黄芪、牛磺酸联合辅酶Q_(10)治疗小儿病毒性心肌炎30例

目的探讨黄芪注射液、牛磺酸联合辅酶Q10治疗病毒性心肌炎（VMC）的临床疗效。方法将60例急性VMC患者随机分成两纽，治疗纽用黄芪注射液＋牛磺酸＋辅酶Q10＋常规治疗，对照纽仅用常规治疗。结果治疗纽总有效率96．7％，明显高于对照纽73．3％（P〈0．05），治疗纽治疗后血清肌酸磷酸激酶（CPK）、天冬氨酸转氨酶（AST）及血清乳酸脱氢酶（LDH）较治疗前明显降低，差异有显著性（P〈0，05）；而对照组CPK、AST、LDH治疗前后比较差异均无显著性（P〉0．05）。结论黄芪注射液、牛磺酸联合辅酶Q10治疗VMC具有较好的疗效，值得临床进一步推广。     

黄芪和辅酶Q_(10)联合应用于病毒性心肌炎疗效观察

目的:观察黄芪和辅酶Q10联合应用治疗病毒性心肌炎的疗效及不良反应,以便更好为临床服务。方法:选择急性病毒性心肌炎84例,随机分两组,患者均给常规盐酸吗啉胍、1.6二磷酸果糖、Vit C治疗。治疗组加用黄芪和辅酶Q10联合应用。结果:治疗组显效率为85.71%,总有效率为97.66%,无效率为2.38%,未见不良反应;对照组显效率为57.14%,有效率为30.95%,总有效率为88.09%,无效率为11.90%,未见不良反应。结论:黄芪和辅酶Q10联合应用治疗病毒性心肌炎安全、高效,不良反应少,值得临床推广。     

辅酶Q_(10)辅治急性肾炎60例疗效观察

目的　观察辅酶Q10 辅助治疗急性肾炎 (AGN)的疗效。方法　 118例急性肾炎随机分为联合组和对照组 ,联合组在对照组的治疗基础上加辅酶Q10 ,观察比较两组症状消失时间。结果　联合组在症状消失速度、近期治愈率及减少长期镜下血尿方面均优于对照组 (P <0 .0 5 )。结论　辅酶Q10 对AGN有较理想的治疗疗效     

环磷腺苷葡胺联合辅酶Q10治疗手足口病合并心肌炎的疗效观察

目的:观察环磷腺苷葡胺联合辅酶Q10治疗手足口病合并心肌炎的临床疗效。方法:手足口病合并心肌炎的78例患儿随机分为两组:对照组41例,观察组37例。两组均采用常规治疗,卧床休息,镇静、吸氧、抗病毒、大剂量维生素C滴注等,观察组在对照组基础上加用环磷腺苷葡胺联合辅酶Q10静脉滴注。观察比较两组的临床治疗效果。结果:观察组总有效率为87.80%,对照组总有效率为62.16%,两组比较差异有统计学意义(P<0.05);对照组不良反应发生率为8.1%,观察组不良反应发生率为9.8%,两组比较差异无统计学意义(P>0.05)。结论:环磷腺苷葡胺联合辅酶Q10对手足口病合并心肌炎患儿有较好疗效,不良反应轻微。     

曲美他嗪联合辅酶Q10治疗对慢性心力衰竭患者心功能的影响研究

目的 研究曲美他嗪联合辅酶Q10治疗对慢性心力衰竭患者心功能的影响.方法 选取2019年5月至2020年4月本院收治的60例慢性心力衰竭患者作为研究对象,按照治疗方法不同分为两组,每组30例.在常规治疗的基础上,对照组加用曲美他嗪治疗,观察组在对照组基础上联合辅酶Q10治疗.比较两组hs-CRP水平、实验室相关指标、6 min步行距离、LVEF、临床疗效、用药安全性.结果 治疗后,观察组患者的hs-CRP水平、NT-proBNP、FFA、MDA均低于对照组,SOD水平高于对照组(P<0.05);治疗后,两组6 min步行距离、LVEF、治疗总有效率比较差异具有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义.结论 曲美他嗪联合辅酶Q10治疗慢性心力衰竭患者效果显著,值得临床推广应用.     

中西药物联合治疗病毒性心肌炎的疗效评价

目的 :探讨中西药物联合治疗病毒性心肌炎 (VMC)的疗效。方法 :治疗组 (6 8例 )选用黄芪注射液、美心力 (CAMP)注射液、辅酶 Q10 (C0 - Q10 )胶囊 ,富含维生素 C的水果和严格休息 ;对照组 (5 2例 )选用 GIK极化液、CAMP、C0 - Q10 、富含 Vit C的水果和严格休息。两组患者无禁忌症者均给予β-受体阻滞剂、钙拮抗剂和对症治疗 ,观察治疗前及治疗后 3个月动态心电图、超声心动图、肌酸激酶、柯萨奇病毒 B Ig M、肠道病毒 RNA的变化 ;治疗后随访 6个月柯萨奇病毒 B Ig M、肠道病毒 RNA的变化。结果 :治疗后治疗组与对照组比较 ,心律失常减少 (P<0 .0 1 ) ,肌酸激酶明显下降 (P<0 .0 1 ) ,治疗后 6个月 ,治疗组治疗前后肠道病毒 RNA明显下降 (P<0 .0 1 ) ,与对照组比较肠道病毒 RNA明显下降差异有显著性意义 (P<0 .0 5 ) ,结论 :采用中西药物联合治疗方案是治疗VMC有效途径之一     

磷酸肌酸钠联合辅酶Q10治疗心肌损害患儿的疗效观察

目的:探讨磷酸肌酸钠联合辅酶Q10治疗心肌损害患儿的临床疗效。方法:选取心肌损害患儿128例,随机分为对照组和观察组,每组各64例。两组患儿均给予常规治疗,在此基础上,对照组患儿采取1,6-二磷酸果糖(FDP)治疗,观察组患儿采取磷酸肌酸钠联合辅酶Q10治疗,观察比较两组患儿临床治疗效果及治疗前后心肌酶及心肌肌钙蛋白I(c Tn I)变化情况。结果:观察组患儿治疗总有效率95.31%,明显高于对照组的75.00%(P<0.05);治疗后,两组患儿心肌酶及c Tn I均明显降低(P<0.05),而观察组患儿心肌酶降低更明显(P<0.05)。结论:磷酸肌酸钠联合辅酶Q10可有效治疗心肌损害患儿,恢复心肌功能,可推广应用。     

冠心病早期心功能减退治疗中应用阿托伐他汀联合辅酶Q10的疗效观察

目的:观察阿托伐他汀联合辅酶Q10治疗冠心病早期心功能减退的疗效。方法:选取2016年7月-2017年7月于我院治疗的冠心病早期心功能减退患者112例,将其随机分为对照组及观察组,各56例,对照组口服阿托伐他汀治疗,观察组在此基础上加用辅酶Q10口服治疗,观察两组患者的临床疗效、心功能指标变化、不良反应发生率及生存质量变化。结果:观察组患者整体临床疗效、心功能变化及生存质量均优于对照组,差异有统计学意义(P<0.05);两组不良反应发生率对比差异无统计学意义(P>0.05)。结论:阿托伐他汀联合辅酶Q10治疗冠心病早期心功能减退具有显著临床优势,值得推广及进一步探讨。     

曲美他嗪和辅酶Q10治疗稳定性劳力型心绞痛的对比研究

目的:对比研究曲美他嗪和辅酶Q10治疗稳定性心绞痛的疗效。方法:选择108例稳定性劳力型心绞痛,随机分成曲美他嗪组54例,辅酶Q10组54例,两组常规治疗(阿司匹林联合单一的硝酸酯制剂或β阻滞剂或钙通道阻滞剂)相同,曲美他嗪组给予曲美他嗪20mg,每天三次口服,辅酶Q10组给予辅酶Q1020mg,每天三次口服,疗程均为12周。观察临床疗效指标改善情况。结果:曲美他嗪组心绞痛及心电图改善分别为94.4%和68.5%,辅酶Q10组分别为88.9%和59.3%。组间比较差异有显著意义(P<0.05)。结论:曲美他嗪治疗稳定性劳力型心绞痛的疗效优于辅酶Q10。     

阿托伐他汀、辅酶Q10联合应用治疗冠心病早期心功能减退效果评价

目的探讨阿托伐他汀、辅酶Q10联合应用治疗冠心病早期心功能减退效果。方法选取我院2014年5月至2015年11月所收治的64例冠心病患者,分为两组,观察组及对照组,每组各32例,对照组运用阿托伐他汀进行治疗,观察组则以阿托伐他汀、辅酶Q10联合治疗,比较两组患者的临床疗效及心功能指标。结果观察组患者的临床治疗总有效率为31(96.87%),明显高于对照组的25(78.12%),且观察组患者的心功能指标明显优于对照组,差异具有统计学意义(P0.05)。结论阿托伐他汀、辅酶Q10联合治疗对于冠心病患者早期心功能减退具有较为良好的改善效果,可以安全有效的改善患者的心功能,优化疗效。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.