“三切面法”筛查胎儿心脏畸形的价值分析

目的探讨胎儿心脏四腔心切面加左右心室流出道切面(三切面)在产前筛查胎儿先天性心脏病的临床应用价值。方法对150例高危孕妇行胎儿心脏三切面的扫查,对异常者行详细的胎儿超声心动图检查,并与产后尸解或产后超声心动图的检查结果进行比较。结果心脏四腔切面与左右心室流出道切面检出异常12例,尸解证实7例,产后超声心动图证实5例。结论胎儿心脏四腔切面及左右心室流出道切面探测方法简单,易于掌握,对产前筛查胎儿心脏病具有重要的临床应用价值。     

超声斑点追踪技术对系统性红斑狼疮患者局部心肌收缩功能的评价

目的 应用超声斑点追踪技术(STI)评价系统性红斑狼疮(SLE)患者局部心肌收缩功能.方法 ①SLE组36例,健康对照组24名,分别记录并存储每位被检者心尖位左心室3个长轴切面高帧频二维动态图像,应用自动功能成像软件(AFI)检测左心室壁18节段收缩期峰值应变(S),记录并比较各参数测值.②在对照组中随机取20名被检者,双盲条件下,由同一观察者不同时间及2名观察者分别测量每位被检查者心肌收缩期峰值应变值,2组问计量资料比较采用非配对t检验,并利用Pearson相关分析法分析其相关性.结果 对照组左心室各壁S值自基底段向心尖段逐渐增加,心尖段与基底段、中间段差异有统计学意义(P＜0.05),不同室壁对应节段间差异无统计学意义(P＞0.05);同一室壁各节段心肌收缩期峰值应变达峰时间基本一致.SLE组除前间隔和前壁外各室壁S值自基底段向心尖段逐渐增加[(-18.7+4.2)%,(-16.3±9.4)%,(-18.1±10.5)%与(-19.0±9.0)%,(-18.6±7.9)%,(-17.7±1.4)%],心尖段与基底段、中间段差异均无统计学意义(P＞0.05);SLE组各室壁各节段S值明显低于对照组,差异均有统计学意义(P＜0.05);SLE组同一室壁各节段心肌收缩期峰值应变达峰时间一致性差.同一观察者不同时间及2名观察者问对心肌收缩期峰值应变值的测量相关性良好(P＜0.01).结论 STI技术发现SLE患者与健康对照组差异有统计学意义,SLE患者心肌损害表现为左室局部心肌收缩期峰值应变减低.

Abstract：

Objective To assess the vaIue of speckle tracking imaging (STI) in quantifying the regional myocardial strain in systemic lupus erythematosus (SLE) group.Methods ① Sixty subjects were divided into SLE group and normal group.High frame rate two-dimensional images were recorded from the apical two-chamber view,long-axis view and four-chamber view of the left ventricle (LV).Peak systolic strain of each view of 18 segments were measured by automated functional imaging (AFI) software of 2-DSE.All parameters were compared between the two groups.② Twenty cases were randomly taken from the normal group.The same observer at different times and two observers measure the strain of left ventricular respectively.The results of the measurement between the two groups were compared with unpaired t test and its relevance was analyzed using Pearson's correlation analysis.ResultsLeft ventricular two-dimensional longitudinal strain gradually increased from the base to apex in the normal group.There were statistically differences between the apical segments and the basal,middle segments of every left ventricular wall (P＜0.05).The same wall segment time to peak myocardial systolic peak strain was consistent.Left ventricular two-dimensional longitudinal strain gradually increased from the base to apex in the SLE group,except for the anterio-septal and anterior wall [ (-18.7±4.2)％,(-16.3±9.4)％,(-18.1±10.5)％ vs (-19.0±9.0)％,(-18.6±7.9)％,(-17.7±1.4)％ ].There was no statistically significant difference between the apical segments and the basal,middle segments of every left ventricular wall(P＞0.05).All parameters of S were significantly higher in the normal group than those of the SLE group.The difference was statistically signoficant (P＜0.05).The time to peak systolic peak strain of every segments was not consistent.The results from the same observer at different times and peak systolic myocardial strain measurements by the two observers were correlated well(P＜0.01).Conclusion The myocardial function assessment by STI technology in the SLE patients is significantly different from that of the normal control:SLE patients with left ventricular myocardial damage can be manifested as reduced regional myocardial systolic peak strain.     

变色马兜铃中银袋内酯乙、丙的结构测定

从变色马兜铃(Aristolochia versicolar S M Hwang)的块根中分离到两个新倍半萜内酯,分别命名为银袋内酯乙(versicolactone B)和银袋内酯丙(versicolactone C)。前者分子式C₁₅H₂₀O₃,熔点135～136℃;后者分子式C₁₅H₂₂O₄,熔点181～182℃,[α]_D³⁶—11.4°(C,2.6,EtOH)。经光谱(UV,IR,¹H NMR,¹³SCNMR,MS)分析和化学方法证明,并经x-衍射证实,两者的结构分别为(Ⅰ)和(Ⅲ)。银袋内酯丙系一新型骨架的奠类倍半萜内酯。     

变色马兜铃石油醚可溶性成分的分离和鉴定

从变色马兜铃Aristolochia versicolar S.M.Hwang块根醇提物的石油醚溶解部分中分得12个结晶性成分,其中8个化合物经化学和光谱测定分别鉴定为豆甾-4-烯-3,6-二酮、豆甾烷-3,6-二酮、β-谷甾醇、马铃兜酸A、马兜铃酸A-甲酯、6-甲氧基马兜铃次酸甲酯、胡罗卜甙和硬酯酸。其余三个可能为新化合物。经药理试验,马兜铃酸A和6-甲氧基马兜铃次酸甲酯(B_5)具抗生育作用,豆甾-4-烯-3,6-二酮具细胞毒活性。     

绿药膏中有效成分薄层鉴别方法的探讨

绿药膏中有效成分薄层鉴别方法的探讨张锁西，起霞芬，张玖（江苏省药品检验所南京２１０００８）绿药膏为江苏省地方标准收载品种［１］；该药具有良好抗菌排脓作用。绿药膏是一种复方软膏制剂；含有盐酸林可霉素及盐酸利多卡因两种主要成分。按原标准［１］，在鉴别项下...     

栽培昆明山药与铁棍山药品质比较

目的:通过鲜品折干率和干品的水浸出物、醇浸出物、淀粉、蛋白质、粗脂肪以及水溶性多糖等各项指标的测定,对比云南栽培昆明山药和河南铁棍山药的品质,以寻找优良品种。方法:上述各项指标分别采用干燥失重法、冷浸法、热浸法、碘蓝法、凯氏定氮法、索氏抽提法和分光光度法。结果:云南栽培山药的鲜品折干率略低于河南铁棍山药,干品中除粗脂肪含量低于铁棍山药外,其余各项指标均高于或等于铁棍山药,尤其是水溶性多糖,高出64%。结论:云南栽培山药品质好,且产量高,鲜品口感亦好,是值得关注的优良品种。     

灯心草化学成分研究

目的对灯心草进行化学成分研究.方法运用柱层析和波谱技术分离鉴定其化学成分.结果共分离鉴定了8个化合物,分别为木犀草素、圣草酚、2',5',5,7-四羟基黄酮、木犀草素-7-O-β-D-葡萄糖苷、对羟基苯甲酸甲酯、香草酸、棕榈酸、正十四烷.结论除木犀草素和木犀草苷外,其余六个化合物均系首次从该植物中分离得到.     

忍冬叶黄酮-磷脂复合物的降血脂作用

目的:研究忍冬叶黄酮-磷脂复合物对高脂饲料喂养鹌鹑高血脂症的影响。方法:健康雄性鹌鹑80只,随机分成6组,任意取1组设定为正常对照组喂以基础饲料,其他5组均喂高脂饲料,12 d后检测动物颈静脉血清总胆固醇(TC)和甘油三酯(TG)含量,确定已经造成高血脂模型后,喂食含忍冬叶总黄酮(20 mg.kg-1.d-1)、忍冬叶黄酮-磷脂复合物高、低剂量(80,20 mg.kg-1.d-1)的高脂饲料,45 d后检测颈静脉血清TC,TG,高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C)含量及肝脏中脂肪含量;观察肝组织切片。结果:与高脂模型组比较,忍冬叶黄酮-磷脂复合物高、低剂量组(80,20 mg.kg-1)对血清TC降低作用明显,降低率分别为55.58%,24.91%,剂量间有高度显著性差异(P<0.01);忍冬叶黄酮-磷脂复合物能减轻肝细胞水肿和脂肪浸润,使肝脏脂肪含量显著下降(P<0.05)。结论:忍冬叶黄酮-磷脂复合物具有降血脂和抗脂肪肝作用。     

STI评价原发性高血压与尿毒症左室壁增厚患者的左室纵行心肌应变

目的:应用斑点追踪技术成像(speckle tracking imaging,STI)评价原发性高血压与尿毒症左室壁增厚患者的左室纵行心肌应变。方法:正常对照组20例,原发性高血压组40例,尿毒症组30例。常规心脏数据测量后,连接胸导联心电图,分别采集心尖位3个长轴切面的二维灰阶动态图,取3个连续稳定心动周期,脱机分析18个节段收缩期峰值应变、二腔切面总应变、三腔切面总应变、四腔切面总应变及3个切面的平均总应变,记录并比较各参数测值。结果:正常对照组左室各壁收缩期峰值应变自基底段至心尖段逐渐增加;同一室壁各节段心肌收缩期峰值应变达峰时间基本一致。原发性高血压组左室前间隔中间段、心尖段与后壁中间段、心尖段,后间隔基底段收缩期峰值应变降低,与正常对照组差异有统计学意义,余室壁收缩期峰值应变、二腔切面总应变、三腔切面总应变、四腔切面总应变及3个切面的平均总应变与正常对照组差异无统计学意义;同一室壁各节段心肌应变曲线紊乱,收缩期峰值应变达峰时间一致性差。尿毒症组左室各壁收缩期峰值应变、二腔切面总应变、三腔切面总应变、四腔切面总应变及3个切面的平均总应变明显降低,与另外2组相比差异均有统计学意义;同一室壁各节段心肌应变曲线紊乱,收缩期峰值应变达峰时间一致性差。结论:STI能准确、快速地测定原发性高血压和尿毒症左室壁增厚患者左室局部心肌收缩期峰值应变的减低,提示患者左室整体收缩功能正常情况下存在节段性收缩功能降低。