能量多普勒定量检测甲状腺肿瘤血管生成的应用研究

目的:应用能量多普勒(CDE)在体外检测甲状腺肿瘤血管生成,并进行定量分析,期望发展一种无创性评价肿瘤血管生成方法,提高良恶性肿瘤诊断准确率.方法:入选经病理证实的35例甲状腺良性肿瘤(结节性甲状腺肿21例,腺瘤14例)和21例甲状腺癌病人术前均行能量多普勒(CDE)检查,包括CDE值、血流动力学参数、血流频谱.并对其差异进行分析.结果:良恶性肿瘤的CDE值及血流动力学参数(Vmax、RI)存在极显著差异(P<0.01);良恶性肿瘤的血流频谱特征存在差异:收缩期峰值位置存在极显著差异(P<0.01),舒张期始波位置存在显著差异(P<0.05).结论:CDE能够在体外原位评价甲状腺肿瘤血管生成及其活性,对鉴别甲状腺良恶性肿瘤具有重要意义.     

彩色多普勒超声对甲状腺良恶性肿瘤的鉴别诊断

为探讨彩色多普勒超声对甲状腺良恶性肿瘤的鉴别诊断价值 ,对 110例患者在二维超声基础上行彩色多普勒血流显像检查 ,观察血流信号分布情况 ,估测最高动脉流速 ( Vmax)、搏动指数 ( PI)、阻力指数 ( RI)等参数。对照组织病理学检查结果 ,良、恶性肿瘤超声诊断符合率分别为 94.2 5 %和 86 .96 %。恶性肿瘤 2 3例检出血流 2 1例 ( 91.3 0 % ) ,血流信号以内部多见 ( 6 0 .87% ) ,Vmax0 .3 0± 0 .0 7ms;良性肿瘤 87例检出血流 5 7例 ( 6 5 .5 2 % ) ,血流信号均以周边多见 ( 47.13 % ) ,Vmax0 .19± 0 .10 m/s。两者相比差异均有显著性 ( P<0 .0 5 )。提示 ,恶性肿瘤表现为肿瘤内部有较丰富的高速血流信号分布 ,良性肿瘤彩超特征为肿瘤周边见有环状低速血流信号 ,彩超对鉴别甲状腺良恶性肿瘤有较高临床应用价值     

二维超声及彩色多普勒血流显像在原发性骨肿瘤诊断中的价值

目的：探讨二维超声检查及彩色多普勒血流显像（CDFI）技术在骨肿瘤诊断中的应用价值。方法：采用Acuson 128XP／10型及G-50型彩色多普勒显像仪。对93例原发性骨肿瘤患者进行二维及彩色多普勒超声检测观察骨质、骨膜及周围软组织情况，测量血流动力学指标。结果：骨质破坏、骨膜反应、周围软组织肿物在二维图像中显示清晰。CDFI可清晰显示肿瘤内部血流情况。恶性肿瘤收缩期最大血流速度（Vmax），舒张期最小血流速度（Vmin）高于良性肿瘤（P〈0．01），阻力指数（RI），搏动指数（PI）则恶性肿瘤低于良性肿瘤（P〈0．01）。结论：通过二维图像及CDFI观察肿瘤形态及血流动力肇参数时原发性骨肿瘤的诊断及良、恶性鉴别诊断有很大的临床价值。     

彩色多普勒超声对乳腺肿块良、恶性的鉴别诊断

目的 利用彩色多普勒(CDFI)和二维超声及结合临床病理学检查提高乳腺肿块良、恶性鉴别诊断.方法 采用直接接触扫查法.首先观察病灶的二维图像特征,然后用彩色多普勒血流显像测定肿块内血流峰值血流速度、阻力指数(RI).选择流速最高的一束血流脉冲多普勒参数.结果 118例患者经手术病理证实为乳腺实质性肿块,其中良性78例,恶性40例.结论 彩色多普勒血流显像结合二维声像图及RI值对诊断乳腺肿块良、恶性有临床意义.     

彩色多普勒超声在乳腺肿瘤诊断中的价值

目的：探讨彩色多普勒超声在诊断乳腺良、恶性肿块中的应用价值。方法：使用高频及彩色多谱勒成像技术,对乳腺肿块二维图像及彩色多普勒的血流和血管频谱、动力学参数进行观察、分析。结果：乳腺良、恶性肿瘤在肿瘤形态、边界、回声、与周围组织有无浸润、彩色多普勒血流情况等方面均具有明显差异。结论：二维超声与彩色多普勒超声联合检测,可以提高乳腺良、恶性肿瘤的诊断及鉴别诊断。     

彩超在乳腺肿瘤诊断与鉴别诊断中的应用价值探讨

目的:探讨高频彩超诊断与鉴别诊断乳腺肿瘤的准确性.方法:使用(5~10)MHz高频探头和彩超观察肿瘤的特征性二维声像图和彩色多普勒的血流和血管的动力学参数、阻力指数、频谱形态,并且对其进行分析诊断.结果:98例乳腺肿瘤患者中,75例为良性肿瘤患者,23例为恶性肿瘤患者,其中4例良性肿瘤曾被误诊为恶性肿瘤.结论:利用彩超观察乳腺肿瘤的二维声像图特征和彩色血管形态和血流频谱能够为诊断和鉴别诊断乳腺肿瘤的良恶性提供准确的诊断依据,是临床诊断中的首选方法.     

高频彩超对腮腺肿瘤的诊断价值

目的:探讨高频彩超对腮腺肿瘤的诊断价值.方法:应用高频彩色多普勒超声对腮腺肿瘤49例行二维超声及彩色多普勒超声显像,经频谱多普勒测量肿瘤血流的收缩期峰值流速和阻力指数.结果:腮腺良恶性肿瘤的二维超声声像图无明显特异性,而彩色多普勒血流参数、收缩期峰值流速和阻力指数两者比较差异均有统计学意义(P＜0.05).结论:高频彩超对腮腺良恶性肿瘤的鉴别诊断提供了重要的诊断方法.     

多普勒超声动脉血流参数在鉴别乳腺良恶性肿瘤中的应用

目的 探讨多普勒超声动脉血流参数在乳腺良恶性肿瘤鉴别诊断中的价值.方法 选择38例乳腺良性肿瘤患者及58例乳腺恶性肿瘤患者,采用美国GE-LOGIQ9彩色多普勒超声诊断仪检测96例患者的肿瘤血流动力学参数,如收缩期峰值血流速度(PSV)、阻力指数(RI)及搏动指数(PI).比较PSV及RI诊断乳腺良、恶性肿瘤的准确性、敏感度、特异度及阳性预测值.结果 乳腺恶性肿瘤组PSV、RI、PI与良性肿瘤组比较,差异有统计学意义(P<0.01).以PSV>20 cm/s,RI>0.7作为恶性肿瘤判定标准,PSV与RI的定性诊断乳腺肿瘤的准确性分别为66.8%和82.1%,敏感度分别为70.3%和83.2%,特异度分别为65.2%和82.6%,阳性预测值分别为73.2%和85.5%.PSV与RI联合诊断乳腺肿瘤的准确性、敏感度、特异度、阳性预测值分别为83.2%、84.6%、82.5%和85.7%.结论 多普勒超声血流动力学参数PSV、RI对乳腺良、恶性肿瘤的鉴别诊断具有重要应用价值,RI的鉴别诊断价值优于PSV.     

超声对乳腺良恶性肿瘤的诊断价值

目的探讨乳腺良恶性肿块的鉴别诊断,对恶性肿瘤早期发现,早期治疗。方法观察186例乳腺肿块的二维图象特征及彩色多谱勒血流显像持点。结果乳腺良恶性的鉴别,主要以肿瘤的边界、内部回声及血流信号、RI为鉴别要点。恶性肿瘤形态不规则,无完整包膜．彩色多谱勒检出丰富血流信号．频谱为高速高阻,RI在0．8以上。RI越高,恶性肿瘤可能性越大。良性肿瘤边界清．有包膜,内回声均质,血流信号少,RI低。结论二维及彩色多谱勒超声对乳腺良恶性肿瘤鉴别诊断符合率较高,方法简便．具有较大的临床价值。     

彩超对乳腺良恶性肿瘤的诊断与鉴别诊断进展

目的：探讨彩超对乳腺肿瘤诊断与鉴别诊断的准确性与诊断进展。方法：使用彩超和5～12MHz高频探头观察肿瘤的特征性二维声像图和彩色多普勒的血管和血流频谱形态、阻力指数、动力学参数等进行分析诊断。结果：96例乳腺肿瘤中36例为恶性肿瘤,60例为良性肿瘤,3例良性肿瘤开始误诊为恶性肿瘤。结论：彩超通过观察乳腺肿瘤的二维声像图特征和彩色血流频谱和血管形态等对于乳腺肿瘤良恶性的诊断与鉴别诊断可提供准确的诊断依据,是首选的检查方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.