经颞路及经鼻蝶窦入路开颅手术患者给予帕瑞昔布的镇痛效果及焦虑缓解

目的探讨帕瑞昔布(PS)对经颞、鼻蝶窦入路开颅手术患者术后镇痛效果及焦虑情绪的影响。方法将择期行经颞、鼻蝶窦入路开颅手术患者90例,随机分为A组、B组及C组,各30例。A组术前20min予以40mg PS静注,B组术毕予以40mg PS静注,C组术毕予以10mL生理盐水静注。比较三组术前(T_0)、术后2h(T_1)、6h(T_2)、12h(T_3)、24h(T_4)及48h(T_5)各时间点的疼痛评分(VAS)、焦虑评分(SAS)、血浆皮质醇(Cor)含量及血清β-内啡肽(β-EP)及术后不良反应。结果 T_1~T_4各时间点,A组及B组的VAS评分、SAS评分、β-EP及Cor浓度均显著低于C组(P0.05),且A组显著低于B组(P0.05);T_5时A组的β-EP及Cor浓度显著低于B组及C组(P0.05);术后48h内,A组、B组的颅痛定使用率及焦虑、躁动发生率均显著低于C组(P0.05)。结论 PS对经颞、鼻蝶窦入路开颅手术患者具有镇痛及抗焦虑作用,能够降低应激反应,且术前给药效果更好。     

氟比洛芬酯与曲马多开颅术后镇痛的临床效果比较

目的比较氟比洛芬酯与曲马多用于颅脑手术术后镇痛的临床效果及不良反应。方法选择择期颅脑手术术后患者60例,随机分为两组,每组30例。A组：于手术结束前30min静脉给予氟比洛芬酯1．5mg／kg,B组于手术结束前30min静脉给予曲马多2mg／kg,观察术后1h、3h、6h内的疼痛视觉模拟评分（visual analogue scale,VAS）、镇静、恶心、呕吐现象,记录血氧、心率、呼吸频率。结果A组各时段镇痛满意程度明显高于B组（P〈0．05）;不良反应中恶心、呕吐普遍低于B组（P〈0．05）;结论氟比洛芬酯静脉推注用于颅脑手术术后镇痛效果确切,不良反应发生率较曲马多显著降低。     

帕金森病伴慢性疼痛的临床调查分析

目的 初步研究帕金森病(PD)患者伴慢性疼痛的发生与分布情况、与疾病发展的关系以及对生活质量的影响.方法 对113例原发性PD患者进行视觉模拟评分法(VAS)、简易疼痛量表(BPI)、统一PD评分量表(UPDRS)、Hoehn-Yahr(H-Y)分期、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HRSD)、匹兹堡睡眠质量指数(PSQI)等评估.将患者分为无疼痛组、PD相关慢性疼痛组及非PD相关慢性疼痛组,其中PD相关慢性疼痛组再分为直接相关组和间接相关组.对各组进行分析比较.结果 PD相关慢性疼痛的发生率为42.5%(48/113).与无疼痛组相比,PD相关慢性疼痛组患者的起病早、病程长,且UPDRS Ⅲ评分、H-Y分期、HRSD、HAMA分值以及左旋多巴剂量均高于无疼痛组,差异均具有统计学意义;PD相关慢性疼痛组患者与非PD相关慢性疼痛组相比,其起病年龄(57.4±9.6与65.9±8.7,t=-2.596,P=0.012)、HRSD(12.9±7.9与8.7±3.7,t=2.605,P=0.014)以及疼痛强度VAS(61.6±25.9与38.0±30.1,U=-2.290,P=0.022)差异具有统计学意义.对PD直接疼痛及间接疼痛相关组的BPI 7项指标进行比较,除行走与交流能力外,其余5项指标的分值在直接相关组更高,两者差异具有统计学意义.结论 疼痛在PD患者中很普遍,其中绝大多数为PD相关慢性疼痛,患者起病早且生活质量较差.     

昂丹司琼预防曲马多术后静脉镇痛所致恶心呕吐的疗效观察

目的观察昂丹司琼对曲马多术后静脉镇痛所致恶心呕吐的预防作用。方法 200例择期骨科手术并接受曲马多术后静脉自控镇痛(PCIA)患者随机分为2组,每组100例。A组于手术结束前30 min给予昂丹司琼8 mg,并给予曲马多1 mg/kg负荷量。B组于手术结束前30 min给予胃复安10 mg,并给予曲马多1 mg/kg负荷量,然后接PCIA。记录2组术后4、8、12、24、364、8 h患者VAS评分及恶心呕吐情况。结果术后4、8、12、24、36、48 h VAS评分差异无统计学意义,术后恶心、呕吐发生率A组比B组显著降低(P<0.05或P<0.01)。结论昂丹司琼用于预防曲马多术后静脉镇痛所致的恶心呕吐比胃复安更加有效。     

曲马多预先给药对切口痛大鼠脊髓NOS活性和NO含量的影响

目的评价曲马多对切口痛大鼠脊髓NOS活性和NO含量的影响,探讨曲马多镇痛效应的机制。方法成年雄性SD大鼠24只,体质量200～250g,随机分为3组,每组6只,对照组(C组)仅给与麻醉及腹腔注射生理盐水5ml,切口痛组(Ⅰ组)于手术前30min腹腔注射生理盐水5ml,曲马多组(T组)于手术前注射曲马多10mg/kg。制备大鼠右后爪切口痛模型,采用累积疼痛评分法评定痛行为学,于术前30min和术后2h测定大鼠机械痛阈和热痛阈,并测定脊髓NOS活性和NO含量。结果与对照组比较,术后2h切口痛组大鼠的累计疼痛评分明显升高(P<0.01),机械痛阈和热痛阈明显降低(P<0.01)。与切口痛组比较,曲马多组术后2h的疼痛累计评分明显降低(P<0.01),机械痛阈和热痛阈明显升高(P<0.01)。与对照组比较,切口痛组NOS活性和NO含量均明显增加(P<0.01)。与切口痛组比较,曲马多组NOS活性,NO含量均明显减少(P<0.01)。结论曲马多10mg/kg腹腔内预先给药,术后疼痛累积评分明显降低,机械痛阈和热痛阈升高,并且能使脊髓NOS活性明显降低,NO含量明显减少。     

全麻下腹部手术患者的围术期睡眠质量对术后恢复的影响

目的探讨全麻患者围手术期睡眠质量对腹部手术患者术后胃肠功能恢复、疼痛程度及麻醉药物用量的影响。方法纳入2018年2月~2019年10月在XX医院胃肠外科行全麻手术的胃肠道疾病患者100例,术前1天采用匹兹堡睡眠质量指数量表对患者近1月睡眠状况进行评估,分为睡眠障碍组和对照组,比较两组患者围手术期麻醉药品丙泊酚、瑞芬太尼用量、记录两组患者术后胃肠道功能恢复情况、采用疼痛视觉模拟评分量表(VAS)对患者术后疼痛状况进行评分,于出院时采用多维疲乏量表对患者围手术期疲劳程度进行评分。结果睡眠障碍组围手术期丙泊酚用量高于对照组(P<0.05);(2)睡眠障碍组术后首次排气时间、肠鸣音恢复时间、首次排便时间高于对照组(P<0.05);(3)术后12h、24h、48h、72h两组VAS评分均呈下降趋势(F趋势=34.991,15.799,P<0.05);睡眠障碍组术后12h、24h、48h、72h VAS评分高于对照组(P<0.05);(4)MFI-20评分显示,睡眠障碍组心理疲劳、躯体疲劳、精神疲劳及平均疲劳程度评分高于对照组(P<0.05);结论伴有睡眠障碍的腹部手术患者其围手术期丙泊酚用量更大、术后疼痛感更强,更易感觉疲劳,术后胃肠道功能恢复更慢。     

劳拉西泮缓解脊膜瘤切除术后伤口疼痛临床研究

目的探讨劳拉西泮对行脊膜瘤切除术的患者术后伤口疼痛和焦虑情绪的缓解作用。方法共106例气管插管全身麻醉下行脊膜瘤切除术患者随机分为劳拉西泮组(53例)和对照组(53例),劳拉西泮组于手术前一晚和术后6 h服用劳拉西泮0.50 mg、对照组于手术前一晚和术后6 h服用复合维生素B,分别于术前和术后48 h采用Mc Cormick神经功能分级和焦虑自评量表(SAS)评价脊髓功能和焦虑情绪,术后48 h采用视觉模拟评分(VAS)评价术后伤口疼痛程度。结果两组患者均于手术显微镜下全切除肿瘤,并安全度过围手术期,无一例发生感染等手术相关并发症,术后神经功能均不同程度恢复,无神经功能损害加重患者。与对照组相比,劳拉西泮组患者术后48 h SAS评分降低(P=0.000);与治疗前相比,术后48 h劳拉西泮组患者SAS评分降低(P=0.000)。劳拉西泮组患者术后48 h VAS评分低于对照组[(5.40±1.24)分对(7.15±1.12)分;t=7.593,P=0.000]。结论脊膜瘤切除术患者术前和术后应用劳拉西泮抗焦虑治疗,可以有效缓解术后伤口疼痛。     

氟比洛芬酯联合罗哌卡因棉球用于小儿扁桃体术后镇痛的观察

目的探讨氟比洛芬酯联合罗哌卡因棉球用于小儿扁桃体切除术后镇痛的效果。方法择期扁桃体切除术患儿60例,ASA分级Ⅰ级,年龄6～12岁,随机分为RF组(氟比洛芬酯联合罗哌卡因组)、R组(罗哌卡因组)、F组(氟比洛芬酯组)各20例。术前15 min,RF组静注氟比洛芬酯1 mg/kg,F组静注氟比洛芬酯1.5 mg/kg,R组静注生理盐水1 mg/kg。RF组与R组在扁桃体切除止血彻底时,用0.5%的罗哌卡因棉球紧紧填塞于扁桃体窝5 min;F组用生理盐水棉球填塞5 min取出棉球。术后采用视觉模拟评分法(visual analogue scale,VAS)评估患儿术后拔管即刻(T0)、术后30 min(T1)、2 h(T2)、4 h(T3)、8 h(T4)、6 h(T5)、12 h(T6)、24 h(T7)的疼痛评分,记录患儿首次追加镇痛药时间、例数以及苏醒期躁动的发生率、恶心、呕吐及呼吸抑制等不良事件的发生率。结果 RF组各时点的VAS评分低于F组与R组(P0.05);R组T0～T4的VAS评分低于F组(P0.05);RF组术后首次追加镇痛药的时间长于R组和F组(P0.05);RF组和R组发生苏醒期躁动的比例低于F组(P0.05)结论氟比洛芬酯联合罗哌卡因用于小儿扁桃体切除术后镇痛效果确切。     

右美托咪定复合曲马多在开颅术后镇痛镇静效果的临床观察

目的 观察右美托咪定(Dex)复合曲马多对开颅术后病人镇痛和镇静的效果.方法 60例择期开颅手术病人随机分为对照组、Dex 0.2 μg组和Dex 0.4μg组,每组20例.Dex 0.2 μg组和Dex 0.4μg组均于麻醉诱导前10 min静脉泵人Dex(1μg/kg),而后再分别以0.2、0.4 μg/(kg·h)的速率泵注至术后24h.3组均于硬脑膜缝合完毕时静脉注射曲马多(1.5 mg/kg),术毕连接镇痛泵.并根据视觉模拟量表(VAS)评分、镇痛泵总按压次数和Ramsay评分等指标评价3组开颅术后镇痛、镇静的效果.结果 VAS评分:除术后2h外,Dex 0.4 μg组＜Dex 0.2μg组＜对照组(P＜0.05).Ramsay评分:在术后各时间点,Dex 0.2 μg组和Dex 0.4 μg组均显著高于对照组(P＜0.05);术后6～24 h,Dex 0.4μg组均显著高于Dex 0.2 μg组(P＜0.05).镇痛泵总按压次数:Dex 0.4 μg组＜Dex 0.2 μg组＜对照组(P＜0.05).术后恶心呕吐的发生率:Dex 0.4 μg组明显低于Dex 0.2 μg组和对照组(P＜0.05).结论 Dex能提高曲马多的镇痛效果,并可提供良好的镇静作用,减少术后不良反应的发生率.     

脊髓背根入髓区切开术治疗脊髓和马尾神经损伤后慢性疼痛:二例报告并文献复习

目的探讨脊髓背根入髓区切开术治疗脊髓和马尾神经损伤后慢性疼痛之疗效。方法 采用脊髓背根入髓区切开术治疗2例脊髓和马尾神经损伤后慢性疼痛患者,观察术后疗效及并发症。结果术后2周时1例症状明显减轻但仍需口服卡马西平(300 mg/d)、1例症状完全消失且随访3年6个月未出现疼痛,术后无一例发生严重并发症。结论脊髓背根入髓区切开术是治疗脊髓和马尾神经损伤后慢性疼痛的有效方法。     

Administration of MK-801 decreases c-Fos expression in the trigeminal sensory nuclear complex but increases it in the midbrain during experimental movement of rat molars

Various studies reported c-Fos expression in the neurons in the trigeminal sensory nuclear complex (TSNC) following experimental tooth movement, which implies pain transmission to the central nervous system. Meanwhile, MK-801, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, was shown to markedly reduce the expression of c-Fos in the trigeminal subnucleus caudalis (Vc) following noxious stimulation but to enhance c-Fos expression markedly in other brain regions, i.e., the neocortex, dorsal raphe and thalamic nuclei. In the present study, we examined the nature of c-Fos expression in the brainstem including the TSNC and midbrain following administration of MK-801 and/or experimental movement of the rat molars. Twelve hours after the beginning of experimental tooth movement, c-Fos was expressed bilaterally in the superficial laminae of Vc (Vc I/II), dorsomedial areas of the trigeminal subnucleus oralis (Vodm) and rostro-dorsomedial areas of the trigeminal subnucleus oralis (Vor) with the ipsilaterally dominant distribution, but hardly in the periaqueductal gray (PAG), dorsal raphe nucleus (DR) and Edinger-Westphal nucleus (EW). Intraperitoneal administration of MK-801 (0.03, 0.3 and 3.0 mg/kg) prior to the onset of experimental tooth movement reduced c-Fos in the TSNC (Vc I/II, Vodm and Vor) but increased it in the nucleus raphe magnus (NRM), ventrolateral PAG (vl PAG), DR and EW. These results highly emphasize that during experimental tooth movement, a blockade of NMDA receptors induces neuronal suppression in the TSNC but increases neuronal activity in the descending antinociceptive system including the NRM, vl PAG, DR and EW.     

鞘内药物输注系统植入术治疗难治性神经病理性疼痛初步疗效观察

目的观察鞘内药物输注系统植入术治疗难治性神经病理性疼痛的疗效,以及对患者生活质量的改善情况。方法采用鞘内药物输注系统植入术治疗3例典型神经病理性疼痛且药物治疗效果欠佳,或出现严重药物不良反应患者,共随访6~14个月,观察疼痛缓解率、睡眠改善程度、镇痛药物服用剂量及药物不良反应。结果治疗后3例患者视觉模拟评分均显著下降,由术前的中至重度疼痛改善至术后轻度疼痛,爆发痛次数减少;镇痛药物服用剂量约降至术前的10%;睡眠质量明显改善。随访期间均未发生手术相关性并发症和吗啡不良反应。结论鞘内药物输注系统对经鞘内吗啡试验镇痛效果满意的难治性神经病理性疼痛患者具有较为肯定的近期疗效。     

肌病伴微管聚集患者六例临床特点

目的报道6例肌病伴微管聚集患者的临床特点。方法6例就诊于北京大学第一医院神经内科的肌病伴微管聚集的患者，回顾性分析其临床表现，并对所有患者进行肌电图检查和骨骼肌活体组织检查，对标本进行组织学、酶组织化学和电子显微镜检查。结果6例均为男性散发患者，发病年龄5—50岁，例1、2以肢带型肌无力综合征为主要表现，其中例1逐渐出现活动后肌痛；例3出现持续性肌无力伴随多巴反应性肌张力不全；例4、5出现周期发作的四肢无力；例6主要表现为运动后肌痛。所有患者血钾正常，3例患者的血肌酸激酶轻度增高。肌电图检查例1、6出现神经源性损害，例4、5出现肌源性损害，其他2例无异常，例1、2低频重复刺激出现递减现象。所有患者均在Ⅱ型肌纤维内发现异常沉积物，占所有肌纤维的4％-40％。沉积物在改良Gomori三色染色为红色，还原型辅酶Ⅰ四氮唑还原酶染色为显著深染，非特异性酯酶略深染，在琥珀酸脱氢酶和肌丝ATP酶染色不着色。电镜检查显示沉积物为大量平行排列的微管结构。结论肌病伴微管聚集具有不同临床表现类型，可以伴随肌张力不全等其他系统损害，表现为肢带型肌无力综合征的患者也可以出现活动后肌痛。     

体外发散式冲击波治疗带状疱疹后遗神经痛短期疗效观察

目的观察体外发散式冲击波治疗带状疱疹后遗神经痛的临床疗效。方法采用MP100型体外冲击波治疗系统治疗26例带状疱疹后遗神经痛患者,采用视觉模拟评分(VAS)和神经病理性疼痛量表(NPS)评价治疗前、治疗第2次时、治疗第1和第2个疗程时的临床效果。结果 26例患者中2例因治疗不便、2例因疗效欠佳而改用其他方法,其余22例均完成冲击波治疗。第1疗程结束时,疼痛症状不同程度缓解,VAS和NPS评分分别由治疗前的(8.41±1.11)和(1.88±0.59)分降至(6.15±1.23)和(1.38±0.60)分,治疗前后差异具有统计学意义(均P=0.000);第2疗程结束时,疼痛症状显著缓解,VAS和NPS评分持续下降,分别为(3.57±1.30)和(1.04±0.31)分,差异亦有统计学意义(均P=0.000)。结论体外发散式冲击波治疗可显著改善带状疱疹后遗神经痛患者的疼痛症状,是一种带状疱疹后遗神经痛保守治疗的有效方法。     

Brain imaging of visceral functions in healthy volunteers and IBS patients

From experience, most people know about a link between psychological processes and gastrointestinal sensory and motor functions. Cognitive processes (e.g., attention) as well as affective processes (e.g., fear) play a role in gastrointestinal sensations in healthy controls and patients with irritable bowel syndrome (IBS) alike. However, the exact nature of this relationship has not been completely understood yet. Brain imaging techniques allow for the study of brain-gut interactions in vivo. Accordingly, positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) have been widely used to study neural mechanisms underlying visceral sensations. This article will summarize the results of functional brain imaging studies in healthy controls and selected studies assessing the influence of psychological processes on gastrointestinal functions. Subsequently, this article will deal with those brain areas activated by visceral stimulation in IBS patients. Special attention will be paid to recently published studies concerning psychological factors and novel research questions.     

加巴喷丁治疗带状疱疹后遗神经痛疗效的Meta分析

目的 系统评价加巴喷丁治疗带状疱疹后遗神经痛的疗效和安全性.方法 计算机检索美国国立医学图书馆(PubMed)、英国Cochrane图书馆随机对照临床试验资料库、荷兰医学文摘(EMBASE),以及中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)、中国知识基础设施工程(CNKI)和万方数据库,并手工检索相关杂志,由两位研究者独立进行质量评价及数据分析,RevMan 5.0统计软件对数据进行Meta分析.结果 根据Cochrane5.0.2版随机对照临床试验质量评价标准,共纳入5项随机对照临床试验计1225例带状疱疹后遗神经痛患者.结果显示,加巴喷丁组患者平均每日疼痛评分改变高于安慰剂组(SMD=-0.920,95％CI:-1.330～-0.520;P=0.000);简易McGill疼痛问卷平均视觉印象评分改变高于安慰剂组(SMD=-2.650,95％CI:-3.410 ～-1.890;p=0.000);平均每日睡眠干预评分改变高于安慰剂组(SMD=-2.480,95％CI:-3.750～-1.200;P=0.000).加巴喷丁组与安慰剂组失访率差异无统计学意义(P=0.240).治疗期间常见药物不良反应为头晕、嗜睡、水肿等.结论 现有临床证据表明,加巴喷丁治疗带状疱疹后遗神经痛疗效显著,治疗保留率高;但应注意其所引起的头晕、嗜睡、水肿等药物不良反应.     

Influence of transcutaneous nerve stimulation (TNS) on acute pain

Summary Using transcutaneous nerve stimulation (TNS) simple surgical procedures such as tooth extractions and nerve biopsies can be performed without the usual anesthetics.Estimation of threshold and suprathreshold intensities of painful electrical stimuli show no significant change during TNS. Only the threshold for non-painful electrical stimuli is slightly increased. Cortical potentials evoked by electrical peripheral nerve stimulation are not significantly modulated by TNS. Latencies of the early components 0, I–III are unchanged, the amplitudes only slightly reduced.These observations are in contradiction to the gate-control theory of pain.Supported by Sonderforschungsbereich Hirnforschung und Sinnesphysiologie (SFB 70) der Deutschen Forschungsgemeinschaft (DFG) and Bundesminister für Arbeit und Sozialordnung, Bonn-Bad Godesberg, Federal Republic of Germany     

Age changes in pain perception: A systematic-review and meta-analysis of age effects on pain and tolerance thresholds

Demographic changes, with substantial increase in life expectancy, ask for solid knowledge about how pain perception might be altered by aging. Although psychophysical studies on age-related changes in pain perception have been conducted over more than 70 years, meta-analyses are still missing. The present meta-analysis aimed to quantify evidence on age-related changes in pain perception, indexed by pain thresholds and pain tolerance thresholds in young and older healthy adults. After searching PubMed, Google Scholar and PsycINFO using state-of-art screening (PRISMA-criteria), 31 studies on pain threshold and 9 studies assessing pain tolerance threshold were identified. Pain threshold increases with age, which is indicated by a large effect size. This age-related change increases the wider the age-gap between groups; and is especially prominent when heat is used and when stimuli are applied to the head. In contrast, pain tolerance thresholds did not show substantial age-related changes. Thus, after many years of investigating age-related changes in pain perception, we only have firm evidence that aging reduces pain sensitivity for lower pain intensities.     

Pain,pain catastrophizing,and past mental healthcare utilization

Objective

Pain symptoms have been associated with a number of psychiatric disorders, particularly mood and anxiety disorders as well as personality disorders. However, to our knowledge, no study to date has examined pain symptoms in terms of participants' past mental healthcare utilization—the focus of the present study.

Methods

Using a cross-sectional approach and a self-report survey methodology in a sample of 242 consecutive internal medicine outpatients, we examined pain symptoms at assessment, over the past month, and over the past year as well as pain catastrophizing in relationship to 4 mental healthcare variables (i.e., ever seen a psychiatrist, ever been in a psychiatric hospital, ever been in counseling, and ever been on medication for “nerves”).

Results

Only three of the four mental-healthcare-utilization variables were analyzed due to response rate (i.e., ever been hospitalized in a psychiatric hospital was infrequently endorsed and not analyzed), and each demonstrated statistically significant relationships with self-reported pain levels at all three time-points and with pain catastrophizing at the p < .001 level.

Conclusions

In this study, primary care outpatients with histories of mental health treatment evidenced statistically significantly higher levels of pain as well as statistically significantly higher levels of pain catastrophizing than their peers.     

Tolérance à la détresse et expérience de la douleur chronique

IntroductionChronic pain is a highly prevalent condition that is associated with distressing somatic and emotional experiences. Consequently, an individual's distress tolerance, the perceived capacity to tolerate negative psychological and physical states, may influence their pain experience. This effect could be explained in part by a reduction in the catastrophic interpretation of pain which is associated with increased pain intensity and interference in everyday activities.AimsThe first aim of this study was to explore the association between the components of the 5-factor model of distress tolerance and (1) pain intensity and (2) pain interference in everyday activities. The secondary aim was to assess the potential mediating effect of pain catastrophizing in the eventual association between components of distress tolerance and (1) pain intensity or (2) pain interference in everyday activities.MethodThis is a cross-sectional study of adult (18 years or older) university students and staff with chronic pain (3 months). They were invited to complete the online questionnaire through an email invitation. Pain intensity and interference in everyday functioning were assessed with the corresponding subscales of the Brief Pain Inventory. The following instruments were used to assess the components of the 5-factor model of distress tolerance: Ambiguity Tolerance Scale (tolerance to ambiguity), Intolerance to Uncertainty Scale (reversed score: tolerance to uncertainty), Discomfort Intolerance Scale (reversed score: discomfort tolerance), Distress Tolerance Scale (tolerance to negative emotions), Frustration Discomfort Scale (tolerance to frustration). Participants also completed the Pain Catastrophizing Scale.ResultsEighty participants were recruited (57 % women, mean age = 33.09; standard deviation = 12,87). Tolerance to negative emotions was the only component of distress tolerance that was associated with pain (ß = ?0.04; 95% CI): ?0.07–?0.01; t (78) = ?3.06, p < 0.01) or pain interference in everyday functioning (ß = ?0.07; 95% CI: ?0.10–?0.03; t (78) = ?3.97, p < 0.01), independently of the others. Combined with age, these factors explained 16.2 % of the variance in pain intensity and 19.4 % of the variance in pain interference. Pain catastrophizing partially mediated the association between tolerance to negative emotions and pain interference in everyday functioning, but it was not involved in the association between tolerance to negative emotions and pain intensity.ConclusionTolerance to negative emotions appears to be the most relevant aspect of distress tolerance in the context of chronic pain and is a potential clinical target that is independent and complementary from pain catastrophizing.