腹腔镜阑尾切除术与传统阑尾切除术疗效对比

目的：比较腹腔镜阑尾切除术（laparoscopic appendectomy，LA）与传统剖腹阑尾切除术（openappendectomy，OA）的临床疗效。方法：将156例阑尾炎病例随机分成两组，一组72例行LA，另一组84例行OA．比较两种术式的手术时间、平均住院费用、住院时间，切口长度、术后镇痛剂应用、术后6h开始下床活动、术后24h内肛门排气例数、放置引流管率、切口感染等指标。结果：LA组的术后24h内肛门排气时间、放置引流管率、切口感染、平均住院时间、切口长度、粘连性肠梗阻、镇痛剂应用例数、术后6h开始下床活动例数与OA组比较，差异均有统计学意义（P〈0.05）；而两组手术时间比较差异无统计学意义（P〉0.05）；LA组住院费用较OA组明显增高（P〈0.05）。结论：LA与OA比较，有手术损伤小、疼痛轻、恢复快、住院时间短、并发症少等优点，可作为大多数阑尾炎的首选手术方式。     

腹腔镜阑尾切除术与传统手术疗效的比较

目的研究对比传统开腹阑尾切除术(open appendectomy,OA)和腹腔镜阑尾切除术(laparoscop icappendectomy,LA)的临床疗效。方法随机将193例阑尾炎患者分为两组,LA组85例,OA组108例。比较两种术式在手术时间、术后24h内肛门排气率、切口感染率、术后镇痛剂应用、平均住院时间和费用等。结果 LA组手术时间明显短于OA组(P<0.01),LA组术后24h内肛门排气率、放置引流管率、切口感染率、粘连性肠梗阻发生率、镇痛剂应用率也明显低于OA组,平均住院时间也较OA组短(P<0.01),LA组住院费用明显高于OA组(P<0.01)。结论 LA具有手术损伤小,出血少,患者疼痛轻、恢复快、并发症少、住院时间短等优点,可作为多数阑尾炎患者的首选术式。     

腹腔镜与传统开放阑尾切除术的比较研究

目的对比分析隐蔽三孔法腹腔镜阑尾切除术(LA)与传统开放阑尾切除术(OA)在治疗阑尾炎中的手术效果。方法将137例阑尾炎病例随机分为两组,一组65例行隐蔽三孔法LA,另一组72例行OA。比较两种术式的手术时间、术后肛门排气时间、住院时间、住院费用、止痛剂使用率、放引流管率、切口感染发生率、粘连性肠梗阻发生率等。结果LA组术后肛门排气时间、住院时间、止痛剂使用率、放引流管率、切口感染发生率、粘连性肠梗阻发生率均较OA组明显降低(P<0.05),两组手术时间的差异无统计学意义(P>0.05),LA组住院费用较OA组明显增加(P<0.05)。结论隐蔽三孔法LA具有切口小、隐蔽,双极电凝阶梯凝闭法简单有效,阑尾根部以可吸收线Roeder结套扎安全简便,无异物残留等优点,与OA相比,行LA者创伤小、恢复快、并发症少和住院时间短,可作为绝大多数阑尾炎的首选术式。     

腹腔镜与开腹阑尾切除术的临床分析

目的观察比较腹腔镜与开腹阑尾切除术的临床疗效。方法回顾分析30例腹腔镜阑尾切除术﹙LA﹚和同期开腹阑尾切除术﹙OA﹚30例的手术资料,对2组手术时间、术后肛门排气时间、术后止痛剂的使用、切口感染、平均住院天数、术后下床活动时间、术后并发症及住院费用等进行比较。结果 LA组手术时间、术后排气时间、下床活动时间、止痛剂的使用、切口感染、粘连性肠梗阻情况、住院天数与OA组比较,差异均有统计学意义﹙P〈0.01﹚,但住院费用较OA组高。结论 LA与OA相比较,有手术损伤小,疼痛轻,住院时间短,并发症少等优点,在无禁忌证的情况下,可作为大多数阑尾炎的首选手术方式。     

电凝处理阑尾残端在阑尾切除术中的应用探讨

目的探讨电凝处理阑尾残端在阑尾切除术中应用的可行性及其临床疗效。方法回顾性分析江宁医院普外科2007年10月至2008年10收治的行阑尾切除术患者病例152例临床资料,其中阑尾残端传统处理组94例,阑尾残端电凝处理组58例,比较分析2组手术时间、切口长度、术后镇痛剂使用率、放引流管率、切口感染发生率、粘连性肠梗阻发生率、术后6h开始下床活动与术后24h内肛门排气例数等临床资料。结果电凝处理组较传统处理组手术时间缩短（P〈0.05）,而2组切口长度、放引流管率、术后镇痛剂使用率、术后6h开始下床活动例数、术后肛门排气时间、切口感染发生率、肠瘘发生率、阑尾残端脓肿或腹腔脓肿发生情况、阑尾残株炎发生情况、腹腔粘连或粘连性肠梗阻发生率等指标差别不显著（P〉0.05）。结论阑尾切除术中应用电凝处理阑尾残端安全可靠,临床疗效与传统阑尾残端处理方法并无差别,但操作方法简单易行更为便捷。     

腹腔镜与开腹阑尾切除术的临床对比研究

目的比较腹腔镜与开腹行阑尾切除术的临床效果。方法选取35例在我院门诊或住院行腹腔镜阑尾切除术(LA)治疗急性阑尾炎患者的临床资料,同时选取同期行开腹阑尾切除术(OA)的35例患者的临床资料,对比两种手术方式的手术时间、术中出血量、术后肛门排气时间、术后止痛药使用、住院时间、住院费用、切口感染和粘连性肠梗阻等指标。结果LA组的腹腔内其他病变探查率、术后肛门排气时间、下床时间、止痛药使用、切口感染发生、粘连性肠梗阻、腹腔残余感染情况及住院费用与OA组比较,差异均有统计学意义(P0.01)。手术时间两组差异无统计学意义(P0.05)。结论LA与OA相比具有创伤小、恢复快、住院时间短、美容等优点,在无禁忌证的情况下,可推荐患者行LA。     

腹腔镜阑尾切除术468例分析

目的探讨腹腔镜阑尾切除术(laparosc opic appendectomy,LA)的临床效果。方法我院2005年6月～2010年6月收治阑尾炎810例,随机分为两组,其中468例采用LA,另外342例采用传统剖腹阑尾切除术(open appendectomy,OA),对两组患者术后的手术时间、平均住院时间、切口平均长度及术后感染情况等进行比较。结果 LA组的平均住院时间、住院费用、切口长度、切口感染率及术后肛门排气例数均显著优于0A组(P0.05),两组患者的平均手术时间及住院时间无显著差异(P0.05)。结论腹腔镜阑尾切除术具有创伤小、恢复快、住院时间短、切口感染率低等优点,可作为大多数阑尾炎的首选手术方式。     

开放式阑尾切除术与腹腔镜阑尾切除术的临床效果比较

目的对比分析隐蔽三孔法腹腔镜阑尾切除术(LA)与开放阑尾切除术(oA)的治疗效果。方法将185例阑尾炎病例随机分为两组,一组87例行LA,另一组98例行OA。比较两种术式的平均手术时间、术后胃肠功能恢复时间、出血量、住院天数、切口感染、住院费用,以及术后粘连性肠梗阻发生情况。结果两组手术时间的差异无统计学意义(p>0.05),LA组术后胃肠功能恢复时间、出血量、住院时间、切口感染发生率、粘连性肠梗阻发生率均较OA组明显降低(p<0.05),LA组住院费用较OA组明显增加(p<0.05)。结论LA具有切口小、隐蔽,无异物残留等优点,与OA相比,行LA手术者创伤小、并发症少和住院时间短。     

腹腔镜阑尾切除术与开腹阑尾切除术的比较分析

目的比较开腹阑尾切除和腹腔镜阑尾切除术的临床疗效。方法将120例急性阑尾炎患者分成两组:腹腔镜组(LA)80例,开腹手术组(OA)40例,比较两组患者的手术时间、术中出血量、肛门排气时间、住院时间、住院费用、术后切口感染发生率。结果 LA组术中出血量明显少于OA组(P0.01),且LA组肛门排气时间、术后住院天数及切口感染率均少于OA组(P0.05),LA组住院总费用略高于OA组,手术时间少于OA组,但差异无统计学意义(P0.05)。结论用超声刀行腹腔镜阑尾切除术具有创伤性小、机体恢复快、并发症和后遗症少及平均住院时间短等优点,值得临床推广应用。     

腹腔镜与开腹阑尾切除术在急性穿孔性阑尾炎治疗中的疗效分析

目的：比较分析腹腔镜和开腹阑尾切除术在治疗急性穿孔性阑尾炎中的手术效果。方法：采用回顾性分析的方法,以2007年1月～2009年12月就诊于我院的穿孔性阑尾炎并行手术治疗的患者为研究对象,其中行开腹阑尾切除术（open appendectomy,OA）30例,行腹腔镜阑尾切除术（laparoscopic appendectomy,LA）25例。结果：LA组的手术费用高于OA组,LA组的手术时间长于OA组,但是LA组患者术后排气时间、进食时间、下床活动时间早于OA组,住院天数少于OA组,LA组切口感染、腹腔感染和肠梗阻发生率要低于OA组。两组比较,差异有统计学意义（P〈0.05）。结论：腹腔镜治疗穿孔性阑尾炎具有创伤小、恢复快、术后并发症少等优点,是一种安全、可靠、有效的治疗方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.