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盆腔肿块伴腹水是卵巢癌患者就诊的常见临床表现,是否采用术前化疗尚无定论。我院自1993年起采用先化疗后手术的方法治疗卵巢癌伴腹水患者共18例,疗效较好,现报道如下。材料与方法一 病例选择 自1993年1月—1998年5月间在本院就诊的卵巢癌伴腹水患者共18例,年龄33—70岁,平均(5633±1072)岁。妇科检查及B超证实有肿块伴中至大量腹水,腹水脱落细胞检查找到恶性细胞。术后临床分期(1985年FIGO标准):Ⅰ期2例,Ⅲ期7例,Ⅳ期5例,转移性癌4例。病理诊断:浆液性腺癌9例,内膜样癌3例,粘液性癌1例,浆液性及内膜样癌1例,转移性癌4例。二 治疗方… 相似文献
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Objective To investigate natural spontaneous menopausal age , menstruation span and their relationship with menarche age and parity in Pudong district of Shanghai. Methods From Jan 2007 to Jul 2008, 15 083 spontaneous menopause women undergoing cervical cancer screening were enrolled in this study. The questionnaire included menarche age, parity, spontaneous menopausal age and menstruation span. Those women were divided into four groups based on age, which were group of 56 -60, 61 -65, 66 -70 and more than 70. Analysis of variance (ANOVA) was used for comparing difference between menopausal age and menstruation span. Multiple factor regressions was used to analyze the relationship between menarche age, parity and menopausal age and menstruation span. Results (1) Spontaneous menopausal age: the minimum was 29 years old, the maximum was 61 years old, and the mean age was (50.6 ±3.7)years old. The mean spontaneous menopause age were (50.9 ± 3.4), ( 50.7 ± 3.7 ), (50.0 ± 4.1 ), (49.6 ±4.0) years in groups of 56 -60, 61 -65, 66 -70 and more than 70 years. With the increasing age range in four groups, the increasing trends of menopausal age were observed, which the difference of 1.36 year was shown between groups of 56 - 60 and more than 70 years. (2) Menstruation span: the mean of menstruation span was (34.3 ± 4.1 ) years, which the minimal age of 12 years and maximal age of 48 years were recorded. (34.6 ± 3.8), (34.3 ± 4.1 ), (33.9 ± 4.6), (33.2 ± 4. 5) were observed in groups of 56 - 60,61 -65, 66 -70 and more than 70 years. With the increasing age range in four groups, the increasing trends of menstruation span were observed, which the difference of 1.41 year was shown between groups of 56 –60 and more than 70 years. (3)The impact of menarche age on menopausal age and menstruation span: there was no correlation between menarche age and menopausal age ( r = 0.02); however, menstruation span was found to be negatively correlated with the menarche age ( r = - 0.43 ). (4) The impact of parity on menopausal age and menstruation span: the mean menopausal age of women who had 1 -2 deliveries was significantly higher than those had no delivery or more than 3 deliveries ( P < 0.05 ). However, there was no difference in menopausal age between women with 1 and 2 deliveries or between women without delivery and more than 3 deliveries (P > 0.05). Menstruation span of women with 1 delivery was significantly longer that those with more than 1 delivery( P < 0.05 ), similarly, women with 2 deliveries had longer menstruation span than women without delivery or more than 3 deliveries(P < 0.05 ). There were no difference in menstruation span between women with more than 3 deliveries and without delivery ( P >0.05 ). (5) Multifactor regression analysis for menstruation span: menarche age was correlated with menstruation span negatively ( r = - 0.97,P <0.001 ). There was significantly different menstruation span between group of 61 -65, 66 -70 or more than 70 years and group of 56-60 (r= -0. 18, P=0.020; r= -0.78,P <0.001 and r= - 1.23,P<0.001). Menstruation span in women with 1 -2 deliveries was significantly longer than that of women without delivery or more than 3 deliveries. (6)Multifactor logistic analysis of menopausal age: there was no association between menarche age and menopausal age, however, significant differences were found in mean menopausal age between different groups, which show that menopausal age of group 56 - 60 years was significant higher than the other groups, including age-group 61 -65 years ,66 -70 years and over 70 years ( r = - 0.18, P = 0.020; r = - 0.78,P < 0.001; r = - 1.23, P < 0.001 ). Menopausal age in women with 1 - 2 deliveries was significantly higher than those of women without delivery or with more than 3 deliveries,however, no difference between women with 1 and 2 deliveries or between women without deliveries and more than 3 deliveries was observed. Conclusion (1) Menopausal age and menstruation span exhibited increasing trends in Pudong district of Shanghai. (2) Menarche age and parity were the important factors influencing menopausal age and menstruation span. (3) With younger age of menarche, the menstruation span become longer. (4) Deliveries of 1 -2 times can significantly delay the menopause and prolong menstruation span, however, the multiple deliveries ( ≥ 3 times) had no significant impact on menopausal age and menstruation span. 相似文献
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近20年来,虽然许多药物已被证实为治疗妇科肿瘤的有效药物,但仍未能有效地提高病人的生存率。因此,各国学者在已有基础上不断开发出更为有效,毒副作用更少的新药。有的新药已投入市场,有的已在进一步研究其应用价值。 相似文献
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同源框基因(Homeobox gene,Hox gene)是胚胎发育过程中编码对尿殖管、外生殖管分化发育有重要意义的一系列转录因子.该轴打开的时间及模式可决定副中肾管的发育过程,而激素是Hox基因正常的表达调控者.雌、孕激素及其受体可直接与Hox基因中雌激素受体和孕激素受体结合位点结合而调控Hox基因的表达;此外,孕激素还对内膜腺上皮Hox基因通过间质细胞介导起负调控作用;雄激素可通过雄激素受体介导机制调节Hox基因的表达;维生素D则通过与受体蛋白结合DNA结合蛋白在蛋白基因水平上起作用. 相似文献
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目的 检测不同宫颈病变组织中凋亡相关蛋白Survivin、Fas、FasL的表达,分析宫颈癌组织中Survivin与Fas/FasL表达的关系.方法 采用免疫组织化学SP法检测47例宫颈癌、25例宫颈上皮内瘤样变(CIN)、20例慢性宫颈炎及20例正常宫颈组织中Survivin、Fas和FasL的表达,分析Survivin、Fas和FasL表达与宫颈癌临床病理特征的关系.采用Spearman秩相关法分析宫颈癌组织中Survivin与Fas/FasL表达的关系.结果 Survivin在宫颈癌组织中的阳性表达率(68.1%)明显高于正常宫颈组织(0%)、慢性宫颈炎组织(15.0%)和CIN组织(36.0%),差异均有统计学意义(P<0.05);Fas在宫颈癌组织中的阳性表达率(48.9%)明显低于正常宫颈组织(90.0%)、慢性宫颈炎组织(85.0%)和CIN组织(80.0%),差异均有统计学意义(P<0.05);FasL在宫颈癌组织中的阳性表达率(93.6%)明显高于正常宫颈组织(0)、慢性宫颈炎组织(50.0%)和CIN组织(68.0%),差异也均有统计学意义(P<0.05).Survivin的表达与宫颈癌临床分期、是否有淋巴结转移有关(P<0.05);FasL的表达与宫颈癌的临床分期、病理分级、是否有淋巴结转移有关(P<0.05).宫颈癌组织中,Survivin与Fas的表达呈负相关(r=-0.517,P<0.01),与FasL的表达呈正相关(r=0.381,P<0.01).结论 宫颈癌能通过Survivin和FasL高表达及Fas低表达逃避机体免疫监视,促使肿瘤发生、发展及转移.FasL可作为宫颈癌患者病程进展和预后的预测指标之一. 相似文献
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目的 通过观察促卵泡激素(FSH)、活性氧(ROS)及其特异性抑制剂对卵巢癌细胞中红系衍生的核因子2相关因子2(nuclear factor-erythroid 2-related factor-2,Nrf2)表达的影响,探讨FSH是否通过ROS途径调控卵巢癌细胞Nrf2的表达.方法 (1)采用免疫组织化学方法检测Nrf2在卵巢癌良恶性组织中的表达.(2)用不同浓度的FSH刺激卵巢癌Hey细胞不同时间,采用蛋白质印迹法检测细胞内Nrf2蛋白的表达.(3)采用ROS检测试剂盒检测80 mIU/ml的FSH刺激后不同时间Hey细胞内ROS的生成情况.(4)Hey细胞经不同浓度的H2O2刺激48 h后,或经ROS特异性抑制剂N-乙酰半胱氨酸(NAC)预处理后加入150 mmol/L的H2O2处理48 h,观察细胞内Nrf2的表达.(5)Hey细胞经不同浓度的NAC预处理1h,加入80 mIU/ml的FSH共孵育48 h,观察细胞内Nrf2表达的变化.结果 (1)10例良性卵巢囊肿组织中仅3例有Nrf2蛋白的弱阳性表达,而64例卵巢癌组织中42例(65.6%)有Nrf2蛋白的阳性表达,两组差异有统计学意义(P=0.042).(2)FSH可上调Hey细胞内Nrf2的表达,并呈一定的剂量、时间依赖效应.(3) FSH可促进Hey细胞ROS的产生.(4) H2O2可诱导Hey细胞Nrf2蛋白的表达,且其作用可被NAC阻断.(5)NAC可阻断FSH所诱导的Nrf2蛋白的表达.结论 FSH可促进卵巢癌Hey细胞中ROS产生,上调Nrf2蛋白表达,抑制ROS途径可阻断FSH诱导的Nrf2高表达.提示FSH可能通过ROS途径调控卵巢癌Nrf2的表达,进而促进肿瘤发生. 相似文献
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