门头沟区消化性溃疡发病情况的研究

目的:了解门头沟区消化性溃疡的发病情况.方法:1997-10/2002-02我院内镜室应用电子胃镜(富士能WG_88FP)共检查有消化道症状的患者1351例,其中消化性溃疡病例331例.对消化性溃疡(PU)的检出率、性别、年龄、发病季节和溃疡部位分布进行分析讨论.结果:1351例胃镜检查中发现PU331例,检出率为24.5%,高于北京地区23所医院10a间(1984-1993年)内镜检查结果多中心分析PU平均检出率(16.04%),与西藏地区PU检出率(23.27%)相近.其中十二指肠球部溃疡(duodenalulcer,DU),胃溃疡(gastriculcer,GU),复合性溃疡(compositeulcer,CU)的检出率分别为17.69%,5.62%,1.18%.PU中,DU>GU>CU.其中DU与GU之比为3.14﹕1.不同季节PU的检出率不尽相同,本组春夏季节低于秋冬季节.检出率最高的月份为冬季(12-2mo)19.15%,表明PU好发于天气寒冷和气温变化大的季节.PU的发病年龄集中在青壮年.41-50岁占30.21%,31-40岁占26.89%.DU发病高峰在31-40岁占31.38%,GU发病高峰在41-50岁占34.21%,CU发病高峰在41-50岁占68.75%,显示DU发病比GU、CU提前一个年龄组.本组PU331例,男性236例(71.30%),女性95例(28.70%),男女之比为2.48﹕1.DU239例中,男女之比2.68﹕1.GU76例中,男女之比2.30﹕1.CU16例中,男女之比1.29﹕1.PU与性别的关系以DU、GU为突出,其原因可能与女性吸烟少、饮酒少及生活规律有关.PU有其好发部位,DU中以球前壁为明显多见(47.58%),其次为大弯(22.30%).GU中以胃窦为多见(62.37%),其次为胃角(19.35%).结论:门头沟区消化性溃疡的发病特点为:(1)内镜检出率高,秋冬季为多发季节;(2)以青壮年男性为多发;(3)以DU发病为主;(4)DU中以球前壁多见,GU中以胃窦多见.如何防治本病,降低我区人群PU的发病仍是一项十分艰巨的任务.     

2 473例消化性溃疡临床分析

目的 为研究不同民族、地区消化性溃疡（PU）的发病特点。方法 回顾性分析我院15年内2473例消化性溃疡的临床资料。结果 PU的检出率为12.53%，男女之比为3.67:1，其中汉族检出率为13.42%，回族检出率为10.66%，十二指肠溃疡（DU）占44.4%，胃溃疡（GU）占50.63%，两者之比为0.88:1。结论 PU检出率汉族高于回族，GU多于DU，PU好发于气温易变的春秋季节， 好发部位 DU以球部前壁与大弯为多；GU以胃角与胃窦为多；PU的高峰年龄为21-50岁；PU的并发症以出血为最多。     

中华分支睾吸虫感染与消化性溃疡

在中华分支睾吸虫(华支睾虫)感染流行地区,5年间337例感染该虫的住院病人中,有消化性溃疡(PU)163例,占43.24%.其中十二指肠球部溃疡(DU)居首位38例,占22.81%,胃溃疡(GU)53例,占14.60%.复合溃疡24例,占6.37%.GU发生部位:幽门窦部45例,占84.91%,胃体下部7例,占     

单纯疱疹病毒I型与消化性溃疡的关系

消七性溃疡(PU)的病因和发病机制尚未完全明了.近年来,有人认为HSV-I与PU可能有关[1-3],我们合成了一对DNA聚合酶序列中的特异性引物,应用PCR技术检测PU患者及正常人的胃和十二指肠粘膜中HSV-I DNA,试图了解HSY-I与PU的关系. 1材料和方法 1.1材料有复发性口唇疱疹病史及其他HSV-I感染者不纳入本试验.入选病例年龄为18岁～65岁复合性溃疡不入选.对照组30例,均为健康成人,男15例,女15例,平均年龄32.5岁.内镜检查胃和十二指肠粘膜正常,于胃窦小弯侧(GNor)和十二指肠球部前壁(DNor)各钳取粘膜组织1块.DU组30例,男20例,女10例,平均年龄36.6岁.内镜检查证实溃疡长径≥0.5 cm,为活动期,而胃粘膜大致正常或轻微浅表性胃炎,分别于溃疡边缘(DU1),溃疡对侧球部正常粘膜(DU2)及胃窦小弯侧(GNor)各钳取粘膜组织1块.GU组11例,男7例,女4例,平均年龄42.3岁.内镜检查证实溃疡长径≥0.25 cm,为活动期,活检排除胃癌,而十二指肠粘膜大致正常者,分别于溃疡边缘(GU1),溃疡对侧正常粘膜(GU2)及十二指肠球部(DNor)各钳取粘膜组织1块.以上病例标本均为孙逸仙纪念医院消化疾病研究室内镜室提供.     

内镜检查4868例患者的临床分析

本文报告内镜检查患者4868例,溃疡检出率为19.88%,其中十二指肠溃疡(DU)730例(占75.41%),胃溃疡(GU)190例(占19.63%),二者之比3.841.PU中756例(占78.10%),女212例(占21.90%).DU中男568例(占77.80%),女162例(占22.19%),男女之比为3.51.复合性溃疡(CU)48例中,男44例,女4例,男女之比为111.DU21岁～30岁占33.29%.本组主要并发症有合并出血95例,恶变68例(占PU患者中7.02%,占GU患者中的20.83%),DU患者中无一例恶变,提示对GU(含CU)病患者要严密观察并发症,以便及时治疗.     

消化性溃疡的特点

目的为了进一步探讨消化性溃疡（PU）的特点．方法内镜检查确诊的1432例PU，从其检出率、性别、年龄、季节、分布、大小、部位、并发症等方面进行了分析．结果PU：①发病率，十二指肠明显高于胃溃疡（GU）；②年龄，GU随年龄增长而增加，60岁以后下降，十二指肠溃疡（DU）以20岁～30岁青壮年发病率高，51岁以后开始减少，平均年龄DU比GU小10岁；③性别，男性明显高于女性；④季节，GU春季发病率较低，夏秋季发病率开始上升，冬季发病率最高，DU春季和秋季发病率高，冬春季和夏季发病率相对较低；⑤大小，多为＜1．0cm；⑥部位，GU依次为胃角＞胃窦＞胃体＞胃底＞幽门管，DU下壁＞前壁＞后壁＞上壁＞球后；⑦并发症，出血较多，梗阻较少，DU多于GU．结论PU的发病与年龄、性别、季节都有一定的关系，GU与DU略有不同     

广东东莞地区上消化道疾病临床流行病学调查(附10580例胃镜分析)

目的 为了解本地区各种上消化道疾病的发病特点、发病率、年龄分布、季节分布及性别比例情况。方法 对我院门诊和住院患者的10580例胃镜结果进行回顾性分析。结果 慢性胃炎7556例，其中慢性浅表性胃炎（CSG）7286例，男3710例，女3576例，男女之比1．04：1；慢性萎缩性胃炎（CAG）370例，男317例，女53例，男女之比5．98：1；消化性溃疡（PU）2736例，其中十二指肠溃疡（DU）2349例，男1824例，女525例，男女之比3．47：1，胃溃疡（GU）295例，男236例，女59例，男女之比4：1，复合性溃疡（CU）92例，男71例，女21例，男女之比3．38：1，DU与GU之比7．96：1；发病年龄≤20岁：DU占3，58％，GU占2．03％．CSG占4．17％：21-30岁：DU占36，02％，GU占12．2％，CSG占50，4l％；31-40岁：DU占34．7％，GU占21．02％，CSG占34．89％；41-50岁：DU占21．2％，GU占24．75％，CSG占8．25％；51-60岁：DU占3，24％，GU占30_5l％，CSG占l，54％；≥60岁：DU占1．28％，GU占9．49％．CSG占0．74％：DU好发部位球前壁（55．05％），大弯（22．01％），小弯（12．98％），后壁（8％）。球后（1．96％）；GU胃角（40．68％），幽门管（28．81％），胃窦（13．56％），胃体（10．85％），胃底贲门（6．1％）；PU1、2、3、11、12月份检出率分别为31．36％、33．04％、30．96％、31．04％、32，56％。结论 ①上消化道疾病中以慢性胃炎检出率最高．其次为溃疡病；DU及CSG好发青壮年．比GU发病平均年龄早十年以上。②DU发病明显高于GU．男性发病明显多于女性，工作压力及烟酒是其高发原因；DU好发部位的顺序为球前壁、大弯、小弯、后壁、球后，GU为胃角、幽门管、胃窦、胃体、胃底贲门。③PU好发于冬春气温易变之季。     

老年人消化性溃疡246例

目的分析246例老年人消化性溃疡(PU)的内镜及临床表现,以讨论其临床特点.方法246例均为近年我院内镜证实、年龄≥60岁的PU患者,男169例,女77例;年龄60岁～81岁.病程3mo～50a,超过10a者117例(47.6%).十二指肠溃疡(DU)79例(32.1%),胃溃疡(GU)156例(63.4%),复合性溃疡(CU)11例(4.5%).溃疡直径0.5cm～3.5cm,>2.5cm30例.167例GU(含CU)中胃体26例(15.6%)、胃底贲门21例(12.6%)、胃窦部64例(38.3%)、胃角56例(33.5%).PU中节律性腹痛58例(23.6%),腹痛无节律性110例(44.7%),上腹部不适161例(65.4%),食欲下降84例(34.1%),出血112例(45.5%),吞咽困难、胸骨后疼痛39例(15.9%).溃疡并发出血112例、穿孔2例、梗阻7例、恶变14例.结果本组老年性PU男女之比为2.21,病程近半数超过10a,GU与DU之比为1.971,溃疡面积大而深.老年人PU的1临床症状多不典型,高位溃疡发病率高,表现酷似食管病变、不典型心绞疼及心肌梗塞,应注意鉴别.并发症以消化道出血常见,但穿孔时缺乏典型的症状与体征,易延误诊治,更应注意良恶性溃疡的鉴别.结论老年人PU的发病部位、临床表现、并发症等均有一定的特点,应引起临床医师的注意.     

高原地区农牧民消化性溃疡特征分析

背景:高原地区地理环境和农牧民饮食结构的特殊性可能导致消化性溃疡(PU)在这一特定地域人群中的发生情况有一定特异性。目的:分析高原地区农牧民PU的特征。方法:纳入2010~2012年拉萨市人民医院经内镜检查确诊PU并排除恶性溃疡的成年农牧民,对其溃疡发生情况进行回顾性分析。结果:共309例PU患者纳入研究,其中青年(18~40岁)、中年(41~65岁)、老年(≥66岁)分别占31.1%、54.7%和14.2%;胃溃疡(GU)156例(50.5%),十二指肠球部溃疡(DU)129例(41.7%),复合性溃疡24例(7.8%)。不同年龄组间GU、DU和复合性溃疡构成比差异有统计学意义(P=0.000),青年组DU较多(57.3%),老年组以GU为主(75.0%)。不同年龄组间GU发生部位差异无统计学意义(P=0.070),但存在青年组以胃角溃疡为主(50.0%)、老年组以胃体溃疡为主(45.5%)的趋势。结论:高原地区农牧民PU患者中半数为GU,以中青年为主。老年人以GU为主,尤以胃体溃疡居多,DU则多见于青年人。     

十二指肠溃疡与萎缩性胃炎相关性研究

背景:愈来愈多的迹象表明胃溃疡(GU)与胃癌发生的危险性增加相关,而十二指肠溃疡(DU)则与胃癌的发生负性相关.目的:研究DU与萎缩性胃炎的相关性.方法:对DU、GU和复合性溃疡(CU)患者胃窦、胃窦胃体交界处和胃体黏膜以及慢性胃炎(CG)患者胃窦黏膜活检标本进行组织学检查,统计各自胃黏膜的萎缩、肠化、慢性炎症、活动性和幽门螺杆菌(H.pylori)感染的发生率及其严重程度.结果:DU患者胃窦、胃窦胃体交界处和胃体黏膜的萎缩发生率分别为54.2%、9.5%和12.4%,肠化发生率分别为18.9%、2.5%和1.5%.其胃窦黏膜肠化的发生率明显低于相应的GU、CU或CG者.3种消化性溃疡和CG患者均存在胃窦部慢性炎症,且消化性溃疡患者胃体部炎症的发生率较高,其胃炎活动性以胃窦部为主,且均较CG者高(P<0.05).DU、GU和CU患者胃窦部Ⅰ型肠化的发生率分别为68.1%、43.8%和45.0%;而其Ⅲ型肠化的发生率则分别为6.4%、25.0%和20.0%(P<0.05).结论:DU患者的胃窦部可有灶性萎缩和肠化发生,其胃窦黏膜肠化发生率和Ⅲ型肠化的发生率最低,这可能是DU患者罹患胃癌危险性较低的原因之一.     

CHANGES IN MUCOSAL PHOSPHOLIPID‐RELATED PROTECTION IN SOME GASTRIC DISEASES

Background: Phospholipids play an important role in gastric mucosal protection. The purpose of the present study was to investigate changes in various phospholipids in the fundic and pyloric gland mucosae of patients with gastric mucosal disease. Methods: One hundred and five patients with superficial gastritis, duodenal ulcer, gastric ulcer or gastric cancer were studied. Patients underwent endoscopy to obtain biopsy specimens from both the fundic and pyloric gland mucosae. The phospholipid contents were measured by high performance liquid chromatography. Results: Total phospholipid level was significantly greater in the fundic gland mucosa than in the pyloric gland mucosa (P = 0.037), and the level in the fundic gland mucosa was high in all four gastric diseases studied. The difference was significant in patients with gastric ulcers (P = 0.0156). Total phospholipid levels were the highest in superficial gastritis, followed by duodenal ulcer, gastric ulcer and gastric cancer. In all four gastric diseases, phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC) levels were high, while phosphatidylinositol, lysophosphatidylcholine, and sphingomyelin levels were low. The PE and PC levels were higher in the fundic gland mucosa than in the pyloric glandular mucosa, whereas the PS level was higher in the pyloric gland mucosa than in the fundic gland mucosa. Conclusions: The fundic gland mucosa has stronger phospholipid‐related protection than the pyloric gland mucosa, based on the levels of mucosal phospholipids. The main phospholipids for gastric mucosal protection are PC and PE (in the fundic gland mucosa) and PS (in the pyloric gland mucosa). Phospholipid‐related protection is strong in superficial gastritis and duodenal ulcer, but is reduced in the pyloric gland mucosa in patients with gastric ulcers, and in both gastric gland mucosae in patients with gastric cancer.     

急性胰腺炎患者并发消化性溃疡的危险因素分析

目的探讨急性胰腺炎（AP）患者并发消化性溃疡（PU）的临床特征,并分析并发PU的危险因素。方法回顾性分析2008年1月-2012年1月本院收治的156例AP患者的临床资料。所有患者入院后48 h内均进行胃镜检查,以评估其PU和幽门螺杆菌感染情况。应用Ranson评分、APACHEⅡ评分和CT严重指数评估AP严重程度。应用独立样本t检验和χ2检验对伴发PU和无PU的AP患者临床特征进行统计学分析,同时应用单因素和多因素Logistic回归分析AP患者并发PU的危险因素。结果156例AP患者中,88例患者胃镜检出PU,检出率为56.4%。88例PU患者中,只有28（31.8%）例检测到幽门螺杆菌。28例幽门螺杆菌阳性的PU患者中,22例发生胃溃疡,6例同时发生胃溃疡和十二指肠溃疡,没有发现单独的十二指肠溃疡;而60例幽门螺杆菌阴性PU患者中,25例发生胃溃疡,26例发生十二指肠溃疡,9例同时发生胃溃疡和十二指肠溃疡。单因素Logistic回归分析发现,男性、酒精源性胰腺炎、吸烟、饮酒、高甘油三酯水平和高C反应蛋白水平、APACHEⅡ评分≥8分与AP患者并发PU显著相关。然而,多因素Logistic回归分析发现,只有APACHEⅡ评分≥8分（OR=8.54,95%CI：4.52～16.15,P〈0.01）是AP患者并发PU的独立危险因素。结论 AP患者容易并发PU,而幽门螺杆菌感染率较低。APACHEⅡ评分≥8分是AP患者并发PU的独立危险因素。     

Relationship between site of peptic ulceration and gastric acid-peptic activity: new evaluation of gastric analysis in patients with acute gastric bleeding and chronic peptic ulcer.

In an attempt to elucidate the etiology of acute gastric bleeding and/or erosion and chronic peptic ulcer, a measurement of gastric juice and mucosal pepsin was carried out in surgically-treated patients. Patients with massive gastric mucosal bleeding in the fundic gland area showed high levels of fundic mucosal pepsin without acid-pepsin appearance in the gastric contents. In these patients, a significantly high value of the peptic activity ratio of gastric mucosa to gastric juice (MJPR, 36.4 +/- 6.7) was observed. It can be suggested that transient blockage of pepsin output from peptic cells with occur in the course of the acute mucosal bleeding, while acid-peptic digestion could be carried out within the fundic gland mucosa. On the other hand, a close correlation between relatively high acid-and-pepsin concentration of the gastric contents and a low level of MJPR (5.6 +/- 1.2) was observed in patients with chronic gastric ulcer. Patients who had a gastric ulcer within the pyloric gland mucosa had a highest acid-peptic activity among three groups with ulcers in fundic gland area, border zone and pyloric gland area. There is a rule that acid-peptic activity becomes low when the site of gastric ulcer moves from pylorus to fundus. A marked increase in acid-and-pepsin secretion into the gastric cavity was observed in patients suffering from chronic duodenal ulcer showing the lowest level of MJPR (3.40 +/- 0.50).     

门脉高压性胃病患者幽门螺杆菌感染率调查

目的探讨幽门螺杆菌（Hp）与肝硬化并发胃和十二指肠病变的关系。方法采用快速尿素酶试验和改良的Giemsa染色法检测Hp感染。结果在264例肝硬化患者,Hp阳性183例（69．4％）,在262例慢性胃炎（EG）患者,Hp阳性172例（66．4％,19〉0．05）;在79例肝硬化伴有PHG患者,Hp阳性60例（75．9％）,在114例肝硬化不伴PHG患者,Hp阳性75例（65．8％）,在37例肝硬化伴轻型PHG患者,Hp阳性26例（70．2％）,在42例肝硬化伴重型PHG患者,Hp阳性34例（80．9％,P〉0．05）;在56例肝硬化伴十二指肠溃疡（DU）患者,Hp阳性48例（85．7％）,在109例肝硬化不伴消化性溃疡（Pu）患者,Hp阳性67例（61．4％,P〈0．05）;在125例DU患者,Hp阳性112例（89．6％）;在28例肝硬化伴胃溃疡（GU）患者,Hp阳性20例（71．4％）,在47例GU患者,Hp阳性43例（91．5％）。结论肝硬化伴DU患者Hp感染率较高。     

A study on the distribution of G-cells in human gastric mucosa

The distribution of G-cells in the gastric glands was studied quantitatively using the indirect immunoperoxidase method in 37 resected stomachs: 11 for esophageal cancer, 14 for gastric cancer, 4 for gastric ulcer, 7 for duodenal ulcer, and 1 for atypical epithelium. G-cells were seen in the pyloric glands and in the pseudopyloric glands in the atrophic fundic gland area. No G-cells were found in the fundic glands or in the cardiac glands. There was a significant correlation between the number of G-cells and the pyloric and/or pseudopyloric glandular tubes (p less than 0.01). The number of G-cells per glandular tube was 1.9 +/- 0.5 in the pyloric glands and 1.2 +/- 0.4 in the pseudopyloric glands on the pyloric part of the atrophic fundic gland area. G-cells were rarely seen in the pseudopyloric glands on the cardiac part of the atrophic fundic gland area. It is suggested that the pseudopyloric glands without G-cells in the cardiac region are akin to cardiac glands.     

幽门螺杆菌cagG基因在胃黏膜中的表达及其意义

目的 研究cagG基因在不同上消化道疾病患者中的分布及其与幽门螺杆菌(Helico-bacter pylori,Hp)感染相关疾病的关系。方法 合成特异性引物,应用聚合酶链式反应(PCR)法扩增145株分离培养自上消化道疾病患者的Hp菌株cagG片段,其中慢性胃炎72例,胃溃疡17例,十二指肠球部溃疡48例,复合溃疡8例。比较cagG阳性、阴性的胃黏膜炎症程度。结果 Hp菌株cagG片段总检出率为91.7％(133/145),在慢性胃炎、胃溃疡、十二指肠溃疡、复合性溃疡中cagG阳性率分别为90.3％。88.2％、93.8％和 100.0％,各组间差异无显著性意义:(P>0.05)。结论 cagG有较高的保守性,在不同的消化道疾病患者的Hp中均有较高的检出率,在不同疾病中的分布无特异性,与胃黏膜炎症程度无明显关系,cagG尚不能单独作为某种疾病致病的相关基因。     

Locations of peptic ulcers in children

The locations of peptic ulcers in children were studied in a total of 55 cases; 19 with gastric ulcers, 31 with duodenal ulcers and 5 with a combination of both. The male children were predominantly affected with these three types. The mean age of the children with gastric ulcers was significantly lower than those with duodenal ulcers (P<0.005). Gastric ulcer was markedly predominant in the antrum, and commonly present in the anterior and posterior walls of the stomach, and infrequently on the greater curvature. Ten of 24 cases (42%) had ulcerations on the anterior wall of the antrum. In seven cases, ulcerations were located on the posterior wall. Duodenal ulcers mostly occurred in the bulb. The anterior and/or posterior walls of the bulb were commonly associated with ulcerations. The present observations concerning gastric and duodenal ulcer location are essentially in agreement with results from adult studies. Perforations were demonstrated in the anterior wall or lesser curvature in both gastric and duodenal ulcers. In five of seven replapse cases, ulcerations had recurred in the same area.     

山西省柳林县上消化道疾病流行病学调查

目的调查总结我区上消化道疾病的发病住院情况及其原因．方法我院医生所诊治的全部行内镜检查患者，共3142例，所有受检患者均行幽门螺旋杆菌（Hp）检验，所发现的阳性病例均经本院病理检验得到证实，部分患者经手术治疗后得到证实结果1993－04-01／1997-12－26我院内镜检查3142例，发现胃溃疡（GU）287例，男女比例为2．6：1；十二指肠溃疡（DU）245例，男女比例为3．55：1；胃癌173例，男女比例为2．22：1，食管癌241例，男女比例为1．51：1,GU，DU胃癌Hp感染检出率达98％以上．GU与DU之比为1．17：1．消化性溃疡（PU）总数达672例，占总受检人数的21．39％.恶性肿瘤总数为414例，占总受检人数的的13．17％.综合分析，间接推测，PU、食管癌，胃癌发病率增高；GU在我县的患病远远超过国内报道，且男性发病率高于女性．该种情况的发生，是由于本地区具体的生活环境，饮食习惯所致结论生活条件差是造成Hp感染的根源，而Hp感染是PU、恶性肿瘤的主要致病因素.     

Locations of peptic ulcers in children

The locations of peptic ulcers in children were studied in a total of 55 cases; 19 with gastric ulcers, 31 with duodenal ulcers and 5 with a combination of both. The male children were predominantly affected with these three types. The mean age of the children with gastric ulcers was significantly lower than those with duodenal ulcers (P less than 0.005). Gastric ulcer was markedly predominant in the antrum, and commonly present in the anterior and posterior walls of the stomach, and infrequently on the greater curvature. Ten of 24 cases (42%) had ulcerations on the anterior wall of the antrum. In seven cases, ulcerations were located on the posterior wall. Duodenal ulcers mostly occurred in the bulb. The anterior and/or posterior walls of the bulb were commonly associated with ulcerations. The present observations concerning gastric and duodenal ulcer location are essentially in agreement with results from adult studies. Perforations were demonstrated in the anterior wall or lesser curvature in both gastric and duodenal ulcers. In five of seven relapse cases, ulcerations had recurred in the same area.     

幽门螺杆菌阴性消化性溃疡与出血关系的多中心对照研究

目的明确中国大陆地区幽门螺杆菌（Hp）阴性消化性溃疡与出血的关系。方法拟定于2006年4月至2007年3月期间在国内14个研究中心中进行,每个中心预期调查30例经急诊内镜诊断为胃溃疡和（或）十二指肠溃疡合并出血的患者（PUB组）,同时调查30例不伴出血的胃溃疡和（或）十二指肠溃疡患者作为对照（PU组）。共拟人选840例患者,消化性溃疡合并及不合并出血组各420例。在内镜检查中采用快速尿素酶试验和病理检测却感染,并对初次检查却阴性者于1个月后进行尿素呼气试验复查。结果共617例患者纳入分析,其中PUB组263例、PU组354例,2组在性别比、平均年龄等一般状况方面差异无统计学意义（P均〉0．05）。PUB组却阳性率61．2％（161／263）显著低于PU组的87．9％（311／354）（P〈0．001）;PUB组跏阳性的溃疡出血发生复合溃疡的比例7．5％（12／161）显著高于Hp阴性溃疡出血者1．0％（1／102）（P=0．018）,但两者在平均发病年龄、性别比、呕血发生率、十二指肠球部溃疡发生率、胃溃疡发生率及溃疡平均直径方面差异无统计学意义（P均〉0．05）。对于初次tip阴性的溃疡出血患者,1个月后的呼气试验复查未发现阳性病例。结论目前中国大陆缉,阴性溃疡在消化性溃疡出血中的比例较高,坳阴性溃疡可能更容易并发消化道出血,需要引起消化专科医生的重视。