河南省2010年县区层面狂犬病病例空间聚集性的Poisson分布与负二项分布拟合

目的:对2010年河南省狂犬病病例县区层面空间聚集性进行Poisson分布与负二项分布的拟合。方法:对河南省2010年狂犬病病例县区层面分布数据按发病数进行归类整理,利用Poisson分布与负二项分布原理在县区层面对病例进行拟合与检验。结果:河南省2010年狂犬病病例在县区层面既符合Poisson分布(χ2=4.3317,P=0.2278),又符合负二项分布(聚集性参数k=1.5204,χ2=0.3726,P=0.8300)。结论:河南省2010年狂犬病病例具有空间聚集性,这种聚集的县区同时又有一定的随机分布倾向。     

家庭中乙型肝炎表面抗原携带者的Neyman分布与负二项分布

对湖北省钟祥县官庄湖农场189户942名居民用RPHA法检查HBsAg,122人HBsAg阳性,HBsAg携带率为12.95％。本文提出HBsAg携带者在家庭中分布的资料不符合二项分布与Poisson分布,但符合Neyman分布与负二项分布。结果表明HBsAg携带者在家庭中的聚集性可以用统计的理论分布证明。对本结果的应用与意义进行了讨论。     

长乐县高发胃癌的地质医学病因初探

<正> 长乐县位于福建东部沿海,闽江口南岸,是我国胃癌高发区之一。据国内外文献报道,环境因素在胃癌发病中起着重要作用,胃癌、高低发区的分布具有明显的水域范围。为了探索长乐县高发胃癌的地质医     

2009年福建省恶性肿瘤患病分布分析

目的 了解福建省居民恶性肿瘤的患病分布特征,为建立完善的肿瘤登记报告制度提供支持.方法 对福建省2009年肿瘤患病数据进行流行病学分析,样本构成比比较采用x2检验,样本患病率比较采用Z检验.结果 福建省恶性肿瘤年平均粗患病率为128.77/10万,其中胃癌粗患病率最高为18.85/10万,占全部恶性肿瘤患病的14.64％;常见恶性肿瘤除乳腺癌和宫颈癌外,其余恶性肿瘤患病率男性均高于女性,差异有统计学意义(P＜0.001).男女恶性肿瘤总体标化率差异有统计学意义;全省恶性肿瘤患病高峰年龄段位于55 ～65岁,不同地区恶性肿瘤患病构成比差异有统计学意义.结论 福建省居民恶性肿瘤患病分布存在一定规律,为制定综合防治恶性肿瘤措施提供依据.     

阳城县食管癌死亡病例空间分布的研究

作者用参数法,定差系数法及频数分布拟合法,按照二项分布,Poisson 分布和负二项分布三种理论模式,对山西省阳城县食管癌死亡病例在乡村和家庭中的分布进行了研究探讨。提出该县居民食管癌死亡病例在乡村呈聚集性的负二项分布,在家庭中呈高度分散状态的 Poisson 分布。在资料处理及分析方法上作者指出:宜用多种方法分析比较综合判定,避免仅用简单直观方法以致对总体分布作出错误判断。     

胃粘膜幽门螺杆菌抗原的分布及其意义

目的 探讨幽门螺杆菌(Hp)感染患者Hp抗原分布部位及其与胃癌的关系。方法 收集经病理学检查证实的Hp 阳性胃病患者共84例 ,用免疫组织化学技术检测胃上皮细胞的Hp 抗原。结果 慢性浅表性胃炎、癌前变化和胃癌患者Hp抗原阳性者分别为12例、22例和13例 ;三者胃上皮细胞胞浆Hp 抗原阳性率依次升高 ,分别为0、63.6 %和84.6% (χ2=19.76,P<0.001) ;12例浅表性胃炎患者Hp抗原位于粘液层及腺颈部以上粘膜9例 (75.0% ) ,22例癌前变化患者Hp抗原位于腺颈部及峡部12例 (54.5% ) ,13例胃癌患者Hp抗原位于峡部以下粘膜9例 (69.2% ,χ2=25.30,P<0.001)。结论 在慢性浅表性胃炎→癌前变化→胃癌的变化过程中 ,Hp抗原逐渐由细胞外向细胞内、由浅表粘膜向深部粘膜迁移。     

Poissonf分布理论在结防工作中的应用

本文试图以Poisson分布理论，采用频数分布拟合优度的χ^2检验方法分析结核病在农村的发病传染规律，着重分析以村为单位的集聚性，为今后的结核病防制寻求有效的发现、管理方法，以达到控制肺结核的目的。     

胃癌患者术前红细胞分布宽度与临床病理特征及预后的关系

目的探讨胃癌患者术前红细胞分布宽度（RDW）与临床病理特征及预后的关系。方法收集79例胃癌患者的临床资料，记录术前血常规中RDW值，分析术前RDW值与临床病理特征的关系；应用log-rank检验和Cox回归模型分析术前RDW与胃癌患者手术预后的关系。结果肿瘤的浸润深度、大小、临床分期与胃癌患者术前RDW值的高低有关（P＜0.05或0.01）。术前RDW值高的胃癌患者术后无瘤生存期显著缩短（13.7vs.19.1个月，P＜0.01）。胃癌患者术前RDW值是影响胃癌患者术后无瘤生存期的一个独立危险因素（HR=1.855，95%CI：1.159～2.968，P＜0.05）。结论胃癌患者术前RDW值有望成为预测胃癌患者术后预后的一个新的潜在指标。     

福建省恶性肿瘤死亡率年龄分布的Logistic曲线拟合

恶性肿瘤的死亡率具有随年龄的增长而升高的趋势。采用Ｌｏｇｉｓｔｉｃ曲线，对福建省恶性肿瘤死亡率资料进行数学模拟。建立恶性肿瘤死亡率年龄分布的数学模型。该模型可以表明福建省恶性肿瘤死亡率年龄分布的规律，同时还可用于预测人群中恶性肿瘤的死亡率和死亡数。     

幽门螺杆菌与胃癌

幽门螺杆菌与胃癌一项长达１０年，包括１万名中国和香港受试者研究的初步结果表明，较低的社会经济地位和幽门螺杆菌感染可能是中国大陆胃癌发病率高的主要原因。福建省长乐县是中国胃癌流行普遍、死亡率高的地区，对那里的２４００余名志愿者作了内窥镜检查，约８０／１...     

福建省食管癌流行因素的初步调查

目的探讨福建省食管癌流行的危险因素。方法在福建省１９８９～１９９０年曾进行居民死因回顾性调查的１４个县市６８个抽样点（乡、镇、街道），每个抽样点按１９８１年全国人口标准构成调查４５～７４岁的居民２００人，探讨各抽样点食管癌标化截缩死亡率与人群２０年前饮食、生活习惯之间的相关关系。结果资料的简单Ｓｐｅａｒｍａｎ相关分析发现霉粮、腌制蔬菜、腌制豆类、粗粮占口粮的比例及男性吸烟等因素与食管癌的死亡率呈显著正相关，新鲜蔬菜则可能为保护性因素。进一步的多元中位数回归分析显示进入方程的因素为腌制蔬菜、腌制豆类、新鲜蔬菜及男性的新鲜水果等。未发现鱼露、饮酒、腌制海产品等因素与食管癌死亡率之间的联系。结论食用腌制蔬菜、腌制豆类，少吃新鲜蔬菜、水果可能是福建省食管癌流行的重要危险因素。     

海南省九个农场橡胶工人死因回顾性调查

目的探讨引起海南橡胶工人死亡的主要疾病及其影响因素,为橡胶行业职业防护提供依据。方法本文对海南省橡胶行业2005～2010年海南9个橡胶厂工作时间满1年的在册职工采用流行病学回顾性队列研究方法进行调查。结果 6年间橡胶工人的前4位死因依次为恶性肿瘤（25.61%）、脑血管疾病（23.16%）、呼吸系疾病（19.33%）、心血管疾病（14.57%）;男性前4位的恶性肿瘤为：肺癌、肝癌、胃癌、结直肠癌;女性前4位的恶性肿瘤为：乳腺癌、肺癌、肝癌、胃癌。结论橡胶行业恶性肿瘤死亡有高发的趋势。     

Cancer patterns in Canada.

Cancer is diagnosed in about 70 000 Canadians each year and is the leading cause of the loss of potential years of life before age 75 among women. Life-threatening forms of cancer will develop in at least one of every three Canadian newborns during their lifetimes if current cancer risks are not reduced. Lung and breast cancers are, respectively, the leading causes of premature death due to cancer among men and women. Compared with other countries Canada has low death rates for stomach cancer but high rates for certain smoking-related cancers (those of the lung and of the mouth and throat), leukemia and cancers of the colon, breast and lymphatic tissues. Newfoundland has the highest rates of death from stomach cancer and the lowest rates of death from prostatic cancer, whereas the western provinces have the opposite pattern. The rates of death from lung cancer among men are highest in Quebec, the province with the highest prevalence of smoking. In Canada the overall rates of death from cancer increased by 32% among men from 1951 to 1983. However, among women they declined by 12% from 1951 to 1976 and increased from 1976 to 1983, particularly among those aged 55 to 74. The rising rates of death due to lung cancer were primarily responsible for these increases. Lung cancer will likely displace breast cancer as the leading cancer killer of Canadian women by 1990. Given the relatively low survival rates for cancers caused by smoking and the lack of substantial improvement in rates for the most frequent types of cancer, preventive strategies that include effective measures to reduce tobacco consumption are urgently required.     

长乐、福安鱼露致突变性实验初步结果

从福建长乐、福安两县采集鱼露,用Ames方法检测其致突变性。结果表明,未经过亚硝化的鱼露,其致突变性试验均为阴性;经过亚硝化的鱼露仍有部份致突变性;亚硝化鱼露亚硝酸钠浓度与TA100回变菌落数呈正相关;维生素C有抑制鱼露致突变性且其浓度与TA100回变菌落数呈负相关。     

福建省恶性肿瘤死亡率年龄分布的Logistic曲线拟合

恶性肿瘤的死亡率具有随年龄的增长而升高的趋势。采用Ｌｏｇｉｓｔｉｃ曲线，对福建省恶性肿瘤死亡率资料进行数学模拟，建立恶性肿瘤死亡率年龄分布的数学模型。该模型可以表明福建省恶性肿瘤死亡率年龄分布的规律，同时还可用于预测人群中恶性肿瘤的死亡率和死亡数。     

A PRELIMINARY STUDY OF MIXED FUNCTION OXIDASE ACTIVITY IN GASTRIC MUCOSA AND STOMACH CANCER MORTALITY IN FUJIAN PROVINCE

Mixed function oxidase (MFO) was prepared and analysed for its activity from the mucosa of stomach resected from stomach cancer patients and noncancer ones from counties with different inci- dences of the disease in Fujian Province, which is a high incidence area of gastric cancer in Southeastem China. MFO activity of nonstomach cancer patients in high and low incidence areas is significantly different (p<0.01). MFO activity in stomach cancer and nonstomach cancer patients is also significantly dif- ferent. Meanwhile, differences in the contents of gastric mucosa cytochrome p-450 0f noncancer patients from high and low incidence areas of stomach cancer and in stomach cancer and noncancer ones are not marked (p>0.05). MFO of human gastric mucosa is capable of metabolizing diethylnitrosamine in vitro.     

Frequent Import and Multiple Sources of Dengue Fever have Changed the Epidemic Situation of the Disease in Fujian Province,China

Objective The aim of this study was to update the epidemic situation of dengue fever(DF) and provide new insights for the consideration of disease control in Fujian province,China.Methods Details about DF cases in Fujian reported during 2004–2017 were collected and analyzed.The envelope(E) genes of isolates of dengue virus(DENV) were sequenced for phylogenetic analysis.Results The number of imported DF cases had increased dramatically since 2013,and the source regions expanded from Southeast Asia to South Asia,America,Oceania,and Africa,as well as the surrounding provinces.This resulted in local outbreaks and indigenous cases of DF that occurred more frequently,with 10 of 13 local outbreaks and 85.9%(1,252/1,458) of indigenous cases reported in2013–2017.Compared with only two coastal cities before 2013,four coastal and one inland city in 2013–2017 experienced the local DF outbreaks.The phylogenetic analysis of E genes confirmed that the import of DENV,not only from abroad but also from the surrounding provinces,played an important role in dissemination and local outbreaks of DF in Fujian.Conclusions The frequent import of DF cases from not only abroad but also the surrounding provinces resulted in increased incidence,frequent local outbreaks,and expansion of distribution in Fujian in recent years.There is a need for urgent measures to improve disease control in this province.     

The rs2227481 C>T Polymorphism in the IL22 Gene Promoter Significantly Reduces the Risk of Liver,Lung, and Gastric Cancer in a Han Chinese Population

Cancer is a serious threat to public health and the economy worldwide. Statistical data from the World Health Organization (WHO) in 2018 have demonstrated that lung cancer is the most commonly diagnosed cancer (11.6％ of the total cases) and the leading cause of cancer death (18.4％of the total cancer deaths), closely followed by gastric cancer (5.7％ and 8.2％), and liver cancer (4.7％ and 8.2％)[1]. The situation is similar for these three types of cancer in the Hubei province of China[2]. Interleukin-22 (IL22), a member of the IL-10 family, is regarded as a link between inflammation and cancer. Recent studies have shown that IL22 acts as a tumor promoter and may promote carcinogenesis rather than function in antitumor immunity[3]. Interestingly, evidence of IL22 involvement in carcinogenesis manifests as dysregulation of IL22 expression in patients with many common cancers, including those of the stomach, liver, lung, stoma gut, and skin[4]. Therefore, it is hypothesized that individuals carrying certain genetic variants in the IL22 gene are vulnerable to the challenge of dysimmunity and are more susceptible to cancer. To test this hypothesis, we adopted a two-stage case-control approach to explore the potential contribution of IL22 gene promoter polymorphisms to cancer susceptibility in a Chinese Han population of Hubei province, and further elucidated the specific mechanism underlying the contribution of associated polymorphisms to cancer susceptibility.     

淄博市 2010~2012 年居民恶性肿瘤死因分析

目的 分析淄博市恶性肿瘤死亡率、死亡年龄、性别分布、死因顺位以及死亡水平变化,为制定防控救治措施提供科学依据.方法 从淄博市疾病预防控制中心调取“全国死因登记报告信息系统”中2010～2012年所有淄博市户籍恶性肿瘤死亡个案,采用SPSS 19.0进行统计分析.结果 淄博市恶性肿瘤人群死亡率为189.36/10万,标化死亡率为149.91/10万;恶性肿瘤死亡主要集中于55～＜75岁年龄组;恶性肿瘤死因前5位依次为肺癌、肝癌、胃癌、结直肠癌和食管癌;恶性肿瘤死亡呈逐年上升趋势.结论 恶性肿瘤已经成为严重危害淄博市居民生命健康的疾病.