亚低温治疗对重型颅脑损伤患者颅内压及脑血液生化学指标的影响

目的:探讨亚低温治疗对重型颅脑损伤患者颅内压(ICP)及脑血液生化学指标的影响.方法:回顾性收集81例重型颅脑损伤患者,根据治疗方法的不同分为观察组(n=48)和对照组(n=33),所有患者入院后给予重型颅脑损伤常规治疗,在此基础上,观察组患者给予亚低温治疗,治疗时间为72 h.动态监测所有患者入院时及治疗开始第1～7天ICP,入院时和治疗第7天脑血流指标动态阻力(DR)、脉搏波速(Wv)、脑部平均血流量(Qmean)、平均血流速度(Vmean)和脑氧代谢指标脑氧摄取率(CE-RO2)、颈内静脉血氧饱和度(SjvO2)、CjvO2、CaO2.结果:随着时间的延长,两组患者ICP呈逐渐下降的趋势,差异有统计学意义(F=17.982、6.324,P＜0.05);第2天开始,观察组ICP显著低于对照组,持续至第7天,差异均有统计学意义(P均＜0.05);与入院时比较,两组第7天DR、Wv、CaO2均显著降低,Qmean、Vmean、CjvO2、CERO2、SjvO2显著升高,差异有统计学意义(P＜0.05);与对照组第7天比较,观察组DR、Wv、CaO2显著低于对照组,Qmean、Vmean、CjvO2、CERO2、SjvO2显著高于对照组,差异有统计学意义(P＜0.05).结论:亚低温治疗可以显著降低重型颅脑损伤患者颅内压,改善脑血流和脑氧代谢,具有重要的临床意义.     

持续有创颅内压监测对重型颅脑损伤患者救治的临床价值评估

目的:研究持续有创颅内压监测对重型颅脑损伤患者救治的临床效果。方法:选取2013年1月-2016年12月本院收治的重型颅脑损伤患者100例,根据患者检测颅内压的方法不同分为观察组和对照组,每组50例。观察组予以持续有创颅内压监测,对照组予以传统对颅内压的评定方法,观察两组术后颅内压、术后GCS评分、预后、并发症情况。结果:治疗前两组颅内压比较,差异无统计学意义(P0.05);术后观察组颅内压均较对照组低,差异均有统计学意义(P0.05);两组术前、术后第1天、术后第3天GCS评分比较,差异均无统计学意义(P0.05);术后第7、10天观察组GCS评分均显著高于对照组,差异均有统计学意义(P0.05);观察组恢复良好率显著高于对照组,观察组死亡率和并发症发生率均显著低于对照组,差异均有统计学意义(P0.05)。结论:重型颅脑损伤患者采用持续有创颅内压监测,可及时对病情进行评估,改善预后和降低死亡率,对颅脑损伤患者的救治有着重要的价值,临床应用前景广阔     

亚低温脑保护对重型创伤性颅脑损伤患者预后的影响

目的 探讨亚低温脑保护对重型颅脑损伤患者预后的影响。方法 选取我院收治的重型创伤性颅脑损伤患者资料（2013年3月～2019年12月）,依照治疗方法分为实验组300例和对照组300例。对照组入院后均进行生命体征监护,如呼吸、心率、体温、血压,定期行血常规、血气分析、血电解质、肝肾功能、心肌酶谱、血糖检查等。行脑室外引流监测颅内压,当ICP＞15 mmHg时,静脉给予呋塞米、甘露醇。锁骨下静脉穿刺输液维持水、电解质平衡,给予神经营养药物治疗。实验组在对照组基础上给予患者亚低温脑保护。观察、对比两组患者预后良好率、颅内压、血清抗脑抗体浓度及脑血流动力学。结果 实验组预后良好率为51.00%,对照组为35.62%,差异有统计学意义（P＜0.05）;治疗后,两组颅内压降低,实验组各时间点低于对照组（P＜0.01）;两组血清抗脑抗体浓度均呈上升趋势,实验组整体低于对照组（P＜0.01）;两组Vs、Vm呈升高趋势,PI指数呈下降趋势;两组Vs各时间点比较,差异均有统计学意义（P＜0.01）,Vm、PI指数治疗7 d、14 d比较,差异有统计学意义（P＜0.01）。结论 重型创伤性颅脑损伤患者采用亚低温脑保护治疗,可降低颅内压、血清抗脑抗体含量,增加脑血流量,预后良好。     

高压氧在重型颅脑损伤治疗中的临床应用

【摘要】目的：探讨高压氧治疗重型颅脑损伤的临床疗效。方法：100例重型颅脑损伤患者随机分为对照组和HBOT组，各50例。对照组根据病情采用手术和非手术治疗，HBOT组在对照组基础上给与高压氧治疗，比较治疗后两组患者各项指标及其后期疗效评分。结果：高压氧治疗后HBOT组患者颅内压明显低于对照组(P＜0.05)；高压氧治疗7天，HBOT组脑血流情况均优于对照组(P＜0.05)，HBOT组脑氧摄取率均高于对照组(P＜0.05 )。从总有效率看，HBOT组在伤后6月的治疗明显高于对照组(P＜0.05)。结论：对重型颅脑损伤患者实施高压氧的治疗措施，能明显降低颅内压，改善脑血流量，促进脑氧摄取率，改善患者预后。     

参附注射液对重型颅脑损伤患者脑血流动力学及颅内压的影响

目的观察参附注射液对重型颅脑损伤患者脑血流动力学及颅内压的影响。方法将86例重型脑损伤患者随机分为对照组与治疗组各43例。对照组采用常规治疗，治疗组采用常规治疗加参附注射液静滴。治疗过程中应用经颅多普勒（TCD）监测脑血流动力学及应用颅内压监护仪监测颅内压。结果治疗组GCS评分在参附注射液治疗5d后不同记录时间点均显著高于对照组（P〈0．05和P〈0．01）；治疗组脑血流动力学Vs、Vm、PI值在治疗3d后与对照组相比明显改善（P〈0．01和P〈0．001）；治疗组在3d后平均颅内压明显低于对照组（P〈0．001）。结论参附注射液可改善重症颅脑损伤引起的脑血流动力学紊乱，降低颅内压，改善患者预后。     

亚低温冬眠联合颅内压控制治疗脑挫伤疗效观察

目的：观察亚低温冬眠联合颅内压控制治疗脑挫伤的疗效。方法：回顾性分析2019年9月—2022年9月我院收治的140例脑挫伤患者临床资料,根据治疗方式不同分为对照组(n=64,颅内压控制+常规治疗)和观察组(n=76,亚低温冬眠+颅内压控制+常规治疗),对比两组患者治疗前后颅内压变化、脑血流指标、意识障碍情况、并发症发生情况,并于2个月后随访两组患者预后情况。结果：治疗前,两组患者颅内压水平无显著差异(P>0.05),治疗1d、3d、6d,两组患者颅内压水平均下降,且观察组低于对照组,差异具有统计学意义(P<0.05);治疗前,两组患者脑部平均血流速度(Vmean)、平均血流量(Qmean)、脉搏波速(Wv)指标值无显著差异(P>0.05),治疗7d,两组Vmean、Qmean均上升,Wv下降,且观察组Vmean、Qmean高于对照组,Wv低于对照组,差异具有统计学意义(P<0.05);治疗前,两组患者格拉斯哥(GCS)昏迷评分无显著差异(P>0.05),治疗7d,两组GCS评分均上升,且观察组明显高于对照组,差异具有统计学意义(P<0.05);两组并...     

高容量血液滤过对重型颅脑损伤患者颅内压及血流动力学的影响

目的观察高容量血液滤过(HVHF)对重型颅脑损伤患者颅内压及血流动力学的影响。方法选取90例广泛脑挫裂伤、脑干损伤或颅内血肿、GCS评分3~8分的患者,按治疗方法的不同分为治疗组60例与对照组30例,对照组给予颅脑手术、甘露醇脱水降颅内压等常规治疗措施,治疗组在此基础上给予HVHF治疗,观察两组患者颅内压及心率(HR)、平均动脉压(MAP)、心排指数(CI)变化。结果治疗组1 d、3 d、5 d及7 d颅内压(ICP)明显低于对照组(P0.05),治疗组在治疗后24 h心率(HR)明显低于对照组(P0.05),平均动脉压(MAP)、心排指数(CI)明显高于对照组,差异具有统计学意义(P0.05)。结论 HVHF治疗可显著降低重型颅脑损伤患者颅内压增高曲线,更有利于维持重型颅脑损伤患者血流动力学稳定。     

脑池造瘘术及控制性引流对重型颅脑损伤后颅内压的影响

目的:探讨脑池造瘘术联合控制性引流在重型颅脑损伤时对颅内压的影响.方法:76例重型颅脑损伤患者为研究对象,患者就诊时间为2019年12月至2021年1月,根据患者采用的治疗方案将其分为A组和B组,A组为采用脑池造瘘术治疗的38例患者,B组为采用脑池造瘘术联合控制性引流治疗的38例患者;对比两组患者手术前后的格拉斯哥昏迷指数(GCS)评分、颅内压变化.结果:于术后1d、2d、3d、5d时B组患者的GCS评分均高于A组(P<0.05);术后2 h、12 h、24 h、72 h时B组患者的颅内压均低于A组(P<0.05).结论:脑池造瘘术联合控制性引流在重型颅脑损伤中具有较好应用效果,有助于降低患者的颅内压、改善昏迷症状.     

急性颅脑损伤与血B型脑钠肽变化的临床分析

目的 分析研究急性颅脑损伤患者血B型脑钠肽水平的变化情况,总结B型脑钠肽水平和颅脑损伤之后颅内压之间的关系.方法 随机选取2014年3月—2015年3月该院收治的急性颅脑损伤患者资料90例实施回顾性分析,依照患者在入院的时候的GCS评分情况将90例患者分为轻度颅脑损伤组30例,中度颅脑损伤组30例,重度颅脑损伤组30例,另外选取同期30例健康人群作为对照组,在患者入院当天、治疗3~5 d以及治疗15 d检测其血浆样本B型脑钠肽水平,对结果实施统计学分析.结果 与对照组患者比较,颅脑损伤患者的血B型脑钠肽水平显著增加,差异有统计学意义(P<0.05);治疗15 d,重度颅脑损伤组患者血B型脑钠肽水平(200.3±47.6)pg/mL明显高于轻度颅脑损伤组(75.1±41.8)pg/mL和中度颅脑损伤组(102.1±35.1)pg/mL,差异有统计学意义(P<0.05).结论 血B型脑钠肽水平能够作为辨别颅脑损伤严重程度和损伤之后颅内压升高的评价指标.     

丁苯肽联合尤瑞克林对血管性认知障碍的预防作用

目的:观察丁苯肽联合尤瑞克林对于急性脑梗死患者脑血流量的影响及预防认知功能障碍中作用。方法:选取200例的急性脑梗死患者作为研究对象,采取随机法将患者分为对照组和研究组,每组各100例,对照组采用常规抗血小板活血化瘀及脑保护治疗,试验组在对照组的基础上给予丁苯酞和尤瑞克林。观察两组患者的治疗前后的脑血流量的变化及治疗前后认知功能评分的变化。结果:治疗前,两组患者脑血流速度比较,差异均无统计学意义(P0.05);治疗后,试验组患者各主要血管脑血流速度明显高于对照组,两组比较差异均有统计学意义(P0.05)。治疗前,两组患者各亚项认知功能及总MOCA评分比较,差异均无统计学意义(P0.05);治疗后,试验组患者各亚项认知功能及总MOCA评分明显高于对照组,两组比较差异均有统计学意义(P0.05)。结论:丁苯肽联合尤瑞克林可以显著的增加急性脑梗死患者的脑血流速度,并且对认知功能的改善有明显的促进作用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.