疏血通联合依达拉奉注射液治疗急性脑梗死疗效观察

目的 观察疏血通注射液联合依达拉奉注射液治疗急性脑梗死的临床疗效.方法 将入选患者随机分为治疗组(48例)和对照组(40例),治疗组在基础及常规治疗上予以疏血通注射液6mL加入生理盐水250mL静脉输注,1次/日同时给予依达拉奉30mg加入生理盐水100mL静脉滴注,每日两次,连用21d;对照组仅用同剂量、同疗程疏血通,比较两组治疗前后的临床神经功能缺损程度.结果 治疗组总有效率为95.82%,对照组总有效率为77.50%,差异有统计学意义(P＜0.05).结论 疏血通联合依达拉奉注射液治疗急性脑梗死疗效优于单用疏血通治疗.     

疏血通注射液联合丹参注射液治疗急性脑梗死疗效分析

目的探讨疏血通注射液联合丹参注射液治疗急性脑梗死疗效。方法选取我院2006年3月至2008年3月同期住院患者急性脑梗死患者86例,随机分为对照组和治疗组,对照组给予维脑路通0.6g加入低分子右旋糖酐500mL中静滴,每日1次。治疗组治疗组给予疏血8mL,5%葡萄糖或氯化钠注射液250mL中静滴,每天1次;丹参注射液20mL,加入5%葡萄糖注射液500mL静脉滴注,每日1次。观察2组治疗前后神经功能缺损评分,评定疗效。结果2组总显效率有显著差异性（P〈0.01）,治疗组优于对照组。结论疏血通注射液联合丹参注射液治疗急性脑梗死疗效显著,值得推广。     

疏血通注射液联合奥扎格雷钠治疗急性脑梗死疗效分析

目的观察疏血通注射液联合奥扎格雷钠治疗急性脑梗死的临床疗效。方法 142例确诊的急性脑梗死患者,随机分为观察组和对照组各71例,2组患者均酌情给予降血压、降血糖、保护脑细胞、降颅压等综合治疗;在此基础上对照组给予疏血通注射液6 mL加入50 g.L-1葡萄糖250 mL中,每日1次静脉滴注;观察组在对照组的基础上给予奥扎格雷钠80 mg加入250 mL生理盐水中,每日1次静脉滴注;均治疗14 d。结果治疗后观察组总有效率明显高于对照组(P<0.05),治疗后2组神经功能缺损评分均较治疗前显著降低(P<0.05),且观察组神经功能缺失评分显著低于对照组(P<0.05)。结论疏血通注射液联合奥扎格雷钠治疗急性脑梗死疗效确切。     

奥扎格雷钠联合疏血通注射液治疗急性脑梗死疗效观察

目的观察奥扎格雷钠联合疏血通治疗急性脑梗死的疗效。方法将54例确诊为脑梗死的患者随机分为治疗组29例和常规对照组25例,2组均常规控制血压、颅压、对症支持治疗。对照组应用低分子右旋糖酐500 mL、川芎嗪80 mg1日1次静脉滴注,连用2周;治疗组给予奥扎格雷钠80 mg溶于生理盐水250 mL,加用疏血通注射液8 mL加入生理盐水250 mL中1日1次静脉滴注,连用2周。结果治疗组临床疗效及神经功能缺损评分改善情况均较对照组有显著差别（P〈0.05）,治疗过程中无不良反应发生。结论奥扎格雷钠联合疏血通治疗急性脑梗死临床疗效确切、安全。     

赤芍801加水蛭素治疗急性脑梗死疗效观察

目的:观察赤芍801加水蛭素治疗急性脑梗死的临床疗效。方法:选取185例急性脑梗死,按入院顺序随机分为治疗组101例、对照组84例。治疗组用赤芍801注射液6ml加入5%葡萄糖或生理盐水250ml中静脉滴注,1次/d,连用14天。并同时给予水蛭素注射液6 ml加入5%葡萄糖液250 ml中静脉滴注,1次/d,连用7天。对照组仅用赤芍801注射液6ml加入5%葡萄糖或生理盐水250ml中静脉滴注,每日治疗次数和疗程同治疗组。两组患者视病情轻重及合并症给予脱水剂、降血压、降血糖等治疗。结果:治疗组疗效明显优于对照组,具有显著性差异(P<0.05)。结论:赤芍801加水蛭素静滴治疗急性脑梗死安全、有效,无毒副作用。     

赤芍801加水蛭素治疗急性脑梗死疗效观察

目的观察赤芍801加水蛭素治疗急性脑梗死的临床疗效.方法选取185例急性脑梗死,按入院顺序随机分为治疗组101例、对照组84例.治疗组用赤芍801注射液6ml加入5%葡萄糖或生理盐水250ml中静脉滴注, 1次/d,连用14天.并同时给予水蛭素注射液6 ml加入5%葡萄糖液250 ml中静脉滴注,1次/d,连用7天.对照组仅用赤芍801注射液6ml加入5%葡萄糖或生理盐水250ml中静脉滴注,每日治疗次数和疗程同治疗组.两组患者视病情轻重及合并症给予脱水剂、降血压、降血糖等治疗.结果治疗组疗效明显优于对照组,具有显著性差异(P＜0.05).结论赤芍801加水蛭素静滴治疗急性脑梗死安全、有效,无毒副作用.     

舒血宁注射液治疗脑梗死30例临床疗效分析

目的：探讨舒血宁对脑梗死的疗效。方法：对2006年10月-2007年10月住院的62例脑梗死病人随机分为两组，治疗组用舒血宁注射液20ml加入5％葡萄糖或生理盐水250ml中静滴每日1次，对照组用5％葡萄糖250ml加盐酸川芎嗪注射液120mg静滴，每日1次，按1995年全国脑血管病学术会议制定的脑梗死判定标准判断疗效。结果：治疗组用药前后血液流变学各项指标均显著改善，P〈0．05。结论：舒血宁注射液治疗脑梗死疗效好。     

银杏达莫联合路路通治疗急性脑梗死的临床观察

目的观察银杏迭莫联合路路通注射液治疗急性脑梗死的疗效和安全性。方法将65例急性脑梗死患者随机分为治疗组33例和对照组32例。两组均给予路路通注射液20ml加入5％葡萄糖注射液250ml中静脉滴注，1次／d，连用14d；治疗组在此基础上，采用银杏达莫注射液20ml加入生理盐水250ml中静脉滴注，1次／d，连用14d。结果治疗组的显效率为54．55％，而对照组的显效率则为37．5％，两者比较差异有统计学意义（P〈o．05）；治疗组的总有效率为87．88％，与对照组的62．5％比较差异有统计学意义（P〈0．01），且未见明显副作用。结论银杏迭莫联合路路通注射液治疗急性脑梗死安全有效。     

奥扎格雷钠联合正康脑明治疗急性脑梗死疗效分析

目的观察奥扎格雷钠联合正康脑明治疗急性脑梗死的临床疗效。方法将90例急性脑梗死病人随机分为治疗组和对照组,在常规治疗的基础上治疗组45例应用奥扎格雷钠80mg加入生理盐水250mL静脉滴注,每日2次,同时给予正康脑明400mg,加入5％葡萄糖250mL静脉滴注,每日1次,连用14d。对照组45例采用复方丹参注射液20mL加入低分子右旋糖酐注射液500mL静脉滴注,连用14d。结果两组患者治疗前神经功能缺损比较无统计学意义（P〈0．05）,治疗2周后,治疗组显效率及总有效率显著高于对照组,差异有统计学意义（P〈0．05）。结论奥扎格雷钠联合正康脑明治疗急性脑梗死临床疗效显著,安全可行。     

疏血通注射液治疗急性脑梗死的临床观察

目的观察疏血通注射液治疗急性脑梗死的临床疗效和安全性。方法70例急性脑梗死患者随机分为对照组和观察组各35例,对照组给予灯盏花素注射液50mg加生理盐水250ml静滴,每日1次,连用14d。观察组给予疏血通注射液6ml加生理盐水250ml静滴,每日1次,连用14d。14d后判定两组的临床疗效和进行神经功能缺损评分。结果观察组临床显效率和总有效率分别为74.3%和91.4%,优于对照组的51.4%和68.6%,差异有统计学意义(P0.05);两组治疗后神经功能缺损评分均较治疗前明显下降,且观察组优于对照组(P0.05)。结论疏血通注射液治疗急性脑梗死是安全及有效的,值得临床推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.