良性滑膜瘤临床病理分析15例

目的　提高对良性滑膜瘤的诊断和鉴别诊断能力。方法　分析 15例良性滑膜瘤的临床病理学特点。结果　局限型 12例 ,弥漫型 3例 ,两者发病部位和组织病理学特征差别明显。结论　掌握其组织学特征较易诊断 ,但应注意与软组织巨细胞瘤、骨巨细胞瘤、巨细胞肉芽肿、滑膜肉瘤等相鉴别     

良性滑膜瘤临床病理分析15例

目的 提高对良性滑膜瘤的诊断和鉴别诊断能力。方法 分析15例良性滑膜瘤的临床病理学特点。结果 局限型12例，弥漫型3例，两者发病部位和组织病理学特征差别明显。结论 掌握其组织学特征较易诊断，但应注意与软组织巨细胞瘤、骨巨细胞瘤、巨细胞肉芽肿、滑膜肉瘤等相鉴别。     

良性滑膜瘤（附15例报告）

目的：提高对良性滑膜瘤的诊断和鉴别诊断能力；方法：回顾性分析了15例良性滑膜瘤的临床病理学特点；结果：局限型12例，弥漫型3例，两型良性滑膜瘤发病部位和组织病理学特征差别明显；结论：掌握其组织学特征较易诊断，但应注意与软组织巨细胞瘤、骨巨细胞瘤、巨细胞肉芽肿、滑膜肉瘤等相鉴别。     

颌骨外周性及颌骨外型巨细胞肉芽肿11例

巨细胞性损害在口腔的主要表现为颌骨内巨细胞肉芽肿(CG CG)、骨巨细胞瘤(GC(?))及发生在软组织的外周性巨细胞肉芽肿(PG CG).巨细胞肉芽肿(GCG)病损不仅出现在颌骨内,也可作为非特异性修复过程,发生在颌骨,即颌骨外型巨细胞肉芽肿。     

不规则骨骨巨细胞瘤影像诊断探讨

目的探讨不规则骨骨巨细胞瘤影像表现及鉴别诊断。方法回顾性分析经手术病理证实的17例不规则骨骨巨细胞瘤的CT、MRI表现。结果CT主要表现为膨胀性病变、溶骨性骨质破坏和软组织肿块。MRI检查病变在T1WI呈等或低信号,T2WI为低到高不均匀信号,病变边缘比较清楚。结论CT结合MRI扫描对不规则骨骨巨细胞瘤的诊断和鉴别诊断具有明显的价值并为临床手术提供可靠的资料。     

颌骨巨细胞肉芽肿20例临床病理分析

对20例颌骨巨细胞肉芽肿和12例颌骨巨细胞瘤的病理学特性进行比较;并对8例颌骨巨细胞肉芽肿和5例颌骨巨细胞瘤的切片做 Wilder's 网状纤维染色和三色染色。结果表明:颌骨巨细胞肉芽肿的网状纤维和胶原纤维较颌骨巨细胞瘤丰富,且灶性分布明显,上述2种染色有助于颌骨巨细胞肉芽肿和颌骨巨细胞瘤的诊断。     

腱鞘巨细胞瘤47例临床病理分析

目的探讨腱鞘巨细胞瘤的临床病理特征,对其鉴别诊断进行探讨。方法收集47例腱鞘巨细胞瘤,根据临床病理学特点、形态学观察及免疫组化染色进行分析。结果 47例腱鞘巨细胞瘤患者中男15例(31.9%),女32例(68.1%),男女比为1:2.1,平均年龄43岁,≥31岁者35例(74.5%),发生于手部29例(61.7%)、足部18例(38.3%)。肿瘤细胞由数量不等的中等大小滑膜样多形性单核细胞、破骨样多核巨细胞、泡沫样吞噬细胞组成,伴有不同程度的胶原化,另见散在及灶性炎细胞浸润,部分组织细胞内有含铁血黄素颗粒存在。结论腱鞘巨细胞瘤是一种起源于腱鞘和关节滑膜层的良性病变,为较少见的纤维组织细胞肿瘤,免疫组化检查可作为诊断及鉴别诊断的重要参考依据。     

肺软组织恶性巨细胞瘤(附1例病例报告)

软组织恶性巨细胞瘤较少见,发生于肺内者国内尚未见报道。对于其组织学来源尚无定论。本文报告1例肺软组织恶性巨细胞瘤,其主要组成为破骨细胞样巨细胞及单核性瘤细胞,组织学上颇似骨巨细胞瘤。通过特殊染色及免疫组化研究,确定其组织来源为组织细胞。     

骨巨细胞瘤中多核巨细胞的来源

目的:研究骨巨细胞瘤中多核巨细胞的来源,探讨骨巨细胞瘤是破骨细胞或者是肿瘤细胞。方法:本次试验标本30例为解放军222医院病理科经病例证实的手术标本。采用链菌素亲生物素一过氧化物酶连接法(sp)免疫组化技术。抗体PCNA、P53、P21、CD68、AACT以及SP染色试剂均为即用型,阳性判断以细胞浆、细胞膜或细胞核着棕色颗粒为阳性反应,以缓冲液PBS代替一抗作阴性对照,确定骨巨细胞瘤中多核巨细胞的来源。结果:30例骨骨细胞瘤中的多核巨细胞均不表达PCNA、p53及c-er Bb2、有8例表达p21,其包浆课件棕褐色的阳性颗粒,所有标本中的巨细胞均呈现CD68强阳性,棕褐色的颗粒绝大多数位于细胞浆中,少数多核巨细胞呈Vimentin阳性反应,还有一部分多核巨细胞呈Lysozyme中性或阳性反应。结论:巨细胞瘤中的多核巨细胞与破骨细胞在形态学及酶组织化学与免疫组织化学与破骨细胞相似。多核巨细胞具有一定的破骨能力,由此可见,多核巨细胞是破骨细胞,属于终末细胞,而不是肿瘤细胞。     

关于网织细胞瘤的形态与组织发生

网织细胞瘤(或称:皮肤巨细胞瘤,网织细胞肉芽肿、巨细胞肉芽肿)是一种少见的皮肤良性肿瘤,其特征是具有大量独特的单核,双核及多核巨细胞,略似神经节细胞,分布于血管丰富的纤维网织内。在巨细胞的胞质中可能含有脂类与含铁血黄素。临床医生和病理解     

The fine structure of sarcoid and tuberculous granulomas

The granulomas of sarcoidosis and non-caseating tuberculosis show similar cell-types: two forms of epithelioid cells, A and B, giant cells, lymphocytes and ‘activated’ mononuclear cells. The morphology of epithelioid cells suggests that they are primarily biosynthetic rather than phagocytic.     

Primary tuberculosis of the thyroid gland: a case report

Tuberculosis of the thyroid gland is an uncommon disease and primary involvement of thyroid is even more rare. It is a rare disease even in countries in which tuberculosis is endemic. The diagnosis is often difficult as the clinical presentation has no distinct characteristics. Clinical course of the disease may resemble toxic goiter or acute thyroiditis or may follow a subacute or chronic growth pattern without specific symptomatology. Histologically presence of necrotizing epithelioid cell granulomas along with langhans type giant cells are the hallmark of thyroid tuberculosis. Demonstration of acid fast bacilli by ZN staining confirms the diagnosis, but this stain is frequently negative in tissue sections.     

家族性巨颌症的诊断与治疗--附7例报告及文献复习

目的 探讨家族性巨颌症,临床特点及治疗。方法 对7例患的临床资料进行回顾性分析。结果 临床表现为广泛性、无痛性和对称性的上下颌骨膨隆,下颌骨(7／7)多于上颌骨(4／7)。3例有家族史。X线表现为多房囊性阴影。4例术前得到正确诊断。5例采用保守的手术治疗。结论 家族性巨颌症应与巨细胞肉芽肿及骨巨细胞瘤相鉴别。由于该病青春期后有自愈性,较轻的患无需手术,较严重的患保守的手术治疗效果理想。     

家族性巨颌症和巨细胞肉芽肿临床病理学分析与比较研究

目的：比较家族性巨颌症（CBM）和颌骨巨细胞肉芽肿（CGCG）的临床病理学特征，确定二者的细胞生物学特性。方法：对12例CBM和24例CGCG进行临床资料分析、组织学观察及细胞测量学比较与统计学分析。结果：多数CBM有家族遗传史，发病年龄明显小于CGCG。组织病理学上表现为骨组织被纤维组织代替，多核巨细胞呈散在或灶性分布于纤维基质中，经比较二者多核巨细胞总面积平均值（FSA）、相对大小指数（RSI）、形态因子平均值及胞核平均个数等评价参数无统计学差别。结论：CBM和CGCG为两种不同的病变，二者细胞学特征具有相似性，需结合临床表现和X线特征进行疾病诊断。     

Tuberculosis of gallbladder with candidiasis, a rare entity

Gallbladder tuberculosis (GT) is an extremely rare condition. This is thought to be due to the protective property of bile against the infection. Clinical and radiological diagnosis of GT is difficult. We describe a case of GT who initially presented to us with jaundice, a right hypochondrial mass and computed tomographic findings suggestive of gallbladder empyema. Diagnosis was made from histopathological examination of the resected gallbladder which revealed epitheloid granulomas with caseating necrosis and presence of Langhan's giant cells. From a literature search and to the best of our knowledge, this is the first GT to be reported in South East Asia.     

Leiomyosarcoma of the rectum with sarcoid-like reaction--a case report

A 57 year-old man was admitted to the hospital because of bloody stools. A barium enema and coloscopy disclosed a tumor of the rectum. The resected tumor was diagnosed as a leiomyosarcoma, histologically. Many epithelioid granulomas with Langhans type giant cells were found in the tumor, and there was no evidence suggestive of generalized sarcoidosis, tuberculosis or mycosis. Thus, the epithelioid granulomas seen in the leiomyosarcoma were interpreted as a sarcoid-like reaction. As far as could be determined, there has been no reported case of a sarcoid-like reaction associated with a leiomyosarcoma. The occurrence of the sarcoid-like reaction in the present case could be due to the reaction to the metabolites or a degenerative substance of the leiomyosarcoma, or to host resistance to the tumor itself.     

Painless giant cell thyroiditis

We describe an atypical case of subacute thyroiditis affecting a 50 year old patient with long lasting fever, weight loss, malaise and a high erythrocyte sedimentation rate. Cytological examination of the thyroid gland showed the classic granulomas with giant cells. However, the patient had neither painful enlargement of the gland nor thyrotoxicosis. This case, as well as others previously described, probably represents a new subtype of subacute thyroiditis, painless giant cell thyroiditis. The presence of painless giant cell thyroiditis should be considered in any patient with undiagnosed pyrexia, weight loss and elevated ESR.     

Giant cell tumor of the talar neck

We describe a patient with a giant cell tumor in the talar head and neck of the left foot who was diagnosed as having osteochondritis dissecans and treated with arthroscopic drilling in this same location 3 years earlier. Giant cell tumors can be confused with several conditions, including giant cell reparative granulomas, brown tumors, and aneurysmal bone cysts. Giant cell tumors of bone typically occur in the epiphysis of long bones, including the distal femur and proximal tibia. They are uncommonly found in the small bones of the foot or ankle, and talar involvement is rare. Despite this rarity, the radiographic appearance and clinical signs of talar lesions should be considered in the differential diagnosis of nontraumatic conditions in the foot.     

人骨巨细胞瘤细胞系GCT-0404的建立和生物学特性

目的:研究骨巨细胞瘤细胞体外培养的生物学特性,并建立人骨巨细胞瘤细胞系. 方法: 采用原代组织块培养法培养骨巨细胞瘤手术标本,对存活细胞进行形态学观察、免疫组织化学染色、细胞周期检查、核型分析、裸鼠移植. 结果: 建立人骨巨细胞瘤细胞系GCT-0404,其形态学表现、免疫组织化学染色均符合骨巨细胞瘤纤维母细胞样基质细胞的特征. 经过近1 a的体外培养,现已传代100次,细胞倍增时间39.7 h,细胞周期测定G1期为67.5%,G2期为8.9%,S期为23.6%. 染色体具有三倍体核型. 裸鼠移植成瘤率100%,无支原体污染. 结论: 人骨巨细胞瘤细胞系GCT-0404可以用于对骨巨细胞瘤的研究.     

骨巨细胞瘤Jaffe分级的PCNA评价

目的观察骨巨细胞瘤Ｊａｆｆｅ组织分级与瘤细胞增殖的关系。方法应用免疫组化ＡＢＣ法对２７例不同组织级别的骨巨细胞瘤进行增殖细胞核抗原（ＰＣＮＡ）检测。结果ＰＣＮＡ的阳性反应仅见于基质细胞的胞核中，多核巨细胞呈阴性反应。不同组织级别的骨巨细胞瘤之间，ＰＣＮＡ阳性检出率无显著差别（Ｐ＞０．０５）。结论骨巨细胞瘤Ｊａｆｆｅ分级系统与肿瘤细胞的增殖情况无关；多核巨细胞非肿瘤细胞。