单边外固定器加简单内固定治疗不稳定的胫腓骨骨折

目的:探讨单边外固定器加简单内固定治疗不稳定胫腓骨骨折的经验。方法:对46例粉碎性、斜型、螺旋型等不稳定胫骨骨折,采用单边固定器外固定加简单内固定(螺钉、钢丝、克氏针、丝线或可吸收缝线)。结果:经术后随访,平均愈合时间8个月,骨不连再手术2例,再移位3例。结论:单边外固定器加简单内固定治疗不稳定胫骨骨折可以弥补单边外固定器固定不牢固的特点,扩大了其适用范围。     

胫骨开放骨折单臂外固定架治疗体会

目的探讨单边外固定架固定治疗开放性、闭合性胫骨干骨折时采用小切口切开复住的临床效果。方法自2000-2003年收治的71倒胫骨骨折,采用小切口有限内固定加外固定器治疗复杂性胫腓骨骨折,取得满意疗效。结论单侧外固定支架具有操作简单、损伤小、骨折愈合快等优点,是固定胫腓骨中下段开放骨折的有效方法之一。     

有限内固定加单边多功能外固定器治疗粉碎性胫腓骨骨折

目的介绍有限内固定加单边多功能外固定器治疗粉碎性胫腓骨骨折的经验.方法对32例较复杂粉碎性胫腓骨骨折,采用小切口有限内固定(螺钉、钢丝、克氏针、丝线或可吸收缝线)后加单边多功能外固定器固定.结果术后随访10个月～24个月,平均愈合时间4个月～5个月,骨不连再手术3例,再移位2例.结论小切口有限内固定结合外固定器治疗复杂胫腓骨骨折可以避免伤口并发症,缩短骨折愈合时间,减少骨折延迟愈合、骨不连的出现,是治疗复杂粉碎性胫腓骨骨折的有效方法.     

应用单边式骨外固定架联合植骨治疗胫骨骨折骨不连

目的观察单边式骨外固定架联合植骨治疗胫骨骨折骨不连的疗效。方法自1999年5月-2008年9月应用单边式骨外固定器并植骨治疗胫骨骨折骨不连22例。结果患者平均住院时间16d,术后2个月～5个月骨折愈合,平均3．2个月。结论外固定支架加植骨治疗胫骨骨折骨不连是一种既简便又切实可行的治疗方法。     

有限内固定加单边多功能外固定器治疗粉碎性胫腓骨骨折

目的：介绍有限内固定加单边多功能外固定器治疗粉碎性胫腓骨骨折的经验。方法：对32例较复杂粉碎性胫腓骨骨折，采用小切口有限内固定（螺钉、钢丝、克氏针、丝线或可吸收缝线）后加单边多功能外固定器固定。结果：术后随访10个月－24个月，平均愈合时间4个月－5个月，骨不连再手术3例，再移位2例。结论：小切口有限内固定结合外固定器治疗复杂胫腓骨骨折可以避免伤口并发症，缩短骨折愈合时间，减少骨折延迟愈合、骨不连的出现，是治疗复杂粉碎性胫腓骨骨折的有效方法。     

单边三维外固定架治疗胫骨骨折83例临床观察

目的 探讨应用单边三维外固定架治疗胫骨骨折的临床疗效。方法 对83例(91例)胫骨骨折病例进行三维外固定架固定治疗，其中19侧辅以拉力螺丝钉等有限内固定。结果平均随访11个月，骨折固定稳定可靠，除1例骨折不愈合经植骨Ⅱ期愈合外全部愈合，愈合时间短，无骨髓炎、断钉等并发症，膝踝关节功能恢复良好。结论 应用单边三维外固定架治疗胫骨骨折具有操作简单安全，疗效确定，病人康复快的特点。     

单边球柱式外固定器的研制与应用

目的:介绍新型单边球柱式外固定器的研制并观察其治疗胫腓骨骨折的疗效.方法:采用金属与尼龙制作单边球柱式外固定器,治疗胫腓骨骨折30例,与交锁髓内钉治疗胫腓骨骨折30例做对比,并评价其疗效.结果:外固定组在下床活动时间、骨折愈合率及临床骨折愈合时间方面优于髓内钉对照组.结论:单边球柱式外固定器适合治疗胫腓骨骨折,操作简单,固定牢靠,便于应用.     

单侧多功能外固定器治疗胫骨不稳定骨折的体会

目的：探讨单侧多功能外固定器在治疗胫骨不稳定骨折的作用。方法：对单胫骨不稳定骨折24例采用单侧多功能外固定器固定。结果：获得满意骨性愈合19例,针道感染1例,术后再移位1例,再骨折1例,骨不连1例。结论：只要操作得当,利用单侧多功能外固定器治疗不稳定胫骨骨折可获得满意效果。     

外固定器治疗复杂性骨折临床分析

目的：探讨外固定器治疗复杂性骨折临床分析效果。方法：2011年1月～2015年8月,应用外固定器治疗多段骨折3例,Pilon 骨折6例,右胫骨近端骨巨细胞瘤病理性骨折1例,右胫骨远端骨折内固定术不愈合合并骨质疏松1例,左股骨干骨折内固定术感染性不愈合1例,B3型左胫骨干骨折内固定术感染性不愈合1例。必要时结合有限切开内固定。结果：共运用该技术13例,并取得了良好的效果。结论：应用外固定器治疗复杂性骨折,避免了内固定治疗的一些缺陷,显示其特殊的优势。     

小切口有限内固定加单边式骨外固定器治疗老年胫腓骨骨折

目的:探讨小切口有限内固定加单边式骨外固定器治疗老年胫腓骨骨折的疗效情况。方法:分析胫腓骨骨折60例患者的临床资料,依据固定方式不同进行临床分组,对照组30例和观察组30例。结果:观察组老年胫腓骨骨折患者临床治疗的优良率明显高于对照组,差异均有统计学意义(χ2=9.70,P<0.05)。结论:小切口有限内固定加单边式骨外固定器治疗老年胫腓骨骨折患者,操作简便,血运破坏少,并发症少,预后良好,固定刚度可以调控,最大限度地提高了预后的水平,值得临床推广借鉴。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.