全文获取类型
收费全文 | 79000篇 |
免费 | 11259篇 |
国内免费 | 4013篇 |
专业分类
耳鼻咽喉 | 1137篇 |
儿科学 | 1403篇 |
妇产科学 | 1753篇 |
基础医学 | 7900篇 |
口腔科学 | 3597篇 |
临床医学 | 11467篇 |
内科学 | 13761篇 |
皮肤病学 | 1124篇 |
神经病学 | 5295篇 |
特种医学 | 3203篇 |
外国民族医学 | 52篇 |
外科学 | 9660篇 |
综合类 | 8040篇 |
现状与发展 | 31篇 |
一般理论 | 3篇 |
预防医学 | 6550篇 |
眼科学 | 1962篇 |
药学 | 6414篇 |
61篇 | |
中国医学 | 2991篇 |
肿瘤学 | 7868篇 |
出版年
2024年 | 79篇 |
2023年 | 1883篇 |
2022年 | 1567篇 |
2021年 | 3220篇 |
2020年 | 3401篇 |
2019年 | 2567篇 |
2018年 | 3525篇 |
2017年 | 3146篇 |
2016年 | 3354篇 |
2015年 | 4228篇 |
2014年 | 5263篇 |
2013年 | 5144篇 |
2012年 | 5157篇 |
2011年 | 5599篇 |
2010年 | 4282篇 |
2009年 | 4171篇 |
2008年 | 3831篇 |
2007年 | 3623篇 |
2006年 | 3771篇 |
2005年 | 3564篇 |
2004年 | 2435篇 |
2003年 | 2338篇 |
2002年 | 2018篇 |
2001年 | 1616篇 |
2000年 | 1581篇 |
1999年 | 1776篇 |
1998年 | 1404篇 |
1997年 | 1326篇 |
1996年 | 1193篇 |
1995年 | 999篇 |
1994年 | 808篇 |
1993年 | 590篇 |
1992年 | 585篇 |
1991年 | 521篇 |
1990年 | 463篇 |
1989年 | 424篇 |
1988年 | 416篇 |
1987年 | 354篇 |
1986年 | 328篇 |
1985年 | 274篇 |
1984年 | 202篇 |
1983年 | 187篇 |
1982年 | 136篇 |
1981年 | 119篇 |
1980年 | 85篇 |
1979年 | 129篇 |
1978年 | 73篇 |
1977年 | 70篇 |
1975年 | 67篇 |
1974年 | 76篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Major depressive disorder is a serious and common neuropsychiatric disorder that affects more than 350 million people worldwide. Electroconvulsive therapy is the oldest and most effective treatment available for the treatment of severe major depressive disorder. Electroconvulsive therapy modifies structural network changes in patients with major depressive disorder and schizophrenia. And it can also affect neuroinflammatory responses and may have neuroprotective effects. Electroconvulsive therapy plays an irreplaceable role in the treatment of major depressive disorder. 相似文献
2.
3.
采用文献复习和实证研究经验的方法对《医疗质量管理办法》中涉及的医疗质量概念及相关问题进行探讨。《医疗质量管理办法》中的医疗质量的定义存在重大缺失,没有涉及医疗服务的结果,特别是患者安全。医疗质量的定义应与国际相关权威机构保持一致,应高度重视医疗服务的结果,特别是患者安全。 相似文献
4.
5.
6.
7.
目的 探讨滋肾育胎丸加减方预防抗磷脂抗体(ACA)阳性者不良妊娠结局的效果及机制研究。方法 选取2016年2月至2019年2月我院收治的89例ACA阳性,先兆性流产或有习惯性流产(RSA)史患者,将采用西医治疗的40例作为对照组,将采用西医联合滋肾育胎丸加减方治疗的49例作为观察组,比较两组中医证候疗效、中医证候积分、ACA-IgA、ACA-IgM、ACA-IgG、凝血指标[血小板聚集功能(PAF)、活化蛋白C(PC)、抗凝血酶(AT)、纤溶酶原激活抑制物-1(PAI-1)]、Th1/Th2细胞因子[干扰素γ(IFN-γ)、白介素-2(IL-2)、白介素-4(IL-4)、白介素-10(IL-10)]、妊娠结局、安全性。结果 治疗2周后检测ACA,观察组2例未降低,对照组11例未降低,观察组未降低患者占比低于对照组(P<0.05);观察组总有效率100.00%高于对照组85.00%(P<0.05);观察组治疗4周、7周后中医证候积分低于对照组(P<0.05);观察组治疗4周、7周后ACA-IgA、ACA-IgM、ACA-IgG低于对照组(P<0.05);观察组治疗4周、7周后PAF、PAI-1低于对照组,PC、AT高于对照组(P<0.05);观察组治疗4周、7周后IFN-γ、IL-2低于对照组,IL-4、IL-10高于对照组(P<0.05);观察组活产率95.92%高于对照组80.00%(P<0.05);组间不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 动态监测ACA对滋肾育胎丸加减方精准应用具有指导意义,指导滋肾育胎丸加减方通过调理脏腑、气血、经络功能,改善先兆性流产或有RSA史患者临床症状及凝血因子指标,降低ACA水平,并可改善患者免疫耐受功能,提高胎儿活产率,且安全性高。 相似文献
8.
9.
- Children with cancer receive many medications outside the hospital administered by their caregivers.
- The study by Walsh et al. shows the number and types of medication errors in these patients. The study includes data from three different centers.
- Importantly, the study shows the types of errors that cause harm. The authors describe how the harmful errors can be prevented.
- We suggest ways these results can be used to identify which patients and families will benefit from additional attention. Providing more help at clinic and in the home may help prevent harmful medication errors in children with cancer.
10.
Lei Yang You-Ling Shi Yan Ma Wei-Wei Ren Guang-Ming Pang Jiao Liu 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2022,130(1):43-52
Krüppel-like factor 16 (KLF16), a member of the Krüppel-like factor (KLF) family, has been extensively investigated in multiple cancer types. However, the role of KLF16 in oral squamous cell carcinoma (OSCC) remains unknown. Thus, we conducted this study to investigate its related mechanism. KLF16 expression in OSCC cell lines was quantified by western blotting. Then, OECM1 and OC3 cells were divided into Blank, siCtrl, siKLF16#1 and siKLF16#2 groups. Subsequently, cell proliferation was detected using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assays, cell migration and invasion were detected with wound healing and Transwell assays, and cell cycle distribution and cell apoptosis were detected via flow cytometry. KLF16, p21, CDK4, Cyclin D1 and p-Rb expression was detected by western blotting. Finally, xenograft models were established in nude mice to observe the in vivo effects of KLF16 on OSCC. KLF16 protein expression was upregulated in OSCC cells. Compared to the cells in the Blank group, the OECM1 and OC3 cells in the siKLF16#1 group and siKLF16#2 group exhibited a sharp decrease in proliferation but a remarkable increase in apoptosis. Moreover, the proportion of cells in the G0/G1 phase notably increased and that in the S phase decreased, with evident decreases in cell invasion and migration. Moreover, KLF16, cyclin-dependent kinase 4 (CDK4), Cyclin D1 and p-Rb protein expression was upregulated, but p21 expression was downregulated. The mice in the siKLF16#1 and siKLF16#2 xenograft model groups exhibited slower tumour growth and smaller tumours with evident downregulation of Ki67 expression compared to the mice in the Blank group. KLF16 expression was upregulated in OSCC cells, and interfering with KLF16 led to cell cycle arrest, inhibited OSCC cell growth and promoted cell apoptosis. 相似文献