利用TRS建立生物医学开放存取全文期刊资源导航库

结合大连医科大学图书馆的生物医学开放存取（Open Access，OA）全文期刊资源导航库建设实践，侧重OA全文期刊资源整合，论述了应用TRS系统建立数据库的具体步骤，包括网上生物医学OA全文期刊资源的获取、建立TRS数据库、数据库在因特网的发布、数据库的维护更新等几个方面。最后提出OA全文期刊资源数据库发展前景。     

Conners教师评定量表的应用性研究及壮族常模的建立

目的　建立Conners教师评定量表(TRS)的广西壮族儿童常模并检验其信度和效度。方法　在广西壮族居住较密集的城市及县份采集抽样4～16岁壮族儿童3 3 2 8例(男173 9例,女15 89例) ,平均10 .45岁。由教师填写TRS。结果　分半信度、内在一致性信度良好。量表与Conners父母症状问卷的各分量表有显著的相关。采用相关法将TRS各因子分与总分做相关分析,结果显示各因子分与总分相关(P均<0 .0 1) ,差异具有高度显著性(P均<0 .0 1)。结论　Conners教师用评定量表适用于广西壮族儿童多动症的评估。     

German validation of the Conners Adult ADHD Rating Scales-self-report (CAARS-S) I: Factor structure and normative data

Background

Attention-deficit/hyperactivity disorder (ADHD) often persists into adulthood. Instruments for diagnosing ADHD in childhood are well validated and reliable, but diagnosis of ADHD in adults remains problematic. Attempts have been made to develop criteria specific for adult ADHD, resulting in the development of self-report and observer-rated questionnaires. To date, the Conners Adult ADHD Rating Scales (CAARS) are the international standard for questionnaire assessment of ADHD. The current study evaluates a German version of the CAARS self-report (CAARS-S).

Methods

Eight hundred and fifty healthy German control subjects were recruited to fill out the CAARS-S and to answer questions on sociodemographic variables. Explorative and confirmative factor analyses were conducted to obtain the factor structure for the German model and to replicate the factor structure of the original American model. Analyses on gender, age, and education level were calculated for normative data.

Results

The explorative factor analysis of the German sample results in a six-factor solution that explained 52% of the variance. A confirmative analysis that was based on the 42 items of the original American model showed a high model-fit. Analyses of normative data showed significant influences of age, gender, and education level on the emerging subscales.

Conclusion

Even though the explorative factor analysis yields a solution different from the American original, the confirmative factor analysis results in such a high model-fit that use of the American version is justified with respect to international multicenter studies, for which this instrument will be highly valuable.     

Distinct patterns of neuronal inputs and outputs of the juxtaparaventricular and suprafornical regions of the lateral hypothalamic area in the male rat

We have analyzed at high resolution the neuroanatomical connections of the juxtaparaventricular region of the lateral hypothalamic area (LHAjp); as a control and in comparison to this, we also performed a preliminary analysis of a nearby LHA region that is dorsal to the fornix, namely the LHA suprafornical region (LHAs). The connections of these LHA regions were revealed with a coinjection tract-tracing technique involving a retrograde (cholera toxin B subunit) and anterograde (Phaseolus vulgaris leucoagglutinin) tracer. The LHAjp and LHAs together connect with almost every major division of the cerebrum and cerebrospinal trunk, but their connection profiles are markedly different and distinct. In simple terms, the connections of the LHAjp indicate a possible primary role in the modulation of defensive behavior; for the LHAs, a role in the modulation of ingestive behavior is suggested. However, the relation of the LHAjp and LHAs to potential modulation of these behaviors, as indicated by their neuroanatomical connections, appears to be highly integrative as it includes each of the major functional divisions of the nervous system that together determine behavior, i.e., cognitive, state, sensory, and motor. Furthermore, although a primary role is indicated for each region with respect to a particular mode of behavior, intermode modulation of behavior is also indicated. In summary, the extrinsic connections of the LHAjp and LHAs (so far as we have described them) suggest that these regions have a profoundly integrative role in which they may participate in the orchestrated modulation of elaborate behavioral repertoires.     

使用比释动能校准因子测量直线加速器吸收剂量的方法

目的探讨两种使用比释动能校准因子N_k按照TRS 277与TRS 398规范测量吸收剂量方法的差异,旨在为是否可以通过比释动能校准因子N_k按照TRS 398报告测量吸收剂量提供指导。方法首先从理论上对两种校准方法的校准公式进行推导整理,然后寻找其中的差异,最后对差异进行量化;在此基础上,利用整理后的公式,计算3种常用电离室应用于6 MV与10 MV X线的校准因子,并进行比较。结果两种方法的平均偏差小于0.6%。结论可以在只有比释动能校准因子N_k的情况下,执行TRS 398规范测量直线加速器的吸收剂量。     

探讨超声体检在诊断妇科疾病中的应用价值

目的研究TAS与TRS在诊断妇科疾病中的临床应用效果。方法选择我院2012年1～12月在我院接受超声体检的妇科疾病患者268例,患者临床症状主要为阴道不规则性出血、腹痛、月经失调、痛经、停经、闭经、腹部包块等,对所有患者先行TAS检查,然后再行TRS检查。结果 TRS诊断准确率显著高于TAS诊断准确率,差异有统计学意义（P〈0.05）。结论 TRS在诊断妇科疾病中的临床效果明显优于TAS,值得临床上推广应用。     

PubMed的MEDLINE数据格式到TRS系统数据格式的转换

比较分析了PubMed中MEDLINE数据格式与TRS系统数据格式的异同,设计出格式转化程序,实现了MEDLINE数据格式到TRS数据格式的自动转换。     

Reference Dosimetry according to the New German Protocol DIN 6800-2 and Comparison with IAEA TRS 398 and AAPM TG 51

The preceding DIN 6800-2 (1997) protocol has been revised by a German task group and its latest version was published in March 2008 as the national standard dosimetry protocol DIN 6800-2 (2008 March). Since then, in Germany the determination of absorbed dose to water for high-energy photon and electron beams has to be performed according to this new German dosimetry protocol. The IAEA Code of Practice TRS 398 (2000) and the AAPM TG-51 are the two main protocols applied internationally. The new German version has widely adapted the methodology and dosimetric data of TRS-398. This paper investigates systematically the DIN 6800-2 protocol and compares it with the procedures and results obtained by using the international protocols. The investigation was performed with 6 MV and 18 MV photon beams as well as with electron beams from 5 MeV to 21 MeV. While only cylindrical chambers were used for photon beams, the measurements of electron beams were performed by using cylindrical and plane-parallel chambers. It was found that the discrepancies in the determination of absorbed dose to water among the three protocols were 0.23% for photon beams and 1.2% for electron beams. The determination of water absorbed dose was also checked by a national audit procedure using TLDs. The comparison between the measurements following the DIN 6800-2 protocol and the TLD audit-procedure confirmed a difference of less than 2%. The advantage of the new German protocol DIN 6800-2 lies in the renouncement on the cross calibration procedure as well as its clear presentation of formulas and parameters. In the past, the different protocols evoluted differently from time to time. Fortunately today, a good convergence has been obtained in concepts and methods.     

IAEA TRS398与TRS277应用于加速器输出量校准的比较

目的:通过对IAEA TRS398和TRS277号报告推荐方法在加速器输出量校准中的使用比较,分析两者之间的区别和联系,正确指导临床外照射治疗源的校准。方法:用PTW公司UNIDOS E剂量仪和PTW30013指形电离室及NE2570A型剂量仪和2571型电离室,分别按照TRS398和TRS277号报告的要求对Varian 23EX线加速器两档光子线(6 MV,10 MV)吸收剂量进行测量,并对结果进行比较。结果:不同的剂量仪和不同的测量规程得到的结果基本相同。结论:采用TRS277号报告和TRS398号报告所有仪器测量结果偏差均小于1%,结合修正因子的不确定度,认为测量结果是一致的,采用两种规程得到测量结果均是正确的。398号报告应用比277号报告简单,且更接近用户现场测量实际情况。     

No genetic association between SLC7A10 and Japanese patients with schizophrenia

Disrupted glutamatergic neurotransmission may be a pathophysiological feature in the brains from patients with schizophrenia, and glutamatergic amino acids including d-serine have been found to be involved in pathophysiology. Endogenous and exogenous d-serine have shown potential as biological markers for the pathophysiology of schizophrenia and especially as a therapeutic strategy in treatment-resistant schizophrenia (TRS). This is the first study investigating whether SLC7A10, a d-serine transporter gene, is associated with schizophrenia in Japanese patients.We investigated the association between schizophrenia in Japanese patients with SLC7A10 using six tag single nucleotide polymorphisms (SNPs). Results failed to show any association between Japanese schizophrenia and each individual SNP or with two-, three-, or four-window haplotype analyses. We also investigated whether SLC7A10 contributes to TRS in Japanese participants. Results showed no association.In conclusion, SLC7A10 had no apparent degree of association with schizophrenia as a candidate susceptibility gene in the disease per se.