复方黄芩苷口腔缓释膜对大鼠实验性牙周炎的治疗作用

目的:观察复方黄芩苷口腔缓释膜对Wistar大鼠实验性牙周炎的治疗作用。方法:建立Wistar大鼠牙周炎动物模型,将模型动物随机分成5组:复方黄芩苷口腔缓释膜高、中、低剂量组、黄芩苷阳性对照组及模型对照组,观察给药后牙周炎的愈合情况。结果:复方黄芩苷口腔缓释膜各剂量组均能不同程度促进牙周炎愈合。结论:复方黄芩苷口腔缓释膜对Wistar大鼠实验性牙周炎有较好的治疗作用。     

氧化苦参碱抑制大鼠实验性牙周炎牙槽骨吸收的实验研究

目的探讨中药氧化苦参碱对大鼠实验性牙周炎牙槽骨吸收的抑制作用。方法将25只SD大鼠随机分为3组,即正常对照组、空白对照组和实验组。采用钢丝结扎法建立大鼠实验性牙周炎动物模型。实验组在造模期间给予氧化苦参碱灌胃,空白对照组给予等量生理盐水灌胃。灌胃给药6周后处死大鼠,光学显微镜下观察牙周组织病理学变化,测量釉牙本质界到牙槽嵴顶的距离。结果空白对照组及实验组大鼠的牙槽骨均有不同程度的吸收,实验组大鼠牙周组织炎症反应明显轻于空白对照组,牙槽骨吸收量也较小。结论氧化苦参碱可在一定程度上抑制大鼠实验性牙周炎牙槽骨吸收。     

龈上洁治术治疗老年牙周炎临床疗效分析

目的探讨龈上洁治术治疗老年牙周炎的临床疗效。方法选择我院2010年1月～2013年9月收治的80例牙周炎患者,随机将患者分为对照组和试验组,对照组给予阿莫西林及甲硝唑治疗,试验组患者则在上述治疗的基础上应用龈上洁治术治疗,比较两组患者牙龈指数、改良龈沟出血指数、牙周袋深度和附着丧失。结果治疗后两组患者牙龈指数、改良龈沟出血指数、牙周袋深度和附着丧失均明显改善,试验组患者牙龈指数、改良龈沟出血指数、牙周袋深度和附着丧失明显优于对照组,差异有统计学意义（P〈0.05）。结论在阿莫西林及甲硝唑基础上给予龈上洁治术治疗牙周炎患者能够明显减轻牙周炎患者牙龈炎症和减少牙周袋深度和附着丧失,值得在临床上进一步推广。     

正畸联合牙周治疗基于OPG/RANK/RANKL通路对牙周炎模型大鼠的干预作用

目的 分析正畸联合牙周治疗对牙周炎模型大鼠的干预作用,并基于骨保护素(OPG)/核因子кB受体活化因子(RANK)/核因子кB受体活化因子配体(RANKL)通路探讨该治疗的作用机制。方法 选取51只8周龄雄性SD大鼠,随机分为对照组、模型组、观察组,每组17只。对照组不建模、不给予正畸与牙周治疗,模型组建立牙周炎模型但不给予正畸与牙周治疗,观察组建立牙周炎模型并给予正畸与牙周治疗。于加力3 d、28 d后,各组随机选取2只大鼠取牙周组织,光镜下观察病理形态改变。比较干预前及干预结束3 d后各组大鼠牙周探诊深度、菌斑指数、龈沟出血指数,血清白细胞介素(IL)-8、骨形态发生蛋白2(BMP-2)水平,以及干预结束3 d后血清OPG、RANK、RANKL蛋白表达水平。结果 在观察组中,加力3 d后可见成纤维细胞增加、少量成骨细胞及压力侧破骨细胞;加力28 d后压力侧牙周膜缩小变窄,牙周胶原纤维排列不整齐,可见大量骨吸收陷窝及破骨细胞,血管扩张,可见新生成牙骨质细胞。干预后观察组大鼠牙周探诊深度、菌斑指数、龈沟出血指数均较干预前改善,血清IL-8、BMP-2水平均较干预前降低,且以上指标均优于...     

盐酸米诺环素对牙周炎大鼠的治疗效果及对大鼠IL-8、hs-CRP、TNF-α的影响

目的:探究盐酸米诺环素对牙周炎大鼠的治疗效果及对大鼠白细胞介素-8(interleukin-8,IL-8)、超敏C-反应蛋白(hypersensitive C-reactive protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)的影响。方法:将120例Wistar大鼠随机分为基础治疗组和盐酸米诺环素组。两组大鼠均给予常规治疗后,基础治疗组大鼠给予碘甘油治疗,盐酸米诺环素组给予盐酸米诺环素治疗。使用ELISA法检测大鼠外周血及牙龈组织中IL-8、hs-CRP、TNF-α表达,检测患者牙周探诊深度(probing depth,PD)、菌斑指数(plaque index,PLI)、龈沟出血指数(sulcus bleeding index,SBI)及M2腭侧牙槽骨吸收长度和吸收面积。结果:治疗后,盐酸米诺环素组大鼠外周血及牙龈组织中IL-8、hs-CRP、TNF-α表达水平均低于基础治疗组(P<0.05);治疗后,盐酸米诺环素组大鼠的PD、PLI和SBI水平均低于基础治疗组(P<0.05);治疗后,盐酸米诺环素组大鼠M2腭侧牙槽骨吸收长度和吸收面积均明显低于基础治疗组(P<0.05)。结论:盐酸米诺环素可以显著降低牙周炎大鼠外周血及牙龈组织中炎症因子水平,保护牙周组织,降低各项牙部临床指标水平及M2腭侧牙槽骨吸收长度和吸收面积,盐酸米诺环素对牙周炎可能会有显著的治疗效果。     

口服利君沙对70例慢性牙周炎治疗的临床效果评价

目的:分析探讨口服利君沙对慢性牙周炎患者的临床治疗效果的评价,总结治疗方法.方法:选取我院在2014年1月-2016年12月收治的70例牙周病患者,将其分为治疗组与对照组,各组35例.治疗组口服利君沙并结合龈上洁治、龈下刮治及根面平整,对照组仅采用龈上洁治,龈下刮治和根面平整治疗,对比两组患者治疗效果.结果:治疗组治疗后菌斑指数、牙龈沟出血指数、牙周袋深度、平均附着丧失以及探诊出血率均优于对照组,差异显著,有统计学意义.讨论:对牙周病采用口服利君沙配合龈上洁治、龈上洁治、龈下刮治及根面平整治疗,对改善牙周病患者的临床症状有重要意义.     

蜂胶对大鼠实验性牙周炎的治疗效果

目的 较为全面的探讨蜂胶对牙周炎大鼠临床症状,血液等方面的影响.方法 78只诱导成功的牙周炎大鼠模型,随机分成6组:即口泰(阳性对照)组,溶剂对照组,模型组以及3个蜂胶剂量组,每组13只.另取同龄大鼠13只为正常对照组.在成功诱导牙周炎后各组处死1只作模型对照,每组12只动物进入正式实验,4周后,观察蜂胶治疗牙周炎效果.结果 用蜂胶治疗后,各实验组牙龈未见自发出血,其中蜂胶低剂量组应用蜂胶1周时,牙龈红肿消退,溃疡愈合,萎缩修复;蜂胶三剂量组的探诊出血阳性率SBI,菌斑指数PLI,探诊深度PD,牙槽骨吸收值ABL和牙齿松动度TM显著低于模型组,表明蜂胶有较强的抗炎消肿、止血作用,并且能明显改善大鼠牙周炎临床症状;蜂胶低剂量和中剂量治疗组白细胞数与模型组比较,差异显著;中性粒细胞与模型组比较,阳性对照组和三个蜂胶治疗组均表现出极显著差异,表明蜂胶对炎性反应具有控制作用.结论 蜂胶可以明显改善大鼠牙周炎的临床症状,尤其以低剂量效果显著.     

超声洁治结合手工龈下刮治术治疗慢性牙周炎疗效观察

目的:观察超声洁治结合手工龈下刮治术治疗慢性牙周炎的临床效果.方法:采用超声洁治(龈上、龈下)结合手工龈下刮治治疗慢性牙周炎患者90例(牙周袋深度(PD)≥4 mm,探诊出血均≥2,牙龈指数(GI)≥2,龈沟出血指数(BI)≥3),观察治疗前、治疗后2周和治疗后4周的牙周袋深度、探诊出血、牙龈指数、龈沟出血指数等临床指...     

高压氧治疗牙周炎63例疗效观察

目的：观察高压氧治疗对牙周炎患者的临床效果.方法：选取新疆维吾尔自治区人民医院63例,病程2年以上,牙周袋深度＞4mm,有不同程度牙槽骨的吸收,尚未接受抗炎治疗的,无全身系统疾病的牙周炎患者进行常规牙周治疗加30天的高压氧治疗后观察龈指数（GI）,龈沟出血指数（SBI）,牙周袋深度（PD）,厌氧菌培养及菌落计数（AC）的前后变化.结果：采用高压氧治疗后,63例患者中显效45例,有效18例,治疗后PD、GI、SBI、AC治疗前后差异均有显著性（P＜0.05）.结论：高压氧治疗对牙周炎患者有较好的效果.     

布洛芬缓释凝胶联合牙周袋内注入盐酸米诺环素软膏对重度慢性牙周炎患者牙周指数的影响

目的分析布洛芬缓释凝胶联合牙周袋内注入盐酸米诺环素软膏对重度慢性牙周炎患者牙周指数的影响。方法选取驻马店市第二中医院2017年3月至2019年3月收治的96例重度慢性牙周炎患者,依照治疗方案分为对照组与观察组,各48例。对照组采用牙周袋内注入盐酸米诺环素软膏治疗,观察组采用布洛芬缓释凝胶联合牙周袋内注入盐酸米诺环素软膏治疗,比较两组疗效、牙周指数(牙周袋深度、菌斑指数、出血指数)、不良反应。结果观察组总有效率(91.67%)较对照组(75.00%)高(P<0.05);治疗后,观察组牙周袋深度、菌斑指数、出血指数较对照组低(均P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论布洛芬缓释凝胶联合牙周袋内注入盐酸米诺环素软膏治疗重度慢性牙周炎,效果显著,能有效改善患者牙周情况,且安全性好。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.