月经失调女性抗缪勒氏管激素与卵泡刺激素关系的研究

目的:探讨月经失调女性抗缪勒氏管激素(anti-Mullerian hormone,AMH)与卵泡刺激素(follicle-stimulating hormone,FSH)变化趋势及两者之间的相关性。方法:选取2017年1-9月本院就诊的106例月经失调育龄期女性为研究对象,按年龄段分为5组:A组(21~25岁,17例)、B组(26~30岁,23例)、C组(31~35岁,27例)、D组(36~40岁,21例)、E组(41岁,18例)。检测并观察五组血清AMH、FSH水平及其两者相互间的关系。结果:血清AMH水平随年龄的增加而降低,与年龄呈负相关(r=-0.560,P0.000 1)。五组血清AMH水平比较,差异均有统计学意义(P0.05)。血清FSH水平则随年龄增长而缓慢上升(r=0.086,P=0.391)。A组血清FSH水平低于B组,差异有统计学意义(P0.05);其余各组血清FSH水平比较,差异均无统计学意义(P0.05)。血清AMH与FSH呈负相关,差异无统计学意义(r=-0.126,P=0.256)。结论:年龄是影响月经失调女性AMH水平重要因素,其与年龄相关性优于FSH,而AMH与FSH相关性不强,在月经失调患者中用AMH水平预测FSH不可取。     

不同子宫手术方式对因生殖系统疾病行手术治疗的生育期妇女卵巢功能的影响

目的:分析不同子宫手术方式对因生殖系统疾病行手术治疗的生育期妇女卵巢功能的影响。方法:选取2013年9月-2017年10月本院收治的因生殖系统疾病接受不同子宫手术治疗的生育期妇女100例,分别于手术前及术后6个月测定患者血清促卵泡生长激素(follicle stimulating hormone,FSH)、内皮素-2(endothelin-2,ET-2)、抗苗勒氏管激素(antimiillerian hormone,AMH)水平,同时对患者潮热等更年期症状进行评估,评估手术前后患者的卵巢功能衰竭情况,观察不同年龄、不同手术方式及手术途径患者的AMH水平。结果:本组100例患者手术前后均未出现卵巢功能衰竭;40岁及以下患者手术前后AMH水平比较差异均无统计学意义(P0.05),40岁以上患者术后AMH水平均低于术前(P0.05),且年龄越大,患者手术前后的AMH水平均越低;接受子宫肌瘤剔除术、子宫次切术患者手术前后AMH水平比较差异无统计学意义(P0.05),子宫全切术、广泛性子宫切除术患者术后AMH水平均低于术前,比较差异均有统计学意义(P0.05);接受子宫肌瘤剔除术的患者,腹腔镜及开腹手术前后血清AMH水平比较差异均无统计学意义(P0.05),接受子宫切除术的患者,腹腔镜下术后AMH水平低于术前(P0.05),但开腹手术前后血清AMH水平比较差异均无统计学意义(P0.05)。结论:因生殖系统疾病接受子宫手术的患者术后短期不会有卵巢功能衰竭表现,子宫手术后短期内卵巢储备功能下降可能和年龄、子宫切除方式、途径存在相关性。     

不同神经功能缺损评分脑卒中患者血脂及 HCY表达研究

目的 探讨不同神经功能缺损评分脑卒中患者血脂及半胱氨酸(HCY).方法 选取80例住院治疗的脑卒中患者,根据入院时中国脑卒中临床神经功能缺损程度评分量表评分进行分组,0~30分轻中度损伤组(53例)、>30分为重度损伤组(27例).入院后检测血清HCY、甘油三酯(TG)采用酶法检测,总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)水平.结果 轻中度损伤组与重度损伤组患者TG、TC、LDL-C、HDL-C水平比较差异无统计学意义,重度损伤组患者血清HCY水平为(43.29±5.67)μmol/L高于轻中度损伤组(21.45±4.20)μmol/L,比较差异有统计学意义(t=19.48,P<0.05);轻中度损伤组与重度损伤组中缺血性脑卒中与出血性脑卒中患者TG、TC、LDL-C、HDL-C、HCY水平比较差异均无统计学意义.结论 不同神经功能缺损评分脑卒中患者HCY表达明显存在不同,神经功能缺损越严重HCY水平越高,与血脂水平无关,脑卒中类型也对不同神经功能缺损评分脑卒中患者血脂及HCY表达无影响.     

慢性心力衰竭患者血红蛋白与血清可溶性细胞间黏附分子-1及心功能的关系

目的探讨慢性心力衰竭(CHF)患者血红蛋白(Hb)与血清可溶性细胞间黏附分子-1(sICAM-1)及心功能的关系。方法98例CHF患者参照美国纽约心脏协会分级法分为轻中度心力衰竭组48例和重度心力衰竭组50例;并依据Hb水平将CHF患者又分为贫血组30例和非贫血组68例,以健康体检者30例作为对照组,比较各组左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、Hb水平、血清sICAM-1水平,并分析其相关性。结果重度心力衰竭组贫血患病率(40.00%)高于轻中度心力衰竭组(20.83%),差别有统计学意义(P<0.05);重度心力衰竭组Hb水平明显低于轻中度心力衰竭组和对照组(P<0.05);轻中度心力衰竭组血清sICAM-1水平及LVEDD均高于对照组(P<0.05),但低于重度心力衰竭组(P<0.05);轻中度心力衰竭组LVEF与对照组比较差别无统计学意义(P>0.05),但高于重度心力衰竭组(P<0.05)。贫血组血清sICAM-1水平和LVEDD值明显高于非贫血组(P<0.05),而LVEF值明显低于非贫血组(P<0.05)。一元线性相关与回归分析显示,心力衰竭患者Hb水平与LVEDD和sICAM-1呈负相关(P<0.05),Hb水平与LVEF呈正相关(P<0.05)。结论CHF患者常伴有贫血,贫血的程度与心力衰竭的严重程度及血清sICAM-1水平有关,sICAM-1的过度表达可能参与了CHF及贫血的发生和发展过程。     

519例抗缪勒氏管激素检测结果分析

目的:分析抗缪勒氏管激素(AMH)与女性年龄的相关性。方法:回顾性分析519例女性的血清检查结果,采用酶联免疫吸附法检测受试者血清AMH水平。比较各年龄组女性的血清AMH水平,分析年龄与血清AMH水平的相关性。结果:17~25岁组和26~30岁组的AMH水平均明显大于31岁以上各组(P<0.05),31~35岁组、36~40岁组、41~45岁组、46~55岁组AMH水平逐渐降低(P<0.05)。年龄与血清AMH的关系为y=-0.25x+12.07。结论:随着年龄的增长,女性血清中的AMH水平呈下降趋势。     

老年性高血压与阻塞性睡眠呼吸暂停低通气综合征的关系

目的探讨老年性高血压与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的关系。方法采用多导睡眠图检查,对169例老年性高血压患者进行监测。记录患者年龄、呼吸紊乱指数(AHI)、氧减指数(ODI)、体质指数(BMI)。将研究对象按60～69岁、70～79岁8、0岁以上分为A、B、C 3组进行分析。结果 169例老年性高血压病患者中确诊OSAHS 155例(91.7%),正常14例(8.3%)(2=235.28,P<0.01)。OSAHS轻度患者与中度及重度患者比较差异有统计学意义(P<0.01);OSAHS中度患者与重度患者比较差异无统计学意义(P>0.05);在轻度和中度OSAHS患者中,各年龄组之间相互比较差异均无统计学意义(P>0.05)。在重度OSAHS患者中,60～69岁组与70～79岁组比较差异无统计学意义(P>0.05);60～69岁组与80岁以上组比较以及70～79岁组与80岁以上组比较,差异有统计学意义(P<0.01)。结论老年性高血压病与OSAHS存在明显的相关性,而且发生率较高;而年龄越大,发生重度OSAHS的机会就越大。     

血清HE4、AMH、INHB在卵巢子宫内膜异位囊肿中的表达及意义

目的探讨人附睾分泌蛋白E4(HE4)、抗苗勒氏管激素(AMH)、抑制素B(INHB)在卵巢子宫内膜异位囊肿中的表达及意义。方法选取2016年1月至2018年1月在我院治疗的卵巢子宫内膜异位囊肿患者42例(卵巢子宫内膜异位囊肿组)和卵巢单纯囊肿患者53例(卵巢单纯囊肿组),检测两组血清HE4、AMH、INHB水平。结果卵巢子宫内膜囊肿组HE4水平为(65. 22±10. 41) pmol/L,明显高于卵巢单纯囊肿组,差异有统计学意义(P<0. 05),而AMH和INHB分别为(1. 41±0. 52) ng/m L和(24. 41±2. 80) pg/m L,明显低于卵巢单纯囊肿组,差异有统计学意义(P <0. 05);Spearman秩相关分析显示AMH、INHB与患者年龄呈负相关(r=-0. 435和-0. 401,P<0. 05);单双侧子宫内内膜异位囊肿患者HE4、AMH、INHB比较差异无统计学意义(P>0. 05);血清HE4、AMH、INHB鉴别子宫内内膜异位囊肿的ROC曲线下面积分别为0. 776、0. 926和0. 867(P<0. 05)。结论血清HE4、AMH、INHB在卵巢子宫内膜异位囊肿鉴别诊断中有一定应用价值,同时AMH和INHB与患者年龄相关,与单双侧受累无明显关系。     

血清HE4、AMH、INHB在卵巢子宫内膜异位囊肿中的表达及意义

目的探讨人附睾分泌蛋白E4(HE4)、抗苗勒氏管激素(AMH)、抑制素B(INHB)在卵巢子宫内膜异位囊肿中的表达及意义。方法选取2016年1月至2018年1月在我院治疗的卵巢子宫内膜异位囊肿患者42例(卵巢子宫内膜异位囊肿组)和卵巢单纯囊肿患者53例(卵巢单纯囊肿组),检测两组血清HE4、AMH、INHB水平。结果卵巢子宫内膜囊肿组HE4水平为(65. 22±10. 41) pmol/L,明显高于卵巢单纯囊肿组,差异有统计学意义(P<0. 05),而AMH和INHB分别为(1. 41±0. 52) ng/mL和(24. 41±2. 80) pg/mL,明显低于卵巢单纯囊肿组,差异有统计学意义(P <0. 05);Spearman秩相关分析显示AMH、INHB与患者年龄呈负相关(r=-0. 435和-0. 401,P<0. 05);单双侧子宫内内膜异位囊肿患者HE4、AMH、INHB比较差异无统计学意义(P>0. 05);血清HE4、AMH、INHB鉴别子宫内内膜异位囊肿的ROC曲线下面积分别为0. 776、0. 926和0. 867(P<0. 05)。结论血清HE4、AMH、INHB在卵巢子宫内膜异位囊肿鉴别诊断中有一定应用价值,同时AMH和INHB与患者年龄相关,与单双侧受累无明显关系。     

高血压患者运动试验中血压变化与靶器官损伤的关系研究

目的探讨轻中度高血压患者在运动试验中血压变化程度与靶器官损伤的关系。方法选择112例Ⅰ、Ⅱ级高血压患者,根据运动试验中患者血压升高的水平,分为轻度升高组(21例)、中度升高组(48例)和重度升高组(43例)。记录3组患者的临床资料,检测血脂、血同型半胱氨酸、肾小球滤过率、尿微量清蛋白、颈动脉内中膜层厚度(IMT)、左室质量指数(LVMI)。结果重度升高组的年龄、体质指数、静息时心率、女性比例、吸烟率与中度升高组和轻度升高组比较,差异均有统计学意义(P<0.05),且中度升高组与轻度升高组比较,差异均有统计学意义(P<0.05)。3组患者血脂水平和高血压家族史发生率的差异均无统计学意义(P>0.05)。重度升高组的尿微量清蛋白、肾小球率过滤、颈动脉IMT和LVMI与中度升高组和轻度升高组比较,差异均有统计学意义(P<0.05),且中度升高组与轻度升高组比较,差异均有统计学意义(P<0.05)。结论高血压患者运动试验中血压升高程度可提示靶器官损伤。     

高血压患者运动试验中血压变化与靶器官损伤的关系研究

目的探讨轻中度高血压患者在运动试验中血压变化程度与靶器官损伤的关系。方法选择112例Ⅰ、Ⅱ级高血压患者,根据运动试验中患者血压升高的水平,分为轻度升高组(21例)、中度升高组(48例)和重度升高组(43例)。记录3组患者的临床资料,检测血脂、血同型半胱氨酸、肾小球滤过率、尿微量清蛋白、颈动脉内中膜层厚度(IMT)、左室质量指数(LVMI)。结果重度升高组的年龄、体质指数、静息时心率、女性比例、吸烟率与中度升高组和轻度升高组比较,差异均有统计学意义(P<0.05),且中度升高组与轻度升高组比较,差异均有统计学意义(P<0.05)。3组患者血脂水平和高血压家族史发生率的差异均无统计学意义(P>0.05)。重度升高组的尿微量清蛋白、肾小球率过滤、颈动脉IMT和LVMI与中度升高组和轻度升高组比较,差异均有统计学意义(P<0.05),且中度升高组与轻度升高组比较,差异均有统计学意义(P<0.05)。结论高血压患者运动试验中血压升高程度可提示靶器官损伤。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.