨质疏松症有效,在生化指标上起到调节作用,显著优于采用钙尔奇Ｄ治疗的对照组。     

壮骨胶囊治疗原发性骨质疏松症临床研究

目的：评价壮骨胶囊对于原发性骨质疏松症的临床疗效。方法：本研究主要针对80例原发性骨质疏松症患者,采取随机、平行对照的方法,随机分入中医治疗组和对照组,通过治疗前后患者的症状评分、腰椎和股骨颈骨密度、甲状旁腺激素、降钙素等来评价壮骨胶囊的临床疗效。结果：壮骨胶囊能显著改善患者治疗后临床症状,提高腰椎和股骨颈骨密度和降钙素值,适度降低甲状旁腺激素水平,且指标均明显优于对照组,临床无不良反应发生。结论：壮骨胶囊显著改善原发性骨质疏松症患者的临床症状,增加骨密度,调节骨代谢,具有较好的临床疗效。     

壮骨胶囊治疗Ⅰ型骨质疏松症74例X线比较观察

Ⅰ型骨质疏松症 (即绝经后妇女骨质疏松症 )是由于妇女绝经后卵巢功能衰退 ,雌激素水平低落所致骨代谢紊乱 ,致骨吸收大于骨形成 ,使骨量丢失 ,骨质疏松患者Ｘ线表现有骨小梁稀疏、模糊及椎体压缩契形变等。现就我院利用壮骨胶囊治疗Ⅰ型骨质疏松症74例观察其前后Ｘ线变化情况报告如下 :1　临床资料1.1　对象　绝经后妇女 10 5例 ,随机分为两组 :①中药壮骨胶囊 (治疗组 ) :74例 ,年龄 4 9～ 76岁 ,平均62 .4 9岁。停经史 :≤ 5年 8例 ,6～ 10年 2 2例 ,11～ 15年 18例 ,>15年 2 6例 ,平均 13.91年。②钙尔奇Ｄ治疗组 (对照组 ) :31例 ,年龄…     

壮骨胶囊对72例Ⅰ型骨质疏松症治疗前后雌激素变化的临床观察

７２例Ⅰ型骨质疏松症经用中药壮骨胶囊（益肾、健脾、养肝）治疗，结果表明：临床治疗得到了改善；骨密度（ＢＭＤ）显著提高（Ｐ〈０．０１）；血清雌二醇（Ｅ２）的含量比治疗前有显著上升（Ｐ〈０．０１），间接地表明了壮骨胶囊治疗Ⅰ型骨质疏松症具有类雌激素样的作用。     

益肾壮骨汤联合仙灵骨葆胶囊治疗骨质疏松症的临床疗效研究

目的:探讨分析益肾壮骨汤联合仙灵骨葆胶囊治疗骨质疏松症的临床疗效。方法:选取我院2013年4月至2015年3月期间接收治疗的100例骨质疏松症患者作为研究分析对象,将所选患者随机分为对照组和研究组,每组各50例,研究组采用益肾壮骨汤联合仙灵骨葆胶囊进行治疗,对照组单一采用仙灵骨葆胶囊进行治疗,比较两组患者临床治疗状况。结果:比较两组患者治疗过程中疼痛评分,研究组明显优于对照组,组间数据有统计学意义(P0.05);比较两组患者治疗后骨代谢生化指标状况,包含碱性磷酸酶、β-CTX、骨钙素、血清钙等几方面,研究组明显优于对照组,且组间数据有统计学意义(P0.05)。结论:益肾壮骨汤联合仙灵骨葆胶囊治疗骨质疏松症的临床疗效明显,患者各指标可得到很好的改善,临床应用价值较大。     

脉冲电磁场治疗116例绝经后妇女骨质疏松症患者的疗效分析

目的 分析脉冲电磁场对绝经后妇女骨质疏松症的疗效。方法 对116例绝经后妇女骨质疏松症患者采用骨质疏松症治疗仪进行治疗,1次／d,40min／次,10d为1个疗程,每个患者均完成3～5个疗程治疗,观察患者骨痛的缓解情况、治疗前和治疗后6个月腰椎L2-4BMD及髋部Neck、Ward’s三角区、大转部Troch骨密度变化情况。结果 治疗后患者骨痛症状有效缓解率达95.4％（P〈0．05）,治疗后6个月骨密度提高5.3％～7．2％。结论 脉冲电磁场能有效缓解原发性骨质疏松症患者的骨痛症状,提高骨密度,是一种安全而有效的治疗绝经后妇女骨质疏松症的方法。     

中药合钙剂的合理应用治疗原发性骨质疏松症的临床研究100例报告

目的讨论原发性骨质疏松症中医中药治疗的途径,探讨钙剂如何在骨质疏松症治疗中的合理应用。方法用自研"壮骨散"内服并配合钙尔奇D合理服用100天的全程治疗。结果100例原发性骨质疏松症患者治疗完毕3个月后随访,优58例、良37例、差5例,有效率95%。结论原发性骨质疏松症患者用中药补肾健脾,活血壮骨联合钙尔奇D的合理应用能有效地改善骨痛肢软的症状,提高骨量有确定的效果。     

益骨饮治疗绝经后骨质疏松症的临床观察

[目的]观察中药制剂益骨饮治疗绝经后骨质疏松症的临床疗效。[方法]将93例绝经后骨质疏松症随机分为两组，A组47例内服中药益骨饮，B组46例采用西药“钙＋D”作为对照组，2个月为1个疗程。治疗前后检测血、尿常规，肝、肾功能，血糖、钙、磷、雌激素及骨密度等指标。[结果]治疗后两组间的碱性磷酸酶、雌二醇、睾酮及骨密度均略有上升；疼痛NRS指数、尿钙／肌酐比值也均有相对降低趋势；中药组总有效率达84．4％，对照组总有效率为77．7％，中药组总体疗效优于对照组。[结论]中药益骨饮对绝经后骨质疏松症有较好的防治作用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.