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排序方式: 共有489条查询结果,搜索用时 46 毫秒
1.
目的探讨对妊娠高血压综合征患者给予硫酸镁联合硝苯地平以及酚妥拉明治疗的临床效果。方法抽取医院在2018年2月-2019年2月所接收的156例妊娠高血压综合征患者,将其按照数字随机表的方法分为单纯组和联合组,每组分别为78例。单纯组给予单纯的硫酸镁进行治疗,联合组在单纯组给予硝苯地平以及酚妥拉明进行联合治疗,比较患者的治疗效果。结果联合组的治疗有效率显著高于单纯组,治疗前血压水平差异无统计学意义(P>0.05),治疗后联合组的收缩压和舒张压水平均低于单纯组,P<0.05,两组差异有统计学意义。结论对妊娠高血压综合征患者给予硫酸镁联合硝苯地平和酚妥拉明进行联合治疗,有效改善患者的血压水平。 相似文献
2.
EffectsofPhentolamineonHemorrheologyandHemodynamicsinDogswithAcuteLiverDamageDANZili(但自力);ZHANGWenying(张文英);LIShaobai(李绍白)(In... 相似文献
3.
电刺激膈神经中枢端引起降压反应的外周机理 总被引:1,自引:0,他引:1
电刺激麻醉家兔膈神经中枢端呆引起动脉血压下降,此降压反应不能被剪断双侧迷走神经所阻断;但可被静脉注射心得1.0mg/kg部分阻断;也可被静注射酚妥拉明2.0mg/kg部分阻断,去除缓冲神经后其降压效应更为明显。 相似文献
4.
5.
目的研究甲磺酸帕珠沙星对兔体内氨茶碱药动学的影响。方法采用自身对照法,以HPLC测定兔单用氨茶碱及与甲磺酸帕珠沙星合用后的茶碱血清浓度,计算药动学参数。结果经BAPP2.3药动程序拟合,甲磺酸帕珠沙星使兔血清中茶碱的曲线下面积AUC由152.0mg·h·L-1增加到361.4mg·h·L-1;半衰期t1/2由2.292h延长至6.823h;MRT由4.944h延长到9.383h,均有非常显著性差异(P<0.01)。结论家兔体内合用甲磺酸帕珠沙星对氨茶碱的消除药动学有显著抑制作用。 相似文献
6.
Okumura Katsuhiko Kiyohara Yoshifumi Komada Fusao Iwakawa Seigo Hirai Midori Fuwa Tohru 《Pharmaceutical research》1990,7(12):1289-1293
The healing effect of human epidermal growth factor (hEGF) on open wounds was studied in rats. No improvement in wound healing was found by topical application of EGF alone to open wound sites. We found an ointment containing EGF and a protease inhibitor, nafamostat mesilate or gabexate mesilate, or gelatin accelerated the healing rate of open wounds. Significant increases in the dry weight of the wound site granulation tissue, uronic acid (as an index of acid mucopolysaccharide) and hydroxyproline (as an index of collagen) were observed by treatment with EGF ointment containing nafamostat compared with the controls. The effects of the protease inhibitor on wound healing were dose dependent. Nafamostat was more efficient than gabexate or gelatin on wound healing. The degradation of 125I-EGF in wound tissue homogenate was significantly decreased in the presence of a protease inhibitor, such as nafamostat or gabexate, or gelatin. These findings indicate that the stabilization of EGF at the wound site is an important factor in permitting the expression of its healing effects and suggest that the ointment containing EGF and a stabilizing agent would be a suitable dosage form for acceleration of wound repair. 相似文献
7.
健康成年人自愿受试者10例,随机分为3组,分别住院静脉注射加贝酯200mg/d、300mg/d、400mg/d。结果除高浓度(300mg加贝酯溶于5%G-S500ml)组,在滴速60滴/min时,1例出现局部发红,疼痛及2例于停药后1周出现轻度表浅静脉炎外,未发现过敏,血压下降,ECG改变,肝、肾功能损伤等其它不良反应,说明国产加贝酯注射剂临床应用安全,成人每d可用100~400mg,以100~200mg溶于5%葡萄糖液500ml静滴为宜,但10例中有6例(60%)因药液外渗,引起局部刺激症状,故应尽量避免高浓度,快速静滴,并防止液体外溢皮下。 相似文献
8.
Kiyofumi Morishita Satomi Inoue Toshio Baba Jyun-ichi Sakata Teruhisa Kazui Tomio Abe 《Artificial organs》1997,21(7):822-824
Abstract: We have used heparin-bonded partial cardio-pulmonary bypass to support distal aortic circulation during aortic cross-clamping. However, there were no cardiotomy reservoirs with fully reliable thromboresistance. To resolve this problem, a short-acting anticoagulant (nafamostat mesilate) was added into a cardiotomy reservoir. The present study was designed to evaluate the efficacy of our distal perfusion system. From May 1995 through the end of May 1996, 27 patients underwent descending thoracic and thoracoabdominal aortic aneurysm repairs with this adjunct, 4 being excluded from the experiment. Twenty patients who had undergone conventional partial cardiopulmonary bypass were defined as the control group. There were no significant differences between the 2 groups in the morbidity, mortality, gas transfer, or transfusion requirements despite the fact that more complicated surgical procedures (shown by a two-fold increase in the prevalence of reoperation) were required in the group that had received the current distal perfusion adjunct. the heparin-bonded group. In conclusion, our perfusion system is very effective for descending thoracic and thoracoabdominal aortic aneurysm repairs. 相似文献
9.
MASASHI YOSHIDA GO WAKABAYASHI HIDEKI ISHIKAWA YOSHIHIDE OTANI MOTOHIDE SHIMAZU TETSURO KUBOTA KOICHIRO KUMAI IWAO KUROSE SOICHIRO MIURA HIROMASA ISHII MASAKI KITAJIMA 《Journal of gastroenterology and hepatology》1998,13(1):104-108
The effects of camostat mesilate, a synthetic serine protease inhibitor on gastric microcirculation and active oxygen species generated by leucocytes from the gastric and jugular veins in the early period after thermal injury were assessed. Male Wistar rats were anaesthetized and a 30% full skin-thickness dorsal burn was inflicted. Camostat mesilate (100 mg/kg) was dissolved in distilled water and administered orally to rats 40 min before thermal injury (the camostat group). The control animals (the vehicle group) were administered distilled water orally. Rolling leucocytes as well as Monastral blue B deposits in venules were observed using in vivo microscopy. Active oxygen species were measured by chemiluminescence. Camostat mesilate decreased the total length of gastric erosion, venular deposits of Monastral blue B, and rolling of leucocytes in venules, and relatively increased luminol-dependent chemiluminescence activity generated by zymosan-stimulated leucocytes 15 min after thermal injury. These results suggest that serine proteases are involved in the formation of gastric erosions and gastric microcirculatory disturbance in the early period after thermal injury. 相似文献
10.
目的 观察多巴酚丁胺、硝酸甘油、酚妥拉明对顽固性心衰(RHF)患者的疗效。方法 静脉点滴多巴酚丁胺、硝酸甘油、酚妥拉明治疗RHF患者38例,观察其临床疗效及治疗前后临床指标的变化。结果 心功能改善Ⅱ级20例(占52.6%),改善Ⅰ级(占42.1%),总有效率为94.7%。用药后心率、血压、呼吸明显好转,X线心胸比率、腹围、BUN、MOC明显下降,尿量明显增多(P值均<0.01),未见不良反应。结论 多巴酚丁胺、硝酸甘油、酚妥拉明治疗RHF安全有效。 相似文献