基于"热者寒之"理论探讨含碘中药治疗Graves病的作用机理

Graves病属中医学"瘿病"范畴,历代医家治疗瘿病经验丰富,《肘后备急方》首次提出应用海藻、昆布等含碘中药治疗瘿病,随着现代医学对于Graves病的认识不断深入,含碘中药在Graves病治疗中的作用愈发显著.诸多医家证明Graves病的发生发展与中医火热之邪密切相关,含碘中药则多味苦咸、性寒,契合"热者寒之"用药理论.基于"热者寒之"中药药性理论探讨含碘中药治疗Graves病的作用机理主要体现在调控细胞凋亡与自噬、调控表观遗传、调控细胞因子及信号通路等方面,以期为含碘中药在Graves病中规范化、标准化使用提供理论依据.     

现代化中医药名词术语双语数据库构建与应用

中医药名词术语正随着学科发展不断扩充,现代化中医药名词术语是指在中医药现代化过程中产生的名词术语,既沿袭了传统中医药理念,又具有新时代特征。建立专门的现代化中医药名词术语双语数据库有助于推动中医药名词术语英译标准化。文中通过收集相关著作、论文和医药产品英文介绍提取名词术语,建立“现代化中医药名词术语双语数据库”进行应用研究,对探索现代化中医药名词术语英译策略的规范化以及当代中医学术发展和对外交流具有重要意义。     

Graves病合并白细胞减少症中医治疗进展

Graves病合并白细胞减少症是Graves病严重的并发症之一。祖国医学将其归属于"瘿病"、"虚劳"等范畴。现代医学认为本病的病因主要与免疫异常、遗传因素、药物毒物作用等方面相关。临床治疗主要采用中药治疗(辨证施治、专方专药)、中西医结合治疗等。中医药治疗Graves病合并白细胞减少症具有一定的优势和特色,可提高临床疗效,今后应进一步加强中医药及中西医结合治疗研究。     

中医药辨治Graves眼病研究进展

Graves眼病是Graves病的常见并发症,其病因主要包括先天禀赋不足、情志损伤、饮食劳倦、环境因素等,对病机的认识总属本虚标实。在治疗方面,中医辨证论治的观点主要包括活动期与非活动期分期辨治、早中后三期分期辨治、抓主症顾兼症等,针灸治疗主要包括针药结合、整体辨证综合取穴等。中医药对Graves眼病的研究仍有待进一步发展。     

甲状腺肿大的中医辨证施治

地方性甲状腺肿大属中医的“瘿病”范畴。早在公元前3世纪,我国已有关于瘿病的记载。《吕氏春秋·尽数篇》所说的“轻水所,多秃与瘿人”,不仅记载了瘿病的存在,而且观察到瘿病的发病与地理环境有密切关系。唐《千金要方·瘿病》提出了石瘿、气瘿、劳瘿、土瘿、忧瘿等五瘿的分类     

燕树勋教授从痰气论治甲状腺癌术后经验探析

燕树勋教授系国家中医药管理局首批中医学术流派-湖北陈氏中医瘿病(甲状腺病)学术流派主要传承人,从事中医瘿病学临床、科研和教学工作20余年,具有深厚的中医理论知识和丰富的临床经验,尤其对甲状腺癌的诊疗有独到之处。甲状腺癌和甲状腺癌术后均属于中医"瘿瘤""石瘿"的范畴,燕教授认为甲状腺癌术后的病因有肝气郁结、饮食失调、起居失常、体质因素、水土因素、手术损伤、碘及激素治疗等,病机为本虚标实,标实以气郁、痰阻、血瘀、热毒为主,本虚包括气血阴阳俱虚。其中主要常见病机为气郁、痰阻,临床症候以气郁痰阻多见,治疗从痰气论治,以理气化痰为主,采用柴胡疏肝散合二陈汤加减,取得了满意的临床疗效。     

中医名词术语走向规范

7月24日,科技部科技基础性工作和社会公益研究专项项目“中医内妇儿科名词术语规范与审定”通过专家验收,其主要研究成果“中医药学名词.内科妇科儿科”即将由全国科学技术名词审定委员会审定公布。据悉,该项研究是2000年科技部基础性工作项目“中医药基本名词术语规范化研究”     

半夏厚朴汤治疗瘿病体会

半夏厚朴汤源自《金匮要略》,是主治咽喉部有异物感的专方。导师谢春光教授在临床应用中多有发挥,用该方加减治疗瘿病,并对瘿病的病因病机有新的认识,导师在瘿病原有病机气、痰、瘀的基础上,重视肝火这一病理因素。故治疗上除理气化痰、消瘿散结为基本原则以外,引入去肝火的治疗原则,取得了良好的疗效。同时中医内科保守治疗亦避免和减轻了因外科手术给患者带来的痛苦和术后诸多并发症的问题。     

低场MRI在甲状腺相关性眼病的应用及诊断价值分析

甲状腺相关性眼病(thyroid associated ophthalmopathy,TAO)是Weetman在1991年提出,TAO是眼眶最常见的疾病之一,也被称为浸润性突眼、Graves病等。根据甲状腺功能是否异常分为:Graves眶病(甲状腺功能异常且伴有眼部症状者)和眼型Graves病(仅有眼部症状而甲状腺功能正常者)。本研究论     

标本兼顾论治甲状腺机能亢进症

甲状腺机能亢进症 (简称甲亢 )与中医瘿病 ,虽两者关系密切 ,但不能完全划等号。历代医家把瘿病责之于肝 ,强调气滞、痰浊、瘀血等邪实因素为主要病机 ;现代医家多认为甲亢的病机是以阴虚为本 ,以火郁、痰凝、血瘀为标 ,表现为本虚标实、虚实夹杂的证候。故甲亢的治疗应始终坚持标本兼顾的原则 ,具体治法以养阴、降火、化痰、活血为主。1　“甲亢”与“瘿病”的关系甲亢是多种原因引起的甲状腺功能过高、甲状腺激素分泌过多所致的综合症 ,其可使人体多系统受累 ,严重威胁着人类的健康。许多人认为甲亢属于中医的瘿病范畴 ,笔者认为甲亢与瘿…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.